Clarifying the underlying mechanisms of schizophrenia focusing on the abnormalities of neuronal activities and immune responses.

• Project/Area Number: 16H02666
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: kanba Shigenobu 九州大学, 医学研究院, 教授 (50195187)
• Co-Investigator(Kenkyū-buntansha): 牧之段 学 奈良県立医科大学, 医学部, 講師 (00510182)
• Research Collaborator: Hirano Yoji ; Kato Takahiro A.
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000); Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2016: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
• Keywords: 統合失調症 / 脳活動 / ガンマオシレーション / ミクログリア / 橋渡し研究 / サイトカイン / 気分障害 / トランスレーショナルリサーチ / ペリニューロナルネット / 炎症免疫 / 脳波 / 神経免疫 / γオシレーション

Outline of Final Research Achievements

In this study, we have conducted a translational research focusing on the two hypothesis; (1) the neuronal activity abnormality hypothesis and (2) the neuroimmune abnormality hypothesis in psychiatric disorders especially schizophrenia and mood disorders. We have clarified some interesting abnormalities using the EEG analysis and blood biomarker analysis in a variety of psychiatric disorders.

Academic Significance and Societal Importance of the Research Achievements

統合失調症の病態はいまだ十分には解明されていません。本研究では、統合失調症およびその関連精神神経疾患（うつ病、双極性障害、てんかん性精神病、発達障害など）における脳神経活動異常と免疫異常の双方に着目し、その精査をヒトを中心とした橋渡し研究アプローチですすめてきました。3年間の研究で、疾患の判別や重症度に関連する脳波異常や血液マーカーを見出すことに成功しました。今回の知見をさらに深めることで、統合失調症を初めとする多くの精神疾患の病態の本質を解明し、将来的には治療法開発に繋げてゆければ幸いです。

Research Products

• [Journal Article] Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies (2019)
  • Author(s): Suzuki H, Ohgidani M, Kuwano N, Chrétien F, Lorin de la Grandmaison G, Onaya M, Tominaga I, Setoyama D, Kang D, Mimura M, Kanba S, Kato TA*
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 13 Pages: 31-31
  • DOI: 10.3389/fncel.2019.00031
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development and validation of the 22-item Tarumi's modern-type depression trait scale; Avoidance of social roles, Complaint and low Self-esteem (TACS-22) (2019)
  • Author(s): Kato TA, Katsuki R, Kubo H, Shimokawa N, Sato-Kasai M, Hayakawa K, Kuwano N, Umene-akano W, Tateno M, Setoyama D, Kang D, Watabe M, Sakamoto S, Teo AR, Kanba S
  • Journal Title: Psychiatry and clinical neurosciences Volume: in press Issue: 8 Pages: 448-457
  • DOI: 10.1111/pcn.12842
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study. (2018)
  • Author(s): Kuwano N, Kato TA, Setoyama D, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Kishimoto J, Kang D, Kanba S
  • Journal Title: Journal of Affective Disorders Volume: 231 Pages: 74-82
  • DOI: 10.1016/j.jad.2018.01.014
  • Peer Reviewed
• [Journal Article] Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya (2018)
  • Author(s): Kato Takahiro A.、Kanba Shigenobu
  • Journal Title: American Journal of Psychiatry Volume: 175 Issue: 5 Pages: 483-484
  • DOI: 10.1176/appi.ajp.2018.17121404r
  • Peer Reviewed
• [Journal Article] Development and validation of the 25-item Hikikomori Questionnaire (HQ-25) (2018)
  • Author(s): Teo AR*, Chen JI, Kubo H, Katsuki R, Sato-Kasai M, Shimokawa N, Hayakawa K, Umene-Nakano W, Aikens, JE, Kanba S, Kato TA
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 72(10) Issue: 10 Pages: 780-788
  • DOI: 10.1111/pcn.12691
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study (2018)
  • Author(s): Kuwano N, Kato TA*, Mitsuhashi M, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Sakurai T, Kanba S
  • Journal Title: Journal of Affective Disorders Volume: 240 Pages: 88-98
  • DOI: 10.1016/j.jad.2018.07.040
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Microglial CD206 gene has potential as a state marker of bipolar disorder (2017)
  • Author(s): 1.Ohgidani M, Kato TA, Haraguchi Y, Matsushima T, Mizoguchi Y, Murakawa-Hirachi T, Sagata N, Monji A, Kanba S.
  • Journal Title: Frontiers in Immunology Volume: 7 Pages: 676-676
  • DOI: 10.3389/fimmu.2016.00676
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7 (2016)
  • Author(s): Sato-Kasai M, Kato TA, Ohgidani M, Mizoguchi Y, Sagata N, Inamine S, Horikawa H, Hayakawa K, Shimokawa N, Kyuragi S, Seki Y, Monji A, Kanba S.
  • Journal Title: Schizophrenia Research Volume: 178(1-3) Issue: 1-3 Pages: 35-43
  • DOI: 10.1016/j.schres.2016.08.022
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Directly induced glial/neuronal cells from human peripheral tissues: A novel translational research for neuropsychiatric disorders (2016)
  • Author(s): Kato TA, Ohgidani M, Sagata N, Kanba S
  • Journal Title: Advances in Neuroimmune Biology Volume: 6(2) Issue: 2 Pages: 95-105
  • DOI: 10.3233/nib-160109
  • Peer Reviewed / Acknowledgement Compliant