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Develoment of advanced therapy targeting tumor heterogeneity in refractory cancers

Research Project

Project/Area Number 16H02670
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TANAKA Shinji  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420)

Co-Investigator(Kenkyū-buntansha) 森 正樹  大阪大学, 医学系研究科, 教授 (70190999)
島田 周  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (20609705)
秋山 好光  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (80262187)
深町 博史  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (70134450)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Keywords癌 / 幹細胞 / ゲノム編集技術 / クロマチン動的変動 / クロマチン再構築 / ヒストン修飾 / 分子サブタイプ / トランスレーショナルリサーチ / 遺伝子 / ゲノム / 外科 / DNA損傷 / 腫瘍変異負荷 / クロマチンリモデリング / ゲノム編集 / 高頻度変異
Outline of Final Research Achievements

Heterogeneity is one of the essential hallmarks of malignancies. Our stemness-visualization system revealed that epigenetic heterogeneity in chromosomal dynamics and histone modifications can regulate in vitro and in vivo intractability of cancers. Using genome editing technology, we elucidated the biological role and clinical significance of ARID2 chromatin remodeling factor in hepatocellular carcinoma (J Hepatol 2017), DAXX heterochromatin regulator in pancreatic tumor (Endocr Relat Cancer 2018), KDM6A histone modifier in pancreatic cancer (Int J Cancer 2019), and PRMT6 histone arginine methylase in gastric cancer (Carcinogenesis 2019). Identification of molecular subtypes is expected to realize the precise medicine based on the subtype-specific molecules and immune microenvironments (EBioMedicine 2019). Development of multiplex genome editing system can design the actionable strategy and revolutionize advanced therapy targeting tumor heterogeneity in refractory cancers.

Academic Significance and Societal Importance of the Research Achievements

本研究成果の意義は、癌難治性克服におけるクロマチン・ヒストン制御の重要性を明らかにしたことである。高効率のゲノム編集技術の開発により、クロマチン・ヒストン異常のサブタイプ機序を解明しただけでなく、サブタイプ特異的治療も同定しており、予定以上の成果が得られた。さらに臨床検体の解析により新しい分子免疫サブタイプ分類を提唱し、新たな多重ゲノム編集技術の開発にも着手している。免疫正常モデルを用いたサブタイプ・パネルを構築し、どのサブタイプに対して、どのような組み合わせで、どのタイミングが最適であるかを明確にして、免疫複合治療への応用を進めている。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (70 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (36 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 36 results,  Open Access: 19 results,  Acknowledgement Compliant: 6 results) Presentation (18 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Book (3 results) Remarks (10 results)

  • [Int'l Joint Research] Brown University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Seoul National University/Korea Res Inst Biosci Biotech(韓国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Brown University(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence.2019

    • Author(s)
      Shimada S, Mogushi K, Akiyama Y, Furuyama T, Watanabe S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Tanabe M, Wands JR, Tanaka S.
    • Journal Title

      EBioMedicine

      Volume: 40 Pages: 457-470

    • DOI

      10.1016/j.ebiom.2018.12.058

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.2019

    • Author(s)
      Okuno K, Akiyama Y, Shimada S, Nakagawa M, Tanioka T, Inokuchi M, Yamaoka S, Kojima K, Tanaka S.
    • Journal Title

      Carcinogenesis

      Volume: 40 Issue: 1 Pages: 15-26

    • DOI

      10.1093/carcin/bgy147

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors2019

    • Author(s)
      Fukamachi H、Kim SK、Koh J、Lee HS、Sasaki Y、Yamashita K、Nishikawaji T、Shimada S、Akiyama Y、Byeon SJ、Bae DH、Okuno K、Nakagawa M、Tanioka T、Inokuchi M、Kawachi H、Tsuchiya K、Kojima K、Tokino Takashi、Eishi Y、Kim YS、Kim WH、Yuasa Y、Tanaka S
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 38 Issue: 1 Pages: 127-127

    • DOI

      10.1186/s13046-019-1121-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality2019

    • Author(s)
      Watanabe S, Shimada S, Akiyama Y, Ishikawa Y, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S.
    • Journal Title

      International Journal of Cancer

      Volume: - Issue: 1 Pages: 192-205

    • DOI

      10.1002/ijc.32072

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orotate phosphoribosyltransferase as a predictor of benefit from S-1 adjuvant chemotherapy for cholangiocarcinoma patients2019

    • Author(s)
      Akahoshi K, Ban D, Kuboki R, Oba A, Ono H, Mitsunori Y, Kudo A, Tanaka S, Tanabe M.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: - Issue: 6 Pages: 1108-1115

    • DOI

      10.1111/jgh.14477

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new era for understanding genetic evolution of multistep carcinogenesis2019

    • Author(s)
      Shimada S, Tanaka S.
    • Journal Title

      Journal of Gastroenterology

      Volume: - Issue: 7 Pages: 667-668

    • DOI

      10.1007/s00535-019-01576-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple and practical index predicting the prognoses of the patients with well-differentiated pancreatic neuroendocrine neoplasms.2019

    • Author(s)
      Liu B, Kudo A, Kinowaki Y, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Tanaka S, Akashi T, Tanabe M.
    • Journal Title

      J Gastroenterol.

      Volume: - Issue: 9 Pages: 819-828

    • DOI

      10.1007/s00535-019-01570-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The clinical implications of peripancreatic fluid collection after distal pancreatectomy2019

    • Author(s)
      Yoshino J, Ban D, Ogura T, Ogawa K, Ono H, Mitsunori Y, Kudo A, Tanaka S, Tanabe M
    • Journal Title

      World Journal of Surgery

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Precision medicine based on surgical oncology in the era of genome-scale analysis and genome editing technology.2018

    • Author(s)
      Tanaka S.
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: - Issue: 2 Pages: 106-115

    • DOI

      10.1002/ags3.12059

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma2018

    • Author(s)
      Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 106-106

    • DOI

      10.1038/s41598-017-18323-9

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.2018

    • Author(s)
      Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.
    • Journal Title

      British Journal of Cancer

      Volume: - Issue: 7 Pages: 972-984

    • DOI

      10.1038/s41416-018-0008-y

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors2018

    • Author(s)
      Chiyonobu Norimichi、Shimada Shu、Akiyama Yoshimitsu、Mogushi Kaoru、Itoh Michiko、Akahoshi Keiichi、Matsumura Satoshi、Ogawa Kosuke、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Kudo Atsushi、Arii Shigeki、Suganami Takayoshi、Yamaoka Shoji、Ogawa Yoshihiro、Tanabe Minoru、Tanaka Shinji
    • Journal Title

      Am. J. Pathol.

      Volume: 188 Issue: 5 Pages: 1213-1224

    • DOI

      10.1016/j.ajpath.2018.01.012

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs.2018

    • Author(s)
      Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
    • Journal Title

      Endocr Relat Cancer

      Volume: 25(6) Issue: 6 Pages: 619-631

    • DOI

      10.1530/erc-17-0328

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sunitinib shrinks NET-G3 pancreatic neuroendocrine neoplasms2018

    • Author(s)
      Mizuno Yuki、Kudo Atsushi、Akashi Takumi、Akahoshi Keiichi、Ogura Toshiro、Ogawa Kosuke、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Tanaka Shinji、Tateishi Ukihide、Tanabe Minoru
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: - Issue: 6 Pages: 1155-1163

    • DOI

      10.1007/s00432-018-2636-2

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid growth speed of cysts can predict malignant intraductal mucinous papillary neoplasms.2018

    • Author(s)
      Akahoshi K, Ono H, Akasu M, Ban D, Kudo A, Konta A, Tanaka S, Tanabe M.
    • Journal Title

      J Surg Res

      Volume: 231 Pages: 195-200

    • DOI

      10.1016/j.jss.2018.05.056

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Splenic artery as a simple landmark indicating difficulty during laparoscopic distal pancreatectomy2018

    • Author(s)
      Ishikawa Yoshiya、Ban Daisuke、Watanabe Shuichi、Akahoshi Keiichi、Ono Hiroaki、Mitsunori Yusuke、Kudo Atsushi、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: - Issue: 1 Pages: 81-87

    • DOI

      10.1111/ases.12485

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells2018

    • Author(s)
      Tamari K, KonnoM , Asai A, Koseki J, Hayashi K, Kawamoto K, Murai N, Matsufuji S, Isohashi F, Satoh T, Gotoh N, Tanaka S, Doki Y, Mori M, Ogawa K, Ishii H.
    • Journal Title

      Cell Death Discovery

      Volume: 4 Issue: 104 Pages: 104-104

    • DOI

      10.1038/s41420-018-0117-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Downregulated Pancreatic Beta Cell Genes Indicate Poor Prognosis in Patients With Pancreatic Neuroendocrine Neoplasms.2018

    • Author(s)
      Kudo A, Akahoshi K, Ito S, Akashi T, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Tateishi U, Tanaka S, Tanabe M.
    • Journal Title

      Ann Surg.

      Volume: - Issue: 4 Pages: 732-739

    • DOI

      10.1097/sla.0000000000002911

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARID2 modulates DNA damage response in human hepatocellular carcinoma cells.2017

    • Author(s)
      Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S.
    • Journal Title

      Journal of Hepatology

      Volume: in press Issue: 5 Pages: 942-951

    • DOI

      10.1016/j.jhep.2016.12.026

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma.2017

    • Author(s)
      Ohata Y, Akiyama Y, Shimada S, Mogushi K, Nakao K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: in press Issue: 6 Pages: 1155-1165

    • DOI

      10.1158/1535-7163.mct-16-0728

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A simple morphological classification to estimate the malignant potential of pancreatic neuroendocrine tumors2017

    • Author(s)
      Oba Atsushi、Kudo Atsushi、Akahoshi Keiichi、Kishino Mitsuhiro、Akashi Takumi、Katsuta Eriko、Iwao Yasuhito、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Tanaka Shinji、Eishi Yoshinobu、Tateishi Ukihide、Tanabe Minoru
    • Journal Title

      Journal of Gastroenterology

      Volume: 52 Issue: 10 Pages: 1140-1146

    • DOI

      10.1007/s00535-017-1349-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Refractory Long-Term Cholangitis After Pancreaticoduodenectomy: A Retrospective Study2017

    • Author(s)
      Ueda Hiroki、Ban Daisuke、Kudo Atsushi、Ochiai Takanori、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      World Journal of Surgery

      Volume: 41 Issue: 7 Pages: 1882-1889

    • DOI

      10.1007/s00268-017-3912-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emergency cholecystectomy for patients on antiplatelet therapy.2017

    • Author(s)
      Akahoshi K, Ochiai T, Takaoka A, Kitamura T, Ban D, Kudo A, Tanaka S, Tanabe M.
    • Journal Title

      American Surgeon

      Volume: 83(5) Pages: 486-490

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical pitfalls of jejunal vein anatomy in pancreaticoduodenectomy2017

    • Author(s)
      Ishikawa Yoshiya、Ban Daisuke、Matsumura Satoshi、Mitsunori Yusuke、Ochiai Takanori、Kudo Atsushi、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 24 Issue: 7 Pages: 394-400

    • DOI

      10.1002/jhbp.451

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pathogenesis and targeted therapy of pancreatic cancer.2016

    • Author(s)
      Tanaka S.
    • Journal Title

      Annals of Surgical Oncology

      Volume: 23 Issue: S2 Pages: 197-205

    • DOI

      10.1245/s10434-015-4463-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis.2016

    • Author(s)
      Ito H, Tanaka S, Akiyama Y, Shimada S, Adikrisna R, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Yamaoka S, Tanabe M.
    • Journal Title

      Plos One

      Volume: - Issue: 1 Pages: e0146564-e0146564

    • DOI

      10.1371/journal.pone.0146564

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteasome activity is required for the initiation of precancerous pancreatic lesions.2016

    • Author(s)
      Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27044-27044

    • DOI

      10.1038/srep27044

    • NAID

      120006775931

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Autophagy controls centrosome number by degrading Cep63.2016

    • Author(s)
      Watanabe Y, Honda S, Konishi A, Satoko Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 13508-13508

    • DOI

      10.1038/ncomms13508

    • NAID

      120007129257

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer stem-like properties in colorectal cancer cells with low proteasome activity.2016

    • Author(s)
      Munakata K, Uemura M, Tanaka S, Kawai K, Kitahara T, Miyo M, Kano Y, Nishikawa S, Fukusumi T, Takahashi Y, Hata T, Nishimura J, Takemasa I, Mizushima T, Ikenaga M, Kato T, Murata K, Carethers JM, Yamamoto H, Doki Y, Mori M.
    • Journal Title

      Clinical Cancer Research

      Volume: 22 Issue: 21 Pages: 5277-5286

    • DOI

      10.1158/1078-0432.ccr-15-1945

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.2016

    • Author(s)
      Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
    • Journal Title

      Int. J. Oncol.

      Volume: 48 Issue: 2 Pages: 657-669

    • DOI

      10.3892/ijo.2015.3299

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.2016

    • Author(s)
      Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M.
    • Journal Title

      International Journal of Oncology

      Volume: 48 Issue: 9 Pages: 657-69

    • DOI

      10.1007/s00535-015-1159-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression.2016

    • Author(s)
      Akiyama Y, Koda Y, Byeon S, Shimada S, Nishikawaji T, Sakamoto A, Chen Y, Kojima K, Kawano T, Eishi Y, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S.
    • Journal Title

      Oncotarget

      Volume: 7(4) Issue: 4 Pages: 3966-3983

    • DOI

      10.18632/oncotarget.6681

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Overexpression of histone methyltransferase SETDB2 acts an oncogene in gastric cancer.2016

    • Author(s)
      Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 41 Pages: 67251-67265

    • DOI

      10.18632/oncotarget.11625

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.2016

    • Author(s)
      Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Sayuri Nitta S, Watanabe T, Otani S, Taniguchi M, Goto F, Nagata H, Kaneko S, Tasaka-Fujita M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Takano S, Fukasawa M, Sakamoto M, Maekawa S, Enomoto N, Watanabe M.
    • Journal Title

      Journal of Gastroenterology

      Volume: 51 Issue: 5 Pages: 473-486

    • DOI

      10.1007/s00535-015-1126-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation analysis in hepatocellular carcinoma.2016

    • Author(s)
      Yamada N, Yasui K, Dohi O, Gen Y, Tomie A, Kitaichi T, Iwai N, Mitsuyoshi H, Sumida Y, Moriguchi M, Yamaguchi K, Nishikawa T, Umemura A, Naito Y, Tanaka S, Arii S, Itoh Y.
    • Journal Title

      Oncol Rep.

      Volume: 35 Issue: 4 Pages: 2228-2236

    • DOI

      10.3892/or.2016.4619

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy.2016

    • Author(s)
      Furuyama T, Kudo A, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Tanaka S, Tanabe M.
    • Journal Title

      Journal of Hepatobiliary Pancreatic Sciences

      Volume: 23 Issue: 12 Pages: 763-770

    • DOI

      10.1002/jhbp.400

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Precision medicine for HCC and pancreatic cancer (Symposium)2018

    • Author(s)
      Shinji Tanaka
    • Organizer
      The 7th International Forum of The Japanese Society of Gastroenterology Jointly with the 12th International Symposium on ALPD and Cirrhosis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Precision immunotherapy for hypermutator and immunogenic subtypes of hepatocellular carcinoma (Workshop)2018

    • Author(s)
      Shinji Tanaka, Atsushi Oba, Shu Shimada, Yoshimitsu Akiyama, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Minoru Tanabe
    • Organizer
      73rd General Meeting of the Japanese Society of Gastroenterological Surgery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular target therapy for liver cancer under precision medicine (Symposium)2018

    • Author(s)
      Shinji Tanaka
    • Organizer
      77th Annual Meeting of Japanese Cancer Association
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 肝臓外科からみた代謝関連肝癌の分子機序と治療戦略(シンポジウム)2018

    • Author(s)
      田中真二
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 肝癌の予後不良サブタイプの同定とゲノム編集による治療戦略(ワークショップ)2018

    • Author(s)
      田中真二、水野裕貴、田邉稔
    • Organizer
      第16回日本消化器外科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 代謝関連肝癌の特異的バイオマーカーおよび治療標的の同定(ワークショップ)2018

    • Author(s)
      田中真二、小川佳宏、田邉稔
    • Organizer
      第22回日本肝臓学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シンポジウム「肝胆膵がんの分子サブタイプと治療抵抗性解析によるprecision medicineの展開」2017

    • Author(s)
      田中真二、島田周、秋山好光、松村聡、光法雄介、藍原有弘、落合高徳、伴大輔、工藤篤、有井滋樹、田邉稔
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ワークショップ「プレシジョン・メディシンによる肝細胞癌の予後予測と治療展開」2017

    • Author(s)
      田中真二、大庭篤志、小川康介、小野宏晃、光法雄介、伴大輔、工藤篤、有井滋樹、田邉稔
    • Organizer
      第73回日本消化器外科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ワークショップ「生体内における治療抵抗性獲得メカニズム解明と高度進行肝癌への臨床応用」2017

    • Author(s)
      田中真二、大畠慶映、田邉稔
    • Organizer
      第15回日本消化器外科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ワークショップ「 肝がん難治性サブタイプのゲノム編集解析とプレシジョン・メディシンによる治療戦略」2017

    • Author(s)
      田中真二、大庭篤志、島田周、秋山好光、小川康介、小野宏晃、光法雄介、伴大輔、工藤篤、有井滋樹、田邉稔
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シンポジウム:臨床検体のゲノム解析に基づいた遺伝子改変およびゲノム編集技術の臨床応用2016

    • Author(s)
      田中真二、島田周、古山貴基、大庭篤志、茂櫛薫、秋山好光、水野裕貴、小川康介、深町博史、伊藤浩光、光法雄介、松村聡、藍原有弘、伴大輔、落合高徳、工藤篤、川口義弥、田邉稔
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      リーガロイヤルホテル大阪(大阪府、大阪市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] シンポジウム:肝癌の幹細胞性解析とゲノム編集技術を用いた治療応用2016

    • Author(s)
      田中真二、藍原有弘、田邉稔
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都、新宿区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] シンポジウム:肝がん個別化分類に基づいた生体内バイオマーカーの同定による新規分子標的治療の開発と臨床展開2016

    • Author(s)
      田中真二、佐藤公太、田邉稔
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ幕張(千葉県、幕張市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] シンポジウム指定演者:基礎研究から臨床応用への展望2016

    • Author(s)
      田中真二
    • Organizer
      第14回日本肝がん分子標的治療研究会
    • Place of Presentation
      梅田スカイビルタワー(大阪府、大阪市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] パネルディスカッション基調講演:がん分子サブタイプと臨床情報に基づく個別化治療戦略2016

    • Author(s)
      田中真二
    • Organizer
      第52回日本肝癌研究会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都、港区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] シンポジウム:肝胆膵がん個別化分類に基づいた癌幹細胞の治療抵抗性機序の解明と治療展開2016

    • Author(s)
      田中真二、伊藤浩光、古山貴基、藍原有弘、松村聡、光法雄介、伴大輔、落合高徳、工藤篤、田邊稔
    • Organizer
      第72回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール(徳島県、徳島市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 癌幹細胞のエピジェネティック変化と転移性および治療抵抗性獲得機序2016

    • Author(s)
      田中真二、島田周、秋山好光
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ワークショップ:肝癌分子標的薬の生体内感受性バイオマーカー探索と臨床展開2016

    • Author(s)
      田中真二、大畠慶映、田邉稔
    • Organizer
      第14回日本消化器外科学会大会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県、神戸市)
    • Related Report
      2016 Annual Research Report
  • [Book] Molecular analysis for therapeutic targets of pancreatic cancer. IN: Molecular diagnosis and targeting for thoracic and gastrointestinal malignancy2018

    • Author(s)
      Tanaka S. (eds. Shimada Y, Yanaga K)
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report
  • [Book] Molecular diagnosis and targeting for thoracic and gastrointestinal malignancy2018

    • Author(s)
      Tanaka S.
    • Publisher
      Springer
    • ISBN
      9789811064685
    • Related Report
      2017 Annual Research Report
  • [Book] Human Stem Cell Toxicity (ed. Sherley JL)2016

    • Author(s)
      Tanaka S.
    • Total Pages
      299
    • Publisher
      Royal Society of Chemistry (London)
    • Related Report
      2016 Annual Research Report
  • [Remarks] 胃がんにおいてヒストン修飾の異常により悪性度を増すメカニズムを解明

    • Related Report
      2018 Annual Research Report
  • [Remarks] 予後不良膵癌サブタイプにおけるヒストン修飾遺伝子の不活化の意義を解明

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20181218_1.pdf

    • Related Report
      2018 Annual Research Report
  • [Remarks] 肝細胞癌の分子生物学的・免疫学的サブタイプ分類を確立

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20190111_1.pdf

    • Related Report
      2018 Annual Research Report
  • [Remarks] New liver cancer subtypes revealed immunologically

    • URL

      https://www.eurekalert.org/pub_releases/2019-02/tmad-ctd020119.php

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/grad/monc/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 肝がん変異遺伝子ARID2による発がんメカニズムを解明

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20170227.pdf

    • Related Report
      2017 Annual Research Report
  • [Remarks] がんが生体内で治療抵抗性を獲得するメカニズムを解明

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20170301.pdf

    • Related Report
      2017 Annual Research Report
  • [Remarks] 肝がんがロイシン欠乏耐性を獲得するメカニズムを解明

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20180108_1.pdf

    • Related Report
      2017 Annual Research Report
  • [Remarks] メタボ関連肝がんに特異的なバイオマーカーを発見

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20180216_1.pdf

    • Related Report
      2017 Annual Research Report
  • [Remarks] 化合物スクリーニングによりスキルス胃がん特異的に作用する薬剤を発見

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20180313_2.pdf

    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2022-10-07  

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