| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
C1-microorganisms that can utilize C1 compounds, such as methane and methanol, can be used for the bioprocess in the low carbon society “methanol economy”. In this project, we investigated molecular basis of C1-metabolism in C1-microorganisms and its application. We elucidated novel molecular functions of transcriptional regulators and signal transducers responsible for methanol-induced gene expression in methylotrophic yeasts which are used for heterologous protein production. Furthermore, we developed the basic technology of methanol production from biomass-derived sugar compounds and elucidated cellular functions relating to plant colonization of methylotrophic bacteria.
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