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Toxicological assessment of organohalogen contaminants in cat (Felis catus) omics approach

Research Project

Project/Area Number 16H02989
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental risk control and evaluation
Research InstitutionEhime University

Principal Investigator

Nomiyama Kei  愛媛大学, 沿岸環境科学研究センター, 准教授 (30512686)

Co-Investigator(Kenkyū-buntansha) 水川 葉月  北海道大学, 獣医学研究院, 博士研究員 (60612661)
国末 達也  愛媛大学, 沿岸環境科学研究センター, 教授 (90380287)
Research Collaborator Ishizuka Mayumi  
Iwata Hisato  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywordsネコ / PCBs / OH-PCBs / トランスクリプトーム / メタボローム / in vivo / PBDEs / イエネコ / 腎集積 / 免疫異常 / 甲状腺ホルモン / オミックス / イヌ / 脳移行 / プロテオーム / 酸化的リン酸化 / リスク評価 / トキシコロジー / 代謝 / メタボロミクス / 酸化ストレス
Outline of Final Research Achievements

In vivo exposure of 12 PCB congeners mixture were conducted on cats, and analyzed transcriptome and metabolome in blood, liver and brain.
Of the 21890 genes in the transcriptome, 531 genes showed significant differences in the PCBs-exposed group. As a result of the pathway analysis, the inflammation and infection related pathways are affected, and the influence on the immune system by PCBs was suggested.
In metabolome analysis of serum, 122 metabolites showed significant difference. As a result of pathway analysis, metabolome related to central carbon metabolism such aspentose phosphate pathway and histidine metabolic system decreased, suggesting suppression of these metabolic pathways accompanying PCBs exposure.

Academic Significance and Societal Importance of the Research Achievements

本研究によりネコが有機ハロゲン化合物に高濃度曝露され、免疫系や甲状腺系、酸化ストレスの増大等の多様な悪影響を受けていることが示唆された。ネコのin vivo試験を実施した研究は極めて少なく、ペット動物の汚染実態と生理学的健康リスクの評価といった包括的なアプローチを試みた研究は世界的にみても例がなく、本申請研究成果は先導的である。
ネコは身近なペット動物であるにも関わらず、化学物質による汚染の実態と生体影響を調査した事例は乏しい。ヒトと生活環境を共にすることで、ネコは多種多様な化学物質に曝露されていることが予想される。本研究で化学物質の曝露と影響の一端が示され、学術的・社会的波及効果は大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (60 results)

All 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (44 results) (of which Int'l Joint Research: 25 results,  Invited: 4 results) Remarks (1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] Kasetsart University(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Mongolian University of Life Sciences(モンゴル)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Aveiro(ポルトガル)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] CNRS LabEx DRIIHM(Portugal)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Kasetsart University(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Kasetsart University/Veterinary Medicine(Thailand)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Determination of free thyroid hormones in animal serum/plasma using ultrafiltration in combination with ultra-fast liquid chromatography-tandem mass spectrometry2018

    • Author(s)
      Rumi Tanoue, Imari Kume, Yasuo Yamamoto, Kohki Takaguchi, Kei Nomiyama, Shinsuke Tanabe, Tatsuya Kunisue
    • Journal Title

      Journal of Chromatography A

      Volume: 1539 Pages: 30-40

    • DOI

      10.1016/j.chroma.2018.01.044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Species- and tissue-specific profiles of polybrominated diphenyl ethers and their hydroxylated and methoxylated derivatives in cats and dogs2017

    • Author(s)
      Kei Nomiyama , Kohki Takaguchi, Hazuki Mizukawa, Yasuko Nagano, Tomoko Oshihoi, Susumu Nakatsu, Tatsuya Kunisue, Shinsuke Tanabe
    • Journal Title

      Environmental Science & Technology

      Volume: 51 Issue: 10 Pages: 5811-5819

    • DOI

      10.1021/acs.est.7b01262

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anthropogenic and naturally produced brominated phenols in pet blood and pet food in Japan2017

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Susumu Nakatsu, Miyuki Yamamoto, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe
    • Journal Title

      Environmental Science & Technology

      Volume: 51 Issue: 19 Pages: 11354-11362

    • DOI

      10.1021/acs.est.7b01009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uridine Diphosphate-Glucuronosyltransferase (UGT) 2B Subfamily Interspecies Differences in Carnivores2017

    • Author(s)
      Kondo Takamitsu、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomiyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
    • Journal Title

      Toxicological Sciences

      Volume: 158 Issue: 1 Pages: 90-100

    • DOI

      10.1093/toxsci/kfx072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uptake and Metabolism of Human Pharmaceuticals by Fish: A Case Study with the Opioid Analgesic Tramadol2017

    • Author(s)
      Rumi Tanoue, Luigi Margiotta-Casaluci, Belinda Huerta, Tamsin J. Runnalls, Kei Nomiyama, Tatsuya Kunisue, Shinsuke Tanabe, John P. Sumpter
    • Journal Title

      Environmental Science & Technology

      Volume: 51 Issue: 21 Pages: 12825-12835

    • DOI

      10.1021/acs.est.7b03441

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Species Differences in Xenobiotic Metabolism in Non-experimental Animals.2017

    • Author(s)
      Mizukawa H, Ikenaka Y, Kakehi M, Nakayama S, Ishizuka M
    • Journal Title

      Yakugaku Zasshi

      Volume: 137(3) Pages: 257-263

    • NAID

      130005396880

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polybrominated diphenyl ethers (PBDEs) and their hydroxylated and methoxylated analogues in the blood of harbor, Dall's and finless porpoises from the Japanes e coastal waters2016

    • Author(s)
      Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Matsuda, A., Shiozaki, A., Matsuishi, T., Amano, M., Iwata, H., Tanabe, S.
    • Journal Title

      Marine Environmental Research

      Volume: 1136(16) Pages: 30260-30264

    • DOI

      10.1016/j.marenvres.2016.11.004

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 有機ハロゲン化合物曝露によるネコの生化学マーカーの変化および甲状腺機能に及ぼす影響評価2018

    • Author(s)
      水川葉月・Khidkhan. K.・高口倖暉・横山 望・市居 修・滝口満喜・笹岡一慶・池中良徳・中山翔太・Tsendayush, S.・野見山 桂・田辺信介・石塚真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血清中メタボローム解析によるペットネコ(Felis catus)の有機ハロゲン化合物毒性影響評価2018

    • Author(s)
      野見山 桂・江口哲史・西川博之・水川葉月・山本恭央・滝口満喜・中山翔太・池中良徳・石塚真由美・田辺信介
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] LC-MS/MSを用いた脳中甲状腺ホルモンの高感度分析法の開発2018

    • Author(s)
      小野純華・高口倖暉・田上瑠美・国末達也・田辺信介・野見山 桂
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 液体クロマトグラフタンデム質量分析計(LC-MS/MS)を用いた脳中神経伝達物質とその代謝物の分析法開発2018

    • Author(s)
      野島由衣・野見山 桂・田上瑠美・国末達也・田辺信介
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ポリ塩化ビフェニル曝露によるイヌ・ネコの甲状腺ホルモン恒常性への影響,2018

    • Author(s)
      高口倖暉・野見山 桂・西川博之・水川葉月・田上瑠美・草木桃子・横山 望・市居 修・滝口満喜・中山翔太・池中良徳・石塚真由美・岩田久人・国末達也・田辺信介
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of polychlorinated biphenyls (PCBs) in cats: Exhaustive gene expression analysis approach2018

    • Author(s)
      Mizukawa, H., Khidkhan, K., Ikenaka, Y., Nakayama, S. M. M., Nomiyama, K., Yokoyama, N., Ichii, O., Takiguchi, M., Tsend-ayush, S., Tanabe, S and Ishizuka
    • Organizer
      38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contamination status and global comparison of organohalogen compounds and their related compounds in the pet cats in Thailand2018

    • Author(s)
      Shimasaki, M., Nomiyama, K., Mizukawa, H., Saengtienchai, A., Ngamchirttakul, A., Pencharee, D., Ikenaka, Y., Nakayama, S., Kunisue, T. and Tanabe, S
    • Organizer
      38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tissue distribution and CYP expression related-PCBs exposure in cats.2018

    • Author(s)
      Khidkhan, K., Mizukawa, H., Ikenaka, T., Nakayama, S., Darwish, W.S., Nomiyama, K., Takiguchi, M., Yokoyama, N., Ichii, O., Tanabe, S. and Ishizuka, M
    • Organizer
      38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pilot study on the toxicological assessment of organohalogen compounds in pet cat (Felis catus) serum using metabolomics approach2018

    • Author(s)
      Nomiyama, K., Eguchi, A., Mizukawa, H., Yamamoto, Y., Nishikawa, H., Takiguchi, M., Nakayama, S., Ikenaka, Y., Isizuka, M. and Tanabe, S.
    • Organizer
      38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PCBs as an environmental obesogen in dogs: evidence from hepatic transcriptome, metabolome, and lipidome analyses.2018

    • Author(s)
      Tamura, S., Agusa, T., Hirano, M., Eguchi, A., Nomiyama, K., Li, L., Kannan, K., Tanabe, S., Kim, E. Y. and Iwata, H.
    • Organizer
      38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro and in silico approaches for assessing the activation of Baikal seal estrogen receptors by bisphenols and OH-PCBs2018

    • Author(s)
      Yoshinouchi, Y., Hirano, M., Nakata, H., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H.
    • Organizer
      38th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous determination of neurotransmitters and their precursors/metabolites in animal brain tissue2018

    • Author(s)
      Nojima, Y., Tanoue, R., Kunisue, T., Tanabe, S. and Nomiyama, K.
    • Organizer
      SETAC North America 39th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of PCB exposure on thyroid hormone levels in serum of dogs and cats2018

    • Author(s)
      Takaguchi, K., Nishikawa, H., Mizukawa, H., Tanoue, R., Yokoyama, N., Ichii, O., Takiguchi, M., Nakayama, S. M., Ikenaka, Y., Kunisue, T., Ishizuka, M., Tanabe, S., Iwata, H. and Nomiyama, K.
    • Organizer
      SETAC North America 39th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 薬物・環境化学物質の代謝活性化と甲状腺ホルモンへの影響2018

    • Author(s)
      野見山 桂
    • Organizer
      環境ホルモン学会第 32 回講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] UDP-glucuronosyltransferase (UGT) among pinnipedia and other carnivores.2017

    • Author(s)
      Kondo, T., Ikenaka, Y., Nakayama, S. M. M., Kawai, Y. K., Mizukawa, H., Mitani, Y., Nomiyama, K., Tanabe, S. and Ishizuka, M.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification for the biotransformation of BDE209 by in vivo toxicokinetic analysis in Felis catus.2017

    • Author(s)
      Tanaka, K., Nomiyama, K., Mizukawa, H., Takaguchi, K., Tanoue, R., Saengtienchai, A., Sainnoxoi, T., Yokoyama, N., Ichii, O., Takiguchi, M., Nakayama, S. Ikenaka, Y., Ishizuka, M., Iwata, H., Kunisue, T. and Tanabe, S.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of PCB-exposure on thyroid hormone homeostasis of dogs and cats.2017

    • Author(s)
      Takaguchi, K., Nomiyama, K., Nishikawa, H., Mizukawa, H., Tanoue, R., Yoshinouchi, Y., Yokoyama, N., Ichii, O., Takiguchi, M., Nakayama, S., Ikenaka, Y., Ishizuka, M., Iwata, H., Kunisue, T. and Tanabe, S.
    • Organizer
      19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo exposure to PCBs in cats: Analysis of metabolic capacities and effects on the thyroid hormone homeostasis.2017

    • Author(s)
      Mizukawa, H., Nomiyama, K., Nishikawa, H., Maehara, M., Takai, N., Yokoyama, N., Ichii, O., Takiguchi, M., Ikenaka, Y., Shouta, M. M., Takaguchi, K., Tanabe, S. and Ishizuka, M.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tissue distribution of polychlorinated biphenyls and their metabolites in dog and cat.2017

    • Author(s)
      Takaguchi, K., Nomiyama, K., Nagano, Y., Mizukawa, H., Nakatsu, S., Kunisue, T. and Tanabe, S.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification for the biotransformation of BDE209 by in vivo toxicokinetic analysis in Felis catus.2017

    • Author(s)
      Tanaka, K., Nomiyama, K., Mizukawa, H., Takaguchi, K., Tanoue, R., Saengtienchai, A., Sainnoxoi, T., Yokoyama, N., Ichii, O., Takiguchi, M., Nakayama, S., Ikenaka, Y., Ishizuka, M., Kunisue, T. and Tanabe, S.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DecaBDE might be associated with inhibition of thyroid hormone levels in serum of Japanese cats.2017

    • Author(s)
      Nomiyama, K., Yamamoto, Y., Mizukawa, H., Takiguchi, M., Eguchi, A., Nakayama, S., Ikenaka, Y., Ishizuka, M., Kunisue, T. and Tanabe, S.
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum biochemical responses in cats exposed to organohalogen compounds.2017

    • Author(s)
      Kraisiri, K., Mizukawa, H., Ikenaka, Y., Nakayama, S. M. M., Nomiyama, K., Yokoyama, N., Sasaoka, K., Ichii, O., Takiguchi, M., Nishikawa, H., Tanaka, K., Takaguchi, K., Tanabe, S. and Ishizuka, M.
    • Organizer
      Chemical Hazard Symposium (Joint Seminar on Environmental Chemistry and Toxicology)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリ塩化ビフェニル(PCBs)暴露によるネコ甲状腺機能への影響評価~甲状腺ホルモンの脱ヨード化と代謝能の解析~2017

    • Author(s)
      水川葉月・高居名菜・横山 望・市居 修・滝口満喜・野見山 桂・高口倖暉・西川博之・池中良徳・中山翔太・Sainnoxoi, T.・田辺信介・石塚 真由美
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PCBs 曝露がイヌ・ネコの甲状腺ホルモン恒常性へ及ぼす影響2017

    • Author(s)
      髙口倖暉・野見山 桂・西川博之・水川葉月・田上瑠美・芳之内 結加・横山 望・市居 修・滝口満喜・中山翔太・池中良徳・石塚 真由美,・岩田久人・国末達也・田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イエネコのin vivo長期曝露試験:デカブロモジフェニルエーテル(BDE209)の生体内変化,2017

    • Author(s)
      田中啓介・野見山 桂・水川葉月・髙口倖暉・田上瑠美・Saengtienchai, A.・Sainnoxoi, T.・横山 望・市居 修・滝口満喜・中山翔太・池中良徳・石塚 真由美・国末達也・田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血清中メタボローム解析によるイエネコのPCBs毒性影響評価2017

    • Author(s)
      野見山 桂・西川博之・水川葉月・髙口倖暉・Sainnoxoi, T.・横山 望・市居 修・滝口満喜・石塚 真由美・池中良徳・中山翔太・江口哲史・国末達也・田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 野生生物に残留するハロゲン化フェノール類の蓄積特性と毒性影響評価2017

    • Author(s)
      野見山桂
    • Organizer
      第5回バイオシグナル研究会「生命環境と生物シグナル応答-基礎から応用まで-」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 野生生物に残留するハロゲン化フェノール類の蓄積特性と毒性影響評価2017

    • Author(s)
      野見山桂
    • Organizer
      第26回環境化学討論会,ウェリントンラボラトリーズランチョンセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Accumulation features of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis.2016

    • Author(s)
      Nomiyama, K., Yamamoto, Y., Mizukawa, H., Eguchi, A., Nakayama, S. M., Ikenaka, Y., Ishizuka, M., Kunisue, T. and Tanabe, S.
    • Organizer
      SETAC North America 37th Annual Meeting/7th SETAC World Congress
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristic for biotransformation of polychrolinated biphenyls in cats.2016

    • Author(s)
      Mizukawa, H., Maehara, M., Yokoyama, N., Ichii, O., Takiguchi, M., Nomiyama, K., Nishikawa, H., Ikenaka, Y., Nakayama, S. M., Takaguchi, K., Tanabe, S., Ishizuka, M.
    • Organizer
      SETAC North America 37th Annual Meeting/7th SETAC World Congress
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cross omics analysis for PCBs toxicity in the dog brain - Effect on mitochondrial functions-2016

    • Author(s)
      Takaguchi, K., Nomiyama, K., Yoo, J., Mizukawa, H., Iwata, H., Kunisue, T. and Tanabe, S.
    • Organizer
      SETAC North America 37th Annual Meeting/7th SETAC World Congress
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro and in silico assessment of cytochrome P450-dependent biotransformation capacity of PCBs in the Caniformia; the Baikal seal vs the beagle dog2016

    • Author(s)
      Iwata, H., Yoo, J., Tamura, S., Hirano, M., Nomiyama, K. and Tanabe, S.
    • Organizer
      SETAC North America 37th Annual Meeting/7th SETAC World Congress
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Toxicological assessment of PCBs and OH-PCBs in the brain of dogs using metabolic approach.2016

    • Author(s)
      Nomiyama, K., Takaguchi, K., Eguchi, A., Mizukawa, H., Yoo, J., Tamaru, S., Oshihoi, T., Iwata, H., Kunisue, T. and Tanabe, S.
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      神戸国際会議場, 兵庫, 神戸市
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vivo analysis of PCB metabolic capacities and effects on the thyroid hormone in cats.2016

    • Author(s)
      Mizukawa, H., Maehara, M., Yokoyama, N., Ichii, O., Takiguchi, M., Nomiyama, K., Nishikawa, H., Takakuchi, K., Saengtienchai, A., Sainnoxoi, T., Ikenaka, Y., Nakayama, S. M. M., Tanabe, S. and Ishizuka, M.
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      神戸国際会議場, 兵庫, 神戸市
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Disruption of mitochondrial functions by PCB exposure in the dog brain: Toxicological assessment using cross omics.2016

    • Author(s)
      Takaguchi, K., Nomiyama, K., Eguchi, A., Claret, L. M., Kusaki, M., Yoo, J., Mizukawa, H., Iwata, H., Kunisue, T. and Tanabe, S.
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      神戸国際会議場, 兵庫, 神戸市
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hepatic transcriptome analysis to assess the effects of polychlorinated biphenyls on beagle dogs2016

    • Author(s)
      Tamura, S., Agusa, T., Hirano, M., Eguchi, A., Nomiyama, K., Tanabe, S., Kim, E. and Iwata, H.
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      神戸国際会議場, 兵庫, 神戸市
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative structure-relationships (QSAR) models for prediction of gas chromatography retention of methoxylated polychlorinated biphenyl using regularized multiple linear regressions2016

    • Author(s)
      Eguchi, A., Nomiyama, K., Takaguchi, K. and Mori, C.
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      神戸国際会議場, 兵庫, 神戸市
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis.2016

    • Author(s)
      Nomiyama, K., Yamamoto, Y., Mizukawa, H., Takaguchi, K., Takiguchi, M., Eguchi, A., Nakayama, S., Ikenaka, Y., Ishizuka, M., Kunisue, T. and Tanabe, S.
    • Organizer
      36th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2016)
    • Place of Presentation
      Firenze, Italy
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] クロスオミックスによるイヌ脳のPCBs毒性評価2016

    • Author(s)
      高口倖暉・野見山 桂・Claret, L. M.・Jean, Y.・水川葉月・岩田久人・国末達也・田辺信介
    • Organizer
      日本プロテオーム学会2016年大会
    • Place of Presentation
      北里大学薬学部白金キャンパス, 東京, 港区
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタボローム解析を用いたイエネコにおけるPCBsの毒性影響評価2016

    • Author(s)
      西川博之・野見山桂・水川葉月・横山 望・市居 修・滝口満喜・石塚真美・池中良徳・中山翔太・江口哲史・国末達也・田辺信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター, 新潟, 新潟市
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] ネコにおけるポリ塩化ビフェニル(PCBs)の異物代謝機構解明と甲状腺ホルモンへの影響評価2016

    • Author(s)
      水川葉月・前原美咲・横山 望・市居 修・滝口満喜・野見山 桂・西川博之・池中良徳・中山翔太・高口倖暉・田辺信介・石塚 真由美
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター, 新潟, 新潟市
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有機ハロゲン化合物によるコンパニオンアニマルの汚染実態と甲状腺ホルモンへの影響評価2016

    • Author(s)
      野見山 桂・山本恭央・水川葉月・江口哲史・滝口満喜・中山翔太・池中良徳・石塚 真由美・国末 達也・田辺信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター, 新潟, 新潟市
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] クロスオミックスによるイヌ脳へのPCBs 毒\性評価:ミトコンドリア機能へ及ぼす影響解析2016

    • Author(s)
      高口倖暉・野見山 桂・Claret, L. M.・草木桃子・Jean, Y.・水川葉月・岩田久人・国末達也・田辺信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター, 新潟, 新潟市
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタボロミクスアプローチを用いたイヌ脳へのOH-PCBs 毒性機序の解明2016

    • Author(s)
      野見山 桂・高口倖暉・江口哲史・水川葉月・Jean, Y.・田村沙弥・忍穂井 智子・岩田久人・国末達也・田辺信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター, 新潟, 新潟市
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Remarks] 愛媛大学沿岸環境科学研究センター化学汚染・毒性解析部門

    • URL

      http://kanka.cmes.ehime-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] 2nd Chemical Hazard Symposium2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Chemical Hazard Symposium (Joint Seminar on Environmental Chemistry and Toxicology)2017

    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2022-09-27  

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