| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Outline of Final Research Achievements |
Pancreatic cancer has the histological character that a well-developed fibrous stroma covers cancer cell nests. Due to this character, artificially synthesized gene vectors with a particle size of approximately 100 nm cannot reach cancer cells. In this study, we developed a gene vector with an extremely small particle size of 50 nm by an innovative methodology of dissociating double-helical DNA and packaging the flexible single strands into a gene vector. The gene vector was applied to a mouse model of pancreatic cancer, and the therapeutic gene was successfully expressed in cancer cells after intravenous administration to yield a significant therapeutic effect.
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