| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
|
|---|
| Outline of Final Research Achievements |
We found that theta waves in the hippocampus are deeply involved in memory retrieval related to action plans. Breakthroughs have been made in the development of techniques to manipulate replay phenomena that are reactivated within tens of milliseconds, both in electrophysiological recording methods and in neural stimulation methods using optogenetics. Furthermore, by directly linking these methods in real time, we are developing methods to selectively and real time manipulate the activity of only parvalbumin-positive cells depending on the specific phase of the theta-band LFP. To investigate the retrieval mechanism of episodic memory, we developed a reconfigurable maze and successfully constructed a task to force animals to experience multiple episodes in the same external environment.
|
