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Undertanding the heterogeity of chronic airway diseases and their potential treatment strategies based on phenoypes

Research Project

Project/Area Number 16H02652
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionHokkaido University

Principal Investigator

Masaharu Nishimura  北海道大学, 医学研究院, 名誉教授 (00208224)

Co-Investigator(Kenkyū-buntansha) 鈴木 雅  北海道大学, 大学病院, 助教 (10374290)
今野 哲  北海道大学, 医学研究院, 教授 (20399835)
清水 薫子  北海道大学, 大学病院, 特任助教 (40399853)
牧田 比呂仁  北海道大学, 医学研究院, 客員研究員 (70533537)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2019: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2018: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2017: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2016: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Keywords気管支喘息 / COPF / コホート / 閉塞性肺疾患 / COPD / 慢性閉塞性肺疾患 / コホート研究 / オーバーラップ
Outline of Final Research Achievements

Hokkaido Severe Asthma Cohot Study: Adominal visceral and subcutaneous fat were assessed by computed tomography (CT) scan in 206 asthmatic subjects.We demonstraed that only abdominal visceral fat was associated with low AQLQ, higher gastroesophageal reflux disease (GERD) and depression scores.
We have bee analyzed the factors associated with annual decline in FEV1 for 6 years follow-up and will present the data this year. PIRICA study:Now a total of 700 suvjects werte enrolled to this study. The final goal of the number of subjects will be 1150, and will be complerted by enf of this year.

Academic Significance and Societal Importance of the Research Achievements

慢性気道炎症、気流閉塞を特徴とする気管支喘息と慢性閉塞性肺疾患(COPD)は、独自の定義と異なる研究施設により別個に扱われてきた。喘息研究では喫煙者が除外され、COPD研究では喘息症状を有する患者が除外され、高い喫煙率を有し高齢化社会を迎える本邦において、閉塞性障害を有する大半の患者が研究対象外となっている。近年、両疾患の共通病態を示す群が注目され、喘息-COPDオーバーラップ(ACO)という疾患概念が提唱された。本研究では前向き観察研究の結果を元に、気管支喘息とCOPDの共通病態及び閉塞性肺疾患の多様性の理解に向け、実臨床に還元すべくエビデンスを構築することを目的とする。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (13 results)

All 2019 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (7 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Serum alpha-1 antitrypsin levels and the clinical course of chronic obstructive pulmonary disease2019

    • Author(s)
      Takei N, Suzuki M, Makita H, Konno S, Shimizu K, Kimura H, Kimura H, Nishimura M
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 14 Pages: 2885-2893

    • DOI

      10.2147/copd.s225365

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Annual change in FEV1 in elderly 10-year survivors with established chronic obstructive pulmonary disease.2019

    • Author(s)
      Suzuki M, Nishimura M, et al.
    • Journal Title

      Sci Rep

      Volume: 14 Issue: 1 Pages: 2073-2073

    • DOI

      10.1038/s41598-019-38659-8

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms.2019

    • Author(s)
      Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M
    • Journal Title

      The Journal of Allergy and Clinical Immunology: In Practice.

      Volume: 7 Issue: 4 Pages: 1222-1229

    • DOI

      10.1016/j.jaip.2018.11.014

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers.2017

    • Author(s)
      Kimura H, et al
    • Journal Title

      Ann Am Thorac Soc

      Volume: 14 Issue: 3 Pages: 332-341

    • DOI

      10.1513/annalsats.201606-463oc

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computed tomography (CT)-assessed bronchodilation induced by inhaled indacaterol and glycopyrronium/indacaterol in COPD.2016

    • Author(s)
      Shimizu K, et al.
    • Journal Title

      Respir Med

      Volume: 119 Pages: 70-77

    • DOI

      10.1016/j.rmed.2016.08.020

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asthma-like Features and Clinical Course of Chronic Obstructive Pulmonary Disease. An Analysis from the Hokkaido COPD Cohort Study.2016

    • Author(s)
      Suzuki M, et al
    • Journal Title

      Am J Respir Crit Med

      Volume: 194 Issue: 11 Pages: 1358-1365

    • DOI

      10.1164/rccm.201602-0353oc

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] COPDにおける呼吸機能のパラメータと胸郭内/外気道内腔体積実測値ならびに肺容量に対する比との関連2019

    • Author(s)
      小熊昴、清水薫子、鈴木 雅、今野 哲、西村正治
    • Organizer
      日本呼吸器学会学術講演会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Determination of cut-off value of Th2 markers for prediction of future exacerbation in severe asthma2019

    • Author(s)
      Kimura H, KonnoS, Shimiuzu K, Suzxuki M, Nishimura M.
    • Organizer
      American Thoracic Society Annual Congress
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 北海道COPDコホート研究における死亡原因からみたCOPDの自然史2019

    • Author(s)
      牧田比呂仁、鈴木 雅、清水薫子、今野 哲、西村正治
    • Organizer
      日本呼吸器学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] COPDにおける呼吸機能のパラメータと胸郭内/外気道内腔体積実測値ならびに肺容量に対する比との関連2019

    • Author(s)
      小熊昴、清水薫子、鈴木 雅、今野 哲、西村正治
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 北海道COPDコホート研究における死亡原因からみたCOPDの自然史2019

    • Author(s)
      牧田比呂仁、鈴木 雅、清水薫子、今野 哲、西村正治
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Asthma-like Features and Clinical Course of Chronic Obstructive Pulmonary Disease. An Analysis from the Hokkaido COPD Cohort Study.2016

    • Author(s)
      Suzuki M, et al
    • Organizer
      Am Thorac Soc International meeting
    • Place of Presentation
      San Francisco, US
    • Year and Date
      2016-05-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers.2016

    • Author(s)
      Kimura H, et al
    • Organizer
      Am Thorac Soc International meeting
    • Place of Presentation
      San Francisco, US
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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