• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of homeodynamics induced by food factors through GI tract sensing

Research Project

Project/Area Number 16H03042
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionShibaura Institute of Technology

Principal Investigator

Naomi Osakabe  芝浦工業大学, システム理工学部, 教授 (30554852)

Co-Investigator(Kenkyū-buntansha) 成川 真隆  東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (50432349)
Research Collaborator Yasuoka Akihito  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords消化管センシング / 脳腸相関 / 渋味 / 辛味 / ホメオダイナミクス / 機能性食品 / ストレス応答反応 / 食品因子 / 交感神経 / TRP / 消化管
Outline of Final Research Achievements

In this study, Cinnamtannin A2 (A2) was recognized by the sensory nerves deisributed in GI tract and caused stress response as well as Capsaicin(CA). Resulting in enhanced sympathetic activity induced the change in peripheral hemodynamics according the results shown in below. 1. By addition of A2 or CA to dorsal root ganglion cells derived from YC 3.60 tg mice, significant Ca 2+ uptake was observed. 2. After oral administration of A2, cfos and CRH mRNA expression in the hypothalamic paraventricular nucleus increased remarkably. 3. After oral administration of A2 and CA to rats, a transient increase in blood pressure and heart rate was observed.

Academic Significance and Societal Importance of the Research Achievements

本研究ではポリフェノールの一種であり強い渋味を呈するCinnamtannin A2 (A2)が辛味成分であるCapsaicin(CA)と同様に消化管感覚神経によって認識され生体にストレス応答反応を引き起こした結果、交感神経活動が亢進し、末梢の循環動態に変化をもたらすことを初めて明らかにした。ポリフェノール類はトクホや機能性表示食品の関与成分として一般に広く用いられているが、生体利用性が低いことからこれまでメカニズムが不明であった。本研究の結果その作用メカニズムが明らかになったことは、国民の機能性食品の利用に大きく役立つと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (33 results)

All 2019 2018 2017 2016 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (22 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Remarks (3 results)

  • [Journal Article] Polyphenol Analysis in Black Tea with a Carbon Nanotube Electrode2019

    • Author(s)
      MURAKAMI Satoshi、TAKAHASHI Shota、MUGURUMA Hitoshi、OSAKABE Naomi、INOUE Hitoshi、OHSAWA Tatsuya
    • Journal Title

      Analytical Sciences

      Volume: 35 Issue: 5 Pages: 529-534

    • DOI

      10.2116/analsci.18P516

    • NAID

      130007644145

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2019-05-10
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acylated anthocyanins derived from purple carrot (Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole2019

    • Author(s)
      Tsutsumi Ayaka、Horikoshi Yukari、Fushimi Taiki、Saito Akiko、Koizumi Ryo、Fujii Yasuyuki、Hu Qing Qiang、Hirota Yoshihisa、Aizawa Koichi、Osakabe Naomi
    • Journal Title

      Food & Function

      Volume: 10 Issue: 3 Pages: 1726-1735

    • DOI

      10.1039/c8fo02125b

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Possible mechanisms of postprandial physiological alterations following flavan 3-ol ingestion2018

    • Author(s)
      Osakabe Naomi、Terao Junji
    • Journal Title

      Nutrition Reviews

      Volume: 76 Issue: 3 Pages: 174-186

    • DOI

      10.1093/nutrit/nux070

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus2018

    • Author(s)
      Fujii Yasuyuki、Suzuki Kenta、Hasegawa Yahiro、Nanba Fumio、Toda Toshiya、Adachi Takahiro、Taira Shu、Osakabe Naomi
    • Journal Title

      Neuroscience Letters

      Volume: 682 Pages: 106-111

    • DOI

      10.1016/j.neulet.2018.06.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice2018

    • Author(s)
      Nakagawa Yuta、Ishimura Kana、Oya Satomi、Kamino Masaki、Fujii Yasuyuki、Nanba Fumio、Toda Toshiya、Ishii Takeshi、Adachi Takahiro、Suhara Yoshitomo、Osakabe Naomi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 0201203-0201203

    • DOI

      10.1371/journal.pone.0201203

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Separationless and Adsorptionless Quantification of Individual Catechins in Green Tea with a Carbon Nanotube?Carboxymethylcellulose Electrode2018

    • Author(s)
      Muguruma Hitoshi、Murakami Satoshi、Takahashi Shota、Osakabe Naomi、Inoue Hitoshi、Ohsawa Tatsuya
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 67 Issue: 3 Pages: 943-954

    • DOI

      10.1021/acs.jafc.8b05540

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Green tea extract and black tea extract differentially influence cecal levels of short-chain fatty acids in rats2018

    • Author(s)
      Unno Tomonori, Osakabe Naomi
    • Journal Title

      Food Science and Nutrition

      Volume: 印刷中 Issue: 4 Pages: 728-735

    • DOI

      10.1002/fsn3.607

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Onset of a hypotensive effect following ingestion of flavan 3-ols involved in the activation of adrenergic receptors.2016

    • Author(s)
      Saito A, Inagawa K, Ebe R, Fukase S, Horikoshi Y, Shibata M, Osakabe N.
    • Journal Title

      Free Radic Biol Med

      Volume: 99 Pages: 584-592

    • DOI

      10.1016/j.freeradbiomed.2016.09.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] in vivo カルシウムイメージング法による食品成分の消化管における認識機構の解明2019

    • Author(s)
      福田 陽大、越阪部 奈緒美、安達 貴弘
    • Organizer
      2019年農芸化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食品因子による消化管センシングを介した生理発現機構2018

    • Author(s)
      越阪部奈緒美
    • Organizer
      第72回日本栄養食糧学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Flavan 3-ols構成成分の循環刺激作用の検証2018

    • Author(s)
      小泉 涼、齋藤 晃子、難波 文男、戸田 登志也、越阪部 奈緒美
    • Organizer
      第72回日本栄養食糧学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stress response in hypothalamic paraventricular nucleus (PVN) after a single dose of procyanidin supplementation2018

    • Author(s)
      Fujii Y, Kawagoe A, Suzuki K, Hasegawa Y, Osakabe N
    • Organizer
      256th ACS National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The interaction between brain activation and peripheral physiological alteration2018

    • Author(s)
      Osakabe N
    • Organizer
      256th ACS National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Capsaicin のTRP channel およびTMEM を介した認識機構の検討2018

    • Author(s)
      海野 裕真、松尾 瑠美、守谷 佳奈美、越阪部 奈緒美、廣田 佳久
    • Organizer
      Food Congress 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Flavan 3-ols 反復投与のマウス骨格筋および脂肪細胞代謝に対する影響2018

    • Author(s)
      神野 将希、大矢 さとみ、五十嵐 悠樹、石井 結子、手島 知洋、難波 文男、 戸田 登志也、越阪部 奈緒美
    • Organizer
      Food Congress 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] CinnamtanninA2 投与後の視床下部室傍核におけるストレス応答反応の検証2018

    • Author(s)
      鈴木 健太、藤井 靖之、長谷川 八尋、平 修、須原 義智、越阪部 奈緒美
    • Organizer
      Food Congress 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] in vivo カルシウムイメージング法による食品成分の消化管における認識機構の解明2018

    • Author(s)
      福田 陽大、安達 貴弘、越阪部 奈緒美
    • Organizer
      Food Congress 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 消化管知覚神経細株F11 に対するB タイプprocyanidin の細胞毒性の比較2018

    • Author(s)
      藤井 靖之、鋤柄 雄祐、戸田 登志也、難波 文男、廣田 佳久、越阪部 奈緒美
    • Organizer
      Food Congress 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] フードファクターによる消化管センシングと機能性2018

    • Author(s)
      越阪部 奈緒美
    • Organizer
      Food Congress 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 消化管によるcinnamtannin A2の認識機構の探索2018

    • Author(s)
      羽里 直幹、黒木 麻由、難波 文男、戸田 登志也、安達 貴弘、越阪部 奈緒美
    • Organizer
      2018年 日本農芸化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 難吸収性ポリフェノールの消化管-脳軸を介した恒常性に対する影響2018

    • Author(s)
      越阪部奈緒美
    • Organizer
      第15回レドックス・ライフイノベーションシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Possible mechanisms of postprandial physiological alterations following flavan 3-ol ingestion2017

    • Author(s)
      Osakabe N Terao J
    • Organizer
      8th International Conference on Polyphenols and Health
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stress response in PVN induced by flavan 3-ols2017

    • Author(s)
      Fujii Y Suzuki K Hasegawa Y Osakabe N
    • Organizer
      8th International Conference on Polyphenols and Health
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible Mechanisms of Postprandial Physiological Alterations Following Flavan 3-Ol Ingestion.2017

    • Author(s)
      Osakabe N.
    • Organizer
      12th SEATUC Symposium ? Engineering Education and Research for Sustainable Development.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 難吸収性ポリフェノールの消化管センシングを介した作用メカニズムの解明2017

    • Author(s)
      越阪部奈緒美
    • Organizer
      2018年農芸化学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Flavan 3-olsの代謝亢進作用の解明2017

    • Author(s)
      大矢 さとみ、神野 将希、難波 文男、戸田 登志也、越阪部 奈緒美
    • Organizer
      2018年 日本農芸化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 消化管によるcinnamtannin A2の認識機構の解明2016

    • Author(s)
      羽里直幹、高橋李沙、越阪部奈緒美
    • Organizer
      第31回日本酸化ストレス学会関東支部会
    • Place of Presentation
      芝浦工業大学
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice2016

    • Author(s)
      Osakabe N
    • Organizer
      1st International Conference on Food and Bioactive and Health
    • Place of Presentation
      Norwich, UK
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CinnamtanninA2とcapsaicinの循環刺激作用の比較2016

    • Author(s)
      齊藤 晃子、深瀬 忍、難波 文男、戸田 登志也、柴田 政廣、越阪部 奈緒美
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cinnamtannin A2の褐色脂肪活性化作用機序の解明2016

    • Author(s)
      石村 佳菜、中川 湧太、荒川 優、難波 文男、戸田 登志也、須原 義智、越阪部 奈緒美
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Remarks] 芝浦工業大学 システム理工学部 生命科学科 食品栄養学研究室

    • URL

      http://www.web.se.shibaura-it.ac.jp/seimei/osakabe-lab/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 芝浦工業大学 QOL向上とライフサイエンスコンソーシアム

    • URL

      http://plus.shibaura-it.ac.jp/sitrbp/Lifesci/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 芝浦工業大学「QOL向上とライフサイエンス」コンソーシアム

    • URL

      http://plus.shibaura-it.ac.jp/sitrbp/Lifesci/03-1.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-03-11  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi