• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Diagnosis Support System for Arteriosclerosis toward the Final Stage of Real Application

Research Project

Project/Area Number 16H02875
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Soft computing
Research InstitutionYamaguchi University

Principal Investigator

Uchino Eiji  山口大学, 大学院創成科学研究科, 教授 (30168710)

Co-Investigator(Kenkyū-buntansha) 末竹 規哲  山口大学, 大学院創成科学研究科, 教授 (80334051)
廣 高史  日本大学, 医学部, 准教授 (10294638)
江口 正徳  一般財団法人ファジィシステム研究所, 研究部, 主任研究員 (60613594)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywords心筋梗塞 / 動脈硬化診断 / 血管内超音波法 / プラーク組織性状判別 / ソフトコンピューティング / 学習 / 確率的情報処理
Outline of Final Research Achievements

Myocardial infarction is caused by a rupture of plaque built up inside an artery. Evaluation of the progression of the atherosclerotic plaque and its rupture-prone risk is a crucial task in order to prevent its fatal consequences. Intravascular ultrasound (IVUS) technique allows us to investigate the inside of the coronary artery using ultrasound. We developed soft computing based medical diagnosis system to characterize plaque tissue, and then to provide medical doctors with the structure of the plaque piled up inside the coronary artery. This leads to the easy understanding of the state of the plaque (stable or unstable), and the medical doctors can make decisions whether a treatment is necessary or not. The validation was carried out on many human data towards the practical application of the proposed system.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した診断支援システムは医師の経験や診断プロセスをソフトコンピューティング理論を用いて具現化したものであり,従来の古典的な信号処理,画像処理では実現できなかったものである.本システムにより,血管内のプラークが組織ごとに色分けされ,構造も表示されるので,医師も治療方針が立てやすくなった.また,本システムにより質の高い医療が一般に提供できるようになり,さらには,プラークが構造とともに可視化されることにより,不必要なステント治療の抑制により医療コストの低減にもつながる.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016 Other

All Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (15 results) (of which Int'l Joint Research: 8 results,  Invited: 4 results) Remarks (2 results)

  • [Journal Article] Recognition of Coronary Atherosclerotic Plaque Tissue on Intravascular Ultrasound Image by Using Misclassification Sensitive Training of Discriminative Restricted Boltzmann Machines2018

    • Author(s)
      Kuong Trong Nguyen, Eiji Uchino and Noriaki Suetake
    • Journal Title

      Journal of Biomimetics, Biomaterials and Biomedical Engineering

      Volume: 37 Pages: 85-93

    • DOI

      10.4028/www.scientific.net/jbbbe.37.85

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coronary Plaque Classification with Accumulative Training of Deep Boltzmann Machines2018

    • Author(s)
      Kuong Trong Nguyen, Eiji Uchino and Noriaki Suetake
    • Journal Title

      ICIC Express Letters

      Volume: 12 Issue: 09 Pages: 881

    • DOI

      10.24507/icicel.12.09.881

    • ISSN
      1881-803X
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recognition of Coronary Atherosclerotic Plaque Tissue on Intravascular Ultrasound Images by Using Misclassification Sensitive Training of Discriminative Restricted Boltzmann Machine2018

    • Author(s)
      Kuong Trong Nguyen, Eiji Uchino, Noriaki Suetake
    • Journal Title

      Journal of Biomimetics, Biomaterials and Biomedical Engineering

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coronary Plaque Classification with Accumulative Training of Deep Boltzmann Machines2018

    • Author(s)
      Kuong Trong Nguyen, Eiji Uchino, Noriaki Suetake
    • Journal Title

      Innovative Computing, Information and Control Express Letters

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IVUS Tissue Characterization of Coronary Plaque by Classification Restricted Boltzmann Machine2017

    • Author(s)
      Nguyen Trong Kuong, Eiji Uchino, Noriaki Suetake
    • Journal Title

      Journal of Advanced Computational Intelligence and Intelligent Informatics

      Volume: 21 Issue: 1 Pages: 67-73

    • DOI

      10.20965/jaciii.2017.p0067

    • NAID

      130007520143

    • ISSN
      1343-0130, 1883-8014
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronary Plaque Characterization Considering Continuity of Tissue by Sparse Modeling of 2D IVUS Signal2016

    • Author(s)
      Shota Furukawa, Eiji Uchino, Tadahiro Azetsu, Noriaki Suetake
    • Journal Title

      International Journal of Biomedical Soft Computing and Human Sciences, The Best Paper Award

      Volume: Vol.20 Pages: 23-29

    • NAID

      110010039418

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Human-Like Advanced Coronary Plaques in Low-Density Lipoprotein Receptor Knockout Pigs and Justification for Statin Treatment Before Formation of Atherosclerotic Plaques2016

    • Author(s)
      Y. Li, D. Fuchimoto, M. Sudo, H. Haruta, Q.F. Lin, T. Takayama, S. Morita, T. Nochi, S. Suzuki, S. Sembon, M. Nakai, M. Kojima, M. Iwamoto, M. Hashimoto, S. Yoda, S. Kunimoto, T. Hiro, T. Matsumoto, M. Mitsumata, M. Sugitani, S. Saito, A. Hirayama, A. Onishi
    • Journal Title

      Journal of American Heart Association

      Volume: Vol.5 Issue: 4

    • DOI

      10.1161/jaha.115.002779

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple k-Nearest Neighbor Classifier and Its Application to Tissue Characterization of Coronary Plaque2016

    • Author(s)
      Eiji Uchino, Ryosuke Kubota, Takanori Koga, Hideaki Misawa, Noriaki Suetake
    • Journal Title

      IEICE Transactions on Information and Systems

      Volume: Vol.E99-D Pages: 1920-1927

    • NAID

      130005160316

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Soft Computing-Based Intelligent Diagnosis of Arteriosclerosis - Coronary Arteries and Retinal Vessels -2019

    • Author(s)
      Eiji Uchino
    • Organizer
      KES International Conference on Innovation in Medicine and Healthcare, Keynote Speech
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Tissue Characterization of Coronary Plaque by Using Multiple SVMs with Tree Structure2019

    • Author(s)
      Kota Hirano, Hiroaki Koga, Noriaki Suetake and Eiji Uchino
    • Organizer
      2019 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分類組織のクラス不均衡性と組織間の実距離を考慮した冠動脈プラークの組織分類法2018

    • Author(s)
      平野貢大, 古賀裕章, 末竹規哲, 内野英治
    • Organizer
      バイオメディカル・ファジィ・システム学会第31回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Should the Strategy for Secondary Prevention of Coronary Artery Disease be Different in Diabetic Patients?2017

    • Author(s)
      Takafumi Hiro
    • Organizer
      66th Annual Scientific Session and Expo of the American College of Cardiology
    • Place of Presentation
      Washington DC(USA)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Future Technology of Intravascular Ultrasound and Optical Imaging2017

    • Author(s)
      Takafumi Hiro
    • Organizer
      66th Annual Scientific Session and Expo of the American College of Cardiology
    • Place of Presentation
      Washington DC(USA)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVUS Tissue Characterization in Time-Frequency Domain Using Discriminative Restricted Boltzmann Machines2017

    • Author(s)
      Nguyen Trong Kuong, Eiji Uchino, Noriaki Suetake
    • Organizer
      2017 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Place of Presentation
      Guam(USA)
    • Year and Date
      2017-02-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple Tissue Characterization of Coronary Plaque Based on One-Versus-the-Rest Classifier Using Sparse Features2017

    • Author(s)
      Shota Furukawa, Eiji Uchino, Noriaki Suetake
    • Organizer
      2017 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Place of Presentation
      Guam(USA)
    • Year and Date
      2017-02-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多段SVM による冠動脈プラークの組織性状判別2017

    • Author(s)
      平野貢大,古賀裕章,末竹規哲,内野英治
    • Organizer
      2017年電子情報通信学会通信ソサイエティ大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 判別難易性に基づくツリー状配置SVMを用いた血管内プラークの組織同定2017

    • Author(s)
      平野貢大, 古賀裕章, 末竹規哲, 内野英治
    • Organizer
      第50回日本人間工学会中国・四国支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ソフトコンピューティングによる医用画像解析-冠動脈と網膜血管の動脈硬化診断-2017

    • Author(s)
      内野英治
    • Organizer
      平成29年度 日本知能情報ファジィ学会中国・四国支部大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] IVUS Tissue Characterization in Time-Frequency Domain Using Discriminative Restricted Boltzmann Machines2017

    • Author(s)
      Kuong Trong Nguyen, Eiji Uchino, Noriaki Suetake
    • Organizer
      2017 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple Tissue Characterization of Coronary Plaque Based on One-Versus-the-Rest Classifier Using Sparse Features2017

    • Author(s)
      Shota Furukawa, Eiji Uchino, Tadahiro Azetsu, Noriaki Suetake
    • Organizer
      2017 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coronary Plaque Classification with Discriminitive Restricted Boltzmann Machine and Adaptive Synthetic Sampling2017

    • Author(s)
      Kuong Trong Nguyen, Eiji Uchino, Noriaki Suetake
    • Organizer
      19th IEEE Hiroshima Section Student Symposium
    • Related Report
      2017 Annual Research Report
  • [Presentation] 複数組織から構成される冠動脈プラークのスパースコーディングによる組織性状判別2016

    • Author(s)
      古川翔大, 内野英治, 末竹規哲
    • Organizer
      第32回ファジィシステムシンポジウム
    • Place of Presentation
      佐賀大学(佐賀県・佐賀市)
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] スパース特徴量と部分空間法による冠動脈プラークの複数組織同定2016

    • Author(s)
      古川翔大, 内野英治, 末竹規哲
    • Organizer
      第49回日本人間工学会中国・四国支部大会
    • Place of Presentation
      香川大学(香川県・高松市)
    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究代表者ホームページ

    • URL

      http://www.ic.sci.yamaguchi-u.ac.jp/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.ic.sci.yamaguchi-u.ac.jp/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi