Research and development for energy expending anti-obesity functional food
| Project/Area Number |
16H03035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Asahikawa Medical College (2017-2018)
Kanazawa University (2016) |
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Principal Investigator |
Ota Tsuguhito 旭川医科大学, 医学部, 教授 (60397213)
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| Research Collaborator |
Nagata Naoto
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 肥満 / 褐色脂肪組織 / 炎症 / 脂肪肝 / インスリン抵抗性 / エネルギー代謝 / 腸内細菌 / 機能性食品 / 褐色脂肪 |
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| Outline of Final Research Achievements |
Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) alleviates obesity and insulin resistance in mice; however, Nrf2 inducers are not clinically available owing to safety concerns. Thus, we examined whether dietary glucoraphanin, a stable precursor of the Nrf2 inducer sulforaphane (SGS), ameliorates systemic energy balance, chronic inflammation, insulin resistance, and NAFLD in high-fat diet (HFD)-fed mice. SGS supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity in HFD-fed wild-type mice but not in HFD-fed Nrf2-knockout mice. In HFD-fed mice, SGS increased energy expenditure and the protein expression of uncoupling protein 1 (Ucp1) in inguinal and epididymal adipose depots.By promoting fat browning, limiting metabolic endotoxemia-related chronic inflammation, and modulating redox stress, SGS may mitigate obesity, insulin resistance, and NAFLD.
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| Academic Significance and Societal Importance of the Research Achievements |
既存の抗肥満薬は、食欲抑制や消化管の脂肪吸収阻害等、エネルギー摂取を低下させる作用が主であり、抑うつや下痢等の副作用が少なくない。ゆえに現在、エネルギー消費を増大させ、肥満を抑制する新たな薬物や食品因子が求められている。
本研究では、ブロッコリーの新芽（スプラウト）に多く含まれるスルフォラファンの肥満抑制効果が得られた。スルフォラファンはブロッコリー由来の食品因子であり、長年の食経験からその安全性は極めて高いと考えられる。また、経口摂取によるNrf2活性化と抗酸化作用による細胞保護効果も期待できるため、特色のある機能性食品や創薬シードになり得る。
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Impacts of Diabetes and an SGLT2 Inhibitor on the Glomerular Number and Volume in db/db Mice, as Estimated by Synchrotron Radiation Micro-CT at SPring-82018
Author(s)
Takiyama Y, Sera T, Nakamura M, Ishizeki K, Saijo Y, Yanagimachi T, Maeda M, Bessho R, Takiyama T, Kitsunai H, Sakagami H, Fujishiro D, Fujita Y, Makino Y, Abiko A, Hoshino M, Uesugi K, Yagi N, Ota T, Haneda M
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Journal Title
EBioMedicine
Volume: 36
Pages: 329-346
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice.2018
Author(s)
L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, J Kamei, H Ishikawa, Y Komatsu, S Kaneko, T Ota.
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Journal Title
Oncotarget
Volume: 9
Issue: 19
Pages: 15047-15060
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.2017
Author(s)
Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 16978-16978
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017
Author(s)
Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S and Ota T.
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Journal Title
Diabetes
Volume: 印刷中
Issue: 5
Pages: 1222-1236
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor.2016
Author(s)
Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
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Journal Title
Cell reports
Volume: 14
Issue: 10
Pages: 2362-2374
DOI
Related Report
Peer Reviewed / Open Access
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