Research Project
Grant-in-Aid for Scientific Research (B)
Hematopoietic tissues are highly sensitive to radiation and prone to radiation injury. It is feared that hematopoietic failure develops and, as a result of the later effects, hematopoietic abnormalities such as leukemia could be induced. We have analyzed effects of low dose-rate radiation exposure on hematopoietic tissues, that have largely remained elusive, and aimed to contribute for establishing a basic theory for preventing the adverse effects of low dose-rate exposure. We found that low dose-rate radiation exposure specifically decreased the number and activity of immature hematopoietic cells including hematopoietic stem cells. We then detailed the mechanism underlying the decrease at the molecular and cellular levels, further at the single cell level. Not only DNA repair responses against the genome damage but also apoptosis and cellular differentiation were induced in immature hematopoietic cells, which may give rise to specific reduction of immature hematopoietic cells.
本研究では、今まで充分には明らかにされて来なかった低線量率放射線被ばくの造血システムへの影響について細胞レベルから分子レベルまで詳細に解析した。原発作業や宇宙開発などの環境下では、長期間に渡る低線量率放射線被ばくが生ずることが危惧され、本研究で明らかにしたように造血幹細胞の特異的な減少や機能障害によって造血不全や免疫不全が引き起こされる危険性が考えられる。本研究成果を基に、低線量率放射線被ばくによって造血幹細胞障害が引き起こされるメカニズムが更に明らかにされ、新たな防御法の開発に道が開かれることを期待したい。
All 2019 2018 2017 2016
All Journal Article (5 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 5 results, Open Access: 4 results) Presentation (20 results) (of which Int'l Joint Research: 2 results)
Epigenomes
Volume: 印刷中
Nature Communications
Volume: 9 Issue: 1 Pages: 2202-2202
10.1038/s41467-018-04441-z
Volume: 1(3) Issue: 3 Pages: 22-22
10.3390/epigenomes1030022
放射線生物研究
Volume: 52(4) Pages: 336-349
