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Development of a nano-pharmaceutical strategy for safely and effectively treating pregnant cancer patients

Research Project

Project/Area Number 16H03179
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Cabral Horacio  東京大学, 大学院工学系研究科(工学部), 准教授 (10533911)

Co-Investigator(Kenkyū-buntansha) 永松 健  東京大学, 医学部附属病院, 准教授 (60463858)
持田 祐希  公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 (60739134)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
KeywordsPlacenta / Nanomedicine / Size control / Pre-term birth / Pre-eclampsia / Placental barrier / Size effect / Preterm birth / Preeclampsia / Polymeric micelles / Star-shaped polymers / 高分子ナノメディシン / 胎盤輸送 / 抗癌治療 / 抗炎症治療 / マクロファージ標的 / Cancer / Anticancer drugs / ナノバイオ / ナノデバイス
Outline of Final Research Achievements

To identify the size of materials to pass through the placenta, we performed ex vivo human placental perfusion studies by using nano-sized agents. We found that there is cut-off of the size between 20-30 nm. Based on these results, we developed indomethacin-loaded micelles (Indo/m; 50 nm) for treatment of pre-term birth, PEGylated-recombinant thrombomodulin (PEG-rTM; 30 nm) for treating pre-eclampsia and size-controlled polymeric micelles loading (1,2-diaminocyclohexane)platinum (II) (DACHPt/m; 30 and 70 nm) for treating cancer. Indo/m were able to safely suppress pre-term birth in a model of uterine inflammation to promote the delivery of healthy pups. PEG-rTM was effective in a mouse model of pre-eclampsia induced by angiotensin II administration. Finally, both 30 and 70 nm DACHPt/m were active against breast cancer models. However, only 70-nm DACHPt/m could avoid placenta accumulation, allowing the delivery of normal pups.

Academic Significance and Societal Importance of the Research Achievements

Our results indicate the importance of size control of nanomedicines for generating safe therapies during pregnancy. We have patented these findings, and are looking to translate the developed systems to clinical application in collaboration with industry, expecting to benefit pregnant patients.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (134 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (28 results) (of which Int'l Joint Research: 28 results,  Peer Reviewed: 28 results,  Open Access: 12 results,  Acknowledgement Compliant: 5 results) Presentation (96 results) (of which Int'l Joint Research: 47 results,  Invited: 12 results) Remarks (1 results) Patent(Industrial Property Rights) (8 results) (of which Overseas: 5 results) Funded Workshop (1 results)

  • [Journal Article] Enhanced MRI‐Guided Gadolinium (III) Neutron Capture Therapy by Polymeric Nanocarriers Promoting Tumor Accumulation and Intracellular Delivery2020

    • Author(s)
      Qin Changyuan、Hou Xuan、Khan Thahomina、Nitta Nobuhiro、Yanagawa Masashi、Sakurai Yuriko、Suzuki Minoru、Masunaga Shin‐Ichiro、Tanaka Hiroki、Sakurai Yoshinori、Takahashi Hiroyuki、Aoki Ichio、Yanagie Hironobu、Cabral Horacio
    • Journal Title

      ChemNanoMat

      Volume: 6 Issue: 3 Pages: 412-419

    • DOI

      10.1002/cnma.201900730

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nanomedicines blocking adaptive signals in cancer cells overcome tumor TKI resistance.2020

    • Author(s)
      H. Kinoh, H. Shibasaki, X. Liu, T. Yamasoba, H. Cabral, K. Kataoka
    • Journal Title

      J. Control. Release

      Volume: 321 Pages: 132-144

    • DOI

      10.1016/j.jconrel.2020.02.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Polymeric Micelles Loading Proteins through Concurrent Ion Complexation and pH‐Cleavable Covalent Bonding for In Vivo Delivery2019

    • Author(s)
      Tao Anqi、Huang George Lo、Igarashi Kazunori、Hong Taehun、Liao Suiyang、Stellacci Francesco、Matsumoto Yu、Yamasoba Tatsuya、Kataoka Kazunori、Cabral Horacio
    • Journal Title

      Macromolecular Bioscience

      Volume: 20 Issue: 1 Pages: 1900161-1900161

    • DOI

      10.1002/mabi.201900161

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer.2019

    • Author(s)
      T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 13 Issue: 11 Pages: 12732-12742

    • DOI

      10.1021/acsnano.9b04676

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] One-Pot Synthesis of PEG-Poly(amino acid) Block Copolymers Assembling Polymeric Micelles with PEG-Detachable Functionality2019

    • Author(s)
      Miyazaki Takuya、Igarashi Kazunori、Matsumoto Yu、Cabral Horacio
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: - Issue: 11 Pages: 5727-5733

    • DOI

      10.1021/acsbiomaterials.8b01549

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bundling mRNA strands to prepare nano-assemblies with enhanced stability towards RNase for in vivo delivery.2019

    • Author(s)
      N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 58 Issue: 33 Pages: 11360-11363

    • DOI

      10.1002/anie.201905203

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment.2019

    • Author(s)
      Martin JD, Panagi M, Wang C, Khan TT, Martin MR, Voutouri C, Toh K, Papageorgis P, Mpekris F, Polydorou C, Ishii G, Takahashi S, Gotohda N, Suzuki T, Wilhelm ME, Melo VA, Quader S, Norimatsu J, Lanning RM, Kojima M, Stuber MD, Stylianopoulos T, Kataoka K, Cabral H.
    • Journal Title

      ACS Nano.

      Volume: 13 Issue: 6 Pages: 6396-6408

    • DOI

      10.1021/acsnano.8b07865

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration2019

    • Author(s)
      Kurimoto Shota、Yoshinaga Naoto、Igarashi Kazunori、Matsumoto Yu、Cabral Horacio、Uchida Satoshi
    • Journal Title

      Molecules

      Volume: 24 Issue: 7 Pages: 1303-1303

    • DOI

      10.3390/molecules24071303

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.2019

    • Author(s)
      N. Yoshinaga, S. Uchida, M. Naito, K. Osada, H. Cabral, K. Kataoka
    • Journal Title

      Biomaterials

      Volume: 197 Pages: 255-267

    • DOI

      10.1016/j.biomaterials.2019.01.023

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors2019

    • Author(s)
      Suzuki Kazumi、Miura Yutaka、Mochida Yuki、Miyazaki Takuya、Toh Kazuko、Anraku Yasutaka、Melo Vinicio、Liu Xueying、Ishii Takehiko、Nagano Osamu、Saya Hideyuki、Cabral Horacio、Kataoka Kazunori
    • Journal Title

      Journal of Controlled Release

      Volume: 301 Pages: 28-41

    • DOI

      10.1016/j.jconrel.2019.02.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Robust Polyion Complex Vesicles (PICsomes) under Physiological Conditions Reinforced by Multiple Hydrogen Bond Formation Derived by Guanidinium Groups2018

    • Author(s)
      Hori Mao、Cabral Horacio、Toh Kazuko、Kishimura Akihiro、Kataoka Kazunori
    • Journal Title

      Biomacromolecules

      Volume: 19 Issue: 10 Pages: 4113-4121

    • DOI

      10.1021/acs.biomac.8b01097

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeting ability of self-assembled nanomedicines in rat acute limb ischemia model is affected by size2018

    • Author(s)
      Suhara Masamitsu、Miura Yutaka、Cabral Horacio、Akagi Daisuke、Anraku Yasutaka、Kishimura Akihiro、Sano Masaya、Miyazaki Takuya、Nakamura Noriko、Nishiyama Ayako、Kataoka Kazunori、Koyama Hiroyuki、Hoshina Katsuyuki
    • Journal Title

      Journal of Controlled Release

      Volume: 286 Pages: 394-401

    • DOI

      10.1016/j.jconrel.2018.07.049

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Block Copolymer Micelles in Nanomedicine Applications2018

    • Author(s)
      Cabral Horacio、Miyata Kanjiro、Osada Kensuke、Kataoka Kazunori
    • Journal Title

      Chemical Reviews

      Volume: 118 Issue: 14 Pages: 6844-6892

    • DOI

      10.1021/acs.chemrev.8b00199

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effective treatment of drug resistant recurrent breast tumors harboring cancer stem-like cells by staurosporine/epirubicin co-loaded polymeric micelles2017

    • Author(s)
      J. Zhang, H. Kinoh, L. Hespel, X. Liu, S. Quader, J. Martin, T. Chida, H. Cabral, K. Kataoka,
    • Journal Title

      Journal of Controlled Release, "Vol. 264, pp. 127-1335, 2017

      Volume: 264 Pages: 127-135

    • DOI

      10.1016/j.jconrel.2017.08.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity2017

    • Author(s)
      Chen Shaoyi、Florinas Stelios、Teitgen Abigail、Xu Ze-Qi、Gao Changshou、Wu Herren、Kataoka Kazunori、Cabral Horacio、Christie R. James
    • Journal Title

      Sci. Technol. Adv. Mater.

      Volume: 18 Issue: 1 Pages: 666-680

    • DOI

      10.1080/14686996.2017.1370361

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells2017

    • Author(s)
      Miyano Kazuki、Cabral Horacio、Miura Yutaka、Matsumoto Yu、Mochida Yuki、Kinoh Hiroaki、Iwata Caname、Nagano Osamu、Saya Hideyuki、Nishiyama Nobuhiro、Kataoka Kazunori、Yamasoba Tatsuya
    • Journal Title

      J Control Release

      Volume: 261 Pages: 275-286

    • DOI

      10.1016/j.jconrel.2017.06.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment.2017

    • Author(s)
      . Matsumoto, A. J. S.-Brown, T. Khan, T. Miyazawa, H. Cabral, K. Kataoka, Y. Miyahara,
    • Journal Title

      Chem. Sci.

      Volume: 8 Pages: 6165-6170

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-κB inhibition"2017

    • Author(s)
      Hailiang Wu, Anqi Tao, John D. Martin, Sabina Quader, Xueying Liu, Kei Takahashi, Louise Hespel, Yutaka Miura, Yoshihiro Hayakawa, Tatsuro Irimura, Horacio Cabral, Kazunori Kataoka
    • Journal Title

      J. Pharm. Sci,

      Volume: - Issue: 9 Pages: 30217-30224

    • DOI

      10.1016/j.xphs.2017.03.031

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors2017

    • Author(s)
      S. Quader, X. Liu, Y. Chen, P. Mi, T. Chida, T. Ishii, Y. Miura, N. Nishiyama, H. Cabral, K. Kataoka
    • Journal Title

      J. Control. Release

      Volume: 258 Pages: 56-66

    • DOI

      10.1016/j.jconrel.2017.04.033

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors.2017

    • Author(s)
      P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka,
    • Journal Title

      J. Control. Release

      Volume: 254 Pages: 1-9

    • DOI

      10.1016/j.jconrel.2017.03.036

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration2017

    • Author(s)
      Yoshinaga Naoto、Ishii Takehiko、Naito Mitsuru、Endo Taisuke、Uchida Satoshi、Cabral Horacio、Osada Kensuke、Kataoka Kazunori
    • Journal Title

      Journal of the American Chemical Society

      Volume: 139 Issue: 51 Pages: 18567-18575

    • DOI

      10.1021/jacs.7b08816

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polymeric micelles for targeted tumor therapy of platinum anticancer drugs2017

    • Author(s)
      Yuki Mochida, Horacio Cabral, Kazunori Kataoka
    • Journal Title

      Expert Opinion on Drug Delivery

      Volume: - Issue: 12 Pages: 1423-1438

    • DOI

      10.1080/17425247.2017.1307338

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular cancer imaging with polymeric nanoassemblies: From tumor detection to theranostics.2017

    • Author(s)
      P. Mi, F. Wang, N. Nishiyama, H. Cabral
    • Journal Title

      Macromol. Biosc.

      Volume: - Issue: 1

    • DOI

      10.1002/mabi.201600305

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nanomedicines eradicating cancer stem-like cells in vivo by pH-triggered intracellular cooperative action of loaded drugs.2016

    • Author(s)
      H. Kinoh, Y. Miura, T. Chida, X. Liu, K. Mizuno, S. Fukushima, Y. Morodomi, N. Nishiyama, H. Cabral, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 10 Issue: 6 Pages: 5643-5655

    • DOI

      10.1021/acsnano.6b00900

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy.2016

    • Author(s)
      P. Mi, D. Kokuryo, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, K. Kataoka,
    • Journal Title

      Nat. Nanotechnol.

      Volume: 11 Issue: 8 Pages: 724-730

    • DOI

      10.1038/nnano.2016.72

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Lipid- and polyion complex-based micelles as agonist platforms for TNFR superfamily receptors2016

    • Author(s)
      R. N. Gilbreth, S. Novarra, L. Wetzel, S. Florinas, H. Cabral, K. Kataoka, J. RiosDoria, R. J. Christie, M. Baca
    • Journal Title

      J. Control. Release

      Volume: 230 Pages: 104-114

    • DOI

      10.1016/j.jconrel.2016.05.041

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG1322016

    • Author(s)
      Matsumoto Y, Miyamoto Y, Cabral H, Matsumoto Y, Nagasaka K, Nakagawa S, Yano T, Maeda D, Oda K, Kawana K, Nishiyama N, Kataoka K, Fujii T
    • Journal Title

      Cancer Sci

      Volume: 107 Issue: 6 Pages: 773

    • DOI

      10.1111/cas.12926

    • NAID

      120007089072

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery2016

    • Author(s)
      Yu Matsumoto, Joseph W. Nichols, Kazuko Toh, Takahiro Nomoto, Horacio Cabral, Yutaka Miura, R. James Christie, Naoki Yamada, Tadayoshi Ogura, Mitsunobu R. Kano, Yasuhiro Matsumura, Nobuhiro Nishiyama, Tatsuya Yamasoba, You Han Bae, Kazunori Kataoka
    • Journal Title

      Nature Nanotechnology

      Volume: - Issue: 6 Pages: 533-538

    • DOI

      10.1038/nnano.2015.342

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Development of polymeric micelles with 5-Boronopicolinic acid ligand to target sialylated epitopes in intratumoral microenvironment"2019

    • Author(s)
      T. Khan, K. Igarashi, A. Matsumoto, H. Cabral, K. Kataoka
    • Organizer
      32nd International Microprocesses and Nanotechnology Conference (MNC 2019)\
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanistic analyses of polymer/lipid-based gene transfection processes through membrane integrity assay using proton sensing transistor2019

    • Author(s)
      E. Boonstra, H. Hatano, T. Goda, S. Uchida, H. Cabral, Y. Miyahara
    • Organizer
      4th International Symposium on Biomedical Engineering, ISBE 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] nteraction analysis between target membrane proteins and ligand molecules attached to the polymeric micelle with different molecular weight of hydrophilic shell2019

    • Author(s)
      N.Nakamura, Y. Anraku, S. Fukushima, K. Tou, H. Cabral, K. Kataoka
    • Organizer
      41st Annual Meeting of the Japanese Society for Biomaterials
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of novel flexible block catiomers for forming stable polyion complex micelles with mRNA directed to in vivo applications2019

    • Author(s)
      W. Yang, T. Miyazaki, S. Uchida, H. Cabral
    • Organizer
      2nd G'L'owing Polymer Symposium in Kanto
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of pH-sensitive polymeric micelles effectively utilizing polymer freeze drying by liquid nitrogen2019

    • Author(s)
      Y. Tachihara, Y. Nakagawa, Y. Anraku, K. Kataoka, H. Cabral
    • Organizer
      10th Research Meeting of Cryogenic Research Center
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 薬剤送達システムへの応用を指向したホストゲスト相互作用による高分子-環状薬剤複合体の構築2019

    • Author(s)
      Y. Tachihara, Y. Nakagawa, Y. Anraku, K. Kataoka, H. Cabral
    • Organizer
      Future Trend in Polymer Science 2018,
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of pH-Sensitive Polymeric Micelles for Targeted Delivery of the Macrocycle Valinomycin via Host Guest Interaction2019

    • Author(s)
      Y. Tachihara, Y. Nakagawa, Y. Anraku, K. Kataoka, H. Cabral
    • Organizer
      68th SPSJ Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Macrocyclic Drug-Loaded pH-Sensitive Polymeric Micelles by Using Host Guest Interaction2019

    • Author(s)
      Y. Tachihara, Y. Nakagawa, Y. Anraku, K. Kataoka, H. Cabral
    • Organizer
      TEJIN MIRAI FORUM 2020
    • Related Report
      2019 Annual Research Report
  • [Presentation] The Development of Placenta Targeting Simvastatin Nano-Micelle Treatment in PE Mouse Model -Challenge for Clinical Application of Drug Delivery System to Avoid Adverse Effect on Fetus During Pregnancy2019

    • Author(s)
      Hiroko Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii, Takuya Miyazaki, Horacio Cabral
    • Organizer
      Japan Society of Obstetrics and Gynecology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Supramolecular Nanomedicines for Targeting Intractable Tumors2019

    • Author(s)
      Horacio Cabral
    • Organizer
      The University of Tokyo - Karolinska Institute Workshop 2019
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Engineering Tumor Microenvironment Toward Enhanced Drug Delivery2018

    • Author(s)
      Horacio Cabral
    • Organizer
      NanoThailand 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of mRNA-loaded nanocarriers based on flexible block ionomers with enhanced affinity for mRNA2018

    • Author(s)
      Horacio Cabral
    • Organizer
      13th Japan-France DDS Symposium
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Real-Time Assessment of Extracellular Vesicles by Intravital Microscopy Imaging2018

    • Author(s)
      Horacio Cabral
    • Organizer
      10th IFAC Symposium on Biological and Medical Systems
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical Challenges towards Next Generation Polymer Therapeutics2018

    • Author(s)
      Horacio Cabral
    • Organizer
      Controlled Release Society (CRS) Annual Meeting & Exposition 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Principles of Probe Design for Molecular Imagers2018

    • Author(s)
      Horacio Cabral
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 白金制がん剤内包高分子ミセルの構造および機能を決定するヘリックス形成の重要性2018

    • Author(s)
      持田祐希,カブラル オラシオ、片岡 一則
    • Organizer
      第67回高分子年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コレステロール基修飾短鎖RNAオリゴマーを用いたmRNA内包高分子ミセルの安定化2018

    • Author(s)
      吉永直人,内田智士、Cabral Horacio、長田健介、片岡一則
    • Organizer
      第67回高分子年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 熱コントロールによる白金制がん剤内包高分子ミセルの大幅安定化と機能制御2018

    • Author(s)
      持田祐希,カブラル オラシオ、片岡 一則
    • Organizer
      第34回日本DDS学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 少数のコレステロール修飾RNAオリゴマーにより誘起されるmRNA内包高分子ミセルの構造安定化およびマウス肺局所投与への応用2018

    • Author(s)
      吉永直人、内田智士、長田健介、位髙啓史、H. Cabral、片岡一則
    • Organizer
      第35回日本DDS学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Interaction analysis of ligand molecules on the polymeric micelle penetrating blood-brain barrier2018

    • Author(s)
      N. Nakamura,Y. Anraku, S. Fukushima, K. Toh, H. Cabral, K. Kataoka
    • Organizer
      Biomaterials International 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Helical polymer structure provides platinum-loaded polymeric micelles with favorable size and stability for effective tumor-targeting2018

    • Author(s)
      Y. Mochida, H. Cabral, Y. Miura, K. Osada, N. Nishiyama, K. Kataoka
    • Organizer
      256th ACS National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of polyplex micelles with phenylboronate ester cross-linking in the core exerting promoted gene transfection through responsivity to intracellular pH and ATP concentration2018

    • Author(s)
      N. Yoshinaga, M. Naito, S. Uchida, H. Cabral, K. Osada, K. Kataoka
    • Organizer
      256th ACS National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel pH-sensitive nanomedicine conjugating (+)-JQ-1 homolog inhibits the tumor growth of c-myc high-expressing tumor2018

    • Author(s)
      H. Shibasaki, H. Kinoh, S. Quader, X. Liu, H. Cabral, K. Kataoka
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血液脳関門突破を指向したDDSキャリアに装着したリガンド分子の標的認識能評価2018

    • Author(s)
      中村乃理子,安楽泰孝、福島重人、藤加珠子、カブラル・オラシオ、片岡一則
    • Organizer
      第67回高分子年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 5-Boronopicolinic acid-installed nano-carriers for targeting sialylated epitopes on cancer cells2018

    • Author(s)
      Thahomina Khan, Akira Matsumoto, Horacio Cabral and Kazunori Kataoka
    • Organizer
      第34回日本DDS学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] グアニジノ基修飾によるmRNA搭載ポリイオンコンプレックスの機能向上2018

    • Author(s)
      堀真緒, 吉永直人、内田智士、H. Cabral、片岡一則
    • Organizer
      第67回高分子年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Spherical polyplex micelles based on ssDNA packaging and its delivery appeal towards hypopermeable pancreatic tumor2018

    • Author(s)
      T.A.Tockary,W. Foo, K. Osada, A. Dirisala, S. Uchida, H. Cabral, X. Liu, K. Kataoka
    • Organizer
      第67回高分子年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of 5-boronopicolinic acid-installed polymeric micelles for targeting sialylated epitopes on cancer cells2018

    • Author(s)
      T. Khan、H. Cabral、松元亮、片岡一則
    • Organizer
      第35回日本DDS学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of 5-boronopicolinic acid-installed polymeric micelles for targeting sialylated epitopes on cancer cels2018

    • Author(s)
      K. T. Tareque, A. Matsumoto, H. Cabral, K. Kataoka
    • Organizer
      Biomaterials International 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] pH及びグルコースに応答してPEGが脱離する高分子ミセルの構築2018

    • Author(s)
      小路恭子、宮崎拓也、持田祐希、L. Hespel、籐加珠子、福島重人、松本有、松元亮、H. Cabral、片岡一則
    • Organizer
      第35回日本DDS学会学術集会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エクソソーム電気泳動解析を高効率化するシアル酸認識高分子の設計と評価2018

    • Author(s)
      鹿谷真紀,松元亮,宮原裕二,合田達郎,田畑美幸,カブラルオラシオ,宮崎拓也,一木隆範,赤木貴則,木下ひろみ
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Supramolecular nanomedicines for effective treatment of tumors bearing cancer stem-like cells2017

    • Author(s)
      Horacio Cabral
    • Organizer
      International Advanced Drug Delivery Symposium
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2017-04-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cooperative Fusion of Imaging and Therapy through Theranostic Nanomedicine2017

    • Author(s)
      Horacio Cabral
    • Organizer
      8th Annual Symposium of the Indian Scientist Association in Japan
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Ligand Strategies for Tumor-Targeted Nanomedicines2017

    • Author(s)
      Horacio Cabral
    • Organizer
      2nd International Symposium on Biomedical Engineering
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cooperative Fusion of Imaging and Therapy through Theranostic Nanomedicine2017

    • Author(s)
      Horacio Cabral
    • Organizer
      第33回日本DDS学会(33rd Japanese DDS Conference)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Supramolecular nanomedicines for effective treatment of tumors bearing cancer stem-like cells2017

    • Author(s)
      Horacio Cabral
    • Organizer
      The 2017 International Advanced Drug Delivery Symposium (IADDS).
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Theranostic Agents and Nanomedicine2017

    • Author(s)
      H. Cabral, P. Mi, I. Aoki, N. Nishiyama, K. Kataoka
    • Organizer
      International Kick-off Symposium of The Alliance for Next Generation MRI & Contrast Agents
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of staurosporine/epirubicin-loaded micelles for cooperative synergistic treatment against cancer cells and cancer stem-like cells2017

    • Author(s)
      J. Martin, J. Zhang, X. Liu, H. Kinoh, H. Cabral, K. Kataoka,
    • Organizer
      The 16th US-Japan Symposium on Drug Delivery Systems (Hawaii, USA)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprogramming by NF-kB inhibition2017

    • Author(s)
      J. Martin, H. Wu, A. Tao, S. Quader, X. Liu, H. Takahashi, L. Hespel, Y. Miura, H. Hayakawa, T. Irimura, H. Cabral, K. Kataoka
    • Organizer
      Gordon Research Conference. Cancer Nanotechnology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Detection of tumor hypoxic region using pH-activatable nanoparticles containing manganese contrast agent2017

    • Author(s)
      D. Kokuryo, P. Mi, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, K. Kataoka
    • Organizer
      ISMRM 25th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
  • [Presentation] Surface modification of polymeric micelle enhances their therapeutic effect against glioblastoma2017

    • Author(s)
      S. Quader, X. Liu, H. Cabral, K. Kataoka
    • Organizer
      4th COINS Symposium "Nanotech → In-body hospitals → Smart Life ~Future Health care with Nanomachine~"
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of smart polymeric micelles for ROS-triggered release of rutin2017

    • Author(s)
      Naoto Nakamura, N. Yoshinaga, Y. Anraku, H. Cabral, K. Kataoka
    • Organizer
      4th COINS Symposium "Nanotech → In-body hospitals → Smart Life ~Future Health care with Nanomachine~"
    • Related Report
      2017 Annual Research Report
  • [Presentation] Interaction analysis between ligands on the surface of nanomachine and target transporte2017

    • Author(s)
      Noriko Nakamura, Y. Anraku, S. Fukushima, K. Toh, H. Cabral, K. Kataoka
    • Organizer
      4th COINS Symposium "Nanotech → In-body hospitals → Smart Life ~Future Health care with Nanomachine~
    • Related Report
      2017 Annual Research Report
  • [Presentation] An active targeting strategy against locally advanced head and neck squamous cell carcinoma harboring cancer stem-like cells via cRGD peptide-installed cisplatin-loaded nanomedicines2017

    • Author(s)
      K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, N. Nishiyama, T. Yamasoba, K. Kataoka
    • Organizer
      The 14th US-Japan Symposium on Drug Delivery Systems Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stabilization and application of polyion complex vesicles (PICsomes) with chemical modifications of polymer side-chain2017

    • Author(s)
      M. Hori, Y. Anraku, C. Horacio, A. Kishimura, K. Kataoka
    • Organizer
      The 14th US-Japan Symposium on Drug Delivery Systems Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] Critical PEG shielding required for rod-shaped polyplex micelles for evading liver sinusoidal endothelial barrier to achieve improved systemic blood circulation activity2017

    • Author(s)
      A. Dirisala, K. Osada, K. Toh, T. A. Tockary, H. Cabral, K. Kataoka
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 白金錯体制がん剤を内包する高分子ミセルの熱処理による安定化と機能評価2017

    • Author(s)
      持田祐希、H. Cabral、片岡一則
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高分子ミセル表層に装着したリガンド分子と標的受容体との相互作用解析2017

    • Author(s)
      中村乃理子、安楽泰孝、渡邉拓也、福島重人、藤加珠子、H. Cabral、片岡一則
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Enhanced activation of SN38 prodrug delivered by pH-sensitive polymeric micelle with modification of histamine on polymer side chains2017

    • Author(s)
      S. Chen, S. Florinas, J. R. Christie, H. Cabral, K. Kataoka
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フェニルボロン酸を高分子ミセルコアの架橋剤として用いるpHおよびATP応答型核酸デリバリーシステムの創成2017

    • Author(s)
      吉永直人、内藤瑞、内田智士、H. Cabral、長田健介、片岡一則
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Safe and effective transport of anti-cancer drug, thru pH-sensitive polymeric micelle.2017

    • Author(s)
      S. Quader, X. Liu, H. Cabral, K. Kataoka
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性酸素種に応答して開裂する抗酸化剤内包高分子ミセルの開発2017

    • Author(s)
      中村直人、安楽泰孝、吉永直人、H. Cabral、片岡一則
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Construction of PEG-rich globular non-viral gene carrier and its evaluation in hypopermeable pancreatic tumor2017

    • Author(s)
      T. A. Tockary, W. Foo, K. Osada, A. Dirisala, H. Cabral, K. M. Takeda, X. Liu, K. Kataoka
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高分子ミセル型DDSの構造と機能に及ぼす内核構造の影響2017

    • Author(s)
      中村直人、吉永直人、安楽泰孝、H. Cabral、片岡一則
    • Organizer
      第33回DDS学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 動的な腫瘍血管透過性(nano eruption)の制御2017

    • Author(s)
      井上雄太、松本有、藤加珠子、宮野一樹、H. Cabral、山岨達也、片岡一則
    • Organizer
      第33回DDS学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] pH応答性スタウロスポリン内包エピルビシンミセルは、スニチニブ耐性獲得腎癌に対しても高い抗腫瘍効果を示す2017

    • Author(s)
      喜納宏昭、H. Cabral、北村貴美子、片岡一則
    • Organizer
      第33回DDS学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フェニルボロン酸を高分子ミセルコアの架橋剤として用いるpHおよびATP応答型mRNAデリバリーシステムの創成-高分子ミセルの安定化およびin vitro環境での機能評価-2017

    • Author(s)
      吉永直人、内藤瑞、内田智士、H. Cabral、長田健介、片岡一則
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性酸素種を引き金とする抗酸化剤放出型高分子ミセルの創製2017

    • Author(s)
      中村直人、吉永直人、安楽泰孝、H. Cabral、片岡一則
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PEG-ポリグルタミン酸の立体構造に着目した白金錯体超分子ミセルの粒径及び腫瘍標的性の制御2017

    • Author(s)
      持田祐希、H. Cabral、三浦裕、長田健介、西山伸宏、片岡一則
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] pH応答性抗癌剤ナノミセルは、 PTEN/VHL発現欠失スニチニブ耐性腎癌に対しても有効である。2017

    • Author(s)
      喜納宏昭、H. Cabral、北村貴美子、片岡一則
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of pH-sensitive polymeric micelles for intracellular delivery of bioactive molecules loaded through imine bond2017

    • Author(s)
      A. Tao, H. Cabral, S. Quader, K. Kataoka
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 細胞外小胞の体内動態解析に向けた標識法の検討2017

    • Author(s)
      乗松純平、赤木貴則、藤加珠子、J. Martin、一木隆範、片岡一則、H. Cabral
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血液脳関門の突破を指向した高分子ミセル表層のリガンド分子と標的トランスポーターの相互作用解析2017

    • Author(s)
      中村乃理子、安楽泰孝、福島重人、藤加珠子、H. Cabral、片岡一則
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of ROS scavenging polymeric micelles with responsivity to oxidative stress2017

    • Author(s)
      中村直人、吉永直人、安楽泰孝、H. Cabral、片岡一則
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-κB inhibition,2017

    • Author(s)
      J. D. Martin, H. Wu, A. Tao, S. Quader, X. Liu, K. Takahashi, L. Hespel, Y. Miura, Y. Hayakawa, T. Irimura, H. Cabral, K. Kataoka,
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of porphyrin/polyaminoacid-based worm-like micelles for drug delivery2017

    • Author(s)
      Y. Onuma, S. Fukushima, H. -J. Kim Y. Anraku, K. Miyata, K. Osada, H. Cabral, K. Kataoka,
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of pH-sensitive polymeric micelles for intracellular delivery of bioactive molecules loaded through imine bond2017

    • Author(s)
      A. Tao, H. Cabral, S. Quader, K. Kataoka
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Safe cancer therapy during pregnancy by using drug-loaded polymeric micelles,2017

    • Author(s)
      J. Wan, K. Mizuno, B. Xiong, Y. Mochida, Y. Miura, K. Kataoka, H. Cabral
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of staurosporine/epirubicin-loaded micelles for cooperative synergistic treatment against cancer cells and cancer stem-like cells2017

    • Author(s)
      J. Zhang, X. Liu, H. Kinoh, H. Cabral, K. Kataoka
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intravital assessment of drug delivery activation through hoechst-loaded polymeric micelles,2017

    • Author(s)
      S. Chen, S. Florinas, K. Toh, Y. Matsumoto, J. R. Christie, K. Kataoka, H. Cabral,
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of polyplex micelles with intracellular environment-responsive cross-linker for efficient gene delivery - Effect of phenylboronic acid based cross-linking on intracellular trafficking -2017

    • Author(s)
      N. Yoshinaga, M. Naito, S. Uchida, H. Cabral, K. Osada, K. Kataoka
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] anomedicine strategies for enhancing efficacy against head and neck squamous cell carcinoma bearing cancer stem-like cells2016

    • Author(s)
      H. Cabral, K. Miyano, M. Wang, Y. Miura, Y. Matsumoto, H. Kinoh, N. Nishiyama, T. Yamasoba, K. Kataoka,
    • Organizer
      Frontiers2016 - Joint Symposium of the EPFL and the University of Tokyo,
    • Place of Presentation
      Swiss Federal Institute of Technology(EPFL)Lausanne, Switzerland,
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Size-modulated polymeric micelles for cancer therapy during pregnancy2016

    • Author(s)
      J. Wan, K. Mizuno, B. Xiong, Y. Mochida, Y. Miura, K. Kataoka, H. Cabral
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan,
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assembly of α-helical polymer chains plays a key role in tumor-targeting performance of platinum-loaded polymeric micelles2016

    • Author(s)
      Y. Mochida, H. Cabral, Y. Miura, K. Osada, N. Nishiyama, K. Kataoka
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] pH-Activatable targeted nanomedicine eradicates orthotopic mesothelioma bearing recalcitrant cancer stem cell sub-population2016

    • Author(s)
      H. Kinoh, Y. Miura, S. Fukushima, H. Cabral, K. Kataoka
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of porphyrin/polyaminoacid-based worm-like micelles for drug delivery2016

    • Author(s)
      Y. Onuma, S. Fukushima, K. Toh, H. Cabral, K. Kataoka,
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Brain tumor targeting by cRGD peptide encircled polymeric micelles loaded with potent antiglioblastoma agent epirubicin2016

    • Author(s)
      S. Quader, X. Liu, Y. Chen, P. Mi, T. Chida, T. Ishii, Y. Miura, N. Nishiyama, H. Cabral, K. Kataoka,
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effective treatment of locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells by cRGD peptide-installed cisplatin-loaded micelles2016

    • Author(s)
      K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, H. Kinoh, N. Nishiyama, T. Yamasoba, K. Kataoka,
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-κB inhibition2016

    • Author(s)
      J. D. Martin, H. Cabral, H. Wu, S. Quader, A. Tao, W. Liu, P. Mi, K. Takahashi, Y. Hayakawa, T. Irimura, K. Kataoka
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of polyplex micelles with pH and ATP dual-responsive cross-linking for efficient gene delivery- Effect of phenylboronic acid based cross-linking on intracellular trafficking-,2016

    • Author(s)
      N. Yoshinaga, M. Naito, S. Uchida, H. Cabral, K. Osada, K. Kataoka
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Messenger RNA-based therapeutics for the treatment of Fas-ligand induced fulminant hepatitis mouse model2016

    • Author(s)
      A. Matsui, H. Cabral, Y. Miura, Y. Matsumoto, H. Kinoh, N. Nishiyama, T. Yamasoba, K. Kataoka,
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultrasmall DNA-loaded spherical polyplex micelles and their evaluation in hypovasculature pancreatic tumor2016

    • Author(s)
      T. A. Tockary, K. Osada, W. Foo, A. Dirisala, K. M. Takeda, H. Cabral, X. Liu, K. Kataoka,
    • Organizer
      3rd International Conference on Biomaterials Science (ICBS2016)
    • Place of Presentation
      to Hall located at The University of Tokyo, Tokyo, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ドラッグ・遺伝子デリバリーのためのポルフィリン/ポリアミノ酸に基づくワーム様ミセルの開発2016

    • Author(s)
      小沼由佳, 長田健介, 宮田完二郎, 片岡一則, H. Cabral
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学横浜キャンパス, 横浜市, 神奈川県,
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of pH-sensitive polymeric micelles for intracellular delivery of bioactive molecules loaded through imine bond2016

    • Author(s)
      A. Tao, H. Cabral, S. Quader, 片岡一則,
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学横浜キャンパス, 横浜市, 神奈川県,
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環状RGDペプチドを修飾した白金制がん剤内包高分子ミセルを用いたリンパ節転移/治療抵抗性がんの治療2016

    • Author(s)
      持田祐希, H. Cabral, 牧野惇, 三浦裕, M. Wang, 西山伸宏, 片岡一則,
    • Organizer
      第65回高分子討論会,
    • Place of Presentation
      神奈川大学横浜キャンパス, 横浜市, 神奈川県
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フェニルボロン酸を用いたATP応答型架橋ポリプレックス型高分子ミセルの創成―高分子ミセルの安定化とin vitro環境における機能検証―2016

    • Author(s)
      吉永直人, 石井武彦, 遠藤泰輔, 内藤瑞, 内田智士, H. Cabral, 長田健介, 片岡一則
    • Organizer
      第26回バイオ・高分子シンポジウム
    • Place of Presentation
      東京工業大学大岡山キャンパス, 目黒区, 東京都
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環状RGDペプチドを修飾した白金制がん剤内包ミセルのがん幹細胞治療への応用2016

    • Author(s)
      持田祐希, M. Wang, H. Cabral, 三浦裕, 西山伸宏, 片岡一則
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸国際会議場・展示場, 神戸市, 兵庫県
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Highly ordered core structure enhances drug delivery performance of polymeric micelles incorporating platinum anticencer agents2016

    • Author(s)
      Y. Mochida, H. Cabral, Y. Miura, A. Francesco, K. Osada, N. Nishiyama, K. Kataoka
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2016-05-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フェニルボロン酸導入高分子ミセルによる扁平上皮がんの治療,2016

    • Author(s)
      三浦裕, 田辺亜弥, H. Cabral, 片岡一則
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸国際会議場・展示場, 神戸市, 兵庫県
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 難治性頭頸部扁平上皮癌に対するリガンド搭載シスプラチンミセルによる治療戦略2016

    • Author(s)
      宮野一樹, 三浦裕, 松本有, 岩田要, 佐谷秀行, 宮園浩平, 西山伸宏, H. Cabral, 山岨達也, 片岡一則,
    • Organizer
      第32回DDS学会学術大会,
    • Place of Presentation
      グランシップ(静岡県コンベンションアーツセンター), 静岡市, 静岡県
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A nanoparticle with pH-triggered contrast amplification ability for tumor malignancy imaging,2016

    • Author(s)
      P. Mi, H. Cabral, I. Aoki, N. Nishiyama, K. Kataoka
    • Organizer
      The 4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2016),
    • Place of Presentation
      Worldhotel Grand DushuLake, Suzhou, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of staurosporine/epirubicin-loaded polymeric micelles as a robust in vivo therapy against differentiated cells and cancer stem-like cells2016

    • Author(s)
      J. Zhang, H. Kinoh, T. Chida, X. Liu, Y. Miura, H. Cabral, K. Kataoka
    • Organizer
      The 11th SPSJ International Polymer Conference (IPC2016)
    • Place of Presentation
      Fukuoka International Confress Center, Fukuoka,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intravital assessment of drug delivery activation through hoechst-loaded polymeric micelles,2016

    • Author(s)
      S. Chen, S. Florinas, K. Toh, Y. Matsumoto, J. R. Christie, H. Cabral, K. Kataoka,
    • Organizer
      The 11th SPSJ International Polymer Conference (IPC2016)
    • Place of Presentation
      Fukuoka International Confress Center, Fukuoka,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of polyplex micelles with intracellular environment-responsive cross-linking for efficient gene delivery -Effect of phenylboronic acid based cross-linking on intracellular trafficking-2016

    • Author(s)
      N. Yoshinaga, M. Naito, S. Uchida, H. Cabral, K. Osada, K. Kataoka
    • Organizer
      The 11th SPSJ International Polymer Conference (IPC2016)
    • Place of Presentation
      Fukuoka International Confress Center, Fukuoka,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-κB inhibition2016

    • Author(s)
      J. D. Martin, H. Cabral, H. Wu, S. Quader, A. Tao, W. Liu, P. Mi, K. Takahashi, Y. Hayakawa, T. Irimura, K. Kataoka
    • Organizer
      3rd COINS International Symposium "Towards Smart Health Society - Challenge of Kawasaki based Medical Innovation -"
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of co-drug delivery micelles for cooperative synergistic cancer treatment,2016

    • Author(s)
      J. Zhang, H. Kinoh, X. Liu,H. Cabral, K. Kataoka,
    • Organizer
      3rd COINS International Symposium "Towards Smart Health Society - Challenge of Kawasaki based Medical Innovation -"
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki, Kanagawa
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] CABRAL LAB HOMEPAGE

    • URL

      http://www.bmc.t.u-tokyo.ac.jp/index.html

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] Drug delivery systems for placenta2019

    • Inventor(s)
      Horacio Cabral, Takuya Miyazaki
    • Industrial Property Rights Holder
      Horacio Cabral, Takuya Miyazaki
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 核酸送達用ポリマー化合物2018

    • Inventor(s)
      カブラル オラシオ、 ミヤザキ タクヤ
    • Industrial Property Rights Holder
      カブラル オラシオ、 ミヤザキ タクヤ
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ミセル及びその使用2017

    • Inventor(s)
      カブラル オラシオ、オヌマ ユカ
    • Industrial Property Rights Holder
      カブラル オラシオ、オヌマ ユカ
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ポリマー、ポリマーの製造方法、及び薬物複合体2017

    • Inventor(s)
      片岡一則、喜納宏昭、カデール サビーナ、カブラル オラシオ
    • Industrial Property Rights Holder
      片岡一則、喜納宏昭、カデール サビーナ、カブラル オラシオ
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ポリマー、ポリマーの製造方法、及び薬物複合体2017

    • Inventor(s)
      片岡一則、カデール サビーナ、カブラル オラシオ
    • Industrial Property Rights Holder
      片岡一則、カデール サビーナ、カブラル オラシオ
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 酵素反応の測定方法、スクリーニング方法及び測定装置2017

    • Inventor(s)
      カブラル オラシオ、持田祐希、片岡一則
    • Industrial Property Rights Holder
      カブラル オラシオ、持田祐希、片岡一則
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 発明の名称:ポリマー、ポリマーの製造方法、及び薬物複合体2016

    • Inventor(s)
      片岡一則 、Quader 、Cabral Horacio
    • Industrial Property Rights Holder
      片岡一則 、Quader 、Cabral Horacio
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-23
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] ポリマー、ポリマーの製造方法、及び薬物複合体2016

    • Inventor(s)
      片岡一則、Quader、Cabral Horacio
    • Industrial Property Rights Holder
      片岡一則、Quader、Cabral Horacio
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-23
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] The University of Tokyo- Nanotechnology Center of Thailand Workshop 20192019

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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