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Development of the optimal medication for individuals exposed to lethal radiation

Research Project

Project/Area Number 16H02667
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHirosaki University

Principal Investigator

Kashiwakura Ikuo  弘前大学, 保健学研究科, 教授 (00177370)

Co-Investigator(Kenkyū-buntansha) 稲波 修  北海道大学, 獣医学研究院, 教授 (10193559)
渡邉 純  弘前大学, 保健学研究科, 教授 (10201188)
中井 雄治  弘前大学, 地域戦略研究所, 教授 (10321788)
吉野 浩教  弘前大学, 保健学研究科, 助教 (10583734)
細田 正洋  弘前大学, 保健学研究科, 講師 (30457832)
床次 眞司  弘前大学, 被ばく医療総合研究所, 教授 (80247254)
山村 仁  弘前大学, 医学研究科, 教授 (10438228)
山盛 徹  北海道大学, 獣医学研究院, 准教授 (00512675)
三浦 富智  弘前大学, 保健学研究科, 准教授 (20261456)
千葉 満  弘前大学, 保健学研究科, 講師 (20583735)
岩岡 和輝  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線防護情報統合センター, 主任研究員(定常) (70466051)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2019: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords被ばく医療 / 薬物療法 / トロンボポエチン受容体作動薬 / 急性放射線症候群 / 骨髄死 / 多臓器不全 / 間葉系幹細胞 / トロンボポエチン受容体 / 放射線緩和剤 / 放射線防護剤 / 被ばくマーカー
Outline of Final Research Achievements

The aim of this study was to establish an effective emergency drug treatment protocol using biomarkers and approved drugs as indicators of disability prediction and treatment efficacy. Microarray results from mouse blood-derived RNAs after 24 h of 0.5 to 3 Gy total body irradiation showed a dose-dependent response of seven different mRNA expressions, suggesting their potential as exposure markers (patent application). Validation of several approved drugs in lethal-dose-irradiated mice revealed that Romiprostim, a drug for chronic idiopathic thrombocytopenic purpura, produced a 100% 30-day survival rate, and its mechanism of action included the reduction and recovery of multiple organ failure by various actions such as promoting DNA damage repair, suppressing cell death and inflammation (patented).

Academic Significance and Societal Importance of the Research Achievements

本研究により,障害予測や治療効果の指標となる幾つかのバイオマーカー候補を複数特定出来たことは,緊急事故後の迅速な被ばく量推定や薬物療法の効果判定への応用の可能性が期待され,キット化も視野に入る.また,血小板減少症治療薬であるロミプロスチムが強い放射線障害軽減効果を示すことから,緊急時に有効な薬物治療プロトコール提言に向けた基礎的検討ができた.ロミプロスチムはサルでの有効性が2019年に報告されており,事故時での活用も可能になってきている.本研究成果は,学術的意義に加えて危機管理対策としての社会的意義も高いと考えられる.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (53 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (17 results) (of which Peer Reviewed: 16 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (31 results) (of which Int'l Joint Research: 13 results,  Invited: 6 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] インドネシア原子力庁(インドネシア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] カターニア大学(イタリア)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Identification of Radiation-Dose-Dependent Expressive Genes in Individuals Exposed to External Ionizing Radiation.2020

    • Author(s)
      Yamaguchi M, Nishida T, Sato Y, Nakai Y, Kashiwakura I.
    • Journal Title

      Radiat Res.

      Volume: 193 Issue: 3 Pages: 274-285

    • DOI

      10.1667/rr15532.1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice.2019

    • Author(s)
      Waga K, Yamaguchi M, Miura S, Nishida T, Itai A, Nakanishi R, Kashiwakura I.
    • Journal Title

      Oxid Med Cell Longev.

      Volume: - Pages: 1-9

    • DOI

      10.1155/2019/5340290

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CHANGES OF ABSORBED DOSE RATE IN AIR BY CAR-BORNE SURVEY IN NAMIE TOWN, FUKUSHIMA PREFECTURE AFTER THE FUKUSHIMA DAIICHI NUCLEAR POWER PLANT ACCIDENT2019

    • Author(s)
      Shiroma Y、Hosoda M、Iwaoka K、Heged?s M、Kudo H、Tsujiguchi T、Yamaguchi M、Akata N、Kashiwakura I、Tokonami S
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 184 Issue: 3-4 Pages: 527-530

    • DOI

      10.1093/rpd/ncz096

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COMPREHENSIVE EXPRESSION ANALYSIS OF MIRNAS IN MICE EXPOSED TO LETHAL RADIATION AND/OR RADIO-MITIGATIVE DRUG2019

    • Author(s)
      Yamaguchi M、Tsujiguchi T、Kashiwakura I
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 184 Issue: 3-4 Pages: 482-485

    • DOI

      10.1093/rpd/ncz113

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Development of an Active Learning Program for the Medical Responders in a Nuclear Disaster2019

    • Author(s)
      Tsujiguchi Takakiyo、Ito Katsuhiro、Sato Daishi、Mikami Junko、Shiroma Yoshitaka、Hasegawa Arifumi、Yamamura Hitoshi、Kashiwakura Ikuo
    • Journal Title

      Disaster Medicine and Public Health Preparedness

      Volume: 13 Issue: 5-6 Pages: 853-858

    • DOI

      10.1017/dmp.2018.168

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NINTH INTERNATIONAL CONFERENCE ON HIGH LEVELS OF ENVIRONMENTAL RADIATION AREAS; FOR UNDERSTANDING CHRONIC LOW-DOSE-RATE RADIATION EXPOSURE HEALTH EFFECTS AND SOCIAL IMPACTS2019

    • Author(s)
      Sohrabi Mehdi、Kashiwakura Ikuo、Tokonami Shinji
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 184 Issue: 3-4 Pages: 275-276

    • DOI

      10.1093/rpd/ncz123

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] INVESTIGATION OF EXTERNAL RADIATION DOSES DURING RESIDENTS’ TEMPORAL STAY TO NAMIE TOWN, FUKUSHIMA PREFECTURE2019

    • Author(s)
      Tsujiguchi T、Shiroma Y、Suzuki T、Tamakuma Y、Yamaguchi M、Iwaoka K、Hosoda M、Tokonami S、Kashiwakura I
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 184 Issue: 3-4 Pages: 514-517

    • DOI

      10.1093/rpd/ncz107

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-Dependent Increase of Nrf2 Target Gene Expression in Mice Exposed to Ionizing Radiation2019

    • Author(s)
      Miura Shuta、Yamaguchi Masaru、Yoshino Hironori、Nakai Yuji、Kashiwakura Ikuo
    • Journal Title

      Radiation Research

      Volume: 191 Issue: 2 Pages: 176-188

    • DOI

      10.1667/rr15203.1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diverse functions of the thrombopoietin receptor agonist romiplostim rescue individuals exposed to lethal radiation.2019

    • Author(s)
      Yamaguchi M, Hirouchi T, Yoshioka H, Watanabe J, Kashiwakura I
    • Journal Title

      Free Radic Biol Med

      Volume: 136 Pages: 60-75

    • DOI

      10.1016/j.freeradbiomed.2019.03.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative Study of Performance using Five Different Gamma-ray Spectrometers for Thyroid Monitoring under Nuclear Emergency Situations.2019

    • Author(s)
      Hosoda M, Iwaoka K, Tokonami S, Tamakuma Y, Shiroma Y, Fukuhara T, Imajyo Y, Taniguchi J, Akata N, Osanai M, Tsujiguchi T, Yamaguchi M, Kashiwakura I
    • Journal Title

      Health Phys

      Volume: 116 Issue: 1 Pages: 81-87

    • DOI

      10.1097/hp.0000000000000954

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The thrombopoietin mimetic romiplostim leads to the complete rescue of mice exposed to lethal ionizing radiation.2018

    • Author(s)
      Yamaguchi M, Hirouchi T, Yokoyama K, Nishiyama A, Murakami S, Kashiwakura I
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 10659-10659

    • DOI

      10.1038/s41598-018-29013-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic effects of retinoic acid-inducible gene-I-like receptors activations and ionizing radiation on cytotoxicity against human non-small lung cancer cells.2018

    • Author(s)
      H. Yoshino, M. Iwabuchi, Y. Kazama, M. Furukawa, I. Kashiwakura.
    • Journal Title

      Oncol Lett

      Volume: 15 Pages: 4697-4705

    • DOI

      10.3892/ol.2018.7867

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Nrf2 knockdown on the properties of irradiated cell conditioned medium from A549 human lung cancer cells.2018

    • Author(s)
      H. Yoshino, K. Murakami, M. Nawamaki, I. Kashiwakura.
    • Journal Title

      Biomed Rep

      Volume: 印刷中 Pages: 461-465

    • DOI

      10.3892/br.2018.1073

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effect of c-mpl agonist romiplostim on megakaryocytopoiesis of human CD34+ hematopoietic progenitor cells exposed to ionizing radiation.2018

    • Author(s)
      S. Monzen, S. Kimura, M. Yamaguchi, I. Kashiwakura.
    • Journal Title

      J Interferon Cytokine Res

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Involvement of reactive oxygen species in ionizing radiation-induced upregulation of cell surface Toll-like receptor 2 and 4 expressions in human monocytic cell.2017

    • Author(s)
      Yoshino H, Kashiwakura I
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中 Issue: 5 Pages: 1-10

    • DOI

      10.1093/jrr/rrx011

    • NAID

      120006559353

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Utilization of Monte Carlo particle transport simulation code on radiation emergency medicine at Hirosaki University.2017

    • Author(s)
      K. Iwaoka, M. Hosoda, T. Tsujiguchi, M. Osanai, S. Tokonami, I. Kashiwakura.
    • Journal Title

      Radiat Emerg Med

      Volume: 6(2) Pages: 104-107

    • NAID

      40021295144

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of endoplasmic reticulum stress on apoptosis induction in radioresistant macrophages.2017

    • Author(s)
      Yoshino H, Kumai Y, Kashiwakura.
    • Journal Title

      Molecular Medicine Reports

      Volume: 15(5) Issue: 5 Pages: 2867-2872

    • DOI

      10.3892/mmr.2017.6298

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Diverse functions of the thrombopoietin receptor agonist romiplostim rescue individuals exposed to lethal total-body irradiation2019

    • Author(s)
      Masaru Yamaguchi and Ikuo Kashiwakura.
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inflammation and aging induced by multiple sub-lethal ionizing radiation in mice.2019

    • Author(s)
      Ikuo Kashiwakura, Masaru Yamaguchi, Teruki Nishida, Akane Chiba, Tokuhisa Hirouchi.
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Romiplostim regulates the activation of the master redox regulator Keap1-Nrf2 system in mice exposed to lethal total-body irradiation2019

    • Author(s)
      Akane Chiba, Masaru Yamaguchi, Teruki Nishida, and Ikuo Kashiwakura.
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of the radiation dose-responsive gene expression in mice exposed to total-body irradiation2019

    • Author(s)
      Teruki Nishida, Masaru Yamaguchi, Yoshiaki Sato, Yuji Nakai, Ikuo Kashiwakura.
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diverse functions of the thrombopoietin receptor agonist romiplostim rescue individuals exposed to lethal total-body irradiation.2019

    • Author(s)
      Masaru Yamaguchi and Ikuo Kashiwakura.
    • Organizer
      2019 KIRAMS-Hirosaki University Joint Symposium.
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The activities of Hirosaki University on radiation sciences.2019

    • Author(s)
      Ikuo Kashiwakura.
    • Organizer
      2019 Unified Radiological Seminar in KIRAMS
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The activities of Hirosaki University on radiation sciences.2019

    • Author(s)
      Ikuo Kashiwakura.
    • Organizer
      2nd Workshop on Radiation Research and Its Related Issues 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 放射線ばく露マウスにおける放射線量応答遺伝子発現の同定2019

    • Author(s)
      西田晃規、山口平、佐藤嘉晃、中井雄治、柏倉幾郎
    • Organizer
      第57回日本放射線腫瘍学会生物部会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 放射線障害軽減作用を有する血小板減少症治療薬の作用機序2019

    • Author(s)
      柏倉幾郎
    • Organizer
      第17回レドックス・ライフイノベーションシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 災害 時の被ばく 医療 -弘前大学の取り組み-2019

    • Author(s)
      柏倉幾郎
    • Organizer
      第4回 北海道 ・東北新潟 ブロックリハコー ディネタ連携推進委員会 連携推進委員会 連携推進委員会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] トロンボポエチン受容体作動薬ロミプロスチムの放射線障害軽減作用~マウスを用いた検討~2019

    • Author(s)
      柏倉幾郎
    • Organizer
      北関東骨髄不全セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 高線量放射線被ばく個体に対する国内承認薬ロミプロスチムの放射線緩和効果2018

    • Author(s)
      山口平,廣内篤久,吉岡治彦,渡邉純,柏倉幾郎
    • Organizer
      日本放射線腫瘍学会第56回生物部会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 放射線ばく露個体におけるKeap1-Nrf2系生体防御遺伝子発現解析2018

    • Author(s)
      三浦柊太,山口平,吉野浩教,中井雄治,柏倉幾郎
    • Organizer
      日本放射線腫瘍学会第56回生物部会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cotreatment with retinoic acid-inducible gene-I-like receptor agonist and ionizing radiation effectively induces apoptosis through caspase-8 mediated apoptotic pathway in human non-small cell lung cancer A5492018

    • Author(s)
      Y. Sato, H. Yoshino, Y. Kazama and I. Kashiwakura
    • Organizer
      The 5th Educational Symposium on Radiation and Health by young scientists (ESRAH2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A gene expression analysis of the keap1-nrf2 biological defence system in mice exposed to ionizing radiation.2018

    • Author(s)
      T. Nishida, S. Miura, M. Yamaguchi and I. Kashiwakura
    • Organizer
      The 5th Educational Symposium on Radiation and Health by young scientists (ESRAH2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The IκB kinase β inhibitor, IMD-0354, attenuated the radiation-induced individual death in mice exposed to lethal ionizing radiation2018

    • Author(s)
      K. Waga, M. Yamaguchi, S. Miura, T. Nishida, A. Itai, R. Nakanishi and I. Kashiwakura
    • Organizer
      The 5th Educational Symposium on Radiation and Health by young scientists (ESRAH2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ionizing radiation enhances double-Stranded RNA-induced apoptosis in human lung epithelial cells through Caspase-8 activation2018

    • Author(s)
      Y. Sato, H. Yoshino, Y. Kazama and I. Kashiwakura
    • Organizer
      9th International Conference on High Levels of Environmental Radiation Areas (ICHLERA) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relationship between the mitigative effects of romiplostim on the survival of mice exposed to lethal ionizing radiation and the serum miRNA expression2018

    • Author(s)
      M. Yamaguchi, T. Tsujiguchi and I. Kashiwakura
    • Organizer
      9th International Conference on High Levels of Environmental Radiation Areas (ICHLERA) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The IκB kinase β inhibitor, IMD-0354, attenuated the radiation-induced individual death in mice exposed to lethal ionizing radiation2018

    • Author(s)
      K. Waga, M. Yamaguchi and I. Kashiwakura
    • Organizer
      9th International Conference on High Levels of Environmental Radiation Areas (ICHLERA) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高線量放射線被ばく個体に対する国内承認薬ロミプロスチムの放射線緩和効果.2018

    • Author(s)
      山口平,廣内篤久,吉岡治彦,渡邉純,柏倉幾郎
    • Organizer
      第19回Pharmaco-Hematology シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高線量放射線被ばく個体に対する国内承認薬ロミプロスチムの放射線緩和効果.2018

    • Author(s)
      山口平,廣内篤久,柏倉幾郎
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Thrombopoietin-Receptor Agonist Romiplostim Attenuates Hematopoietic System Injury By Promoting the Recovery of Early Hematopoiesis and the Hematopoietic Environment in the Bone Marrow and Spleen of Mice Exposed to Lethal Total Body γ-Irradiation.2017

    • Author(s)
      M. Yamaguchi, T. Hirouchi, S. Miura, K. Waga, H. Yoshioka, J. Watanabe, I. Kashiwakura.
    • Organizer
      The 4th Educational Symposium on Radiation and Health by young scientists(ESRAH2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thrombopoietin-Receptor Agonist Romiplostim Attenuates Hematopoietic System Injury By Promoting the Recovery of Early Hematopoiesis and the Hematopoietic Environment in the Bone Marrow and Spleen of Mice Exposed to Lethal Total Body γ-Irradiation.2017

    • Author(s)
      M. Yamaguchi, T. Hirouchi, S. Miura, K. Waga, H. Yoshioka, J. Watanabe, I. Kashiwakura.
    • Organizer
      59th ASH Annual Meeting & Exposition(ASH2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 致死線量放射線ばく露個体に対するトロンボポエチン受容体作動薬の放射線緩和効果.2017

    • Author(s)
      山口 平, 廣内 篤久, 三浦 柊太, 柏倉 幾郎.
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高量放射線照射マウスにおけるIKKβ阻害剤の放射線障害軽減効果の検討.2017

    • Author(s)
      和賀 健吾, 山口 平, 三浦 柊太, 板井 昭子, 中西 玲子, 柏倉 幾郎.
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト単球系細胞の細胞分化に伴う放射線抵抗性獲得とCASAPSE-8の発現制御の関連.2017

    • Author(s)
      吉野 浩教, 今埜 遼香, 小倉 巧也, 柏倉 幾郎.
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高線量放射線ばく露マウス血清中のmicroRNA 発現変化の被ばくマーカーとしての可能性の検討.2016

    • Author(s)
      三浦 柊太, 伊藤 優樹, 山口 平, 千葉 満, 柏倉 幾郎.
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 致死線量放射線ばく露マウスに対するトロンボポエチン受容体作動薬の放射線緩和効果.2016

    • Author(s)
      山口 平, 廣内 篤久, 横山 昂生, 千葉 満, 小村 潤一郎, 柏倉 幾郎.
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低線量γ線照射による細胞遺伝学的線量評価用線量応答曲線の作製.2016

    • Author(s)
      阿部悠, 三浦富智, 吉田光明, 氏家里紗, 黒須由美子, 柳亜希,津山尚宏, 川村文彦, 藤岡来実, 稲葉俊哉, 神谷研二, 坂井晃.
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射線によるToll様受容体の細胞表面発現制御機構の探索.2016

    • Author(s)
      吉野浩教
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] The mitigative effects of Romiplostim,a recombinant c-mpl agonist, on the surivival of mice exposed to lethal ionizing radiation.2016

    • Author(s)
      M. Yamaguchi, K. Yokoyama, Y. Ito, S. Miura, M. Chiba, I. Kashiwakura.
    • Organizer
      The 3rd Educational Symposium on Radiation and Health by young scientists(ESRAH2016)
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 国立大学法人弘前大学大学院保健学研究科 放射線技術科学領域 柏倉研究室

    • URL

      http://www.hs.hirosaki-u.ac.jp/~kashiwakura/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 弘前大学大学院 保健学研究科 柏倉研究室

    • URL

      http://www.hs.hirosaki-u.ac.jp/~kashiwakura/

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 放射線被ばくの検出方法2018

    • Inventor(s)
      柏倉幾郎、中井雄治、山口平
    • Industrial Property Rights Holder
      国立大学法人弘前大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-223161
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-22  

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