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Study on biological measurement technique utilizing angular distribution information of intensity of scattered light

Research Project

Project/Area Number 16H03165
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKanazawa University

Principal Investigator

Hyodo Masaharu  金沢大学, 機械工学系, 教授 (30359088)

Co-Investigator(Kenkyū-buntansha) 的場 修  神戸大学, システム情報学研究科, 教授 (20282593)
宮内 哲  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター企画室, 嘱託 (80190734)
齋藤 伸吾  国立研究開発法人情報通信研究機構, 未来ICT研究所フロンティア創造総合研究室, 主任研究員 (80272532)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords生体情報・計測 / 医用光学 / 生体活動計測 / 角度分解計測
Outline of Final Research Achievements

It was demonstrated by Monte-Carlo simulation of photon migration in biological tissues, that it is possible to identify the change in absorption coefficient in the deep inside of the biological tissues using the angle-resolved measurement that we proposed for the first time. The characteristics of the angle-resolved probe (ARP) were also completely explained by assuming a virtual dipole probe for its spatial sensitivity distribution (SSD). Furthermore, it was shown that the SSD of the ARP can be synthesized by using the analytical solution of the light diffusion equation, and as a result of applying it to the time-resolved measurement, we obtained the prospect that the simulation time would be significantly reduced.

Academic Significance and Societal Importance of the Research Achievements

本研究は,これまで先行研究例がほとんどなかった散乱光強度の角度分布に着目し,生体内での散乱・吸収特性の変化と散乱光強度の角度分布の関係を明らかにした点において学術的な意義がある.また,現在実用化されている光学的脳活動計測装置(NIRS)は計測装置としての性能限界に達しており,本研究の成果によって被験者への負担が少ない最小限のプローブ数で高精度に脳活動を計測可能な新しい計測装置の開発につながるとともに,我が国の技術を発展させて国際的なリーダーシップの獲得につながる意義がある.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (29 results)

All 2020 2019 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Int'l Joint Research: 7 results,  Invited: 9 results) Book (2 results)

  • [Journal Article] 脳波黎明期におけるLoomisの知られざる功績2020

    • Author(s)
      宮内哲
    • Journal Title

      Japanese Journal of Clinical Neurophysiology

      Volume: 48 Issue: 2 Pages: 74-80

    • DOI

      10.11422/jscn.48.74

    • NAID

      130007831298

    • ISSN
      1345-7101, 2188-031X
    • Year and Date
      2020-04-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳波黎明期におけるLoomisの知られざる功績2020

    • Author(s)
      宮内哲
    • Journal Title

      Japanese Journal of Clinical Neurophysiology

      Volume: 48 Issue: 1 Pages: 15-22

    • DOI

      10.11422/jscn.48.15

    • NAID

      130007795468

    • ISSN
      1345-7101, 2188-031X
    • Year and Date
      2020-02-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequency stabilization of dual-mode microchip laser by means of beat frequency stabilization2019

    • Author(s)
      Iyon Titok Sugiarto, Masayoshi Watanabe, Satoshi Sunada, and Masaharu Hyodo
    • Journal Title

      Oprtical Review

      Volume: 27 Pages: 98-107

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Angle-Resolved Measurement of Diffuse Reflected Light2018

    • Author(s)
      Osamu Matoba, Satoru Miyauchi, and Shingo Saito
    • Journal Title

      Proceedings of SPIE

      Volume: 10815 Pages: 18-18

    • DOI

      10.1117/12.2500600

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of coherence-or-power selectable operation of an external-cavity semiconductor diode laser2016

    • Author(s)
      Masayoshi Watanabe, Akira Kawakami, Shingo Saito, and Masaaki Adachi
    • Journal Title

      Applied Optics

      Volume: 55 Issue: 36 Pages: 10204-10210

    • DOI

      10.1364/ao.55.010204

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Experimental Verification of Reconstructed Absorbers Embedded in Scattering Media by Optical Power Ratio Distribution2016

    • Author(s)
      Toshihiko Yamaoki, Hiroaki Hamada, Osamu Matoba
    • Journal Title

      Applied Optics

      Volume: 55 Issue: 25 Pages: 6874-6879

    • DOI

      10.1364/ao.55.006874

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Technique of Digital Control of Laser Oscillation Frequencies by means of Difference Frequency Stabilization of a Microchip Laser2019

    • Author(s)
      Iyon Titok Sugiarto, Takahiro Masaki, and Masaharu Hyodo
    • Organizer
      the 8th Advanced Lasers and Photon Sources (ALPS2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ベルガーの夢 -脳波が脳波になるまで-2019

    • Author(s)
      宮内哲
    • Organizer
      茨城てんかん懇話会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] fMRIと脳波の同時計測による睡眠と意識の研究2019

    • Author(s)
      宮内哲
    • Organizer
      日本精神医学史学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ベルガーの夢 -脳波が脳波になるまで-2019

    • Author(s)
      宮内哲
    • Organizer
      日本てんかん学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ベルガーの夢 -脳波が脳波になるまで-2019

    • Author(s)
      宮内哲
    • Organizer
      日本臨床神経生理学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 視覚探索中の眼球運動による視野特性の計測2019

    • Author(s)
      仲泊聡, 古田歩, 髙橋あおい, 早乙女慶輔, 久保寛之, 堀口浩史, 小出直史, 髙橋政代, 中野匡, 宮内哲
    • Organizer
      第61回日本産業・労働・交通眼科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Characterization of Angle-Resolved Measurement of Diffuse Reflected Light2018

    • Author(s)
      Masaharu Hyodo, Osamu Matoba, Satoru Miyauchi, and Shingo Saito
    • Organizer
      SPIE/COS Photonics Asia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Digital phase conjugation for improving the focused spot in weakly scattering medium for OCT2018

    • Author(s)
      K. Harukaze, N. Nakatani, X. Quan, K. Nitta, O. Matoba
    • Organizer
      OSA 3D Image Acquisition and Display Technology, Perception and Applications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非侵襲脳活動計測と心理学2018

    • Author(s)
      宮内哲
    • Organizer
      第66回 岡山心理学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒューマン・マルチセンシングと脳科学の応用 -脳波とfMRIの同時計測-2018

    • Author(s)
      宮内哲
    • Organizer
      応用脳科学コンソーシアム ヒューマンマルチセンシングワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 拡散反射光の角度分解計測による2層構造強散乱体の吸収係数識別2017

    • Author(s)
      兵頭政春,宮平堅介,的場修,齋藤伸吾,川上彰,宮内哲
    • Organizer
      第20回日本光脳機能イメージング学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Discrimination of absorption variations in two layered structure by using angular distribution of diffuse reflected light2017

    • Author(s)
      Masaharu Hyodo, Kensuke Miyahira, Osamu Matoba, Satoru Miyauchi, Shingo Saito, and Akira Kawakami
    • Organizer
      The 12th Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 散乱光強度の角度分布計測による散乱光の空間感度分布の比較2017

    • Author(s)
      吉田健吾,的場修,齋藤伸吾,川上彰,宮内哲,兵頭政春
    • Organizer
      応用物理学会北陸・信越支部学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 「光トポグラフィーによる精神疾患鑑別診断-有効性の検討-」の検討2017

    • Author(s)
      宮内哲,星詳子
    • Organizer
      第20回日本光脳機能イメージング学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 光トポグラフィーの光と影2017

    • Author(s)
      宮内哲(シンポジスト)
    • Organizer
      第20回日本光脳機能イメージング学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脳科学の知見を「個人」や「社会」に活かす~3つの研究例からの検討~2017

    • Author(s)
      宮内哲(指定討論者)
    • Organizer
      日本心理学会第81会大会シンポジウム064
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 心理学でのfNIRSの使い方2017

    • Author(s)
      宮内哲(シンポジウム企画者・司会者)
    • Organizer
      日本心理学会第81会大会シンポジウム039
    • Related Report
      2017 Annual Research Report
  • [Presentation] Improvement of OCT Signal using Digital Phase Conjugation in Weakly Phase Distorted Medium2017

    • Author(s)
      K. Harukaze, N. Nakatani, K. Nitta, O. Matoba
    • Organizer
      The 24th Congress of the International Commission for Optics (ICO-24)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 強散乱体強散乱体での2層構造各層の吸収係数変化の識別における新手法と従来法の比較2016

    • Author(s)
      宮平堅介,的場修,齋藤伸吾,川上彰,宮内哲,兵頭政春
    • Organizer
      日本光学会年次学術講演会(OPJ2016)
    • Place of Presentation
      筑波大学東京キャンパス文京校舎
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Evaluation of Reduced Scattering Coefficient of Artificial Scattering Medium with Shifted and Layered Random Void Distributions2016

    • Author(s)
      N. Nakatani, O. Matoba, M. Hyodo
    • Organizer
      Optics & Photonics Japan 2016 (OPJ2016)
    • Place of Presentation
      筑波大学東京キャンパス文京校舎
    • Year and Date
      2016-10-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimization of Power Spectral Density and Polarization Compensation for Coherence-Selectable ECDL2016

    • Author(s)
      Masaharu Hyodo, Akira Kawakami, Shingo Saito, Masayoshi Watanabe, Takahiro Kubo, and Masaaki Adachi
    • Organizer
      The 25th International Semiconductor Laser Conference (ISLC2016)
    • Place of Presentation
      神戸メリケンパークオリエンタルホテル
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 脳波の発見 -ハンス・ベルガーの夢-2020

    • Author(s)
      宮内哲
    • Total Pages
      138
    • Publisher
      岩波書店
    • Related Report
      2019 Annual Research Report
  • [Book] 「脳神経化学 脳はいま化学の言葉でどこまで語れるか」(森泰生,尾藤晴彦 編)の「第28章 磁気共鳴画像」2018

    • Author(s)
      宮内哲,寒重之(分担執筆)
    • Total Pages
      359
    • Publisher
      化学同人
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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