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Evaluation of human exposure and ecological risk based on comprehensive analysis and mass-balance approach for endocrine disrupting chemicals

Research Project

Project/Area Number 16H02963
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionEhime University

Principal Investigator

Takahashi Shin  愛媛大学, 農学研究科, 教授 (30370266)

Co-Investigator(Kenkyū-buntansha) 藤森 崇  京都大学, 工学研究科, 助教 (20583248)
野見山 桂  愛媛大学, 沿岸環境科学研究センター, 准教授 (30512686)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords内分泌かく乱物質 / ダイオキシン類縁化合物 / 残留性有機汚染物質 / 抽出可能有機ハロゲン(EOX) / 網羅分析 / マスバランス解析 / レポーター遺伝子アッセイ / 影響指向分析 / ダイオキシン類 / 有機態ハロゲン / 多環芳香族化合物 / 毒性同定評価 / CALUX
Outline of Final Research Achievements

Dust and air samples collected from northern Vietnam and western Japan were examined by comprehensive analysis for multiple classes of organic micro-pollutants including endocrine disrupting chemicals. A considerable risk regarding to PCBs was noted in the waste recycling areas in Vietnam. Significant contributions of unknown compounds to dioxin-like and PAH-related activities detected by reporter gene assays in the samples were suggested in our effect-directed analysis. Based on a mass balance approach we estimated percentages of known/unknown POP-like compounds in total extractable organohalogen (EOX) in the dust, soil and some biological samples, indicating most of the EOX due to unknown compounds in many samples. A part of such unknown compounds were tentatively identified as halogenated PAHs (in a contaminated soil sample) and chlorinated paraffins (in a dust sample) by the newly developed analytical method using high resolution GCxGC-TOFMS.

Academic Significance and Societal Importance of the Research Achievements

本研究で確立した一斉・網羅分析法やマスバランス解析法、in vitroバイオアッセイ法を統合した毒性寄与評価等を活用することで、従来よりもはるかに多くの微量有機汚染物質の測定が可能となるとともに、これまで見落とされてきた毒性寄与物質や残留性・生物蓄積性物質の存在量把握や対象未知物質の推定/同定が容易となる。また本研究により、ダイオキシン様活性や有機態ハロゲンに占める既知・未知物質のマスバランスを解明できたことは、環境・生態系における関連物質の分布や影響の理解にとって学術的に重要な知見であると同時に、今後の化学物質のリスク評価拡充につながる基礎情報となることから、その社会的意義は大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (45 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (10 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (30 results) (of which Int'l Joint Research: 17 results,  Invited: 5 results) Remarks (2 results)

  • [Int'l Joint Research] VNU University of Science(ベトナム)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] CETASD, Hanoi Univ Science, VNU/Dept Chemistry, Hanoi Univ Science, VNU(ベトナム)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Hanoi University of Science, VNU(ベトナム)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A preliminary investigation of 942 organic micro-pollutants in the atmosphere in waste processing and urban areas, northern Vietnam: Levels, potential sources, and risk assessment2019

    • Author(s)
      Anh Hoang Quoc、Tomioka Keidai、Tue Nguyen Minh、Tuyen Le Huu、Chi Ngo Kim、Minh Tu Binh、Viet Pham Hung、Takahashi Shin
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 167 Pages: 354-364

    • DOI

      10.1016/j.ecoenv.2018.10.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of 209 polychlorinated biphenyls in street dust from northern Vietnam: Contamination status, potential sources, and risk assessment2019

    • Author(s)
      Anh Hoang Quoc、Watanabe Isao、Tomioka Keidai、Minh Tu Binh、Takahashi Shin
    • Journal Title

      Science of The Total Environment

      Volume: 652 Pages: 345-355

    • DOI

      10.1016/j.scitotenv.2018.10.240

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative Speciation of Insoluble Chlorine in Environmental Solid Samples2019

    • Author(s)
      Kota Mukai, Takashi Fujimori, Kenji Shiota, Masaki Takaoka, Shinya Funakawa, Akira Takeda, Shin Takahashi
    • Journal Title

      ACS Omega

      Volume: -

    • NAID

      120006644064

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PBDEs and novel brominated flame retardants in road dust from northern Vietnam: Levels, congener profiles, emission sources and implications for human exposure2018

    • Author(s)
      Anh Hoang Quoc、Tomioka Keidai、Tue Nguyen Minh、Tri Tran Manh、Minh Tu Binh、Takahashi Shin
    • Journal Title

      Chemosphere

      Volume: 197 Pages: 389-398

    • DOI

      10.1016/j.chemosphere.2018.01.066

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comprehensive analysis of 942 organic micro-pollutants in settled dusts from northern Vietnam: pollution status and implications for human exposure2018

    • Author(s)
      Anh Hoang Quoc、Tomioka Keidai、Tue Nguyen Minh、Suzuki Go、Minh Tu Binh、Viet Pham Hung、Takahashi Shin
    • Journal Title

      Journal of Material Cycles and Waste Management

      Volume: 21 Issue: 1 Pages: 57-66

    • DOI

      10.1007/s10163-018-0745-2

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Soil Pollution by Chlorobenzenes and Polychlorinated Biphenyls from an Electronic Waste Recycling Area in Northern Vietnam2018

    • Author(s)
      Nishimura, C., Suzuki, G., Matsukami, H., Agusa, T., Takaoka, M., Takahashi, S., Tue, N. M., Viet, P. H., Tanabe, S., Takigami, H., Fujimori, T.
    • Journal Title

      International Journal of Environment and Pollution

      Volume: 63 Issue: 4 Pages: 283-297

    • DOI

      10.1504/ijep.2018.097863

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Occurrence of natural mixed halogenated dibenzo-p-dioxins: specific distribution and profiles in Mussels from Seto Inland Sea, Japan2017

    • Author(s)
      Goto Akitoshi, Tue Nguyen Minh, Someya Masayuki, Isobe Tomohiko, Takahashi Shin, Tanabe Shinsuke, Kunisue Tatsuya
    • Journal Title

      Environmental Science & Technology

      Volume: 51 Issue: 20 Pages: 11771-11779

    • DOI

      10.1021/acs.est.7b03738

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of Total Organohalogens (TOX) in Environmental Solid Samples by Using Combustion-ion Chromatography2017

    • Author(s)
      Mukai, K.; Fujimori, T.; Shiota, K.; Takaoka, M.; Funakawa, S.; Takeda, A.; Takahashi, S.
    • Journal Title

      Organohalogen Compounds

      Volume: 79 Pages: 9743-9746

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PCBs, PBDEs and dioxin-related compounds in floor dust from an informal end-of-life vehicle recycling site in northern Vietnam: contamination levels and implications for human exposure.2016

    • Author(s)
      (1)Takahashi, S., Tue, N.M., Takayanagi, C., Tuyen, L.H., Suzuki, G., Matsukami, H., Viet, P.H., Kunisue, T., Tanabe, S.
    • Journal Title

      Journal of Material Cycles and Waste Management

      Volume: 印刷中 Issue: 4 Pages: 1333-1341

    • DOI

      10.1007/s10163-016-0571-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Soil contamination by halogenated polycyclic aromatic hydrocarbons from open burning of e-waste in Agbogbloshie (Accra, Ghana)2016

    • Author(s)
      (2)Tue, N. M., Goto, A., Takahashi, S., Itai, T., Asante, K. A., Nomiyama, K., Tanabe, S., Kunisue, T.
    • Journal Title

      Journal of Material Cycles and Waste Management

      Volume: 印刷中 Issue: 4 Pages: 1324-1332

    • DOI

      10.1007/s10163-016-0568-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 分子量で分画した様々な媒体における抽出可能性有機塩素・臭素2018

    • Author(s)
      向井康太,藤森崇,Hoang Quoc Anh,福谷哲,高橋真
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 使用済み自動車解体処理現場等における大気中POPs・PAHs 関連物質の存在と発生源解析2018

    • Author(s)
      高橋 真,Hoang Quoc Anh,後河内里佳,冨岡恵大,渡邊 功,Nguyen Minh Tue,Pham Hung Viet,酒井伸一
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The occurrence of polychlorinated biphenyls, polybrominated diphenyl ethers and novel brominated flame retardants in road dusts from some areas in northern Vietnam2018

    • Author(s)
      Hoang Quoc Anh,Keidai Tomioka,Nguyen Minh Tue,Isao Watanabe,Tu Binh Minh,Shin Takahashi
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characterization of Extractable Organohalogens (EOX) in Biological Samples2018

    • Author(s)
      Kota Mukai, Takashi Fujimori, Hoang Quoc Anh, Satoshi Fukutani, Tatsuya Kunisue, Kei Nomiyama, Shin Takahashi.
    • Organizer
      2nd Chemical Hazard Symposium
    • Related Report
      2018 Annual Research Report
  • [Presentation] INTEGRATED EXPOSURE AND EFFECT ANALYSIS FOR DIOXINS AND RELATED COMPOUNDS: HOW TO WATCH THE MIXTURES/HIDDEN HAZARDS?2018

    • Author(s)
      Shin Takahashi, Nguyen Minh Tue, Go Suzuki, Chika Takayanagi, Le Huu Tuyen, Hoang Quoc Anh, Pham Hung Viet, Shinsuke Tanabe
    • Organizer
      2nd Chemical Hazard Symposium
    • Related Report
      2018 Annual Research Report
  • [Presentation] Speciation of Extractable Organhalogens According to Molecular Size in Various Environmental Matrices2018

    • Author(s)
      Mukai, K.; Fujimori, T.; Anh, HQ.; Fukutani, S.; Oshita, K.; Takaoka, M.; Takahashi, S.
    • Organizer
      Dioxin 2018 - 38th International Symposium on Halogenated Persistent Organic Pollutants
    • Related Report
      2018 Annual Research Report
  • [Presentation] Contributions of Known Persistent Organic Pollutants (POPs) to Extractable Organochlorine or Organobromine (EOX) in Various Environmental Matrices: with Consideration of Molecular Size2018

    • Author(s)
      Mukai, K.; Fujimori, T.; Anh, HQ.; Fukutani, S.; Oshita, K.; Takaoka, M.; Takahashi, S.
    • Organizer
      2nd International KAMPAI Symposium & JST Mid-term Evaluation Meeting
    • Related Report
      2018 Annual Research Report
  • [Presentation] 燃焼イオンクロマトグラフィーを用いた環境固体試料中の総有機ハロゲン濃度(TOX)測定:種々の環境固体試料への適用2017

    • Author(s)
      向井康太,藤森 崇,塩田憲司,高岡 昌輝,舟川晋也,武田 晃,高橋 真
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 燃焼イオンクロマトグラフィーを用いた環境固体試料中の総有機ハロゲン濃度(TOX)測定:前処理方法の検討2017

    • Author(s)
      向井康太, 藤森崇, 塩田憲司, 舟川晋也, 高岡昌輝
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ベトナムの使用済み自動車解体処理地域における化学物質汚染(第四報)-GC/MS一斉分析用データベースを用いたダスト試料の測定-2017

    • Author(s)
      高橋 真, Hoang Quoc Anh,Nguyen Minh Tue, 鈴木 剛, Tu Binh Minh, Pham Hung Viet, 酒井伸一
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] GCxGC-TOFMSによる残留性有機汚染物質の網羅的スクリーニング2017

    • Author(s)
      後藤哲智, Nguyen Minh Tue, 磯部友彦, 田辺信介, 国末達也
    • Organizer
      第65回質量分析総合討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] CONTAMINATION AND HUMAN EXPOSURE TO HAZARDOUS SUBSTANCES IN MODERN WASTE RECYCLING SITES IN VIETNAM.2017

    • Author(s)
      Takahashi, S., Tue, N. M., Anh, H. Q., Takayanagi, C., Katsura, K., Suzuki, G., Takigami, H., Viet, P. H., Kunisue, T., Tanabe, S.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HORMONE DISRUPTING ACTIVITIES AND CAUSATIVE COMPOUNDS IN RIVER WATER FROM ASIAN DEVELOPING COUNTRIES2017

    • Author(s)
      Tue, N. M., Matsukami, H., Tuyen, L. H., Takahashi, S., Suzuki, G., Viet, P. H., Subramanian, A., Tanabe, S., Kunisue, T.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nontargeted comprehensive analysis for persistent organohalogen compounds in finless porpoises from Seto Inland Sea2017

    • Author(s)
      9.Nomiyama, K., Motogi, K., Goto, A., Ochiai, M., Tajima, Y., Yamada, T. K., Isobe, T., Kunisue, T. and Tanabe, S.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] APPLICATION OF GC/TOFMS FOR COMPREHENSIVE ANALYSIS OF ORGANOHALOGEN COMPOUNDS IN FINLESS PORPOISE2017

    • Author(s)
      Takemori, H., Takahashi, S., Takasuga, T., Tanabe, S.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SCREENING OF ORGANOHALOGEN COMPOUNDS ACCUMULATED IN MARINE MAMMALS BY USING GC-HRTOFMS.2017

    • Author(s)
      Takemori, H., Takahashi, S., Takasuga, T., Tanabe, S.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SCREENING ANALYSIS OF ORGANIC POLLUTANTS IN DUSTS FROM ELV RECYCLING AND URBAN AREAS IN NORTHERN VIETNAM2017

    • Author(s)
      Anh, H. Q., Tue, N. M., Suzuki, G., Minh, T. B., Viet, P. H., Takahashi, S.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] QUANTIFICATION OF TOTAL ORGANOHALOGENS (TOX) IN ENVIRONMENTAL SOLID SAMPLES BY USING COMBUSTION-ION CHROMATOGRAPHY2017

    • Author(s)
      Mukai, K., Fujimori, T., Shiota, K., Takaoka, M., Funakawa, S., Takeda, A., Takahashi, S.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Occurrence and potential sources of brominated/chlorinated dibenzo-p-dioxins in mussels from the Seto Inland Sea, Japan.2017

    • Author(s)
      Goto, A., Tue, N. M., Someya, M., Isobe, T., Takahashi, S., Tanabe, S., Kunisue, T.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Toxicity Identification Evaluation of Dioxin-Related Compounds in Dust from End-of-Life Vehicle Recycling Sites in Northern Vietnam.2017

    • Author(s)
      Takahashi, S., Takayanagi, C., Tue, N. M., Suzuki, G., Tuyen, L. H., Viet, P. H., Tanabe, S., Sakai, S.-I.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contamination and human exposure to micropollutants including dioxin-related compounds in informal recycling sites for e-waste and end-of-life vehicles (Plenary Speech)2017

    • Author(s)
      Takahashi, S.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Status of Contamination and Emission Sources of POPs and Dioxin-Related Compounds in ELV Recycling Sites in Northern Vietnam2017

    • Author(s)
      Takahashi, S., Anh, H. Q., Takayanagi, C., Tue, N. M., Suzuki, G., Tuyen, L. H., Viet, P. H., Tanabe, S., Sakai, S.-I.
    • Organizer
      Waste Prevention Workshop 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Assessment of Micropollutants Released from Recycling Activities of End-of-Life Vehicles (ELV) in Northern Vietnam.2017

    • Author(s)
      Takahashi, S.*, Anh, H. Q., Tue, N. M., Suzuki, G., Minh, T. B., Viet, P. H., Sakai, S.-I.
    • Organizer
      4th International Conference on Final Sinks.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Heavy Metals and Organohalogen Compounds from Primitive E-Waste Recycling: Pollution, Distribution, Interplay, and Mechanism Implication2017

    • Author(s)
      Fujimori, T.
    • Organizer
      Chemical Hazard Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Total Concentrations and Chemical Forms of Chlorine in Insoluble Fractions of Environmental Solid Samples2017

    • Author(s)
      Mukai, K.; Fujimori, T.; Shiota, K.; Takaoka, M.; Funakawa, S.; Takeda, A.; Takahashi, S.
    • Organizer
      Chemical Hazard Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Halogenation of Carbon by Metals during Thermochemical Formation of Persistent Organic Pollutants2017

    • Author(s)
      Fujimori, T.
    • Organizer
      ISPTS 2017 - The 14th International Symposium on Persistent Toxic Substances
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Different Characteristics of Insoluble Chlorine in Nature, Living Environment and Waste Incineration2017

    • Author(s)
      Mukai, K.; Fujimori, T.; Shiota, K.; Takaoka, M.; Funakawa, S.; Takeda, A.; Takahashi, S.
    • Organizer
      HUST & KU International Symposium on the Education & Research of the Global Environmental Studies in Asia w/ 10th AUN-SEED/Net Regional Conference on Environmental Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PCBs and BFRs in dust and human blood samples from end of life vehicle (ELV) recycling sites in northern Vietnam: comparison with E-waste recycling sites2016

    • Author(s)
      Takahashi, S., Nose, K., Miyai, R., Takayanagi, C., Tue, N. M., Tuyen, L. H., Viet, P. H., Sakai, S.
    • Organizer
      The 9th PCB workshop
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地球環境規模でみたPCB の存在と課題2016

    • Author(s)
      高橋 真
    • Organizer
      第27回廃棄物資源循環学会研究発表会
    • Place of Presentation
      和歌山大学(和歌山市・和歌山県)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ベトナムの使用済み自動車解体処理地域における化学物質汚染(第三報)-ダスト中ダイオキシン様活性物質に関する毒性同定評価2016

    • Author(s)
      高橋 真, 高柳知佳,Tue, N. M., 鈴木 剛, Viet, P. H., 酒井伸一
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      新潟コンベンションセンター(新潟県・新潟市)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Remarks] http://keisoku.deca.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 愛媛大学農学部 環境計測学研究室

    • URL

      http://web.agr.ehime-u.ac.jp/~keisoku/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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