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Hematopoietic stem cell control by amino acids and development of novel therapeutic methods

Research Project

Project/Area Number 16H02661
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

Hiromitsu Nakauchi  東京大学, 医科学研究所, 特任教授 (40175485)

Co-Investigator(Kenkyū-buntansha) 山崎 聡  東京大学, 医科学研究所, 特任准教授 (50625580)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000)
Fiscal Year 2018: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2017: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Keywords造血幹細胞 / 骨髄ニッチ / アミノ酸 / バリン / BCAA / 骨髄移植 / アミノ酸バランス / 骨髄微小環境 / 骨髄環境 / 造血幹細胞移植学 / 培地
Outline of Final Research Achievements

A specialized bone marrow microenvironment (niche) regulates hematopoietic stem cell (HSC) self-renewal and commitment. For successful donor-HSC engraftment, the niche must be emptied via myeloablative irradiation or chemotherapy. However, myeloablation can cause severe complications and even mortality. We found that the essential amino acid valine is indispensable for the proliferation and maintenance of HSCs. Both mouse and human HSCs failed to proliferate when cultured in valine-depleted conditions. In mice fed a valine-restricted diet, HSC frequency fell dramatically within 1 week. Furthermore, dietary valine restriction emptied the mouse bone marrow niche and afforded donor-HSC engraftment without chemoirradiative myeloablation. These project findings a critical role for valine in HSC maintenance and suggest that dietary valine restriction may reduce iatrogenic complications in HSC transplantation.

Academic Significance and Societal Importance of the Research Achievements

研究期間内に我々は,造血にアミノ酸のバランスが非常に重要であることが示された。これらの発見は今後の骨髄ニッチの機能および造血についてのさらなる研究が期待される。また,造血幹細胞と骨髄ニッチとの相互作用と同様の概念が白血病幹細胞においても提唱されていることから、バリンの欠乏した環境が造血幹細胞と同様に白血病細胞など悪性腫瘍においても効果が期待でき、アミノ酸の制御は移植の前処置やがんの分野においても新しい治療法となる可能性が示唆できることから、社会的な意義や波紋は大きかった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (45 results)

All 2019 2018 2017 2016

All Journal Article (24 results) (of which Int'l Joint Research: 24 results,  Peer Reviewed: 24 results,  Open Access: 14 results,  Acknowledgement Compliant: 7 results) Presentation (15 results) (of which Int'l Joint Research: 9 results,  Invited: 15 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 3 results)

  • [Journal Article] Changing concepts in hematopoietic stem cells.2018

    • Author(s)
      Yamamoto R, Wilkinson AC, Nakauchi H.
    • Journal Title

      Science

      Volume: 362 Issue: 6417 Pages: 895-896

    • DOI

      10.1126/science.aat7873

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.2018

    • Author(s)
      van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE.
    • Journal Title

      Cell Rep

      Volume: 25 Issue: 5 Pages: 1109-1117

    • DOI

      10.1016/j.celrep.2018.10.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.2018

    • Author(s)
      1.Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 15855-15867

    • DOI

      10.1038/s41598-018-34193-1

    • NAID

      120006534582

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.2018

    • Author(s)
      Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.
    • Journal Title

      Stem Cell Reports.

      Volume: 11(4) Issue: 4 Pages: 988-997

    • DOI

      10.1016/j.stemcr.2018.08.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.2018

    • Author(s)
      Ishizuka S, Lai CY, Otsu M, Nakauchi H, Nagamune T, Kawahara M.
    • Journal Title

      ACS Synth Biol.

      Volume: 7 Issue: 7 Pages: 1709-1714

    • DOI

      10.1021/acssynbio.8b00163

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress2018

    • Author(s)
      Tadokoro Yuko、Hoshii Takayuki、Yamazaki Satoshi、Eto Koji、Ema Hideo、Kobayashi Masahiko、Ueno Masaya、Ohta Kumiko、Arai Yuriko、Hara Eiji、Harada Kenichi、Oshima Masanobu、Oshima Hiroko、Arai Fumio、Yoshimura Akihiko、Nakauchi Hiromitsu、Hirao Atsushi
    • Journal Title

      Cell Stem Cell

      Volume: 22 Issue: 5 Pages: 713-725

    • DOI

      10.1016/j.stem.2018.04.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.2018

    • Author(s)
      Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.
    • Journal Title

      Exp Hematol.

      Volume: 63 Pages: 12-16

    • DOI

      10.1016/j.exphem.2018.04.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.2018

    • Author(s)
      Yamamoto, R., Wilkinson, A.C., Ooehara, J., Lan, X., Lai, C.Y., Nakauchi, Y., Pritchard, J.K., and Nakauchi, H.
    • Journal Title

      Cell Stem Cell

      Volume: 22 Issue: 4 Pages: 600-607

    • DOI

      10.1016/j.stem.2018.03.013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors2018

    • Author(s)
      Saka Koichiro、Lai Chen-Yi、Nojima Masanori、Kawahara Masahiro、Otsu Makoto、Nakauchi Hiromitsu、Nagamune Teruyuki
    • Journal Title

      Stem Cell Rev. Rep.

      Volume: 14 Issue: 1 Pages: 101-109

    • DOI

      10.1007/s12015-017-9768-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PhysiologicalSrsf2P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice2017

    • Author(s)
      Kon Ayana、Yamazaki Satoshi、Nannya Yasuhito、Kataoka Keisuke、Ota Yasunori、Nakagawa Masahiro Marshall、Yoshida Kenichi、Shiozawa Yusuke、Morita Maiko、Yoshizato Tetsuichi、Sanada Masashi、Nakayama Manabu、Koseki Haruhiko、Nakauchi Hiromitsu、Ogawa Seishi
    • Journal Title

      Blood

      Volume: 131 Issue: 6 Pages: 621-635

    • DOI

      10.1182/blood-2017-01-762393

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method.2017

    • Author(s)
      Tajima Y, Ito K, Umino A, Wilkinson AC, Nakauchi H, Yamazaki S
    • Journal Title

      Sci Rep

      Volume: 18 Issue: 1 Pages: 40684-40684

    • DOI

      10.1038/srep40684

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 1.An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors.2017

    • Author(s)
      Ieyasu A, Ishida R, Kimura T, Morita M, Wilkinson AC, Sudo K, Nishimura T, Ohehara J, Tajima Y, Lai CY, Otsu M, Nakamura Y, Ema H, Nakauchi H, Yamazaki S
    • Journal Title

      Stem Cell Reports

      Volume: 14 Issue: 3 Pages: 500-508

    • DOI

      10.1016/j.stemcr.2017.01.015

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome2017

    • Author(s)
      1.Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonser S, Ohta Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K
    • Journal Title

      Blood

      Volume: 印刷中 Issue: 1 Pages: 59-72

    • DOI

      10.1182/blood-2016-09-738096

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] In?Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos , and Gata2 Overexpression within Teratoma2017

    • Author(s)
      Tsukada Masao、Ota Yasunori、Wilkinson Adam C.、Becker Hans J.、Osato Motomi、Nakauchi Hiromitsu、Yamazaki Satoshi
    • Journal Title

      Stem Cell Reports

      Volume: 9 Issue: 4 Pages: 1024-1033

    • DOI

      10.1016/j.stemcr.2017.08.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease.2017

    • Author(s)
      Ren Y, Sekine-Kondo E, Shibata R, Kato-Itoh M, Umino A, Yanagida A, Satoh M, Inoue K, Yamaguchi T, Mochida K, Nakae S, Van Kaer L, Iwabuchi K, Nakauchi H, Watarai H.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 12765-12765

    • DOI

      10.1038/s41598-017-12475-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity2017

    • Author(s)
      Wilkinson Adam C.、Nakauchi Hiromitsu、G?ttgens Berthold
    • Journal Title

      Cell Syst

      Volume: 5 Issue: 4 Pages: 319-331

    • DOI

      10.1016/j.cels.2017.07.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells.2017

    • Author(s)
      Ayako Aihara, Tomo Koike, Natsuki Abe, Sou Nakamura, Akira Sawaguchi, Takanori Nakamura, Naoshi Sugimoto, Hiromitsu Nakauchi, Taito Nishino and Koji Eto
    • Journal Title

      Blood Advances

      Volume: 1 Issue: 7 Pages: 468-476

    • DOI

      10.1182/bloodadvances.2016000844

    • NAID

      120006488581

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.2017

    • Author(s)
      Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
    • Journal Title

      Stem Cells.

      Volume: 35 Issue: 4 Pages: 989-1002

    • DOI

      10.1002/stem.2524

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche2016

    • Author(s)
      Chen JY, Miyanishi M, Wang SK, Yamazaki S, Sinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL
    • Journal Title

      Nature

      Volume: 530(7589) Issue: 7589 Pages: 223-7

    • DOI

      10.1038/nature16943

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spatiotemporal Reconstruction of the Human Blastocyst by Single-Cell Gene-Expression Analysis Informs Induction of Naive Pluripotency2016

    • Author(s)
      Durruthy-Durruthy, J., Wossidlo, M., Pai, S., Takahashi, Y., Kang, G., Omberg, L., Chen, B., Nakauchi, H., Reijo Pera, R. and Sebastiano, V
    • Journal Title

      Dev Cell

      Volume: 38 Issue: 1 Pages: 100-15

    • DOI

      10.1016/j.devcel.2016.06.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation2016

    • Author(s)
      Ishida, T., Takahashi, S., Lai, C. Y., Nojima, M., Yamamoto, R., Takeuchi, E., Takeuchi, Y., Higashihara, M., Nakauchi, H. and Otsu, M
    • Journal Title

      J Exp Med

      Volume: 213 Pages: 1865-80

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016

    • Author(s)
      Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y,Iwama A.
    • Journal Title

      Blood

      Volume: 128(5) Issue: 5 Pages: 638-649

    • DOI

      10.1182/blood-2016-01-694810

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation2016

    • Author(s)
      Taya, Y., Ota, Y., Wilkinson, A. C., Kanazawa, A., Watarai, H., Kasai, M., Nakauchi, H. and Yamazaki, S
    • Journal Title

      Science

      Volume: 354 Issue: 6316 Pages: 1152-1155

    • DOI

      10.1126/science.aag3145

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II2016

    • Author(s)
      Yokoi, T., Yokoi, K., Akiyama, K., Higuchi, T., Shimada, Y., Kobayashi, H., Sato, T., Ohteki, T., Otsu, M., Nakauchi, H., Ida, H. and Ohashi, T
    • Journal Title

      Mol Genet Meta

      Volume: 119 Issue: 3 Pages: 232-238

    • DOI

      10.1016/j.ymgme.2016.08.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Ex vivo expansion of hematopoietic stem cells: Dream or reality?2019

    • Author(s)
      中内 啓光
    • Organizer
      Prof. Ken-ichi Arai Memorial Symposium
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] iPS細胞から臓器をつくる: 国境を跨いだ挑戦2019

    • Author(s)
      中内 啓光
    • Organizer
      NPO健康医療開発機構 細胞医療の時代2018シリーズ 「第7回 細胞移植から臓器移植へ」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Stable ex vivo HSC expansion: dream or reality?2018

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Cambridge Stem Cell Symposium: UK CSCIS Opening Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clonal analysis of young and aged hematopoietic stem cells2018

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Mini Symposium at Lund University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 幹細胞ニッチ:細胞から臓器へ~2017

    • Author(s)
      中内 啓光
    • Organizer
      東京免疫フォーラム
    • Place of Presentation
      東京大学医科学研究所、東京
    • Year and Date
      2017-03-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 幹細胞ニッチ:細胞から臓器へ2017

    • Author(s)
      中内 啓光
    • Organizer
      東京免疫フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 幹細胞とアミノ酸バランス (Stem Cells and Amino Acid Balance)2017

    • Author(s)
      中内 啓光
    • Organizer
      日本癌学会ランチョンセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 幹細胞ニッチの概念を利用した新しい医療2017

    • Author(s)
      中内 啓光
    • Organizer
      第9回血液疾患免疫療法学会学術集会共催ランチョンセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Clonal Analysis of Young and Aged Hematopoietic Stem Cells2017

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Regenerative Medicine Seminar Series (ReMS)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stem Cell Niche: From Cells to Organs2017

    • Author(s)
      中内 啓光
    • Organizer
      Cell Press Lablinks
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] From Stem Cells to Organs: Exploiting the organ niche for interspecies organogenesis2016

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Erasmus MC workshop
    • Place of Presentation
      Rotterdam, Netherland
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stem Cell niche--from cells to organs2016

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      7th Annual Stem Cell Biology and Regenerative Medicine Retreat
    • Place of Presentation
      Monterey, California,USA
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] From Stem Cells to Organs: Exploiting the organ niche for interspecific organogenesis2016

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Advances in Organogenesis and Tissue Engineering Symposia at John Hopkins University
    • Place of Presentation
      Baltimore, Maryland,USA
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stem Cell Niche-From Cells to Organs2016

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      University of Southern California
    • Place of Presentation
      Los Angeles, California,USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stem cell niche" from cells and organs2016

    • Author(s)
      Hiromitsu Nakauchi
    • Organizer
      Stower’s Li Lab
    • Place of Presentation
      Kansas City, Missouri,USA
    • Year and Date
      2016-05-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] 成人T細胞白血病リンパ腫を処置することに用いるための組成物およびその製造方法2019

    • Inventor(s)
      中内啓光、石垣知寛、山崎聡、田矢祐規
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-531993
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 成人T細胞白血病リンパ腫を処置することに用いるための組成物およびその製造方法2019

    • Inventor(s)
      中内啓光、石垣知寛、山崎聡、田矢祐規
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 成人T細胞白血病リンパ腫を処置することに用いるための組成物およびその製造方法2019

    • Inventor(s)
      中内啓光、石垣知寛、山崎聡、田矢祐規
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 造血幹細胞を減少させる組成物およびその製造方法2018

    • Inventor(s)
      中内啓光、山崎聡、田矢裕規
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 成人T細胞白血病リンパ腫を処置することに用いるための組成物およびその製造方法2017

    • Inventor(s)
      中内啓光、山崎聡、石垣知寛、田矢祐規
    • Industrial Property Rights Holder
      中内啓光、山崎聡、石垣知寛、田矢祐規
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 成人T細胞白血病リンパ腫を処置することに用いるための組成物およびその製造方法2016

    • Inventor(s)
      中内啓光、石垣知寛、山崎聡、田矢祐規
    • Industrial Property Rights Holder
      国立大学法人 東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-05
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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