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Elucidation of the relationship between the positional isomers of various long-chain monoene-type fatty acids specifically contained in fish oil and their ability to inhibit body fat accumulation

Research Project

Project/Area Number 16H03034
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionTokyo University of Marine Science and Technology

Principal Investigator

Gotoh Naohiro  東京海洋大学, 学術研究院, 教授 (60323854)

Co-Investigator(Kenkyū-buntansha) 別府 史章  東京海洋大学, 学術研究院, 助教 (10707540)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords魚油 / モノエン型不飽和脂肪酸 / 異性体 / 体脂肪蓄積抑制 / 機能性食品 / 長鎖モノエン酸 / 多価不飽和脂肪酸 / 脂肪酸異性体 / モノエン / 二重結合位置 / 保健機能 / 脂質代謝 / 長鎖モノ不飽和脂肪酸
Outline of Final Research Achievements

In this study, the relationship between the structure and health function of long-chain monounsaturated fatty acids (LC-MUFAs), abundant in fish oil, was examined. The position of the double bond was found to affect the function of LC-MUFA because c15-20:1 significantly reduced lipid accumulation in cell experiment among 20:1 isomers consisting of 20 carbon atoms and one double bond. Cell experiments using LC-MUFA with carbons of 18, 20, and 22 revealed that the length of the LC-MUFA carbon chain also affected the health function. Furthermore, when LC-MUFA was mixed with DHA or EPA, “c7-C20:1+DHA” significantly inhibited cholesterol synthesis in the cell compared to “DHA+EPA”.

Academic Significance and Societal Importance of the Research Achievements

今回の長鎖モノ不飽和脂肪酸(LC-MUFA)の保健機能に係る研究では、LC-MUFA二重結合位置だけでなく鎖の長さも関係することを明らかとした。さらに、LC-MUFAは同じく魚油に含まれるDHAと相乗的にコレステロール蓄積抑制能を発揮することも明らかにした。このようなことから、本研究成果は脂質代謝研究の重要な礎になり、結果的に、生活習慣病予防のための新しい食事スタイルの提案や、「魚食」の高付加価値化へと繋がると考える。さらに、高コレステロール、糖尿病、脂肪肝治療薬、血中脂質低下薬の開発の基礎的知見としても利用できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Comparison of the Effects of Long-chain Monounsaturated Fatty Acid Positional Isomers on Lipid Metabolism in 3T3-L1 Cells2019

    • Author(s)
      S. Senarath, F. Beppu, K. Yoshinaga, T. Nagai, A. Yoshida, and N. Gotoh
    • Journal Title

      Journal of Oleo Science

      Volume: 68 Issue: 4 Pages: 379-387

    • DOI

      10.5650/jos.ess18223

    • NAID

      130007621686

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differential effect of cis-eicosenoic acid positional isomers on adipogenesis and lipogenesis in 3T3-L1 cells2018

    • Author(s)
      S. Senarath, K. Yoshinaga, T. Nagai, A. Yoshida, F. Beppu, and N. Gotoh
    • Journal Title

      Eur. J. Lipid Sci. Technol.

      Volume: 印刷中 Issue: 6

    • DOI

      10.1002/ejlt.201700512

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative Analysis of the Distribution of<i> cis</i>-Eicosenoic Acid Positional Isomers in Marine Fishes from the Indian Ocean2017

    • Author(s)
      S. Senaratha, K. Yoshinaga, T. Nagai, A. Yoshida, F. Beppu, C. Jayasinghe, C. Devadawsond, and N. Gotoh
    • Journal Title

      Journal of Oleo Science

      Volume: 66 Issue: 2 Pages: 187-197

    • DOI

      10.5650/jos.ess16155

    • NAID

      130005306120

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Differential effect of cis-eicosenoic acid positional isomers on the cellar lipids and fatty acid composition in 3T3-L1 cells2018

    • Author(s)
      S. Senarath, K. Yoshinaga, H. Mizobe, T. Nagai, A. Yoshida, F. Beppu, and N. Gotoh
    • Organizer
      The Asian Conference on Oleo Science 2017 & The 56th Annual Meeting of the Japan Oil Chemists’ Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quaqntitative analysis of distribution of eicosenoic acid positional isomers in marine fishes from the Indian Ocean2016

    • Author(s)
      S. Senaratha, F. Beppu, K. Yoshinaga T. Nagai, A. Yoshida, and N. Gotoh
    • Organizer
      日本油化学会第55回年会
    • Place of Presentation
      奈良女子大学
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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