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Estimation of protein intakes by 24-hour urinalysis-prevention of locomotive syndrome by tailor-made food education

Research Project

Project/Area Number 16H03049
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionMukogawa Women's University

Principal Investigator

YAMORI Yukio  武庫川女子大学, 国際健康開発研究所, 教授 (80025600)

Co-Investigator(Kenkyū-buntansha) 大森 肇  筑波大学, 体育系, 教授 (20223969)
次田 一代  香川短期大学, その他部局等, 教授(移行) (40198528)
磯村 実  島根大学, 学術研究院人間科学系, 教授 (40272497)
並河 徹  島根大学, 学術研究院医学・看護学系, 教授 (50180534)
江口 昭彦  西九州大学, 健康栄養学部, 准教授 (60151966)
宮本 篤  鹿児島大学, 農水産獣医学域獣医学系, 教授 (70219806)
垣渕 直子 (秋山直子)  香川短期大学, その他部局等, 教授(移行) (70310886)
森 真理  東海大学, 健康学部, 准教授 (70399343)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords24時間尿 / 大豆 / 魚 / 食塩 / ロコモ / イソフラボン / タウリン / 葉酸 / 食生活の評価 / 24時間採尿 / ロコモティブシンドローム / 蛋白質摂取量
Outline of Final Research Achievements

For estimating soy and fish protein intakes common in the Japanese, 24-hour urinary isofravones and taurine, biomarkers for soy and fish intakes were analyzed to be high in the Japanese internationally, and these nutrients were related to nearly the lowest mortality rates of coronary heart diseases in the Japanese among developed countries in the world. However, these nutrient intakes were associated with higher salt intake causing hypertension and stroke to increase locomotive syndrome and bed ridden disability. Soy and fish intakes were proven to increase folic acid in the blood together with urinary magnesium which might decrease dementia, and soy intake was proven to decrease insulin resistance, thus to prevent diabetes, as well as to attenuate osteoporosis.
Therefore, by analyzing 24-hour urine samples, we will recommend people to take appropriately salted soy and fish diets together with vegetables for enjoying healthy longevity without locomotive syndrome and dementia.

Academic Significance and Societal Importance of the Research Achievements

ユネスコの無形文化遺産に登録された和食の特性が、24時間尿によるタウリン・イソフラボンの栄養分析で、魚と大豆を摂取している事にあると分った。これらは心臓死を防ぐので、日本人は世界でもトップの平均寿命であるが、過剰な食塩摂取による高血圧・脳卒中の為、ロコモになり、健康寿命は平均寿命より10年も短い。更に本研究は、大豆の常食は高齢者で糖尿病・骨粗鬆症・ロコモ、さらに認知症の予防の可能性も示しており、24時間尿のチェックにより、適塩で大豆や魚、更に食塩の害を抑える野菜などの摂取の定量的評価とそれに基づく個別化した栄養指導が可能となり、ロコモなどの予防による健康寿命の延伸に貢献する道が拓けた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (35 results)

All 2019 2018 2017

All Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (21 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] 和食の特色と「上手な食べ方」 -健康寿命は自分で延ばせる2019

    • Author(s)
      家森幸男
    • Journal Title

      ACADEMIA

      Volume: 171

    • Related Report
      2018 Annual Research Report
  • [Journal Article] マグネシム代謝‐その新たな臨床的意義 【基礎と総論】 マグネシウム摂取と生活習慣病のリスク2019

    • Author(s)
      森真理・荒井喜美・森英樹・家森幸男
    • Journal Title

      腎と透析

      Volume: 86

    • Related Report
      2018 Annual Research Report
  • [Journal Article] マグネシウム濃度と生命予後との関連性-血圧と飲料水を中心に2019

    • Author(s)
      鈴木舞、新居朋昭、松岡由紀、澤佐和子、白石光也、宮本篤
    • Journal Title

      腎と透析

      Volume: 86 Pages: 163-166

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Cross-Sectional Inverse Association of Regular Soy Intake with Insulin Resistance in Japanese Elderly2018

    • Author(s)
      Yamori Y.、Sagara M.、Arai Y.、Kobayashi H.、Kishimoto K.、Matsuno I.、Mori H.、Mori M.
    • Journal Title

      Journal of Nutrition in Gerontology and Geriatrics

      Volume: 37 Issue: 3-4 Pages: 282-291

    • DOI

      10.1080/21551197.2018.1496512

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 健康寿命の延伸を目指したロコモ予防教室―ロコモ度テストと身体・食生活状況との関連―2018

    • Author(s)
      垣渕直子,渡辺ひろ美,上北采佳,次田一代
    • Journal Title

      香川短期大学紀要

      Volume: 46 Pages: 47-56

    • NAID

      40021504858

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Influence of acute exercise on renalase and its regulatory mechanism.2018

    • Author(s)
      Tokinoya K, Shiromoto J, Sugasawa T, Yoshida Y, Aoki K, Nakagawa Y, Ohmori H, Takekoshi K
    • Journal Title

      Life Sciences

      Volume: 210

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of BCAA supplement timing on exercise-induced muscle soreness and damage: A pilot placebo-controlled double-blind study2018

    • Author(s)
      Ra SG, Miyazaki T, Kojima R, Komine S, Ishikura K, Kawanaka K, Honda A, Matsuzaki Y, Ohmori H
    • Journal Title

      The Journal of Sports Medicine and Physical Fitness

      Volume: 58 Pages: 1582-1591

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥満マウスの白色脂肪組織におけるシステインジオキシゲナーゼmRNA発現に及ぼすトレーニングの影響2018

    • Author(s)
      大森肇,水島隆規,時野谷勝幸,青木海,小峰昇一,今野雅生,小林雄晟,石倉惠介,宮﨑照雄,竹越一博
    • Journal Title

      タウリンリサーチ

      Volume: 4 Pages: 44-46

    • NAID

      130007743800

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Soy and fish as features of the Japanese diet and cardiovascular disease risks2017

    • Author(s)
      Yukio Yamori , Miki Sagara, Yoshimi Arai, Hitomi Kobayashi, Kazumi Kishimoto, Ikuko Matsuno, Hideki Mori, Mari Mori
    • Journal Title

      PLOS One

      Volume: 12 Issue: 4 Pages: 10-10

    • DOI

      10.1371/journal.pone.0176039

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Revised definition of predicted left ventricular mass using ambulatory blood pressure in healthy Korean adults2017

    • Author(s)
      Kim BK, Xu E, Choi BY, Lee Y, Kim SG, Yamori Y, Shin J.
    • Journal Title

      Clin Hypertens.

      Volume: 23 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s40885-017-0064-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Natural compound bavachalcone promotes the differentiation of endothelial progenitor cells and neovascularization through the RORα-erythropoietin-AMPK axis2017

    • Author(s)
      Shuang Ling, Rong-zhen Ni, Yunyun Yuan, Yan-qi Dang, Qian-mei Zhou,
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 49 Pages: 86188-86205

    • DOI

      10.18632/oncotarget.21036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Taurine Intake with Magnesium Reduces Cardiometabolic Risks.2017

    • Author(s)
      Yamori Y, Sagara M, Arai Y, Kobayashi H, Kishimoto K, Matsuno I, Mori H, Mori M
    • Journal Title

      Adv Exp Med Biol.

      Volume: 975 Pages: 1011-1020

    • DOI

      10.1007/978-94-024-1079-2_80

    • ISBN
      9789402410778, 9789402410792
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] タウリンと大豆イソフラボンの24時間尿排泄量による和食の摂取度と生活習慣病リスク        Grading of Japanese diet intakes by 24 hour urinary taurine and soy isoflavone excretions in relation to lifestyle related disease risks2019

    • Author(s)
      家森幸男
    • Organizer
      第5回国際タウリン研究会 福井
    • Related Report
      2018 Annual Research Report
  • [Presentation] 伸張性運動が血中タウリン濃度に与える影響2019

    • Author(s)
      三浦征,小峰昇一,宮下菜緒,時野谷勝幸,今野雅生,川津俊輔,*大森肇
    • Organizer
      第5回国際タウリン研究会日本部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Are 24-hour Urinary Biomarkers of Fish and Soy Intakes Useful Predictors for Cardiovascular Risks?2018

    • Author(s)
      Yukio Yamori
    • Organizer
      3rd World Congress on Public Health & Nutrition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between occurrence of heat stroke and nutritional status2018

    • Author(s)
      Mari Mori
    • Organizer
      3rd World Congress on Public Health & Nutrition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cardiovascular Risk Factors with a Focus on 24-hour Urinary Biomarkers of Fish and Soy Intakes as Useful Predictors in the Context of Healthy Aging2018

    • Author(s)
      Yukio Yamori
    • Organizer
      1st International Conference in Nutrition and Dietetics
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 世界調査から見た主食と健康 血糖値上昇の穏やかな機能性米の開発2018

    • Author(s)
      家森幸男
    • Organizer
      第65回 日本栄養改善学会学術総会 新潟
    • Related Report
      2018 Annual Research Report
  • [Presentation] Influence on renalase by acute exercise and its regulatory mechanism2018

    • Author(s)
      Tokinoya K, Shiromoto J, Yoshida Y, Sugasawa T, Ohmori H, Takekoshi K
    • Organizer
      23rd Annual Congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The manufacture of rat model that inhibits phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme of hepatic gluconeogenesis.2018

    • Author(s)
      Ohmori H, Matsumura M, Komine S, Kobayashi H, Kobayashi Y, Shiromoto J, Miyakawa S
    • Organizer
      The 21st International Taurine Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise2018

    • Author(s)
      Ra SG, Choi Y, Akazawa N, Kawanaka K, Ohmori H, Maeda S
    • Organizer
      The 21st International Taurine Meeting
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動に伴う活性酸素産生の功罪2018

    • Author(s)
      大森肇,三上俊夫
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 一過性運動の強度・時間と酸化ストレス応答.運動に伴う活性酸素産生の功罪.2018

    • Author(s)
      大森肇
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 長距離走中に発生する筋痛・筋損傷・酸化ストレスと運動パフォーマンス2018

    • Author(s)
      大森肇,
    • Organizer
      第15回乳酸研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動とブラックジンジャーおよびβ-ヒドロキシ-β-メチル酪酸投与がサルコペニアに及ぼす影響2018

    • Author(s)
      今野雅生,青木海,時野谷勝幸,本多克成,阿部卓哉,武原正明,大森肇.
    • Organizer
      第26回日本運動生理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 持久性運動によるバリン中間代謝物3-ヒドロキシイソ酪酸(3HIB)の骨格筋濃度の変化.2018

    • Author(s)
      宮﨑照雄,松村正隆,大森肇,本多彰
    • Organizer
      第26回日本運動生理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動とブラックジンジャーおよびβ-ヒドロキシ-β-メチル酪酸投与がサルコペニアに及ぼす影響.2018

    • Author(s)
      今野雅生,青木海,城本淳,時野谷勝幸,本多克成,阿部卓哉,永田岳史,武原正明,竹越一博,*大森肇:.
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 一過性運動における骨格筋レナラーゼの変化とそのメカニズム.2018

    • Author(s)
      時野谷勝幸, 城本淳, 菅澤威仁, 吉田保子, 青木海, 中川嘉, 大森肇, 竹越一博
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] N-アセチルタウリンによる骨格筋アセチルCoA量の調整2018

    • Author(s)
      宮﨑照雄,中村優歩,海老名慧,羅成圭,大森肇,池上正,松﨑靖司,本多彰
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] タウリン投与が血中インスリン濃度および血糖値に与える影響2018

    • Author(s)
      海老名慧,小峰昇一,宮﨑照雄,宮川俊平,大森肇.
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳卒中モデルと世界研究で分ったタウリンのより適切な摂取2017

    • Author(s)
      家森幸男 相良未木 森英樹 森真理
    • Organizer
      特集第三回国際タウリン研究会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「栄養で日本を元気に」プロジェクトの報告2017

    • Author(s)
      森 英樹,森 真理,垣渕 直子,次田 一代,磯村 実,江口 昭彦,宮本 篤,
    • Organizer
      第64回 日本栄養改善学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 健康寿命延伸を目指したロコモ予防教室ーロコモ度テストと身体・食生活状況との関連ー2017

    • Author(s)
      垣渕 直子,次田 一代,森 英樹,森 真理,家森幸男
    • Organizer
      第64回 日本栄養改善学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Book] The Encyclopedia of Cardiovascular Research and Medicine. Elsevier Inc2018

    • Author(s)
      Yamori Y., Sagara, M., Mori H. and Mori M.
    • Total Pages
      8
    • Publisher
      Nutrition: Soy and Fish
    • Related Report
      2018 Annual Research Report
  • [Book] 尿バイオマーカーは健康長寿食の尺度!2018

    • Author(s)
      家森幸男
    • Total Pages
      3
    • Publisher
      腎・高血圧の最新治療
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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