| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
The purpose of this research was to visualize early cancer sites in a human body by using information and time-dependent changes of bio-transmitter such as identified 300+ cytokines. A signal amplification concept based on photo-responsive microcapsules that can be applied to various biosensors was proposed in order to possible for measuring cytokines in the concentration of 1 pg/mL. Photo-responsive microcapsules were fabricated. It was shown experimentally that the required characteristics were obtained. Through both text mining of scientific papers and clinical researches, we tried to code by using several cytokines for each cancer site. A combinatorial panel of select cytokines indicated the presence of lung cancer and colorectal cancer. Finally, we proposed a method for visualizing a cancer site as a cytokine model in high accuracy.
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