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Analysis of the occurrence factor in eating-experience induced modification of taste palatability and its effect on eating behavior

Research Project

Project/Area Number 16H03045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionThe University of Tokyo

Principal Investigator

Narukawa Masataka  東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (50432349)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords味 / 食経験 / 嗜好性 / 味嗜好性 / 摂食行動
Outline of Final Research Achievements

The palatability of the food is known to be affected by various factors, such as environment and experience. However, the underlying mechanisms are still unknown. This study was aimed to elucidate the mechanism that mediates the taste palatability modification by eating experience. In addition, we investigated the effect of this modification on eating behaviors. We found that the hypothalamus and amygdala regions are related to the modification of taste palatability by eating experience, and that this modification might affect the food choice.

Academic Significance and Societal Importance of the Research Achievements

食に対する嗜好性は様々な要因によって変化する。しかし、その分子機構は不明である。本研究では食経験に伴う嗜好性の変化に中枢の視床下部や扁桃体が関与している可能性を示した。さらに、食経験が食選択にも影響を及ぼす可能性を見出した。嗜好性の変化を生じるような神経回路を明らかにすることは摂食を抑制・促進するような食品の開発に繋がると期待される。本研究で得られた成果は健康的な食生活を送るための有用な知見になると期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (38 results)

All 2019 2018 2017 2016

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (24 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ2019

    • Author(s)
      Kasahara Y, Sakurai T, Matsuda R, Narukawa M, Yasuoka A, Mori N, Watanabe H, Okabe T, Kojima H, Abe K, Misaka T, and Asakura T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 83 Issue: 2 Pages: 243-250

    • DOI

      10.1080/09168451.2018.1533802

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rat circumvallate papillae2019

    • Author(s)
      Ren E, Watari I, Jui-Chin H, Mizumachi-Kubono M, Podyma-Inoue KA, Narukawa M, Misaka T, Watabe T, and Ono T
    • Journal Title

      Acta Histochemica

      Volume: 121 Issue: 2 Pages: 135-142

    • DOI

      10.1016/j.acthis.2018.10.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor2019

    • Author(s)
      Nakagita T, Ishida A, Matsuya T, Kobayashi T, Narukawa M, Hirokawa T, Hashimoto M, and Misaka T
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 3 Pages: e0213552-e0213552

    • DOI

      10.1371/journal.pone.0213552

    • NAID

      120007133042

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tas2r125 functions as the main receptor for detecting bitterness of tea catechins in the oral cavity of mice2018

    • Author(s)
      Narukawa M, Misaka T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 4 Pages: 2301-2305

    • DOI

      10.1016/j.bbrc.2018.06.152

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of aging-dependent changes in taste sensitivities of the senescence-accelerated mouse SAMP12018

    • Author(s)
      Narukawa M, Kamiyoshihara A, Kawae M, Kohta R, and Misaka T
    • Journal Title

      Experimental Gerontology

      Volume: 113 Pages: 64-73

    • DOI

      10.1016/j.exger.2018.09.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食経験による嗜好性の変化をめぐる分子知見2018

    • Author(s)
      成川真隆、三坂巧
    • Journal Title

      肥満研究

      Volume: 24 Pages: 72-78

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Physiological responses to taste signals of functional food components2018

    • Author(s)
      Narukawa Masataka
    • Journal Title

      Biosci. Biotech. Biochem.

      Volume: 82 Issue: 2 Pages: 200-206

    • DOI

      10.1080/09168451.2017.1422385

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポリフェノールを受容する味覚受容体2017

    • Author(s)
      成川真隆
    • Journal Title

      日本ポリフェノール学会雑誌

      Volume: 6 Pages: 15-17

    • NAID

      40021253416

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Participation of the peripheral taste system in aging-dependent changes in taste sensitivity2017

    • Author(s)
      Narukawa Masataka、Kurokawa Azusa、Kohta Rie、Misaka Takumi
    • Journal Title

      Neuroscience

      Volume: 358 Pages: 249-260

    • DOI

      10.1016/j.neuroscience.2017.06.054

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 味覚系を介した食嗜好の形成2017

    • Author(s)
      成川真隆、三坂巧
    • Journal Title

      実験医学

      Volume: 35 Pages: 906-910

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons2017

    • Author(s)
      Maeda N, Narukawa M, Ishimaru Y, Yamamoto K, Misaka T and Abe K
    • Journal Title

      Neuroscience Letters

      Volume: 印刷中 Pages: 53-58

    • DOI

      10.1016/j.neulet.2017.03.046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1-deficient mice.2016

    • Author(s)
      Ushiama, S., Ishimaru, Y., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H., and Abe, K.
    • Journal Title

      EBioMedicine

      Volume: 8 Pages: 60-71

    • DOI

      10.1016/j.ebiom.2016.04.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 抗炎症剤イブプロフェンの甘味受容体に対する阻害剤としての作用機構解析2019

    • Author(s)
      中北智哉、竹谷千晶、成川真隆、小林拓也、三坂巧
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 加齢依存的な味感受性変化における味修飾因子の関与の検討2019

    • Author(s)
      上吉原絢、成川真隆、三坂巧
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 免疫不全モデルマウスにおける味感受性評価2019

    • Author(s)
      高橋涼佳、成川真隆、三坂巧
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 味刺激により生じる嗜好性変化に関与する脳領域の解析2019

    • Author(s)
      山口雅裕、成川真隆、三坂巧
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Tas2r125 はマウス口腔内においてカテキンの苦味を検出する主要な味覚受容体として機能する2019

    • Author(s)
      成川真隆、三坂巧
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ケミカルライブラリーを用いたhuman ENaC 活性化剤のスクリーニング2019

    • Author(s)
      笠原洋一、松田龍星、成川真隆、安岡顕人、森直紀、阿部啓子、三坂巧、朝倉富子
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カテキンに応答するマウス苦味受容体の同定2018

    • Author(s)
      成川真隆、三坂巧
    • Organizer
      第23回日本フードファクター学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 片側鼻閉はラット味覚受容器に影響を与える2018

    • Author(s)
      任尓舒、渡一平、許瑞瑾、井上カタジナアンナ、成川真隆、三坂巧、渡部徹郎、小野卓史
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗炎症剤イブプロフェンは甘味受容体の強力な阻害剤である2018

    • Author(s)
      中北智哉、成川真隆、小林拓也、三坂巧
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 加齢依存的な味受容機構の変化2018

    • Author(s)
      成川真隆、三坂巧
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 過去の味刺激に伴う味嗜好性変化に関与する脳領域の解析2018

    • Author(s)
      山口雅裕、成川真隆、三坂巧
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 老化促進モデルマウスを用いた加齢依存的な味嗜好性変化とその発生要因の検討2018

    • Author(s)
      上吉原絢、成川真隆、河江真宏、幸田理恵、三坂巧
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 離乳期のマウス大脳皮質において食刺激依存的な発現変動を示す遺伝子の解析2018

    • Author(s)
      河江真宏 成川真隆 三坂巧
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 味細胞の構成割合の変化が味覚神経の存在比に与える影響2018

    • Author(s)
      成川真隆、前田尚廣、石丸喜朗、山本くるみ、阿部啓子、三坂巧
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔・消化管を介するエネルギー代謝2018

    • Author(s)
      萩本政大、成川真隆、中島健一朗、石丸喜朗、朝倉富子、阿部啓子
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食刺激が離乳期のマウス大脳皮質における遺伝子発現へ及ぼす影響2017

    • Author(s)
      河江真宏、成川真隆、三坂巧
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 機能性食品成分の味覚シグナルが中枢を介して発動する生理作用の解析2017

    • Author(s)
      成川真隆
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小腸刷子細胞に発現する遺伝子の生体内機能の検証2017

    • Author(s)
      谷下道大、成川真隆、石渡賢治、吉岡美紗子、朝倉富子、嘉糠洋陸、阿部啓子、石丸喜朗
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メチオナールの旨味受容体活性化メカニズムの解明2017

    • Author(s)
      戸田安香、中北智哉、成川真隆、山下有紀、中島文子、三坂巧
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小腸刷子細胞頂端部に局在する受容体の生体内機能の検証2017

    • Author(s)
      石丸喜朗、谷下道大、成川真隆、戸田安香、石渡賢治、吉岡美紗子、朝倉富子、嘉糠洋陸、益崎裕章、阿部啓子
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 老化による食嗜好性変化における口腔内味受容機構の関与2017

    • Author(s)
      成川真隆、黒川あずさ、幸田理恵、河江真宏、三坂巧
    • Organizer
      第2回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリフェノールを受容する味覚受容体2016

    • Author(s)
      成川真隆
    • Organizer
      第10回日本ポリフェノール学会学術集会
    • Place of Presentation
      芝浦工大(東京都江東区)
    • Year and Date
      2016-08-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 食経験に起因する味嗜好性変化とその発生要因の解析2016

    • Author(s)
      成川真隆、三坂巧
    • Organizer
      第1回食欲・食嗜好の分子・神経基盤研究会
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1 -deficient mice2016

    • Author(s)
      Ishimaru Y, Ushiama S, Narukawa M, Yoshioka M, Kozuka C, Watanabe N, Tsunoda M, Osakabe N, Asakura T, Masuzaki H, and Abe K
    • Organizer
      International Symposium of Olfactory and Taste 2017
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 食嗜好性変化の要因「おいしさの科学とビジネス展開の最前線(都甲潔、柏柳誠編)」2017

    • Author(s)
      成川真隆
    • Total Pages
      439
    • Publisher
      CMC出版
    • Related Report
      2017 Annual Research Report
  • [Book] 生理状態や食経験に起因する味嗜好性変化「おいしさの科学的評価・測定法と応用展開(監修:阿部啓子、石丸喜朗)」2016

    • Author(s)
      成川真隆
    • Total Pages
      212
    • Publisher
      CMC出版
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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