Development of Ultrasound Lithotripsy with High Throughput and Accuracy using Acoustic Cavitation
| Project/Area Number |
16H03160
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
梅村 晋一郎 東北大学, 医工学研究科, 学術研究員 (20402787)
|
|---|
| Project Period (FY) |
2016-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | キャビテーション / 結石破砕 / 集束超音波 |
|---|
| Outline of Final Research Achievements |
A HIFU transducer which has two resonance frequencies was developed. Cavitation bubbles were generated by the newly developed transducer or existing transducers and observed by high-speed photography and ultrasound imaging to investigate the behavior of the cavitation bubbles. A HIFU exposure method was proposed to erode a renal stone using cavitation bubbles efficiently. The result in the experiment of the erosion of model stones in a water tank showed the efficiency of the proposed method.
|
| Academic Significance and Societal Importance of the Research Achievements |
HIFU照射によって発生するキャビテーション気泡は，結石破砕のみならず，HIFUによるがんなどの治療や，HIFUを用いたドラッグデリバリーなどの分野でも利用が期待されている．したがって，本研究で得られたキャビテーション気泡の挙動に関する知見は，それらの分野への展開も期待できる．また，近年はレーザ技術等の進歩により経尿道的尿路結石除去術 （TUL）が発展してきているが，体外式のHIFUを用いた高効率かつ安全な結石破砕法は，より低侵襲で高速な結石破砕を実現できる可能性がある．
|
Report
(5 results)
Research Products
(24 results)
-
-
-
-
[Journal Article] Sonodynamic therapy with anticancer micelles and high-intensity focused ultrasound in treatment of canine cancer2019
Author(s)
Y. Hirose, M. Maeda, Y. Konishi, J. Okamoto, S. Ikuta, Y. Okamoto, H. Ishii, S. Yoshizawa, S. Umemura, T. Ueyama, S. Tamano, A. Sofuni, K. Takemae, K. Masamune, H. Iseki, N. Nishiyama, K. Kataoka, Y. Muragaki
-
Journal Title
Front. Pharmacol.
Volume: 10
Pages: 545-545
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
