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Elucidation of the etiology and development of the novel therapy using stem cells from human exfoliated deciduous teeth for Hirschsprung's disease and its allied disorders

Research Project

Project/Area Number 16H02682
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

TAGUCHI Tomoaki  九州大学, 医学研究院, 教授 (20197247)

Co-Investigator(Kenkyū-buntansha) 松浦 俊治  九州大学, 大学病院, 准教授 (10532856)
吉丸 耕一朗  九州大学, 医学研究院, 講師 (60711190)
桐野 浩輔  九州大学, 大学病院, 助教 (00621707)
山座 孝義  九州大学, 歯学研究院, 准教授 (80304814)
山座 治義  九州大学, 歯学研究院, 准教授 (30336151)
尾崎 正雄  福岡歯科大学, 口腔歯学部, 教授 (10152472)
岡 暁子  福岡歯科大学, 口腔歯学部, 准教授 (60452778)
孝橋 賢一  九州大学, 医学研究院, 准教授 (10529879)
梶岡 俊一  九州大学, 医学研究院, 准教授 (90274472)
大賀 正一  九州大学, 医学研究院, 教授 (60233053)
黒田 達夫  慶應義塾大学, 医学部(信濃町), 教授 (60170130)
増本 幸二  筑波大学, 医学医療系, 教授 (20343329)
田尻 達郎  京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
家入 里志  鹿児島大学, 医歯学域医学系, 教授 (00363359)
木下 義晶  新潟大学, 医歯学系, 教授 (80345529)
柳 佑典  九州大学, 大学病院, 助教 (30596664)
野中 和明  九州大学, 歯学研究院, 教授 (90128067)
高田 英俊  九州大学, 医学研究院, 教授 (70294931)
奥野 博庸  慶應義塾大学, 医学部, 助教 (70445310)
中畑 龍俊  京都大学, iPS細胞研究所, 特定拠点教授 (20110744)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000)
Fiscal Year 2019: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2016: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Keywords幹細胞 / 再生医療 / 腸管蠕動不全 / 移植・再生医療 / 再生医学 / 細胞・組織 / 歯学 / 小児外科学 / 再生医療学 / 乳歯幹細胞学 / 細胞移植 / 組織工学 / 指定難病 / ヒルシュスプルング病 / ヒルシュスプルング病類縁疾患 / 乳歯幹細胞
Outline of Final Research Achievements

Among the above-mentioned disease groups, hypoganglionosis (HYPO), which has a poor prognosis, was focused first. HYPO is characterized by the presence of intestinal ganglion cells, but the number is extremely small. Similarly, a mouse (JF1) in which a decrease in intestinal nerve cells was used to elucidate the effect of stem cells from human exfoliated deciduous teeth (SHED). As a result, JF1 mice gained weight , indicating the effectiveness of SHED. Next, the characteristics of SHED derived from HYPO patients (HYPO-SHED) was analyzed. SHED is one of a mesenchymal stem cell (MSC), and HYPO-SHED has a phenotype consistent with MSC, and analysis was conducted on its proliferative potential and tumorigenity.

Academic Significance and Societal Importance of the Research Achievements

SHEDはiPS細胞と比較し遺伝子導入が不要、作成効率が概ね100%、高い自己再生能、HLAの発現が低く拒絶を受けない点で優れ、さらに低侵襲かつ容易に採取可能である。また、歯髄の状態で凍結保存が可能であるため乳歯幹細胞のバンクをつくることができる。本基盤研究にて、健常児由来SHEDにおけるhypoに対する治療メカニズム・治療効果を詳細に解明した上で、hypo-SHEDの細胞の特性の解析に移行し、自家細胞移植の可能性を模索し、バンク化も目指す乳歯保存の基盤づくりを行った。このように実臨床における治療を視野に自家他家移植いずれも実現することを目標とできた本研究は大きな学術的、社会的意義を有する。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (106 results)

All 2019 2018 2017 2016

All Journal Article (30 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 21 results,  Open Access: 6 results) Presentation (71 results) (of which Int'l Joint Research: 25 results,  Invited: 3 results) Book (5 results)

  • [Journal Article] Acquired isolated hypoganglionosis as a distinct entity:results from a nationwide survey2019

    • Author(s)
      Obata S, Yoshimau K, Kirino K, Izaki T,Ieiri S, Yamataka A, Koshinaga T, Iwai J, Ikeda H, Matsufuji H, Oda Y, Taguchi T
    • Journal Title

      Pediatric Surgery International

      Volume: 35 Issue: 2 Pages: 215-220

    • DOI

      10.1007/s00383-018-4398-y

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of outcome in patients with extensive aganglionosis in Japan2019

    • Author(s)
      Obata S, Ieiri S, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nirasawa Y, Honda S, Nio M, Taguchi T
    • Journal Title

      Pediatric Surgery International

      Volume: 35 Issue: 5 Pages: 547-550

    • DOI

      10.1007/s00383-019-04462-9

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Features, Molecular Genetics, and Long-Term Outcome in Congenital Chloride Diarrhea: A Nationwide Study in Japan.2019

    • Author(s)
      Konishi KI, Mizuochi T, Yanagi T, Watanabe Y, Ohkubo K, Ohga S, Maruyama H, Takeuchi I, Sekine Y, Masuda K, Kikuchi N, Yotsumoto Y, Ohtsuka Y, Tanaka H, Kudo T, Noguchi A, Fuwa K, Mushiake S, Ida S, Fujishiro J, Yamashita Y, Taguchi T, Yamamoto K
    • Journal Title

      J Pediatr.

      Volume: 214 Pages: 151-157

    • DOI

      10.1016/j.jpeds.2019.07.039

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery2019

    • Author(s)
      Taguchi T, Yanagi Y, Yoshimaru K, Zhang XY, Matsuura T, Nakayama K, Kobayashi E,Yamaza H, Nonaka K, Ohga S, Yamaza T
    • Journal Title

      Surgery Today. 2019 Apr 49(4)

      Volume: 49 Issue: 4 Pages: 316-322

    • DOI

      10.1007/s00595-019-01783-z

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic potential of spheroids of stem cells from human exfoliated deciduous teeth for chronic liver fibrosis and hemophilia A.2019

    • Author(s)
      Takahashi Y, Yuniartha R, Yamaza T, Sonoda S, Yamaza H, Kirino K, Yoshimaru K, Matsuura T, Taguchi T.
    • Journal Title

      Pediatr Surg Int

      Volume: 35 Issue: 12 Pages: 1379-1388

    • DOI

      10.1007/s00383-019-04564-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease.2019

    • Author(s)
      Junko Fujiyoshi
    • Journal Title

      Scientific Report

      Volume: 9 Issue: 1 Pages: 1535-1535

    • DOI

      10.1038/s41598-018-38275-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ヒルシュプスルング病 小児科診療ガイドライン ―最新の診療指針―2019

    • Author(s)
      田口智章、吉丸耕一朗、小幡 聡
    • Journal Title

      総合医学社

      Volume: - Pages: 262-266

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 慢性特発性偽性腸閉塞症2019

    • Author(s)
      田口智章
    • Journal Title

      日本医師会雑誌

      Volume: 148 Pages: 234-235

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 特集 境界領域の診療 外科的疾患 Hirschsprung病―類縁疾患を含めて2019

    • Author(s)
      田口智章、小幡 聡、吉丸耕一朗
    • Journal Title

      小児内科

      Volume: 51 Pages: 1532-1537

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Regeneration of diaphragm with bio-3D cellular patch2018

    • Author(s)
      Zhang Xiu-Ying、Yanagi Yusuke、Sheng Zijing、Nagata Kouji、Nakayama Koichi、Taguchi Tomoaki
    • Journal Title

      Biomaterials

      Volume: 167 Pages: 1-14

    • DOI

      10.1016/j.biomaterials.2018.03.012

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 小児外科領域における乳歯肝細胞を用いた再生医療2018

    • Author(s)
      田口智章、吉丸耕一郎、栁佑典、張 秀英、桐野浩輔、山座孝義
    • Journal Title

      周産期医学

      Volume: 48 Pages: 855-862

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児短腸症候群・小腸機能不全の最前線 2.ヒルシュプスルング病およびその類縁疾患-成因から再生医療まで-2018

    • Author(s)
      205吉丸耕一朗、桐野浩輔、栁佑典、河野雄紀、河野淳、入江敬子、髙橋良彰
    • Journal Title

      日本外科学会雑誌

      Volume: 119 Pages: 616-622

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The incidence of chylous ascites after liver transplantation and the proposal of a diagnostic and management protocol2018

    • Author(s)
      Matsuura Toshiharu、Yanagi Yusuke、Hayashida Makoto、Takahashi Yoshiaki、Yoshimaru Koichiro、Taguchi Tomoaki
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 53 Issue: 4 Pages: 671-675

    • DOI

      10.1016/j.jpedsurg.2017.06.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児外科領域における新規治療の開発-難治性疾患に対する乳歯歯髄肝細胞を用いた新規治療-2018

    • Author(s)
      285田口智章、吉丸耕一朗、栁佑典、松浦俊治
    • Journal Title

      第118回日本外科学会定期学術集会

      Volume: 宿題報告 Pages: 61-70

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Current status of Hirschsprung’s disease: based on a nationwide survey of Japan2017

    • Author(s)
      Taguchi Tomoaki、Obata Satoshi、Ieiri Satoshi
    • Journal Title

      Pediatric Surgery International

      Volume: 33 Issue: 4 Pages: 497-504

    • DOI

      10.1007/s00383-016-4054-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The incidence and outcome of allied disorders of Hirschsprung's disease in Japan: Results from a nationwide survey.2017

    • Author(s)
      Taguchi T, Ieiri S, Miyoshi K, Kohashi K, Oda Y, Kubota A, Watanabe Y, Matsufuji H, Fukuzawa M, Tomomasa T
    • Journal Title

      Asian Journal of Surgery

      Volume: 40(1) Issue: 1 Pages: 29-34

    • DOI

      10.1016/j.asjsur.2015.04.004

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pediatric-onset Chronic Nonspecific Multiple Ulcers of Small Intestine2017

    • Author(s)
      Uchida Keiichi、Nakajima Atsushi、Ushijima Kosuke、Ida Shinobu、Seki Yoshitaka、Kakuta Fumihiko、Abukawa Daiki、Tsukahara Hisayuki、Maisawa Shun-ichi、Inoue Mikihiro、Araki Toshimitsu、Umeno Junji、Matsumoto Takayuki、Taguchi Tomoaki
    • Journal Title

      Journal of Pediatric Gastroenterology and Nutrition

      Volume: 64 Issue: 4 Pages: 565-568

    • DOI

      10.1097/mpg.0000000000001321

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondria Regulate the Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth2017

    • Author(s)
      Kato H, Thi Mai Pham T, Yamaza H, Masuda K, Hirofuji Y, Han X, Sato H, Taguchi T, Nonaka K
    • Journal Title

      Cell Structure and Function

      Volume: 42 Issue: 2 Pages: 105-116

    • DOI

      10.1247/csf.17012

    • NAID

      130005982848

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunostaining for Hu C/D and CD56 is useful for a definitive histopathological diagnosis of congenital and acquired isolated hypoganglionosis2017

    • Author(s)
      Yoshimaru Koichiro、Taguchi Tomoaki、Obata Satoshi、Takemoto Junkichi、Takahashi Yoshiaki、Iwanaka Tsuyoshi、Yanagi Yusuke、Kuda Masaaki、Miyoshi Kina、Matsuura Toshiharu、Kinoshita Yoshiaki、Yoshioka Takako、Nakazawa Atsuko、Oda Yoshinao
    • Journal Title

      Virchows Archiv

      Volume: 470 Issue: 6 Pages: 679-685

    • DOI

      10.1007/s00428-017-2128-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo and ex vivo methods of growing a liver bud through tissue connection2017

    • Author(s)
      Yanagi Yusuke、Nakayama Koichi、Taguchi Tomoaki、Enosawa Shin、Tamura Tadashi、Yoshimaru Koichiro、Matsuura Toshiharu、Hayashida Makoto、Kohashi Kenichi、Oda Yoshinao、Yamaza Takayoshi、Kobayashi Eiji
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14085-14085

    • DOI

      10.1038/s41598-017-14542-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 乳歯幹細胞を用いた肝再生研究2017

    • Author(s)
      栁 佑典、山座孝義、山座治義、野中和明、中山功一、吉丸耕一朗、岩中 剛、高橋良彰、Rathi Yuniartha、松浦俊治、孝橋賢一、小田義直、大賀正一、絵野沢伸、小林英司、田口智章
    • Journal Title

      小児外科

      Volume: 49 Pages: 567-571

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 乳歯歯髄幹細胞を用いた腸管神経再生による先天性腸管蠕動不全に対する新規治療法の開発2017

    • Author(s)
      吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、小田義直、田口智章
    • Journal Title

      日本小児栄養消化器肝臓学会雑誌

      Volume: 31 Pages: 84-84

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ヒルシュスプルング病及びその類縁疾患に対する幹細胞を用いた新規治療法の展望2017

    • Author(s)
      吉丸耕一朗、山座孝義、近藤琢也、髙橋良彰、岩中 剛、Ratih Yuniartha、栁 佑典、小幡 聡、江角元史郎、伊崎智子、松浦俊治、木下義晶、田口智章
    • Journal Title

      小児外科

      Volume: 49 Pages: 579-584

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Massive pulmonary hemorrhage before living donor liver transplantation in infants2016

    • Author(s)
      Matsuura T, Yoshimaru K, Yanagi Y, Esumi G, Hayashida M, Taguchi T
    • Journal Title

      Pediatr Transplant

      Volume: 20(1) Issue: 1 Pages: 89-95

    • DOI

      10.1111/petr.12650

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical strategy according to the anatomical types of congenital portosystemic shunts in children2016

    • Author(s)
      Matsuura T, Takahashi Y, Yanagi Y, Yoshimaru K, Yamamura K, Morihana E, Nagata H, Uike K, Takada H, Taguchi T
    • Journal Title

      J Pediatr Surg

      Volume: 51(12) Issue: 12 Pages: 2099-2104

    • DOI

      10.1016/j.jpedsurg.2016.09.046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insufficient portal vein inflow in children without major shunt vessels during living donor liver transplantation2016

    • Author(s)
      Matsuura T, Yoshimaru K, Yanagi Y, Esumi G, Hayashida M, Taguchi T
    • Journal Title

      Ann Transplant

      Volume: 21 Pages: 373-379

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virtually transparent surgical instruments in endoscopic surgery with augmentation of obscured regions2016

    • Author(s)
      Koreeda Y, Kobayashi Y, Ieiri S, Nishio Y, Kawamura K, Obata S, Souzaki R, Hashizume M, Fujie MG
    • Journal Title

      Int J Comput Assist Radiol Surg

      Volume: - Issue: 10 Pages: 1927-1936

    • DOI

      10.1007/s11548-016-1384-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bowel obstruction without history of laparotomy: Clinical analysis of 70 patients2016

    • Author(s)
      Yoshimaru K, Wada M, Esumi G, Takahashi Y, Yanagi Y, Hayashida M, Matsuura T, Ieiri S, Kinoshita Y, Taguchi T
    • Journal Title

      Pediatr Int

      Volume: 58 Issue: 11 Pages: 1205-1210

    • DOI

      10.1111/ped.13003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 小児外科領域の臨床研究:難治性疾患からTRまで(第15回臨床研究セミナー 第3部外科臨床研究の実践)2016

    • Author(s)
      田口智章
    • Journal Title

      日外会誌

      Volume: 117(3) Pages: 236-238

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 新生児生体肝移植の治療選択~産褥期生体ドナーの是非~2016

    • Author(s)
      松浦俊治、髙橋良彰、吉丸耕一朗、栁 佑典、落合正行、日高庸博、加藤聖子、田口智章
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 51(5) Pages: 1451-1454

    • Related Report
      2016 Annual Research Report
  • [Presentation] Transplantation of Hepatocyte-like cells derived from stem cells from human exfoliated deciduous teeth in alternative of liver transplantation in mice2019

    • Author(s)
      田口智章
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 発達障害に伴う消化管症状への漢方治療の可能性2019

    • Author(s)
      宮田潤子
    • Organizer
      第56回日本小児外科学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 歯髄幹細胞を用いたhypoganglionosisに対する新規治療法~克服すべき課題とひらけてきた未来~2019

    • Author(s)
      吉丸耕一朗、山座孝義、梶岡俊一、松浦俊治、小田義直、田口智章
    • Organizer
      第61回日本平滑筋学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Allied Functional Bowel Disorders Simulating Hirschsprung’s Disease2019

    • Author(s)
      Taguchi T
    • Organizer
      ISPSR2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腹部症状に対する黄耆建中湯と小建中湯の処方決定までのプロセスと決め手になった所見に関する考察2019

    • Author(s)
      宮田潤子、入江敬子、貝沼茂三郎、田口智章
    • Organizer
      PSJM2019/第35回日本小児外科学会秋季シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 外科的加療を要する術後腸閉塞の特徴2019

    • Author(s)
      河野 淳、吉丸耕一朗、近藤琢也、高橋良彰、小幡 聡、松浦俊治、伊崎智子、田口智章
    • Organizer
      PSJM2019/第35回日本小児外科学会秋季シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Stem cell therapy and future treatment for congenital refractory hypoperistalsis2019

    • Author(s)
      Matsuura T, Yoshimaru K, Yamaza T, Kajioka S, Takahashi Y, Yanagi Y, Taguchi T
    • Organizer
      1st Seoul International Symposium for Pediatric Surgery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Allied Functional Bowel Disorders Simulating Hirschsprung’s Disease2019

    • Author(s)
      Matsuura T, Taguchi T
    • Organizer
      1st Seoul International Symposium for Pediatric Surgery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 母の腸洗浄により維持されているCIIP症例2019

    • Author(s)
      江角元史郎、中村 睦、河野 淳、近藤琢也、栁 佑典、小幡 聡、松浦俊治、伊崎智子、田口智章
    • Organizer
      第49回日本小児消化管機能研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 産科DICとなった慢性特発性偽牲腸閉塞(CIIP)の1例2019

    • Author(s)
      伊崎智子、栁 佑典、江角元史郎、深水倫子、宮田潤子、小幡 聡、入江敬子、田口智章、城戸咲、片山由大、加藤聖子
    • Organizer
      第49回日本小児消化管機能研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hirschsprung病類縁(H類縁)疾患患者を両親とする児の経過と周産期における問題点2019

    • Author(s)
      髙橋良彰、吉丸耕一朗、栁佑典、松浦俊治、河野淳、桐野浩輔、江角元史郎、田口智章
    • Organizer
      第31回日本小児小腸移植研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Outcomes of Transanal Endorectal Pull-through for Hirschsprung’s Disease Regarding Mucosectomy-commencing Points -According to the Results from a Nationwide Survey in Japan-2019

    • Author(s)
      Obata S, Ieiri S, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nirasawa Y, Honda S, Nio M, Taguchi T
    • Organizer
      PAPS2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト脱落乳歯歯髄幹細胞を用いた腸管神経節細胞僅少症に対する腸管神経再生医療2018

    • Author(s)
      吉丸 耕一朗,山座 孝義,梶岡 俊一,高橋 良彰,栁 佑典,松浦 俊治,小田 義直, 田口 智章
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児外科領域における新規治療の開発-難治性疾患に対する乳歯歯髄肝細胞を用いた新規治療2018

    • Author(s)
      田口 智章
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Outcomes of Laparoscopy-assisted Operation for Rcctosigmoid Hirschsprung’s disease in Japan: Comparison to Non-laparoscopy-assisted Operations2018

    • Author(s)
      Obata S, Souzaki R, Ieiri1 S, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nirasawa Y, Honda S, Nio M, Hashizume M, Taguchi T
    • Organizer
      IPEG’s 27th Annual Congress for Endosurgery in Children
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 間葉系幹細胞を用いた腸管神経節細胞僅少症に対する新規再生医療の確立2018

    • Author(s)
      吉丸 耕一朗,山座 孝義,梶岡 俊一,高橋 良彰,栁 佑典,松浦 俊治,小田 義直, 田口 智章
    • Organizer
      第121回日本小児科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nationwide survey on allied disorders of Hirschsprung’s disease in Japan2018

    • Author(s)
      Taguchi T
    • Organizer
      PAPS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intestinal Neuronal Dysplasia Type B-like Lesion; Possible Finding of Pathological Maturation Process in Immaturity of Ganglia2018

    • Author(s)
      Obata S, Yoshimaru K, Miyoshi K, Esumi G, Miyata J, Izaki T, Taguchi T
    • Organizer
      PAPS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hirschsprung’s disease, Japanese nation-wide survey2018

    • Author(s)
      Taguchi T
    • Organizer
      The 40th Anniversary Memorial Lecture, Division of Pediatric surgery, SNUH
    • Related Report
      2018 Annual Research Report
  • [Presentation] ひらけてきた未来と克服すべき課題~歯髄幹細胞を用いたhypoganglionosis に対する新規治療法の確立~2018

    • Author(s)
      吉丸 耕一朗,山座 孝義,梶岡 俊一,高橋 良彰,栁 佑典,松浦 俊治,小田 義直, 田口 智章
    • Organizer
      第55回日本小児外科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児再生医療の進歩と小児在宅医療2018

    • Author(s)
      田口 智章
    • Organizer
      第43回北九州ブロック医師会全体協議会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Novel Therapy for Congenital Isolated Generalized Hypoganglionosis Using Mesenchymal Stem Cel2018

    • Author(s)
      Taguchi T, Yoshimaru K, Kirino K, Esumi G, Izaki T
    • Organizer
      PCC25
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acquired Hypoganglionosis as a Distinct Entity: Results from a Nationwide Survey2018

    • Author(s)
      Obata S, Yoshimaru K, Kirino K, Izaki T, Ieiri S, Yamataka A, Koshinaga S, Iwai J, Ikeda H, Taguchi T
    • Organizer
      PCC25
    • Related Report
      2018 Annual Research Report
  • [Presentation] Therapeutic Innovation using Stem Cell for Intractable Pediatric Surgical Disease2018

    • Author(s)
      田口 智章
    • Organizer
      PCC25
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Operative Results for Consecutive 200 Cases of Hirschsprung’s Disease with the Focus on Complications in a Single Institution Experiences2018

    • Author(s)
      Ieiri S, Jimbo T, Obata S, Nagata K, Miyoshi K, Miyata J, Izaki T, Taguchi T
    • Organizer
      PCC25
    • Related Report
      2018 Annual Research Report
  • [Presentation] Management of Hypoganglionosis2018

    • Author(s)
      Taguchi T, Yoshimaru K, Kirino K, Esumi G, Izaki T
    • Organizer
      ISPSR2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effective spheroids transplantation of SHED (Stem cells from Human Exfoliated Deciduous Teeth) derived hepatocytes-like cells in liver fibrosis mice2018

    • Author(s)
      Takahashi Y, Yuniartha R,Yamaza T, Kirino K, Yanagi Y, Matsuura T, Taguchi T
    • Organizer
      ISPSR2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Biliary lineage of Hepatocyte-like cells derived from SHED (Stem Cells from Human Exfoliated Deciduous Teeth) in liver fibrosis mice2018

    • Author(s)
      Takahashi Y, Yuniartha R,Yamaza T, Kirino K, Yanagi Y, Matsuura T, Taguchi T
    • Organizer
      ISPSR2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hirschsprung病術後臀部皮膚トラブルへの漢方治療の可能性2018

    • Author(s)
      古澤敬子、宮田潤子、小幡聡、江角元史郎、伊崎智子、田口智章
    • Organizer
      PSJM2018 第23回日本小児外科漢方研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Biliary lineage of Hepatocyte-like cells derived from mesenchymal stem cell(MSC)in liver fibrosis mice model.2018

    • Author(s)
      Taguchi T, Yuniartha R, Yamaza T, Kirino K, Yoshimaru K, Yanagi Y, Matsuura T
    • Organizer
      VCGT2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Radical innovative therapy for congenital isolated generalized hypoganglionosis using stem cells from human exfoliated deciduous teeth(SHED)2018

    • Author(s)
      Yoshimaru K, Yamaza T, Kirino K, Esumi G, Izaki T, Taguchi T
    • Organizer
      VCGT2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hirschaprung’s disease-related Short Bowel Syndrome-High Mortality Rate from a Nationwide Survey Result in Japan2018

    • Author(s)
      Taguchi T, Obata S, Takashi A. Urushihara N, Kawahara H, Kubota M, Kono M, Nirasawa Y, Honda S, Nio M, Ieiri S
    • Organizer
      AAPS2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stem cell therapy for Pediatric Surgical diseases2017

    • Author(s)
      Taguchi T
    • Organizer
      Pediatric Surgery Update Symposium
    • Place of Presentation
      Chittagong, Bangladesh
    • Year and Date
      2017-03-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] hypoganglionosis2017

    • Author(s)
      Taguchi T
    • Organizer
      Pediatric Surgery Update Symposium
    • Place of Presentation
      Chittagong, Bangladesh
    • Year and Date
      2017-03-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成長ホルモン分泌不全性低身長症を合併した超短腸症候群症例の経験2017

    • Author(s)
      江角元史郎、三好きな、永田公二、伊崎智子、田口智章、大久保一宏、高田英俊、関口和人、井原健二
    • Organizer
      第32回日本静脈経腸栄養学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2017-02-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新生児外科の進歩と新規治療の開発2017

    • Author(s)
      田口智章
    • Organizer
      鹿児島大学病院 成育診療リサーチセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Current status of intestinal transplantation in japan2017

    • Author(s)
      Matsuura T, Ueno T, Wada M, Hoshino K, Okajima H, Furukawa H, Taguchi T, Nishida S, Beduschi T, Vianna R
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 成人期に達したヒルシュスプルング病類縁疾患患者の検討2017

    • Author(s)
      江角元史郎,小幡聡,三好きな,吉丸耕一朗,宮田潤子,松浦俊治,伊崎智子,田口智章
    • Organizer
      第54回日本小児外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒルシュスプルング病の診断におけるAChE 染色とHE 染色の併用の有用性2017

    • Author(s)
      吉丸耕一朗,木下義晶,小幡聡,武本淳吉,髙橋良彰,岩中剛,栁佑典,三好きな,江角元史郎,宮田潤子,久田正昭,松浦俊治,考橋賢一,小田義直,田口智章
    • Organizer
      第54回日本小児外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Operative Results For Consecutive 200 Cases Of Hirschsprung’S Disease With The Focus On Redo Surgery Based On Over Half Century Single Institution Experiences2017

    • Author(s)
      Ieiri S, Jimbo T, Obata S, Nagata K, Miyoshi K, Miyata J, Izaki T, Taguchi T
    • Organizer
      Pediatric Colorectal Club 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High Mortality Rate of Hirschsprung’s disease-related Short Bowel Syndrome ?Result from a Nationwide Survey in Japan-2017

    • Author(s)
      Taguchi T, Obata S, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nirasawa Y, Honda S, Nio M, Ieiri S
    • Organizer
      PAPS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Current Trend of Laparoscopy-assisted Operation for Hirschsprung’s disease in Japan2017

    • Author(s)
      Obata S, Ieiri S, Souzaki R, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nirakawa Y, Honda S, Nio M, Hashizume M, Taguchi T
    • Organizer
      PAPS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒルシュスプルング病類縁疾患2017

    • Author(s)
      田口智章
    • Organizer
      第44回日本胆道閉鎖症研究会・第44回日本小児栄養消化器肝臓学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 乳歯歯髄幹細胞を用いた腸管神経再生による先天性腸管蠕動不全に対する新規治療法の開発2017

    • Author(s)
      吉丸耕一朗
    • Organizer
      第44回日本胆道閉鎖症研究会・第44回日本小児栄養消化器肝臓学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児生体肝移植におけるバックテーブル手術~肝静脈再建の工夫~2017

    • Author(s)
      髙橋良彰、松浦俊治、吉丸耕一朗、田口智章
    • Organizer
      PSJM2016&秋季シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hypoganglionosis におけるストーマ閉鎖術前評価の工夫-胃瘻ボタンを用いた疑似閉鎖2017

    • Author(s)
      伊崎智子、江角元史郎、三好きな、小幡聡、川久保尚徳、吉丸耕一朗、船津康孝、鴨打周、田口智章
    • Organizer
      PSJM2017&秋季シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒルシュスプルング病類縁疾患に対する乳歯歯髄幹細胞を用いた腸管神経再生医療2017

    • Author(s)
      吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁佑典、松浦俊治、小田義直、田口智章
    • Organizer
      PSJM2018&秋季シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Experiences of Isolated hypoganglionosis(IH) in Kyushu University2017

    • Author(s)
      Izaki T, Esumi G, Yoshimaru K, Miyoshi K, Taguchi T
    • Organizer
      CSPC
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel therapy for congenital refractory hypoperistalsis using mesenchymal stem cel2017

    • Author(s)
      吉丸 耕一朗
    • Organizer
      台湾小児栄養消化器肝臓学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新生児外科の最近の進歩と移植再生医療2017

    • Author(s)
      田口智章
    • Organizer
      総合周産期母子医療センターセミナー
    • Place of Presentation
      福岡
    • Related Report
      2016 Annual Research Report
  • [Presentation] 間葉系幹細胞を用いた先天性機能的腸管不全に対する新規治療の開発2017

    • Author(s)
      吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、松浦俊治、田口智章
    • Organizer
      第29回日本小腸移植研究会
    • Place of Presentation
      愛知
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pediatric Liver Transplantation for Biliary Atresia2016

    • Author(s)
      Taguchi T, Mastuura T, Yoshimaru K,Takahashi Y
    • Organizer
      31st EPSA,IPEG Middle East Chapter
    • Place of Presentation
      Cairo,Egypt
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New therapeutic proposal for Hirschsprung’s disease and allied disorders using the stem cells2016

    • Author(s)
      Yoshimaru K, Yamaza T, Kajioka S, Nakamura M, Takahashi Y, Yanagi Y, Matsuura T, Izaki T, Taguchi T
    • Organizer
      Annual Conference of Cambodian Society of Surgery
    • Place of Presentation
      Phnom Pehn, Cambodia
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本におけるヒルシュスプルング病の変遷-全国調査よりみえる変遷-2016

    • Author(s)
      田口智章、小幡 聡、秋山卓士、漆原直人、本田昌平、川原央好、河野美幸、窪田正幸、韮澤融司、仁尾正紀、家入里志
    • Organizer
      PSJM2016(第36回日本小児内視鏡外科・手術手技研究会)
    • Place of Presentation
      埼玉
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Current Profile of Hirschsprung’s Disease in Japan - A 5-year Nationwide Survey -2016

    • Author(s)
      Taguchi T, Obata S, JimboT, Ieiri S, Kubota M, Kono M, Nio M, Nirasawa Y, Honda S
    • Organizer
      WOFAPS2016
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bowel Perforation after Liver Transplantation for Biliary Atresia:A Retrospective Study for the Care of the Transition From Children to Adult2016

    • Author(s)
      Yanagi Y, Matsuura T, Hayashida M, Takahashi Y, Yoshimaru K, Esumi G, Taguchi T
    • Organizer
      WOFAPS2016
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rectal mucosal punch biopsy using K-PUNCH for the diagnosis of Hirschsprung’s disease:A thirty-year experience of 954 patients2016

    • Author(s)
      Yoshimaru K, Kinoshita Y, Yanagi Y, Obata S, Iwanaka T, Takahashi Y, Miyata J, Matsuura T, Taguchi T
    • Organizer
      WOFAPS2016
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hypoganlionosis2016

    • Author(s)
      Taguchi T
    • Organizer
      IAPSCON 2016 AGRA
    • Place of Presentation
      Taj Ganj, Agra, India
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 間葉系幹細胞を用いたヒルシュスプルング病類縁疾患に対する新規治療法の開発2016

    • Author(s)
      吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、松浦俊治、田口智章
    • Organizer
      第43回日本小児栄養消化器肝臓学会
    • Place of Presentation
      茨城
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒルシュスプルング病-40年間の全国調査よりみえる本邦での変遷­-2016

    • Author(s)
      小幡 聡、田口智章、神保教広、家入里志
    • Organizer
      第5回日本小児診療多職種研究会
    • Place of Presentation
      神奈川
    • Year and Date
      2016-07-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新生児肝臓移植の適応疾患2016

    • Author(s)
      松浦俊治、髙橋良彰、吉丸耕一朗、栁 佑典、田口智章
    • Organizer
      第52回日本周産期・新生児医学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳歯幹細胞を用いた肝再生医療2016

    • Author(s)
      栁 佑典、吉丸耕一朗、岩中 剛、髙橋良彰、松浦俊治、山座孝義、山座治義、野中和明、田口智章
    • Organizer
      第52回日本周産期・新生児医学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肝オルガノイド移植2016

    • Author(s)
      栁 佑典、中山功一、小林英司、絵野沢伸、髙橋良彰、吉丸耕一朗、松浦俊治、田口智章
    • Organizer
      第34回日本肝移植研究会
    • Place of Presentation
      北海道
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] EFFICACY OF HUC/D AND CD56 IMMUNOSTAINING AS STANDARD HISTOLOGICAL DIAGNOSTIC TOOL FOR CONGENITAL AND ACQUIRED HYPOGANGLIONOSIS2016

    • Author(s)
      Taguchi T, Yoshimaru K, Miyoshi K, Takahashi Y, Takemoto J, Iwanaka T, Obata S, Yanagi Y, Jimbo T, Kuda M, Kinoshita Y, Yoshioka T, Nakazawa A, Oda Y
    • Organizer
      EUPSA2016
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳歯幹細胞を用いた肝再生医療研究2016

    • Author(s)
      栁 佑典、吉丸耕一朗、岩中 剛、高橋良彰、松浦俊治、山座孝義、山座治義、野中和明、田口智章
    • Organizer
      第53回日本小児外科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] A 40-year Nationwide Survey of 4,939 patients of Hirschsprung’s Disease in Japan2016

    • Author(s)
      Taguchi T, Obata S, Jimbo T, Ieiri S, Nakame K, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nio M, Nirasawa Y, Honda S
    • Organizer
      PAPS2016
    • Place of Presentation
      ,Na Pali coast,Kauai,Hawaii
    • Year and Date
      2016-04-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Surgical strategy based on the anatomical types of congenital portosystemic shunts in children2016

    • Author(s)
      Matsuura T, Takahashi Y, Yoshimaru K, Yanagi Y, Taguchi T
    • Organizer
      PAPS2016
    • Place of Presentation
      Na Pali coast,Kauai,Hawaii
    • Year and Date
      2016-04-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acquired Hypoganglionosis in Japan; Based on a Nationwide Survey in 10 Years2016

    • Author(s)
      Obata S, Ieiri S,Yamataka A, Koshinaga T, Iwai J, Ikeda H, Taguchi T
    • Organizer
      PAPS2016
    • Place of Presentation
      Na Pali coast,Kauai,Hawaii
    • Year and Date
      2016-04-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of splenectomy before liver transplantation in biliary atresia patients2016

    • Author(s)
      Takahashi Y, Matsuura T, Yoshimaru K, Yanagi Y, Taguchi T
    • Organizer
      PAPS2016
    • Place of Presentation
      Na Pali coast,Kauai,Hawaii
    • Year and Date
      2016-04-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞の自己組織化を応用した3D プリンティング技術による肝組織構築2016

    • Author(s)
      栁 佑典、小林英司、中山功一、絵野沢伸、髙橋良彰、岩中 剛、吉丸耕一朗、松浦俊治、田口智章
    • Organizer
      第116 回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 体性幹細胞を用いたヒルシュスプルング病とその類縁疾患の新規治療開発2016

    • Author(s)
      吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、松浦俊治、田口智章
    • Organizer
      第116 回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Book] Hirschsprung's Disease and the Allied Disorders2019

    • Author(s)
      Taguchi T, Matsufuji H, Ieiri S
    • Total Pages
      292
    • Publisher
      Springer
    • ISBN
      9789811336065
    • Related Report
      2019 Annual Research Report
  • [Book] Newborn Surgery 4th Edition2017

    • Author(s)
      Prem Puri
    • Total Pages
      1238
    • Publisher
      CRC Press
    • ISBN
      9781482247701
    • Related Report
      2017 Annual Research Report
  • [Book] Operative General Surgery in neonates and Infants Springer Japan 20162016

    • Author(s)
      Taguchi T, Iwanaka T, Okamatsu T
    • Total Pages
      402
    • Publisher
      Springer Japan 2016
    • Related Report
      2016 Annual Research Report
  • [Book] 小児科診療ガイドライン -最新の診療方針-2016

    • Author(s)
      田口智章、吉丸耕一朗、小幡 聡
    • Total Pages
      670
    • Publisher
      株式会社 総合医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 小児慢性特定疾病 診断の手引き2016

    • Author(s)
      虫明聡太郎、鈴木光幸、中山佳子、疋田敏之、窪田正幸、新井勝大、小林一郎、工藤豊一郎、角田知之、十河 剛、佐々木英之、須磨崎亮、杉浦時雄、近藤宏樹、乾あやの、村上 潤、丸尾良浩、上野豪久、和田 基、家入里志、松藤 凡、福澤正洋、曺 英樹、田口智章、渡邉芳夫、黒田達夫
    • Total Pages
      980
    • Publisher
      株式会社 診断と治療社
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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