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Guanine crystals for highly functioned medical small micro-mirror

Research Project

Project/Area Number 16H03169
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionHiroshima University

Principal Investigator

Iwasaka Masakazu  広島大学, ナノデバイス・バイオ融合科学研究所, 教授 (90243922)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywordsバイオミメティクス / バイオフォトニクス / 生体磁気工学 / グアニン結晶 / マイクロ光学素子 / 光干渉 / モアレ縞 / 磁場配向 / 細胞 / マイクロミラー / 微結晶磁気応答 / バイオセンシング / 磁場 / 医療用デバイス / 生体内結晶 / 磁気応答 / マイクロ凝集体 / 細胞診断 / 光計測 / 生体由来微結晶 / 磁気制御 / 細胞計測制御 / 磁気MEMS
Outline of Final Research Achievements

Light reflection properties of guanine crystal platelet were clarified by observing the high speed rotation under magnetic fields and drift motion in a micro-fluidic chamber. We developed a measurement system for time-course of light reflection in guanine crystal platelets rapidly rotating under magnetic fields, by utilizing a pulsed magnetic field generator which produced a maximum 4-T magnetic field. In addition, alignments of guanine crystal platelets in an aqueous solution were controlled by a magnetic tweezer, and it was revealed that the light interference pattern (moire pattern) changed depending on structures of biological tissues such as osteoblast and cilia of comb jelly.

Academic Significance and Societal Importance of the Research Achievements

魚類が自然界にて光を効率良く利用するために進化の過程で獲得したバイオジェニック・ミラーを医療診断に用いる上でのヒントと活用手法について基礎研究を推進した。グアニン結晶ミラー板の磁場下での回転およびマイクロ流路内での動きを高速撮影し、医療用のミラーとして十分な応答性を有することを示した。また、結晶板における光干渉パターン(モアレ縞)が、生体組織(培養骨芽細胞)の構造に依存して変化することを明らかにできた。今後は、新たな細胞診断法へのグアニン結晶の応用が期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (29 results)

All 2019 2018 2017 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (19 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Effects of pulsed magnetic fields on cilia of comb jelly2019

    • Author(s)
      Y. Fukagawa, M. Iwasaka
    • Journal Title

      AIP Advance

      Volume: 9 Issue: 3

    • DOI

      10.1063/1.5079635

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetically Controlled Light Manipulating Properties of Biogenic and Synthetic Guanine Crystals2018

    • Author(s)
      H. Kashiwagi, M. Iwasaka, H. Asada, T. Koyanagi, K. Kishimoto
    • Journal Title

      IEEE Xplore

      Volume: Intermag 2018 Pages: 1-5

    • DOI

      10.1109/intmag.2018.8508139

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical Behavior of Guanine Microcrystals from Aquatic Species upon Exposure to a Magnetic Field2018

    • Author(s)
      H. Kashiwagi, H. Asada, M. Iwasaka
    • Journal Title

      IEEE Xplore

      Volume: Intermag 2018 Pages: 1-5

    • DOI

      10.1109/intmag.2018.8508337

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体関連の磁場効果研究の現状2018

    • Author(s)
      岩坂正和
    • Journal Title

      電気学会マグネティックス研究会資料

      Volume: MAG-18-031 Pages: 1-4

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Remote sensing of microfluidic tracers by light scattering from microcrystals under magnetic fields2017

    • Author(s)
      Y Takanezawa, H Kashiwagi, M Iwasaka
    • Journal Title

      AIP Advances

      Volume: 7 (5) Issue: 5

    • DOI

      10.1063/1.4978406

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Magnetic light cloaking control in the marine planktonic copepod Sapphirina2017

    • Author(s)
      H Kashiwagi, Y Mizukawa, M Iwasaka, S Ohtsuka
    • Journal Title

      AIP Advances

      Volume: 7 (5) Issue: 5

    • DOI

      10.1063/1.4978210

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of magnetic fields on green color formation in frog skin2017

    • Author(s)
      H Kashiwagi, A Kashiwagi, M Iwasaka
    • Journal Title

      AIP Advances

      Volume: 7 (5) Issue: 5

    • DOI

      10.1063/1.4976958

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Magnetically tunable control of light reflection in an unusual optical protein of squid2017

    • Author(s)
      M Iwasaka, K Tagawa, Y Kikuchi
    • Journal Title

      AIP Advances

      Volume: 7 (5) Issue: 5 Pages: 056722-056722

    • DOI

      10.1063/1.4976938

    • NAID

      120006549334

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modulation of light localization in the iridophores of the deep-sea highlight hatchetfish Sternoptyx pseudobscura under magnetic field2017

    • Author(s)
      M Iwasaka, S Ohtsuka
    • Journal Title

      AIP Advances

      Volume: 7 (5) Issue: 5

    • DOI

      10.1063/1.4974977

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Uric acid crystals control firefly bioluminescence under magnetic fields2019

    • Author(s)
      M. Iwasaka, Y. Takeuchi, H. Asada
    • Organizer
      2019 Joint MMM-Intermag Conference
    • Related Report
      2018 Annual Research Report
  • [Presentation] シンポジウム3 パネルディスカッション「バイオ・医療における磁界・磁性材料の応用研究と産学官連携」2018

    • Author(s)
      岩坂正和
    • Organizer
      日本生体磁気学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Magnetic Control of Guanine-Vesicle Hybrid and Its Possible Application in Live Cell Imaging2018

    • Author(s)
      岩坂正和、Mootha Archana, 鈴木謙太郎
    • Organizer
      日本生体磁気学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 13テスラ水平磁場による磁場配向乾燥グアニン薄膜の作製2018

    • Author(s)
      岩坂正和、廣田憲之、浅田裕法
    • Organizer
      日本磁気科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クラゲ構成成分の光散乱挙動に対する最大4テスラのパルス磁場効果の観測2018

    • Author(s)
      深川雄太、岩坂正和
    • Organizer
      日本磁気科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クシクラゲ櫛板の構造色に対する磁場効果の細胞計測応用の可能性2018

    • Author(s)
      林正晃、濱村恭平、岩坂正和
    • Organizer
      日本磁気科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クシクラゲ櫛板とグアニン結晶の光干渉効果の磁気制御2018

    • Author(s)
      濱村恭平、林正晃、岩坂正和
    • Organizer
      日本磁気科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 磁場・電場によるキラル認識2018

    • Author(s)
      木村恒久,木村史子,寺野真維,岩坂正和
    • Organizer
      日本磁気科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Light intensity change of comb jelly fish by pulsednmagnetic fields2018

    • Author(s)
      Y. Fukagawa, M. Iwasaka
    • Organizer
      The 3rd International Symposium on Biomedical Engineering, Hiroshima
    • Related Report
      2018 Annual Research Report
  • [Presentation] Observation of cellular conformation changes in osteoblast under strong magnetic fields2018

    • Author(s)
      M. Hayashi, M. Iwasaka
    • Organizer
      The 3rd International Symposium on Biomedical Engineering, Hiroshima
    • Related Report
      2018 Annual Research Report
  • [Presentation] Analysis of guanine crystal particle stream by using high resolution microscope2018

    • Author(s)
      K. Hamamura, M. Iwasaka
    • Organizer
      The 3rd International Symposium on Biomedical Engineering, Hiroshima
    • Related Report
      2018 Annual Research Report
  • [Presentation] Magnetic Behaviour of Giant Vesicle Containing Guanine Particles as A Model of Irridophore2018

    • Author(s)
      A. Mootha, K. Suzuki, M. Iwasaka
    • Organizer
      Material Analysis and Processing in Magnetic Fields (MAP8)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of Magnetic Fields on Cilia of Comb Jelly2018

    • Author(s)
      M. Iwasaka, N. Hirota
    • Organizer
      Material Analysis and Processing in Magnetic Fields (MAP8)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Magnetic Light Control of Biologically Designed Photonic Materials2018

    • Author(s)
      M. Iwasaka
    • Organizer
      Material Analysis and Processing in Magnetic Fields (MAP8)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生物磁気研究の磁気科学化加速のメリットとデメリット2018

    • Author(s)
      岩坂 正和
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ユーグレナの磁気ストレス応答に対する近赤外分光検出による細胞代謝活性評価法2017

    • Author(s)
      水川 友里,岩坂 正和
    • Organizer
      電気学会A部門大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体内微結晶の磁気特性と医工学への応用展開2017

    • Author(s)
      武内裕香、岩坂正和、松田瑞史
    • Organizer
      電気学会A部門大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疾患を伴う尿酸ナトリウ結晶の配向挙動および偏光特性2017

    • Author(s)
      武内裕香、浜崎亜富、岩坂正和、松田瑞史
    • Organizer
      日本磁気科学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体分子の磁気応答高感度検出のための一手法2017

    • Author(s)
      岩坂正和
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 広島大学 ナノデバイス・バイオ融合科学研究所分子生命情報研究部門 岩坂研究室

    • URL

      http://iwasaka.server-shared.com/

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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