Robustness enhancement and optimization for bionic artificial hydrogel cartilage with superlubricity
Project/Area Number |
16H03170
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Teikyo University |
Principal Investigator |
MURAKAMI TERUO 帝京大学, 福岡医療技術学部, 教授 (90091347)
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Co-Investigator(Kenkyū-buntansha) |
中嶋 和弘 帝京大学, 福岡医療技術学部, 准教授 (70315109)
澤江 義則 九州大学, 工学研究院, 教授 (10284530)
坂井 伸朗 九州工業大学, 大学院工学研究院, 准教授 (60346814)
鈴木 淳史 横浜国立大学, 大学院環境情報研究院, 教授 (90162924)
岡崎 賢 東京女子医科大学, 医学部, 教授 (10398092)
鎗光 清道 首都大学東京, システムデザイン研究科, 助教 (90723205)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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Keywords | 人工軟骨 / ハイドロゲル / バイオトライボロジー / バイオメカニクス / 生体規範超潤滑 |
Outline of Final Research Achievements |
The detailed mechanism of adaptive multimode lubrication in natural synovial joints has been elucidated and subsequently those results have been applied to develop innovative poly(vinyl alcohol) (PVA) hydrogel cartilage. It was shown that the reinforcement by PVA fiber for PVA hydrogel promoted the interstitial fluid pressurization and reduced friction. For PVA hybrid hydrogel of optimized laminated structure, the optimum gamma-ray irradiation as sterilization and cross-linking treatment to the PVA hybrid hydrogel was effective to reduce wear. The PVA hybrid hydrogel with optimized composite structure as a single layer was developed which showed low friction and minimum wear even at high contact pressure.
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Academic Significance and Societal Importance of the Research Achievements |
超高齢社会の進展に伴い関節の機能低下をきたす患者が増加しており、たとえば国内の変形性関節症患者数は2000万人程度と見積もられており適切な対策が必要とされている。重度の症例に対しては、人工関節置換術が適用(年間約20万例)され、運動能力の回復や除痛の効果が得られているが、摩耗粉に起因する骨溶解によるゆるみの発生や脱臼などにより再置換が必要となる症例も生じている。本研究では、ゼロ摩耗を実現するために生体関節の多モード適応潤滑機構を再現できるハイドロゲル人工軟骨の実用化に取組んでおり臨床応用を実現するためにロバスト性の向上を進めた。また、その潤滑原理はその他の摩擦面にも応用可能と期待される。
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Minimum 10-year results of cementless total hip arthroplasty in patients with rheumatoid arthritis2016
Author(s)
Haraguchi A, Nakashima Y, Miyahara H, Esaki Y, Okazaki K, Fukushi JI, Hirata G, Ikemura S, Kamura S, Sakuraba K, Fujimura K, Akasaki Y, Yamada H.
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Journal Title
Mod Rheumatol
Volume: 15
Issue: 4
Pages: 598-604
DOI
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Peer Reviewed
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[Presentation] Superior biotribological properties of poly(vinyl alcohol) hydrogel for artificial cartilage2016
Author(s)
T. Murakami, S. Yarimitsu, N. Sakai, K. Nakashima, S. Omata, S. Sasaki, T. Yamaguchi, Y. Sawae, A. Suzuki
Organizer
3rd International Conference on Bio Tribology
Place of Presentation
Imperial College, London, UK
Year and Date
2016-09-11
Related Report
Int'l Joint Research
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[Presentation] protein adsorption on friction of metal/UHMWPE sliding pair2016
Author(s)
David Necas, Kazuhiro Nakashima, Yoshinori Sawae, T. Fujisawa, Takehiro Morita, Tetsuo Yamaguchi, M. Vrbka, I. Krupka, M. Hartl
Organizer
3rd International Conference on Bio Tribology
Place of Presentation
Imperial College, London, UK
Year and Date
2016-09-11
Related Report
Int'l Joint Research
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[Patent(Industrial Property Rights)] 繊維強化ハイドロゲル及びその製造方法2017
Inventor(s)
村上,澤江,小俣,佐々木,坂井,内村,橋本,鎗光,鈴木
Industrial Property Rights Holder
九州大学,九州工業大学,首都大学東京,横浜国立大学
Industrial Property Rights Type
特許
Industrial Property Number
2017-075501
Filing Date
2017
Related Report