| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Outline of Final Research Achievements |
We successfully improved a method to predict promoters and enhancers, non-coding genomic region to regulate gene expression from neighboring and distal regions, based on transcription initiation activities. Firstly we performed integration of multiple layers of functional genomic data, such as transcription initiation activities, nucleosome structure, and histone modification. Next we revisited the feature of transcription initiation activities from the perspectives of directionalities (unidirectional, bidirectional) and architecture (convergent and divergent). We developed a new prediction method based on the examined feature, in particular the architecture, and succeeded to increase precision and recall of the predicted results. Finally we identified a set of overlooked regulatory regions in the human genome.
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