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Establishment of international diagnostic methods for piroplasmosis by a ring trial.

Research Project

Project/Area Number 16H02768
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Veterinary medical science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

Igarashi Ikuo  帯広畜産大学, 原虫病研究センター, 名誉教授 (80159582)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000)
Fiscal Year 2018: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2017: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Keywordsピロプラズマ病 / 診断法 / 蛍光抗体法 / ELISA / イムノクロマト法 / 遺伝子診断法 / リングトライアル / 疫学調査 / 血清診断法 / 国際標準法 / 国際標準 / 世界的規模 / 国際基準法
Outline of Final Research Achievements

Diagnostic methods for piroplasmosis, worldwide problems for animal industry, were evaluated internationally. By international evaluation, IFA antigen slides for equine piroplasmosis made using cultured protozoa were shown to have a high sensitivity and keep antigenicity after a long term storage. A high possibility of the commercial kit production were suggested for ELISA and immunochromatographic test (ICT) for equine piroplasmosis. Furthermore, a new genotype of Babesia caballi and a new species of bovine Theileria were identified by international epidemiology study. These research achievements were recognized as a worldwide study base of a piroplasmosis.

Academic Significance and Societal Importance of the Research Achievements

ピロプラズマ病は世界的規模で動物の健康や動物の国際的な移動、検疫体制の強化においてで重大な問題となっており、国際的な診断法の確立が求められている。本研究は世界の研究機関や大学各国の検疫所と協力することにより、ピロプラズマ病の国際標準法の確立に貢献した。また、馬ピロプラズマ病の間接蛍光抗体法のスライド抗原を各国の検査機関に供給し、検疫体制の強化に貢献している。更にWHOの動物版組織である国際獣疫事務局(OIE)リファレンスラボラトリーとして、欧米からの依頼により確定診断を実施し国際的な診断拠点として機能し高い評価を得ている。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (71 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (12 results) Journal Article (27 results) (of which Int'l Joint Research: 27 results,  Peer Reviewed: 27 results,  Open Access: 8 results,  Acknowledgement Compliant: 5 results) Presentation (31 results) (of which Int'l Joint Research: 19 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] Institute of Agriculture Technology(アルゼンチン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Institute of Animal Health(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Canadian Food Inspection Agency(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Tai Lung Veterinary Laboratory Hong Kong(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Institute of Animal Health/Kerataro University(メキシコ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Institute of Animal Health(Mexico)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Institute of Agriculture Technology(Argentina)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Canadian Food Inspection Agency(Canada)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Animal and Plant Health Agency(United Kingdom)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Kasetsart University/National Institute of Animal Health(Thailand)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] National Research Centre on Equines(India)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Mongolian Veterinary Institute(Mongolia)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Epidemiological survey of hemoprotozoan parasites in cattle from low-country wet zone in Sri Lanka2019

    • Author(s)
      Gunasekara Erandi、Sivakumar Thillaiampalam、Kothalawala Hemal、Abeysekera Thuduwege Sanath、Weerasingha Amitha Sampath、Vimalakumar Singarayar Caniciyas、Kanagaratnam Ratnam、Yapa Palitha Rohana、Zhyldyz Atambekova、Igarashi Ikuo、Silva Seekkuge Susil Priyantha、Yokoyama Naoaki
    • Journal Title

      Parasitology International

      Volume: 71 Pages: 5-10

    • DOI

      10.1016/j.parint.2019.03.004

    • NAID

      120006603077

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Review on Equine Piroplasmosis: Epidemiology, Vector Ecology, Risk Factors, Host Immunity, Diagnosis and Control2019

    • Author(s)
      Onyiche ThankGod E.、Suganuma Keisuke、Igarashi Ikuo、Yokoyama Naoaki、Xuan Xuenan、Thekisoe Oriel
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 16 Issue: 10 Pages: 1736-1736

    • DOI

      10.3390/ijerph16101736

    • NAID

      120006708986

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Seroepidemiological Survey of Theileria equi and Babesia caballi in Horses in Mongolia2019

    • Author(s)
      Myagmarsuren P, Sivakumar T, Enkhtaivan B, Davaasuren B, Zoljargal M, Narantsatsral S, Davkharbayar B, Mungun-Ochir B, Battur B, Inoue N, Igarashi I, Battsetseg B, Yokoyama N.
    • Journal Title

      Journal of Parasitology

      Volume: 105 Pages: 580-586

    • NAID

      120006875732

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epidemiological survey of <i>Anaplasma marginale</i> in cattle and buffalo in Sri Lanka2019

    • Author(s)
      ZHYLDYZ Atambekova、SIVAKUMAR Thillaiampalam、IGARASHI Ikuo、GUNASEKARA Erandi、KOTHALAWALA Hemal、SILVA Seekkuge Susil Priyantha、YOKOYAMA Naoaki
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 11 Pages: 1601-1605

    • DOI

      10.1292/jvms.19-0242

    • NAID

      130007752559

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic Analysis of Babesia Isolates from Cattle with Clinical Babesiosis in Sri Lanka2018

    • Author(s)
      Sivakumar Thillaiampalam、Tuvshintulga Bumduuren、Zhyldyz Atambekova、Kothalawala Hemal、Yapa Palitha Rohana、Kanagaratnam Ratnam、Vimalakumar Singarayar Caniciyas、Abeysekera Thuduwege Sanath、Weerasingha Amitha Sampath、Yamagishi Junya、Igarashi Ikuo、Silva Seekkuge Susil Priyantha、Yokoyama Naoaki
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 56 Issue: 11

    • DOI

      10.1128/jcm.00895-18

    • NAID

      120006540776

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transovarial persistence ofBabesia ovata DNA in a hard tick, Haemaphysalis longicornis, in a semi-artificialmouse skin membrane feeding system.2018

    • Author(s)
      Umemiya-Shirafuji R, Hatta T, Okubo K, Sato M, Maeda H, Kume A, Yokoyama N,Igarashi I, Tsuji N, Fujisaki K, Inoue N, Suzuki H.
    • Journal Title

      Acta Parasitol.

      Volume: 63 Issue: 2 Pages: 433-433

    • DOI

      10.1515/ap-2018-0051

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serological and molecular detection of Theileria equi and Babesia caballi in Philippine horses2018

    • Author(s)
      Ybanez Adrian P.、Ybanez Rochelle Haidee D.、Talle Maxfrancis G.、Arreglo Rinna Marie T.、Geens Mary Janniel C.、Villas Jun Gelacio I.、Villar Stephanie R.、Laruga Charmen L.、Cao Shinuo、Moumouni Franck Paul Adjou、Liu Mingming、Igarashi Ikuo、Xuan Xuenan
    • Journal Title

      Ticks and Tick-borne Diseases

      Volume: 9 Issue: 5 Pages: 1125-1128

    • DOI

      10.1016/j.ttbdis.2018.04.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serological and molecular prevalence of equine piroplasmosis in Western Java, Indonesia2018

    • Author(s)
      Nugraha Arifin Budiman、Cahyaningsih Umi、Amrozi Amrozi、Ridwan Yusuf、Agungpriyono Srihadi、Taher Dharmawaty Muhammad、Guswanto Azirwan、Gantuya Sambuu、Tayebwa Dickson Stuart、Tuvshintulga Bumduuren、Sivakumar Thillaiampalam、Yokoyama Naoaki、Igarashi Ikuo
    • Journal Title

      Veterinary Parasitology: Regional Studies and Reports

      Volume: 14 Pages: 1-6

    • DOI

      10.1016/j.vprsr.2018.07.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epidemiological survey of a cervine Theileria in wild deer, questing ticks, and cattle in Hokkaido, Japan2018

    • Author(s)
      Shibata Shunya、Sivakumar Thillaiampalam、Igarashi Ikuo、Umemiya-Shirafuji Rika、Inokuma Hisashi、Fukumoto Shinya、Yokoyama Naoaki
    • Journal Title

      Ticks and Tick-borne Diseases

      Volume: 9 Issue: 5 Pages: 1235-1240

    • DOI

      10.1016/j.ttbdis.2018.05.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serosurvey of Babesia bovis and Babesia bigemina in cattle in Mongolia2018

    • Author(s)
      Battsetseg Badgar、Sivakumar Thillaiampalam、Naranbaatar Khandsuren、Narantsatsral Sandagdorj、Myagmarsuren Punsantsogvoo、Enkhtaivan Batsaikhan、Davaasuren Batdorj、Mizushima Daiki、Weerasooriya Gayani、Igarashi Ikuo、Battur Banzragch、Yokoyama Naoaki
    • Journal Title

      Veterinary Parasitology: Regional Studies and Reports

      Volume: 13 Pages: 85-91

    • DOI

      10.1016/j.vprsr.2018.04.003

    • NAID

      120006684091

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular epidemiology of Babesia species, Theileria parva, and Anaplasma marginale infecting cattle and the tick control malpractices in Central and Eastern Uganda2018

    • Author(s)
      Tayebwa Dickson Stuart、Vudriko Patrick、Tuvshintulga Bumduuren、Guswanto Azirwan、Nugraha Arifin Budiman、Gantuya Sambuu、Batiha Gaber El-Saber、et al.
    • Journal Title

      Ticks and Tick-borne Diseases

      Volume: 9 Issue: 6 Pages: 1475-1483

    • DOI

      10.1016/j.ttbdis.2018.06.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Seroprevalence of Babesia bovis , B. bigemina , Trypanosoma evansi , and Anaplasma marginale antibodies in cattle in southern Egypt2017

    • Author(s)
      Fereig Ragab M.、Mohamed Samy G.A.、Mahmoud Hassan Y.A.H.、AbouLaila Mahmoud Rezk、Guswanto Azirwan、Nguyen Thu-Thuy、Ahmed Mohamed Adel Elsayed、Inoue Noboru、Igarashi Ikuo、Nishikawa Yoshifumi
    • Journal Title

      Ticks and Tick-borne Diseases

      Volume: 8 Issue: 1 Pages: 125-131

    • DOI

      10.1016/j.ttbdis.2016.10.008

    • NAID

      120006390997

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of immunochromatographic test (ICT) strips for the serological detection of Babesia bovis and Babesia bigemina infection in cattle from Western Java, Indonesia2017

    • Author(s)
      Guswanto A, Allamanda P, Mariamah ES, Munkjargal T, Tuvshintulga B, Takemae H, Sivakumar T, AbouLaila M, Terkawi MA, Ichikawa-Seki M, Nishikawa Y, Yokoyama N, Igarashi I
    • Journal Title

      Vet Parasitol

      Volume: 印刷中 Pages: 76-79

    • DOI

      10.1016/j.vetpar.2017.04.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites2017

    • Author(s)
      Rizk Mohamed Abdo、El-Sayed Shimaa Abd El-Salam、AbouLaila Mahmoud、Yokoyama Naoaki、Igarashi Ikuo
    • Journal Title

      Experimental Parasitology

      Volume: 179 Pages: 43-48

    • DOI

      10.1016/j.exppara.2017.06.003

    • NAID

      120006407581

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Babesia bovis BOV57, a Theileria parva P67 homolog, is an invasion-related, neutralization-sensitive antigen2017

    • Author(s)
      Ishizaki Takahiro、Sivakumar Thillaiampalam、Hayashida Kyoko、Takemae Hitoshi、Tuvshintulga Bumduuren、Munkhjargal Tserendorj、Guswanto Azirwan、Igarashi Ikuo、Yokoyama Naoaki
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 54 Pages: 138-145

    • DOI

      10.1016/j.meegid.2017.06.025

    • NAID

      120006411414

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular identification and antigenic characterization of Babesia divergens Erythrocyte Binding Protein (BdEBP) as a potential vaccine candidate2017

    • Author(s)
      El-Sayed Shimaa Abd El-Salam、Rizk Mohamed Abdo、Terkawi Mohamad Alaa、Yokoyama Naoaki、Igarashi Ikuo
    • Journal Title

      Parasitology International

      Volume: 66 Issue: 6 Pages: 721-726

    • DOI

      10.1016/j.parint.2017.07.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA-binding activity on Babesia bovis2017

    • Author(s)
      Tuvshintulga Bumduuren、AbouLaila Mahmoud、Sivakumar Thillaiampalam、Tayebwa Dickson Stuart、Gantuya Sambuu、Naranbaatar Khandsuren、Ishiyama Aki、Iwatsuki Masato、Otoguro Kazuhiko、?mura Satoshi、Terkawi Mohamad Alaa、Guswanto Azirwan、Rizk Mohamed Abdo、Yokoyama Naoaki、Igarashi Ikuo
    • Journal Title

      Scientific Report

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-14304-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Performance and consistency of a fluorescence-based high-throughput screening assay for use in Babesia drug screening in mice2017

    • Author(s)
      Rizk Mohamed Abdo、El-Sayed Shimaa Abd El-Salam、AbouLaila Mahmoud、Eltaysh Rasha、Yokoyama Naoaki、Igarashi Ikuo
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-13052-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular and serological detection of bovine babesiosis in Indonesia2017

    • Author(s)
      Guswanto Azirwan、Allamanda Puttik、Mariamah Euis Siti、Sodirun Sodirun、Wibowo Putut Eko、Indrayani Liliek、Nugroho Rudi Harso、Wirata I Ketut、Jannah Nur、Dias Lepsi Putri、Wirawan Hadi Purnama、Yanto Rochmadi、Tuvshintulga Bumduuren、Sivakumar Thillaiampalam、Yokoyama Naoaki、Igarashi Ikuo
    • Journal Title

      Parasites & Vectors

      Volume: 10 Issue: 1 Pages: 10-550

    • DOI

      10.1186/s13071-017-2502-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clofazimine inhibits the growth of Babesia and Theileria parasites in vitro and in vivo.2016

    • Author(s)
      Tuvshintulga, B., AbouLaila, M., Davaasuren, B., Ishiyama, A., Sivakumar, T., Yokoyama, N., Iwatsuki, M., Otoguro, K., Omura, S., and Igarashi, I.
    • Journal Title

      Antimicrob. Agents Chemother.

      Volume: 60 Issue: 5 Pages: 2739-46

    • DOI

      10.1128/aac.01614-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RBC Invasion and invasion-inhibition assays using free merozoites isolated after cold treatment of Babesia bovis in vitro culture.2016

    • Author(s)
      Ishizaki, T., Sivakumar, T., Hayashida, K., Tuvshintulga, B., Igarashi, I., and Yokoyama N.
    • Journal Title

      Exp. Parasitol.

      Volume: 166 Pages: 10-15

    • DOI

      10.1016/j.exppara.2016.03.010

    • NAID

      120006390946

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification and characterization of profilin antigen among Babesia species as a common vaccine candidate against babesiosis.2016

    • Author(s)
      Munkhjargal, T., Aboge, G.O., Ueno, A., Aboulaila, M., Yokoyama, N., and Igarashi I.
    • Journal Title

      Exp. Parasitol.

      Volume: 166 Pages: 29-36

    • DOI

      10.1016/j.exppara.2016.03.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular and biochemical characterization of methionine aminopeptidase of Babesia bovis as a potent drug target.2016

    • Author(s)
      Munkhjargal, T., Ishizaki, T., Guswanto, A., Takemae, H., Yokoyama, N., and Igarashi, I.
    • Journal Title

      Vet. Parasitol.

      Volume: 221 Pages: 14-23

    • DOI

      10.1016/j.vetpar.2016.02.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic diversity and antigenicity variation of Babesia bovis merozoite surface antigen-1 (MSA-1) in Thailand.2016

    • Author(s)
      Tattiyapong, M., Sivakumar, T., Takemae, H., Simking, P., Jittapalapong, S., Igarashi, I., and Yokoyama, N.
    • Journal Title

      Infect. Genet. Evol.

      Volume: 41 Pages: 255-261

    • DOI

      10.1016/j.meegid.2016.04.021

    • NAID

      120006390947

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Recombinant methionine aminopeptidase protein of Babesia microti: immunobiochemical characterization as a vaccine candidate against human babesiosis.2016

    • Author(s)
      Munkhjargal, T., Yokoyama, N., and Igarashi, I.
    • Journal Title

      Parasitol. Res.

      Volume: 115 Issue: 9 Pages: 3669-76

    • DOI

      10.1007/s00436-016-5172-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond2016

    • Author(s)
      Van Voorhis WC, Abd El-Salam El-Sayed S, Igarashi I, Abdo Rizk M, Yokoyama N, et al
    • Journal Title

      PLOS Pathogens

      Volume: 12 Issue: 7 Pages: e1005763-e1005763

    • DOI

      10.1371/journal.ppat.1005763

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Large-scale drug screening against Babesia divergens parasite using a fluorescence-based high-throughput screening assay.2016

    • Author(s)
      Rizk, M.A., El-Sayed, S.A., AbouLaila, M., Tuvshintulga, B., Yokoyama, N., and Igarashi I.
    • Journal Title

      Vet. Parasitol.

      Volume: 227 Pages: 93-7

    • DOI

      10.1016/j.vetpar.2016.07.032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Expressing of Green Fluorescent Protein in intraerythrocytic stage of Theileria equi2019

    • Author(s)
      Arifin Nugraha,Bumduuren Tuvshintulga,Ming Ming Liu,Xuenan Xuan,Naoaki Yokoyama, Ikuo Igarashi
    • Organizer
      第60回日本熱帯医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of unstable resistance to diminazene aceturate in Babesia bovis2019

    • Author(s)
      Bumduuren Tuvshintulga,Thillaiampalam Sivakumar,Naoaki Yokoyama,Ikuo Igarashi
    • Organizer
      第60回日本熱帯医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The in vitro and in vivo inhibitory effect of Moringa olivera leaves on Babesia and Theileria parasites2019

    • Author(s)
      Mohamed A. Rizk, Shimaa El-Sayed, Noakia Yokoyama, Ikuo Igarashi
    • Organizer
      第88回日本寄生虫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] An immunochromatographic test for human babesiosis caused by Babesia microti2018

    • Author(s)
      Ikuo Igarashi
    • Organizer
      The 14th International Congress of Parasitology(
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clofazimine as a potential agent for treating human babesiosis caused by Babesia microti2018

    • Author(s)
      B. Tuvshintulga, T. Sivakumar, N. Yokoyama, I. Igarashi
    • Organizer
      The 14th International Congress of Parasitology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on Babesia and Theileria parasite2018

    • Author(s)
      Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Naoaki Yokoyama, and Ikuo Igarash
    • Organizer
      The 14th International Congress of Parasitology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cryptolepine and ellagic acid inhibit Babesia and Theileria in vitro2018

    • Author(s)
      Amani Magdi Beshbishy, Gaber El-Saber Batiha, Naoaki Yokoyama, Ikuo Igarashi
    • Organizer
      The 14th International Congress of Parasitology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serological and molecular prevalence of equine piroplasmosis in Western Java, Indonesia2018

    • Author(s)
      Arifin Budiman Nugraha, Umi Cahyaningsih, Amrozi, Azirwan Guswanto, Sambuu Gantuya, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi
    • Organizer
      第116会日本獣医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Inhibitory effects of chalcone and trans-chalcone on the growth of Babesia and Theileria2018

    • Author(s)
      Gaber El-Saber Batiha, Amany Magdy Beshbishy, Naoaki Yokoyama and Ikuo Igarashi
    • Organizer
      第116会日本獣医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Evaluation of the Chemotherapeutic Potential of Nitidine chloride and Camptothecin Against Babesia and Theileria2018

    • Author(s)
      Ikuo Igarashi, Dickson S. Tayebwa, Bumduuren Tuvshintulga, Azirwan Guswanto, Thillaiampalam Sivakumar, Naoaki Yokoyama
    • Organizer
      The 67th Annual Meeting of American Society of Tropical Medine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening the Medicines for Malaria Venture Pathogen Box against piroplasm parasites2018

    • Author(s)
      Arifin Budiman Nugraha, Bumdureen Tuvshintulga, Mohamed Abdo Rizk, Sambuu Gantuya, Gaber El-Saber Batiha, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi.
    • Organizer
      第59回日本熱帯医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Inhibitory effects of ivermectin on the growth Babesia and Theileria2018

    • Author(s)
      Gaber El-Saber Batiha, Amany Magdy Beshbishy, Naoaki Yokoyama and Ikuo Igarashi
    • Organizer
      第59回日本熱帯医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance.2018

    • Author(s)
      Mohamed Abdo Rizk, Mahmoud AbouLaila, Shimaa Abd El-Salam El-Sayed, Azirwan Guswanto, Naoaki Yokoyama, and Ikuo Igarashi
    • Organizer
      第87回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular epidemiology of Babesia species, Theileria parva, and Anaplasma marginale infecting cattle in central and eastern Uganda.2018

    • Author(s)
      Dickson Tayebwa, Patrick Vudriko, Bumduuren Tuvshintulga, Azirwan Guswanto, Arifin Budiman Nugrahaa Sambuu Gantuya, Gaber El-Saber Batiha, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi
    • Organizer
      第87回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Research global and live local ~ピロプラズマ病研究を振り返って~2017

    • Author(s)
      五十嵐郁男
    • Organizer
      86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Efficacy of combination chemotherapy with clofazimine and diminazene aceturate against Babesia and Theileria infections2017

    • Author(s)
      Ikuo Igarashi
    • Organizer
      Parasitology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of nitidine chloride and camptothecin on the in vitro growth of Babesia and Theileria2017

    • Author(s)
      Dickson Stuart Tayebwa, Bumduuren Tuvshintulga, Azirwan Guswanto, Mohamed Abdo Rizk, Gantuya Sambuu, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi
    • Organizer
      26th International Conference of the Worl Assocoiation for Advancement of Veterinary Parasitology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular and serological detection of bovine babesiosis in Indonesia.2017

    • Author(s)
      Azirwan Guswanto, Puttik Allamanda, Euis Siti Mariamah, Sodirun Sodirun, Putut Eko Wibowo Liliek Indrayani, Rudi Harso Nugroho, Ketut Wirata, Nur Jannah, Lepsi Putri Dias, Hadi Purnama Wirawan, Rochmadi Yanto, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, and Ikuo Igarashi
    • Organizer
      26th International Conference of the Worl Assocoiation for Advancement of Veterinary Parasitology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epidemiological study of equine piroplasmosis in Western Java, Indonesia.2017

    • Author(s)
      Arifin Nugraha, Umi Cahyaningsih, Amorozi, Azirwan Guswanto, Sambu Gantuya, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, and Ikuo Igarashi
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of in vitro inhibitory effects of clove and green tea extracts on Babesia and Theileria parasites.2017

    • Author(s)
      G.El-S. Batiha, A. M. Marey, N. Yokoyama, and I. Igarashi
    • Organizer
      第63回日本寄生虫学会・日本衛生動物学会北日本支部合同大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Performance and consistency of a fluorescence-based high-throughput screening assay for use in Babesia drug screening in mice.2017

    • Author(s)
      M. A. Rizk, S. A. E. El-Sayed, N. Yokoyama, and I. Igarashi
    • Organizer
      第63回日本寄生虫学会・日本衛生動物学会北日本支部合同大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combination efficacy of clofazimine against piropmamosis.2017

    • Author(s)
      Bumduuren Tuvshintulga, Mahmoud AbouLaila, Thillaiampalam Sivakumar, Dickson Stuart Tayebwa, Sambuu Gantuya, Khandsuren Naranbaatar, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Ohmura Mohamad Alaa Terkawi, Azirwan Guswanto, Mohamed Abdo Rizk, Naoaki Yokoyama, Ikuo Igarashi
    • Organizer
      第66回アメリカ熱帯医学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cinnamon extracts inhibit the growth of Babesia and Theileria in vitro and in vivo.2017

    • Author(s)
      Gaber El-Saber Batiha, Amany Magdy Marey, Bumduuren Tuvshintulga, Dickson Stuart Tayebwa, Thillaiampalam Sivakumar, Naoaki Yokoyama and Ikuo Igarashi
    • Organizer
      第58回日本熱帯医学会大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimization of a fluorescence-based assay for mass drug screening against Babesia and Theileria2016

    • Author(s)
      MA RIZK,, SA El-SAYD, N YOKOYAMA, I IGARASHI
    • Organizer
      第10回国際馬感染症学会
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clofazimine Inhibits the Growth of Babesia and Theileria Parasites In Vitro and In Vivo.2016

    • Author(s)
      Tuvshintulga B, AbouLaila M, Davaasuren B, Ishiyama A, Sivakumar T, Yokoyama N, Iwatsuki M, Otoguro K,Ohmura S, Igarashi I.
    • Organizer
      第12回国際熱帯医学・マラリア学会
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interaction and chemotherapeutic activity of clofazimine and diminazene aceturate against prioplasm parasites,2016

    • Author(s)
      トウブシントラガ ブムドウーレン、横山直明、五十嵐郁男
    • Organizer
      第83回日本寄生虫学会大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Diminazene aceturate-based drug combinations against babesiosis2016

    • Author(s)
      Azirwan Guswanto、横山直明、五十嵐郁男
    • Organizer
      第83回日本寄生虫学会大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Recombinant methionine aminopeptidase protein of Babesia microti: immunobiochemical characterization as a vaccine candidate against human babesiosis2016

    • Author(s)
      ツェエンドルジ ムンフジャルガル、横山直明、五十嵐郁男
    • Organizer
      第83回日本寄生虫学会大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vitro screening of nitidine chlride against Babesia and Theikleria parasites.2016

    • Author(s)
      Tayebwa Dicson, Tuvshintulga B, Guswanto A, Rizk MA, Yokoyama N, Igarashi I.
    • Organizer
      第57回日本熱帯医学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Large-scale drug screening against Babesia divergens parasite using a fluorescence-based high-throughput screening assay2016

    • Author(s)
      Rizk MA, El-Sayed SA, AbouLaila M, Tuvshintulga B, Yokoyama N, Igarashi I.
    • Organizer
      第65回アメリカ熱帯医学会
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation, cultivation and molecular characterization of a new Trypanosoma equiperdum strain in Mongolia.2016

    • Author(s)
      Keisuke Suganuma, Ikuo Igarashi, Narantsatsral Sandagdorj, Battur Banzragch, Shino Yamasaki, Otgonsuren Davaajav, Musinguzi Simon Peter, Davaasuren Batdorj, c, Battsetseg Badgar, Noboru Inoue
    • Organizer
      1st International Conference on Non Tsetse Transmitted Animal Trypanosomosis
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 高度診断学分野

    • URL

      http://www.obihiro.ac.jp/~protozoa/koudosindan_research.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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