Proof of the next generation PET concept "Whole Gamma Imaging"

• Project/Area Number: 16H02641
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Yamaya Taiga 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 計測・線量評価部, チームリーダー(定常) (40392245)
• Co-Investigator(Kenkyū-buntansha): 菅 幹生 千葉大学, フロンティア医工学センター, 准教授 (00294281) ; 高橋 浩之 東京大学, 大学院工学系研究科(工学部), 教授 (70216753)
• Research Collaborator: Yoshida Eiji ; Nishikido Fumihiko ; Tashima Hideaki ; Obata Takayuki ; Tsuji Atsushi ; Nagatsu Kotaro ; Akram Mohammadi ; Shimazoe Kenji
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000); Fiscal Year 2018: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2017: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2016: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: 核医学 / PET / コンプトン / コンプトンカメラ / 医療・福祉 / 医工学 / 放射線計測

Outline of Final Research Achievements

In this work, we proposed a new concept of whole gamma imaging (WGI), which is a novel combination of PET and Compton imaging. An additional detector ring, which was used as the scatterer, was inserted in the field-of-view of a conventional PET ring so that single gamma rays can be detected by the Compton imaging method. We prototyped the insert geometry whereby a scatter ring (24 x 24 array of 1 x 1 x 6 mm3 GAGG crystals, 20 cm in diameter and 5 cm long) was inserted into a PET ring (16 x 16 x 4-DOI array of 2.9 x 2.9 x 7.5 mm3 GSOZ crystals, 66 cm in diameter and 22 cm long). Experimental results showed the initial feasibility of the WGI concept.

Academic Significance and Societal Importance of the Research Achievements

WGIの基本的な考え方は、検出可能なすべてのガンマ線を画像化に利用することである。PET検出器を吸収検出器として利用するコンプトンイメージングにより、単一のガンマ線でも検出できるようになる。さらに、陽電子放出と同時にガンマ線も放出する核種に対しては、PETによる同時計数線とコンプトンコーン（円錐表面）の交点として核種位置を特定できることから、ごくわずかな放射能でも体内位置を推定できるようになる可能性がある。このように、本研究成果は、従来のPETの原理自体を打ち破るものであり、より微量でより多様な診断薬の生体内画像化を可能にするものである。

Research Products

• [Int'l Joint Research] Ludwig-Maximilians-University Munich(ドイツ)
• [Int'l Joint Research] Stanford University(米国)
• [Int'l Joint Research] Ludwig-Maximilians-University Munich(ドイツ)
• [Int'l Joint Research] Stanford University(米国)
• [Int'l Joint Research] Ludwig-Maximilians-University Munich(ドイツ)
• [Int'l Joint Research] Stanford University(米国)
• [Journal Article] Dose reconstruction from PET images in carbon ion therapy: a deconvolution approach (2019)
  • Author(s): T. Hofmann, M. Pinto, A. Mohammadi, M. Nitta, F. Nishikido, Y. Iwao, H. Tashima, E. Yoshida, A. Chacon, M. Safavi-Naeini, A. Rosenfeld, T. Yamaya, K. Parodi,
  • Journal Title: Physics in Medicine & Biology Volume: 64
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Experimental validation of the FLUKA Monte Carlo code for dose and β+-emitter predictions of radioactive ion beams (2018)
  • Author(s): R. S. Augusto, A. Mohammadi, H. Tashima, E. Yoshida, T. Yamaya, A. Ferrari, K. Parodi
  • Journal Title: Physics in Medicine & Biology Volume: 63
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 次世代PET装置開発研究～部位別からリアルタイムへ～ (2018)
  • Author(s): 山谷泰賀
  • Organizer: 第28回日本心臓核医学会総会・学術大会
  • Invited
• [Presentation] Next-Generation Application-Dedicated PET Systems (2018)
  • Author(s): 山谷泰賀
  • Organizer: 第1回量子線イメージング研究会
  • Invited
• [Presentation] 未来PETプロジェクト-OpenPET，頭部専用PET，そしてWGI- (2018)
  • Author(s): 山谷泰賀
  • Organizer: JSRT 2018年度 近畿支部 秋季勉強会
  • Invited
• [Presentation] Current Status of NIRS Imaging Physics Research (2018)
  • Author(s): Taiga Yamaya
  • Organizer: Workshop on Multiple Photon Coincidence Imaging
  • Int'l Joint Research / Invited
• [Presentation] Monolithic LaBr3(Ce) absorber and segmented GAGG scatter detectors in a Compton camera arrangement for medical imaging (2018)
  • Author(s): S. Liprandi, S. Takyu, T. Binder, G. Dedes, K. Kamada, M. Kawula, R. Lutter, F. Nishikido, I. I. Valencia, R. Viegas, T. Yamaya, K. Parodi, P. G. Thirolf
  • Organizer: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Dose Quantification in Carbon Therapy using In-Beam Positron Emission Tomography (2018)
  • Author(s): H. J. Rutherford, A. Chacon, S. Guatelli, Y. Iwao, H. Tashima, E. Yoshida, F. Nishikido, A. Kitagawa, M. Nitta, S. Takyu, G. Akamatsu, T. Hofmann, A. Mohammadi, K. Parodi, T. Yamaya, M. - C. Gregoire, A. B. Rozenfeld, M. Safavi-Naeini
  • Organizer: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Development of silicon detectors of whole gamma imager for low energy gamma ray measurement (2018)
  • Author(s): F. Nishikido, M. Uenomachi, Z. Zhihong, K. Shimazoe, Y. Okumura, E. Yoshida, H. Tashima, K. Parodi, H. Takahashi, T. Yamaya
  • Organizer: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Development of the 4-Layer GAGG DOI Detector for a Scatterer of Compton Camera (2018)
  • Author(s): S. Takyu, E. Yoshida, N. Inadama, F. Nishikido, M. Nitta, K. Kamada, K. Parodi, T. Yamaya
  • Organizer: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Validation of Geant4 Monte Carlo Toolkit Physics Models for Use in Heavy Ion Therapy (2018)
  • Author(s): A. Chacon, H. J. Rutherford, A. Mohammadi, T. Yamaya, G. Akamatsu, Y. Iwao, H. Tashima, M. Nitta, S. Takyu, F. Nishikido, A. Kitagawa, T. Hofmann, M. Pinto, K. Parodi, M. - C. Gregoire, A. B. Rozenfeld, S. Guatelli, M. Safavi-Naeini
  • Organizer: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Sensitivity improvement in 44Sc whole gamma imaging: simulation study (2018)
  • Author(s): Y. Okumura, E. Yoshida, H. Tashima, M. Suga, N. Kawachi, K. Parodi, T. Yamaya
  • Organizer: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Compton-PET imaging of 10C for Range Verification of Carbon Ion Therapy (2018)
  • Author(s): A. Mohammadi, E. Yoshida, Y. Okumura, M. Nitta, F. Nishikido, A. Kitagawa, K. Kamada, K. Parodi, T. Yamaya
  • Organizer: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] 新しいコンセプトの装置「Whole Gamma Imaging」における陽電子・ガンマ線同時放出核種イメージングのための検出器応答関数の提案 (2018)
  • Author(s): 田島英朗, 吉田英治, 奥村勇介, 菅幹生, 河地有木, 鎌田圭, Katia Parodi, 山谷泰賀
  • Organizer: 第37回日本医用画像工学会大会
• [Presentation] Whole gamma imaging (WGI) concept: simulation study of triple-gamma imaging (2017)
  • Author(s): Taiga Yamaya, Eiji Yoshida, Hideaki Tashima, Atsushi Tsuji, Kotaro Nagatsu, Mitsutaka Yamaguchi, Naoki Kawachi, Yusuke Okumura, Mikio Suga, Katia Parodi
  • Organizer: SNMMI 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Whole gamma imaging (WGI) concept: demonstration of 44Sc triple gamma imaging (2017)
  • Author(s): Taiga Yamaya, Eiji Yoshida, Kotaro Nagatsu, Hideaki Tashima, Yusuke Okumura, Mikio Suga, Naoki Kawachi, Kei Kamada, Peter G. Thirolf, Katia Parodi
  • Organizer: 2017 World Molecular Imaging Congress
  • Int'l Joint Research
• [Presentation] Whole gamma imaging: a simulation study of a novel combination of PET and Compton imaging (2017)
  • Author(s): Taiga Yamaya, Eiji Yoshida, Hideaki Tashima, Yusuke Okumura, Mikio Suga, Naoki Kawachi, Katia Parodi
  • Organizer: The 12th Asia Oceania Congress of Nuclear Medicine and Biology (AOCNMB 2017)
  • Int'l Joint Research
• [Presentation] Development of a DOI-based Compton camera for nuclear medicine application (2017)
  • Author(s): S. Takyu, S. Liprandi, F. Nishikido, A. Mohammadi, E. Yoshida, S. Aldawood, T. Binder, M. Mayerhofer, R. Lutter, I. I. Valencia Lozano, G. Dedes, K. Kamada, K. Parodi, P. G. Thirolf, T. Yamaya
  • Organizer: 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Characterization of a Compton camera setup with monolithic LaBr3(Ce) absorber and segmented GAGG scatter detectors (2017)
  • Author(s): S. Liprandi, S. Takyu, S. Aldawood, T. Binder, G. Dedes, K. Kamada, R. Lutter, M. Mayerhofer, A. Miani, A. Mohammadi, F. Nishikido, D. R. Schaart, I. I. Valencia Lozano, E. Yoshida, T. Yamaya, K. Parodi, P. G. Thirolf
  • Organizer: 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Concrete realization of the whole gamma imaging concept (2017)
  • Author(s): Eiji Yoshida, Hideaki Tashima, Yusuke Okumura, Mikio Suga, Naoki Kawachi, Kei Kamada, Katia Parodi, Taiga Yamaya
  • Organizer: 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Whole gamma imaging concept: feasibility study of triple-gamma imaging (2017)
  • Author(s): Taiga Yamaya, Eiji Yoshida, Hideaki Tashima, Yuto Nagao, Mitsutaka Yamaguchi, Naoki Kawachi, Makoto Sakai, Yusuke Okumura, Mikio Suga, Katia Parodi
  • Organizer: 第113回日本医学物理学会学術大会
• [Presentation] Whole gamma imaging concept: Compton-PET imaging simulation for positron emitters (2017)
  • Author(s): Yusuke Okumura, Mikio Suga, Hideaki Tashima, Makoto Sakai, Mitsutaka Yamaguchi, Yuto Nagao, Naoki Kawachi, Taiga Yamaya, Eiji Yoshida
  • Organizer: 第113回日本医学物理学会学術大会
• [Presentation] 新しいコンプトンPET装置の3ガンマイメージングシミュレーション (2017)
  • Author(s): 奥村勇介, 吉田英治, 田島英朗, 菅幹生, 河地有木, Katia Parodi, 山谷 泰賀
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] Whole gamma imaging (WGI)コンセプト －PETとコンプトンイメージングを組み合わせた新手法への挑戦－ (2017)
  • Author(s): 山谷泰賀
  • Organizer: 電子情報通信学会 医用画像研究会(MI), 特別講演
  • Invited
• [Presentation] シンチレータ単結晶は適材適所!? 陽電子断層撮影法(PET)の次世代機の研究開発 (2017)
  • Author(s): 山谷泰賀
  • Organizer: 結晶成長の科学と技術第161委員会第102回研究会「放射線と結晶を用いた分析技術」
  • Invited
• [Presentation] コンプトンカメラ・PET装置の散乱検出器の試作 (2017)
  • Author(s): 田久創大, 吉田英治, 錦戸文彦, 新田宗孝, 鎌田圭, 山谷泰賀
  • Organizer: 第65回応用物理学会春季学術講演会
• [Presentation] Whole gamma imaging (2017)
  • Author(s): Taiga Yamaya, Katia Parodi
  • Organizer: International Open Laboratory Symposium
  • Place of Presentation: 放射線医学総合研究所（千葉県千葉市）
  • Int'l Joint Research / Invited
• [Presentation] PET Innovations at NIRS - How Imaging Improes Quality of Life (2016)
  • Author(s): Taiga Yamaya
  • Organizer: the 5th Intl. Conf. on Informatics, Electronics & Vision (ICIEV)
  • Place of Presentation: Dhaka大学（バングラディッシュ）
  • Int'l Joint Research / Invited
• [Presentation] Sensitivity and spatial resolution simulation of a PET-Compton insert imaging system (2016)
  • Author(s): Eiji Yoshida, Hideaki Tashima, Craig S. Levin, Katia Parodi, Taiga Yamaya
  • Organizer: 2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Strasbourg（フランス）
  • Int'l Joint Research
• [Presentation] Geant4 simulation study of a Compton-PET imaging system using advanced 3D positioning detectors (2016)
  • Author(s): Jianyong Jiang, Eiji Yoshida, Hideaki Tashima, Kohei Shinohara, Mikio Suga, Taiga Yamaya
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Remarks] 次世代PET研究報告2018
  • URL: https://www.nirs.qst.go.jp/usr/medical-imaging/ja/study/pdf/QST_R_11.pdf
• [Remarks] 次世代PET研究報告書2017
  • URL: http://www.nirs.qst.go.jp/usr/medical-imaging/ja/study/pdf/QST_R_7.pdf
• [Remarks] 次世代PET研究報告書2016
  • URL: http://www.nirs.qst.go.jp/usr/medical-imaging/ja/study/pdf/QST_R_4.pdf
• [Patent(Industrial Property Rights)] 部分リングPET装置及びPET装置 (2017)
  • Inventor(s): 山谷泰賀, 田島英朗
  • Industrial Property Rights Holder: 量子科学技術研究開発機構
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017-02-20