Profiling analysis of intestinal endotoxins associated with chronic inflammation in lifestyle-related diseases
| Project/Area Number |
16H03041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡辺 賢二 静岡県立大学, 薬学部, 教授 (50360938)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 炎症 / 分子代謝学 |
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| Outline of Final Research Achievements |
Chronic inflammation associated with deterioration of intestinal flora is regarded as an important factor for lifestyle-related diseases. The most potent inducer of inflammation produced by enterobacteria is the cell wall constituent lipopolysaccharide (LPS) of Gram-negative bacteria. In patients with lifestyle-related diseases, enterobacterial LPS transfers into the blood, which triggers metabolic endotoxemia (hyper-LPS), although LPS undergoes chemical modification depending on the intestinal environment, therefore its activity is not uniform. Lipid A, a lipophilic unit of LPS, is the minimum unit responsible for endotoxin activity of LPS. Changes in lipid A structure depending on bacterial species and growth conditions strongly influence endotoxin activity. In this study, we developed basic research on changes in LPS activity toward the establishment of new prevention, treatment and diagnostic methods for lifestyle-related diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、高LPS血症に関連する各疾患発症メカニズムの解明および早期診断の基盤データの構築を目的とし、これまで全く手付かずの腸管内lipid Aプロファイルの分析化学的解析と生理活性解析に取り組んだ。Lipid Aはそれ自身が直接的に炎症を制御する分子であるため、今後さらに詳細な検討により、腸内環境で疾患依存的に変動するlipid Aの法則が解明されれば、非侵襲的な早期診断が可能になる。
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Effects of sanyaku and its constituent diosgenin on the fasted and postprandial hypertriacylglycerolemia in high fat diet-fed KK-Ay mice.2018
Author(s)
Hashidume, T., Sasaki, K., Hirata, J., Kato, M., Yoshikawa, Y., Iwasaki, Y., Arai, H., Miura, S., and Miyoshi, N.
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Journal Title
Journal of Agricultural and Food Chemistry
Volume: 66
Issue: 38
Pages: 9968-9975
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of Short-Term Intake of Wheat Bran with Different Particle Sizes on the Murine Intestinal Environment2017
Author(s)
Iwai, K., Yoshikawa, Y., Miyoshi, N., Fukutomi, R., Asada, K., and Ohashi, N.
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Journal Title
Food Science and Technology Research
Volume: 23
Issue: 5
Pages: 733-742
DOI
NAID
ISSN
1344-6606, 1881-3984
Related Report
Peer Reviewed
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[Journal Article] Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice.2016
Author(s)
Onuma W, Tomono S, Miyamoto S, Fujii G, Hamoya T, Fujimoto K, Miyoshi N, Fukai F, Wakabayashi K, Mutoh M.
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Journal Title
Oncotarget
Volume: 7
Issue: 8
Pages: 8640-52
DOI
Related Report
Peer Reviewed / Open Access
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