Prospective cohort study for dementia and depression in the Hisayama elderly population based on brain MRI

• Project/Area Number: 16H02644
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyushu University
• Principal Investigator: Ninomiya Toshiharu 九州大学, 医学研究院, 教授 (30571765)
• Co-Investigator(Kenkyū-buntansha): 神庭 重信 九州大学, 医学研究院, 教授 (50195187) ; 北園 孝成 九州大学, 医学研究院, 教授 (70284487) ; 秦 淳 九州大学, 医学研究院, 准教授 (00448432) ; 小原 知之 九州大学, 医学研究院, 助教 (20623630) ; 吉田 大悟 九州大学, 医学研究院, 助教 (10596828)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000); Fiscal Year 2018: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2017: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000); Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 認知症 / うつ病 / 疫学研究 / 頭部MRI / 危険因子 / 頭部MRI検査 / 前向きコホート研究 / 脳画像研究 / 脳・神経、脳神経疾患

Outline of Final Research Achievements

In this study, we investigate the risk factors for the brain structural change by using brain MRI data in the Hisayama elderly population. In 2017, we completed the Brain MRI examination in the Hisayama residents aged 65 years or older. In addition, we have reported the prevalence of microbleeds and their risk factors in the English journal. In 2018, we estimated the association between albuminuria and white matter lesion. As a consequence, higher albuminuria level was significantly associated with greater volume of white matter lesion. Moreover, the investigation regarding the association between serum glycated albumin level and brain volume found the significant negative association between serum glycated albumin level and brain volume, especially hippocampal volumes. We will report these results in English journals.

Academic Significance and Societal Importance of the Research Achievements

精度の高い久山町の前向きコホート研究の成績に頭部MRI検査による詳細な画像データを加えることにより、脳の形態学的変化が将来の認知機能低下及び認知症・うつ病の発症に及ぼす影響を明らかにするとともに、脳形態の縦断的変化に寄与する危険因子を同定する。この研究から得られる成果は、わが国の高齢者における認知症やうつ病の病態解明やその予防対策の確立に寄与し、引いては国民の保健・医療・福祉の向上につながることが期待される。

Research Products

• [Journal Article] Prevalence of adult epilepsy in a general Japanese population: The Hisayama study (2019)
  • Author(s): Tanaka Akihiro、Hata Jun、Akamatsu Naoki、Mukai Naoko、Hirakawa Yoichiro、Yoshida Daigo、Kishimoto Hiro、Ohara Tomoyuki、Mizuno Toshiki、Tsuji Sadatoshi、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Epilepsia Open Volume: 4 Issue: 1 Pages: 182-186
  • DOI: 10.1002/epi4.12295
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study (2018)
  • Author(s): Ohara Tomoyuki、Hata Jun、Tanaka Masashi、Honda Takanori、Yamakage Hajime、Yoshida Daigo、Inoue Takayuki、Hirakawa Yoichiro、Kusakabe Toru、Shibata Mao、Teraoka Tadashi、Kitazono Takanari、Kanba Shigenobu、Satoh-Asahara Noriko、Ninomiya Toshiharu
  • Journal Title: Annals of Neurology Volume: 85 Issue: 1 Pages: 47-58
  • DOI: 10.1002/ana.25385
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community (2018)
  • Author(s): Yubi Tomohiro、Hata Jun、Ohara Tomoyuki、Mukai Naoko、Hirakawa Yoichiro、Yoshida Daigo、Gotoh Seiji、Hirabayashi Naoki、Furuta Yoshihiko、Ago Tetsuro、Kitazono Takanari、Kiyohara Yutaka、Ninomiya Toshiharu
  • Journal Title: Neurology: Clinical Practice Volume: 8 Issue: 3 Pages: 223-231
  • DOI: 10.1212/cpj.0000000000000464
  • Peer Reviewed
• [Journal Article] Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study (2018)
  • Author(s): Shibata Mao、Ohara Tomoyuki、Yoshida Daigo、Hata Jun、Mukai Naoko、Kawano Hiroyuki、Kanba Shigenobu、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Journal of Affective Disorders Volume: 237 Pages: 73-79
  • DOI: 10.1016/j.jad.2018.05.004
  • Peer Reviewed
• [Journal Article] Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: The Hisayama Study (2018)
  • Author(s): Furuta Yoshihiko、Hata Jun、Mukai Naoko、Hirakawa Yoichiro、Ago Tetsuro、Kitazono Takanari、Kiyohara Yutaka、Ninomiya Toshiharu
  • Journal Title: Atherosclerosis Volume: 273 Pages: 84-90
  • DOI: 10.1016/j.atherosclerosis.2018.04.010
  • Peer Reviewed
• [Journal Article] A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: The Hisayama study (2018)
  • Author(s): Tanaka Masashi、Honda Takanori、Yamakage Hajime、Hata Jun、Yoshida Daigo、Hirakawa Yoichiro、Shibata Mao、Inoue Takayuki、Kusakabe Toru、Satoh-Asahara Noriko、Ninomiya Toshiharu
  • Journal Title: Diabetes Research and Clinical Practice Volume: 146 Pages: 225-232
  • DOI: 10.1016/j.diabres.2018.10.007
  • Peer Reviewed
• [Journal Article] Association of daily sleep duration with the risk of dementia and mortality in a Japanese community (2018)
  • Author(s): Tomoyuki Ohara, Takanori Honda, Jun Hata, Daigo Yoshida, Naoko Mukai, Yoichiro Hirakawa, Mao Shibata, Hiro Kishimoto, Takanari Kitazono, Shigenobu Kanba, Toshiharu Ninomiya
  • Journal Title: Journal of the American Geriatrics Society Volume: in press Issue: 10 Pages: 1911-1918
  • DOI: 10.1111/jgs.15446
  • Peer Reviewed / Open Access
• [Journal Article] White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study. (2017)
  • Author(s): Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Hypertens Res Volume: 40 Issue: 11 Pages: 937-943
  • DOI: 10.1038/hr.2017.74
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. (2017)
  • Author(s): Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: Circulation Volume: 136 Issue: 6 Pages: 516-525
  • DOI: 10.1161/circulationaha.116.025667
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Morning and Evening Blood Pressures Are Associated With Intima-Media Thickness in a General Population ― The Hisayama Study ― (2017)
  • Author(s): Sakata S, Hata J, Fukuhara, M, Yonemoto, K, Mukai N, Yoshida D, Kishimoto H, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Circulation Journal Volume: 81 Issue: 11 Pages: 1647-1653
  • DOI: 10.1253/circj.CJ-16-1306
  • NAID: 130006179861
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study (2017)
  • Author(s): Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: J Am Heart Assoc Volume: 7
  • Peer Reviewed / Open Access
• [Journal Article] Alternative measures of hyperglycemia and risk of alzheimer's disease in the community: the Hisayama Study. (2017)
  • Author(s): Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: J Clin Endocrinol Metab Volume: 102 Issue: 8 Pages: 3002-3010
  • DOI: 10.1210/jc.2017-00439
  • Peer Reviewed
• [Journal Article] Dietary protein intake and stroke risk in a general Japanese population: the Hisayama Study (2017)
  • Author(s): Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Stroke Volume: 48 Issue: 6 Pages: 1478-1486
  • DOI: 10.1161/strokeaha.116.016059
  • Peer Reviewed
• [Journal Article] Trends in dementia prevalence, incidence, and survival rate in a Japanese community (2017)
  • Author(s): Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y.
  • Journal Title: Neurology Volume: 印刷中 Issue: 20 Pages: 1925-1932
  • DOI: 10.1212/wnl.0000000000003932
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study. (2016)
  • Author(s): 4.Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
  • Journal Title: Diabetes Care Volume: 39 Issue: 9 Pages: 1543-1549
  • DOI: 10.2337/dc15-2800
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Combination of <i>Helicobacter pylori</i> Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study (2016)
  • Author(s): 5.Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Journal of Epidemiology Volume: 26 Issue: 12 Pages: 629-636
  • DOI: 10.2188/jea.JE20150258
  • NAID: 130005179539
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serum angiopoietin-like protein 2 (ANGPTL2) is a novel risk factor for cardiovascular disease in the community: the Hisayama Study. (2016)
  • Author(s): Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y & Ninomiya T.
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 36 Issue: 8 Pages: 1686-1691
  • DOI: 10.1161/atvbaha.116.307291
  • Peer Reviewed / Open Access
• [Journal Article] Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood: the Hisayama Study. (2016)
  • Author(s): 2.Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M.
  • Journal Title: BMC Psychiatry Volume: 16 Issue: 1 Pages: 215-215
  • DOI: 10.1186/s12888-016-0926-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community – The Hisayama Study – (2016)
  • Author(s): 1.Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: Circulation Journal Volume: 80 Issue: 8 Pages: 1857-1862
  • DOI: 10.1253/circj.CJ-16-0030
  • NAID: 130005166109
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 食事と認知症の関係：久山町研究 (2018)
  • Author(s): 二宮利治
  • Organizer: 第15回日本口腔ケア学会総会・学術大会
  • Invited
• [Presentation] 血圧日間変動と認知症発症との関連：久山町研究 (2018)
  • Author(s): 二宮利治
  • Organizer: 第61回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 健康寿命延伸に必要な認知症予防対策 (2018)
  • Author(s): 二宮利治
  • Organizer: 第54回日本循環器病予防学会学術集会
  • Invited
• [Presentation] 血糖指標とアルツハイマー型認知症：久山町研究の成績より (2018)
  • Author(s): 二宮利治
  • Organizer: 第25回日本未病システム学会学術総会
  • Invited
• [Presentation] Serum soluble TREM2 and risk of dementia: the Hisayama Study (2018)
  • Author(s): Ohara T, Kanba S, Masashi Tanaka M, Yamakage H, Iwaki T, Inoue T, Sato-Asahara N, Ninomiya T
  • Organizer: 第40回日本生物学的精神医学会
• [Presentation] 認知症の危険因子・防御因子：久山町研究 (2018)
  • Author(s): 小原知之, 二宮利治
  • Organizer: 第37回日本認知症学会
  • Invited
• [Presentation] Epidemiological burden of metabolic disorders in a Japanese community: the Hisayama Study (2017)
  • Author(s): Ninomiya T
  • Organizer: The 21th International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017)
  • Int'l Joint Research / Invited
• [Presentation] Japanese perspectives on dietary patterns and dementia (2017)
  • Author(s): Ninomiya T
  • Organizer: IDF World Dairy Summit
  • Int'l Joint Research / Invited
• [Presentation] 地域住民の未破裂脳動脈瘤：久山町研究 (2017)
  • Author(s): 二宮利治
  • Organizer: 第26回日本脳ドック学会総会
  • Invited
• [Presentation] 血圧日間変動と認知症発症との関連：久山町研究 (2017)
  • Author(s): 二宮利治
  • Organizer: 第40回日本高血圧学会総会
  • Invited
• [Presentation] 地域住民における糖尿病と脳疾患の関係：久山町研究 (2017)
  • Author(s): 二宮利治
  • Organizer: 第52回糖尿病学の進歩
  • Invited
• [Presentation] Elevated 2-hour postload glucose levels and longer duration of diabetes are risk factors for hippocampal atrophy in elderly Japanese: the Hisayama Study (2016)
  • Author(s): Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Gotoh, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya
  • Organizer: 第76回 米国糖尿病学会議
  • Place of Presentation: ニューオリンズ (Ernest N. Morial Convention Center)
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Presentation] 地域高齢住民における微小脳出血の有病率と危険因子 - 久山町研究 - (2016)
  • Author(s): 由比智裕、秦淳、永田雅治、向井直子、平林直樹、吾郷哲朗、北園孝成、清原裕、二宮利治
  • Organizer: 第41回日本脳卒中学会総会
  • Place of Presentation: 札幌(ロイトン札幌)
  • Year and Date: 2016-04-16