| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
The objective of this research was to elucidate the effects of surface property and shape of thermoresponsive core-corona type nanoparticles on phagocytosis by macrophages. Hydrophobic particles showed larger phagocytosis than hydrophilic particles regardless of the particle shapes. However, particle shape showed greater influence on phagocytosis, spherical particles were phogocytized than rod-shaped particles regardless of surface properties of particles and hydrophobic and spherical particles showed largest phagocytosis. Such findings would be utilized to selective internalization of DDS carriers by changing shape and surface property by sole temperature changes.
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