Elucidation of the mechanism of heavy metal-induced skin cancer and its application to prediction and prevention

• Project/Area Number: 16H02962
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Shibaura Institute of Technology (2018-2019); Nagoya University (2016-2017)
• Principal Investigator: Yajima Ichiro 芝浦工業大学, システム理工学部, 教授 (80469022)
• Co-Investigator(Kenkyū-buntansha): 大神 信孝 名古屋大学, 医学系研究科, 准教授 (80424919) ; 吉永 雅史 名古屋大学, 医学系研究科, 助教 (80754978)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: ヒ素 / メラノサイト / 皮膚がん / 重金属 / 毒性学 / がん / 皮膚 / 分子生物学 / 色素細胞 / 皮膚癌 / 環境学 / トキシコロジー / 飲用水

Outline of Final Research Achievements

More than 200 million people worldwide have access to drinking water contaminated with heavy metals, including arsenic, and many of them have skin Benign diseases, premalignant conditions, and skin cancer may occur in the United States and are extremely serious. Despite the fact that this is a serious problem, effective methods of prediction and prevention have not yet been established and must be established as soon as possible. In order to solve this problem, it has been reported that heavy metal-induced skin cancer, including heavy metal arsenic, has been detected by new exposure tests. In order to solve this problem, we have been investigating a new type of arsenic-induced skin cancer (arsenic-containing skin cancer) by means of exposure tests. We attempted to elucidate the pathogenic mechanism of arsenic.
By exposing various heavy metal elements, including arsenic, in both single and combined forms, we identified new related molecules and elucidated their new functions.

Academic Significance and Societal Importance of the Research Achievements

本研究計画で着目している環境健康問題はその対象が2億人以上であり、且つ世界の様々な地域で起きている問題についてその解決に取り組んでいる。今回得られた成果は、これまで不明だったヒ素を含む重金属誘導性皮膚癌発症機構の一部が解明されたことを意味しており、この機構をターゲットとして有効な予知・予防法の開発が期待される。このようなことから、本研究成果は学術的にも社会的にも非常に意義のある成果であると言える。

Research Products

• [Journal Article] Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water (2020)
  • Author(s): Kato Masashi、Ohgami Nobutaka、Ohnuma Shoko、Hashimoto Kazunori、Tazaki Akira、Xu Huadong、Kondo-Ida Lisa、Yuan Tian、Tsuchiyama Tomoyuki、He Tingchao、Kurniasari Fitri、Gu Yishuo、Chen Wei、Deng Yuqi、Komuro Kanako、Tong Keming、Yajima Ichiro
  • Journal Title: Environmental Health and Preventive Medicine Volume: 25 Issue: 1 Pages: 16-16
  • DOI: 10.1186/s12199-020-00855-8
  • NAID: 210000158248
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin (2019)
  • Author(s): Iida Machiko、Tazaki Akira、Deng Yuqi、Chen Wei、Yajima Ichiro、Kondo-Ida Lisa、Hashimoto Kazunori、Ohgami Nobutaka、Kato Masashi
  • Journal Title: Chemosphere Volume: 235 Pages: 713-718
  • DOI: 10.1016/j.chemosphere.2019.06.185
  • NAID: 120006777551
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hearing loss in humans drinking tube well water with high levels of iron in arsenic?polluted area (2019)
  • Author(s): He Tingchao、Ohgami Nobutaka、Li Xiang、Yajima Ichiro、Negishi-Oshino Reina、Kato Yoko、Ohgami Kyoko、Xu Huadong、Ahsan Nazmul、Akhand Anwarul Azim、Kato Masashi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 9028-9028
  • DOI: 10.1038/s41598-019-45524-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Arsenic-mediated hyperpigmented skin via NF-kappa B/Endothelin1 signaling in an originally developed hairless mouse model. (2017)
  • Author(s): Yajima I, Kumasaka MY, Iida M, Osino R, Tanihata H, Al Hossain A MM, Ohgami N, Kato M.
  • Journal Title: Arch Toxicol Volume: 91 Issue: 11 Pages: 3507-16
  • DOI: 10.1007/s00204-017-1975-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risk assessment of neonatal exposure to low frequency noise based on balance in mice (2017)
  • Author(s): Ohgami N et al.
  • Journal Title: Front Behav Neurosci Volume: 11 Pages: 30-30
  • DOI: 10.3389/fnbeh.2017.00030
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Limited effectiveness of household sand filters for removal of arsenic from well water in North Vietnam. (2016)
  • Author(s): Ilmiawati C, Thang ND, Iida M, Maeda M, Ohnuma S, Yajima I, Ohgami N, Oshino R, Al Hossain MM, Ninomiya H, Kato M.
  • Journal Title: J Water Health Volume: 14 Pages: 1032-1040
  • NAID: 120006220428
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Manganese-mediated acceleration of age-related hearing loss in mice (2016)
  • Author(s): Ohgami N et al.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 36306-36306
  • DOI: 10.1038/srep36306
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant