| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Chronic inflammation associated with deterioration of intestinal flora is regarded as an important factor for lifestyle-related diseases. The most potent inducer of inflammation produced by enterobacteria is the cell wall constituent lipopolysaccharide (LPS) of Gram-negative bacteria. In patients with lifestyle-related diseases, enterobacterial LPS transfers into the blood, which triggers metabolic endotoxemia (hyper-LPS), although LPS undergoes chemical modification depending on the intestinal environment, therefore its activity is not uniform. Lipid A, a lipophilic unit of LPS, is the minimum unit responsible for endotoxin activity of LPS. Changes in lipid A structure depending on bacterial species and growth conditions strongly influence endotoxin activity. In this study, we developed basic research on changes in LPS activity toward the establishment of new prevention, treatment and diagnostic methods for lifestyle-related diseases.
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