| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2018: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2017: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2016: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
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| Outline of Final Research Achievements |
In hepatitis induced by Diethylnitrosamine, the cell cycle regulatory factor plays an important role for p65-induced transactivation of Ccl2. A novel small-molecule inhibitor against CCRF expression is identified by high-throughput chemical screening, and the inhibitor suppresses liver inflammation in mice. Chronic kidney disease is often exacerbated with an increase in serum retinol. The liver is the major organ responsible for retinol metabolism and the key enzymes of retinol metabolism are reduced in 5/6 nephrectomy(5/6Nx) mice. The accumulation of serum retinol induces the apoptosis of renal cells of 5/6Nx mice fed with a normal diet. The cancer stem cells are often characterized by high aldehyde dehydrogenase(ALDH) activity. Circadian expression of Aldh3a1 in ALDH-positive cells is dependent on that of WNT10a from ALDH-negative cells. The antitumor effects of ALDH inhibitor are enhanced by administration at the time of day when ALDH activity is increased in 4T1 tumor cells.
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