Evaluation of human exposure and ecological risk based on comprehensive analysis and mass-balance approach for endocrine disrupting chemicals
| Project/Area Number |
16H02963
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤森 崇 京都大学, 工学研究科, 助教 (20583248)
野見山 桂 愛媛大学, 沿岸環境科学研究センター, 准教授 (30512686)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 内分泌かく乱物質 / ダイオキシン類縁化合物 / 残留性有機汚染物質 / 抽出可能有機ハロゲン（EOX） / 網羅分析 / マスバランス解析 / レポーター遺伝子アッセイ / 影響指向分析 / ダイオキシン類 / 有機態ハロゲン / 多環芳香族化合物 / 毒性同定評価 / CALUX |
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| Outline of Final Research Achievements |
Dust and air samples collected from northern Vietnam and western Japan were examined by comprehensive analysis for multiple classes of organic micro-pollutants including endocrine disrupting chemicals. A considerable risk regarding to PCBs was noted in the waste recycling areas in Vietnam. Significant contributions of unknown compounds to dioxin-like and PAH-related activities detected by reporter gene assays in the samples were suggested in our effect-directed analysis. Based on a mass balance approach we estimated percentages of known/unknown POP-like compounds in total extractable organohalogen (EOX) in the dust, soil and some biological samples, indicating most of the EOX due to unknown compounds in many samples. A part of such unknown compounds were tentatively identified as halogenated PAHs (in a contaminated soil sample) and chlorinated paraffins (in a dust sample) by the newly developed analytical method using high resolution GCxGC-TOFMS.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で確立した一斉・網羅分析法やマスバランス解析法、in vitroバイオアッセイ法を統合した毒性寄与評価等を活用することで、従来よりもはるかに多くの微量有機汚染物質の測定が可能となるとともに、これまで見落とされてきた毒性寄与物質や残留性・生物蓄積性物質の存在量把握や対象未知物質の推定／同定が容易となる。また本研究により、ダイオキシン様活性や有機態ハロゲンに占める既知・未知物質のマスバランスを解明できたことは、環境・生態系における関連物質の分布や影響の理解にとって学術的に重要な知見であると同時に、今後の化学物質のリスク評価拡充につながる基礎情報となることから、その社会的意義は大きい。
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Soil Pollution by Chlorobenzenes and Polychlorinated Biphenyls from an Electronic Waste Recycling Area in Northern Vietnam2018
Author(s)
Nishimura, C., Suzuki, G., Matsukami, H., Agusa, T., Takaoka, M., Takahashi, S., Tue, N. M., Viet, P. H., Tanabe, S., Takigami, H., Fujimori, T.
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Journal Title
International Journal of Environment and Pollution
Volume: 63
Issue: 4
Pages: 283-297
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] PCBs, PBDEs and dioxin-related compounds in floor dust from an informal end-of-life vehicle recycling site in northern Vietnam: contamination levels and implications for human exposure.2016
Author(s)
(1)Takahashi, S., Tue, N.M., Takayanagi, C., Tuyen, L.H., Suzuki, G., Matsukami, H., Viet, P.H., Kunisue, T., Tanabe, S.
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Journal Title
Journal of Material Cycles and Waste Management
Volume: 印刷中
Issue: 4
Pages: 1333-1341
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Soil contamination by halogenated polycyclic aromatic hydrocarbons from open burning of e-waste in Agbogbloshie (Accra, Ghana)2016
Author(s)
(2)Tue, N. M., Goto, A., Takahashi, S., Itai, T., Asante, K. A., Nomiyama, K., Tanabe, S., Kunisue, T.
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Journal Title
Journal of Material Cycles and Waste Management
Volume: 印刷中
Issue: 4
Pages: 1324-1332
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] CONTAMINATION AND HUMAN EXPOSURE TO HAZARDOUS SUBSTANCES IN MODERN WASTE RECYCLING SITES IN VIETNAM.2017
Author(s)
Takahashi, S., Tue, N. M., Anh, H. Q., Takayanagi, C., Katsura, K., Suzuki, G., Takigami, H., Viet, P. H., Kunisue, T., Tanabe, S.
Organizer
19th International Symposium on Pollutant Responses in Marine Organisms
Related Report
Int'l Joint Research
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[Presentation] HORMONE DISRUPTING ACTIVITIES AND CAUSATIVE COMPOUNDS IN RIVER WATER FROM ASIAN DEVELOPING COUNTRIES2017
Author(s)
Tue, N. M., Matsukami, H., Tuyen, L. H., Takahashi, S., Suzuki, G., Viet, P. H., Subramanian, A., Tanabe, S., Kunisue, T.
Organizer
19th International Symposium on Pollutant Responses in Marine Organisms
Related Report
Int'l Joint Research
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[Presentation] Nontargeted comprehensive analysis for persistent organohalogen compounds in finless porpoises from Seto Inland Sea2017
Author(s)
9.Nomiyama, K., Motogi, K., Goto, A., Ochiai, M., Tajima, Y., Yamada, T. K., Isobe, T., Kunisue, T. and Tanabe, S.
Organizer
19th International Symposium on Pollutant Responses in Marine Organisms
Related Report
Int'l Joint Research
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[Presentation] SCREENING ANALYSIS OF ORGANIC POLLUTANTS IN DUSTS FROM ELV RECYCLING AND URBAN AREAS IN NORTHERN VIETNAM2017
Author(s)
Anh, H. Q., Tue, N. M., Suzuki, G., Minh, T. B., Viet, P. H., Takahashi, S.
Organizer
19th International Symposium on Pollutant Responses in Marine Organisms
Related Report
Int'l Joint Research
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[Presentation] QUANTIFICATION OF TOTAL ORGANOHALOGENS (TOX) IN ENVIRONMENTAL SOLID SAMPLES BY USING COMBUSTION-ION CHROMATOGRAPHY2017
Author(s)
Mukai, K., Fujimori, T., Shiota, K., Takaoka, M., Funakawa, S., Takeda, A., Takahashi, S.
Organizer
37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017
Related Report
Int'l Joint Research
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[Presentation] Occurrence and potential sources of brominated/chlorinated dibenzo-p-dioxins in mussels from the Seto Inland Sea, Japan.2017
Author(s)
Goto, A., Tue, N. M., Someya, M., Isobe, T., Takahashi, S., Tanabe, S., Kunisue, T.
Organizer
37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017
Related Report
Int'l Joint Research
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[Presentation] Toxicity Identification Evaluation of Dioxin-Related Compounds in Dust from End-of-Life Vehicle Recycling Sites in Northern Vietnam.2017
Author(s)
Takahashi, S., Takayanagi, C., Tue, N. M., Suzuki, G., Tuyen, L. H., Viet, P. H., Tanabe, S., Sakai, S.-I.
Organizer
37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017
Related Report
Int'l Joint Research
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[Presentation] Status of Contamination and Emission Sources of POPs and Dioxin-Related Compounds in ELV Recycling Sites in Northern Vietnam2017
Author(s)
Takahashi, S., Anh, H. Q., Takayanagi, C., Tue, N. M., Suzuki, G., Tuyen, L. H., Viet, P. H., Tanabe, S., Sakai, S.-I.
Organizer
Waste Prevention Workshop 2017
Related Report
Int'l Joint Research / Invited
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[Presentation] Assessment of Micropollutants Released from Recycling Activities of End-of-Life Vehicles (ELV) in Northern Vietnam.2017
Author(s)
Takahashi, S.*, Anh, H. Q., Tue, N. M., Suzuki, G., Minh, T. B., Viet, P. H., Sakai, S.-I.
Organizer
4th International Conference on Final Sinks.
Related Report
Int'l Joint Research
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[Presentation] PCBs and BFRs in dust and human blood samples from end of life vehicle (ELV) recycling sites in northern Vietnam: comparison with E-waste recycling sites2016
Author(s)
Takahashi, S., Nose, K., Miyai, R., Takayanagi, C., Tue, N. M., Tuyen, L. H., Viet, P. H., Sakai, S.
Organizer
The 9th PCB workshop
Place of Presentation
神戸国際会議場（兵庫県・神戸市）
Year and Date
2016-10-09
Related Report
Int'l Joint Research
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