• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Hemi-sperical ultrasonic trasducer producing high power at low voltage

Research Project

Project/Area Number 16H03188
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

Umemura Shin-ichiro  東北大学, 医工学研究科, 学術研究員 (20402787)

Co-Investigator(Kenkyū-buntansha) 高木 亮  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (20771885)
吉澤 晋  東北大学, 工学研究科, 准教授 (30455802)
Research Collaborator ITO HIROSHI  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords音響キャビテーション / 圧電トランスデューサ / 超音波治療 / 結石破砕 / キャビテーション / 球殻状トランスデューサ / 円筒状トランスデューサ / パワーMOSFET / 圧電体 / 集束強力超音波治療 / 圧電セラミック / 共振周波数 / 径方向振動 / 球殻型トランスデューサ / 円筒型トランスデューサ / アドミタンス / 集束強力超音波 / 球殻振動 / 第2高調波 / アレイトランスデューサ / 第2高調波 / 2倍高調波 / アレイ型超音波トランスデューサ
Outline of Final Research Achievements

A short ultrasonic pulse at an extremely high pressure is effective to generate acoustic cavitation, which remarkably enhances the efficiency of ultrasonic therapy and lithotripsy. However, if it is for a conventional thickness mode piezoelectric transducer, the required driving voltage may almost exceed the limit of MOSFETs. To overcome this problem, we have suggested a spherical transducer utilizing the co-resonance between a piezoelectric spherical shell and a water sphere. We are further suggesting a cylindrical transducer utilizing the co-resonance between a piezoelectric cylindrical shell and a water cylinder. Its principle was confirmed by a numerical simulation, and a prototype transducer was constructed, which proved that the ratio of acoustic output / driving voltage was in a realistic range.

Academic Significance and Societal Importance of the Research Achievements

同半径の薄い圧電球殻と水玉の共振や,薄い圧電円筒と水円柱の共振を,電気的インピーダンスの低い圧電変換器を実現するのに利用することは,考え方として新規である.本研究の成果により実現される圧電変換器は,音圧出力/駆動電圧の比が優れているため,汎用半導体により構成されたアンプを用いて駆動することにより,超音波治療や結石破砕の効率と適用症例範囲を飛躍的に高める音響キャビテーションを生成できるようになる.これは,有用性の大きな医療機器の実用化に寄与するところ大である.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (42 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (32 results) (of which Peer Reviewed: 32 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 5 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] INSERM(フランス)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Sonodynamic Therapy: Advances and Challenges in Clinical Translation2018

    • Author(s)
      Lafond Maxime、Yoshizawa Shin、Umemura Shin-ichiro
    • Journal Title

      Journal of Ultrasound in Medicine

      Volume: 38 Issue: 3 Pages: 567-580

    • DOI

      10.1002/jum.14733

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles2018

    • Author(s)
      Lafond Maxime、Watanabe Akiko、Yoshizawa Shin、Umemura Shin-ichiro、Tachibana Katsuro
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 7472-7472

    • DOI

      10.1038/s41598-018-25913-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic study of improvement of axial resolution and suppression of time side lobe by phase-corrected Wiener filtering in photoacoustic tomography.2018

    • Author(s)
      Nagaoka Ryo, Yoshizawa Shin, Umemura ShinIchiro, Saijo Yoshifumi
    • Journal Title

      Jpn J Appl Phys.

      Volume: 57 Issue: 7S1 Pages: 07LD11-07LD11

    • DOI

      10.7567/jjap.57.07ld11

    • NAID

      210000149310

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective detection of cavitation bubbles by triplet pulse sequence in high-intensity focused ultrasound treatment2018

    • Author(s)
      Iwasaki Ryosuke、Nagaoka Ryo、Yoshizawa Shin、Umemura Shin-ichiro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 7S1 Pages: 07LF12-07LF12

    • DOI

      10.7567/jjap.57.07lf12

    • NAID

      210000149349

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of scanning the focus on generating cavitation bubbles and reactive oxygen species by using trigger high-intensity focused ultrasound sequence2018

    • Author(s)
      Nishitaka Shinya、Mashiko Daisaku、Yoshizawa Shin、Umemura Shin-ichiro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 7S1 Pages: 07LF25-07LF25

    • DOI

      10.7567/jjap.57.07lf25

    • NAID

      210000149362

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative measurement of ultrasonic pressure field using combination of optical phase contrast and nonlinear acoustic holography methods2018

    • Author(s)
      Nakamura Takuya、Iwasaki Ryosuke、Yoshizawa Shin、Umemura Shin-ichiro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 7S1 Pages: 07LB13-07LB13

    • DOI

      10.7567/jjap.57.07lb13

    • NAID

      210000149280

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of annular focusing of ultrasound on rate of stone erosion using cavitation bubbles2018

    • Author(s)
      Yura Toshiya、Lafond Maxime、Yoshizawa Shin、Umemura Shin-Ichiro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 7S1 Pages: 07LB18-07LB18

    • DOI

      10.7567/jjap.57.07lb18

    • NAID

      210000149285

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a Three-Hydrophone Method for 2-D Cavitation Localization2018

    • Author(s)
      Lafond Maxime、Asquier Nicolas、Mestas Jean-Louis A.、Carpentier Alexandre、Umemura Shin-ichiro、Lafon Cyril
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

      Volume: 65 Issue: 7 Pages: 1093-1101

    • DOI

      10.1109/tuffc.2018.2825233

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of sonodynamic treatment region with sonochemiluminescence in gel phantom2018

    • Author(s)
      Mashiko Daisaku、Nishitaka Shinya、Iwasaki Ryosuke、Lafond Maxime、Yoshizawa Shin、Umemura Shin-ichiro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 7S1 Pages: 07LF13-07LF13

    • DOI

      10.7567/jjap.57.07lf13

    • NAID

      210000149350

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Singular value decomposition of received ultrasound signal to separate tissue, blood flow, and cavitation signals2018

    • Author(s)
      Ikeda Hayato、Nagaoka Ryo、Lafond Maxime、Yoshizawa Shin、Iwasaki Ryosuke、Maeda Moe、Umemura Shin-ichiro、Saijo Yoshifumi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 7S1 Pages: 07LF04-07LF04

    • DOI

      10.7567/jjap.57.07lf04

    • NAID

      210000149341

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of murine lymph vessels using photoacoustic imaging with contrast agents2018

    • Author(s)
      Nagaoka Ryo、Tabata Takuya、Yoshizawa Shin、Umemura Shin-ichiro、Saijo Yoshifumi
    • Journal Title

      Photoacoustics

      Volume: 9 Pages: 39-48

    • DOI

      10.1016/j.pacs.2018.01.001

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound2017

    • Author(s)
      M. Maeda, Y. Muragaki, J. Okamoto, S. Yoshizawa, N. Abe, H. Nakamoto, H. Ishii, K. Kawabata, S. Umemura, N. Nishiyama, K. Kataoka, H. Iseki
    • Journal Title

      Ultrasound Med. Biol.

      Volume: 43 Issue: 10 Pages: 2295-2301

    • DOI

      10.1016/j.ultrasmedbio.2017.06.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Real-Time 3-D Photoacoustic Imaging System Employing Spherically Curved Array Transducer2017

    • Author(s)
      Nagaoka R., Tabata T., Takagi R., Yoshizawa S., Umemura S.-I., Saijo Y.
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

      Volume: 64 Issue: 8 Pages: 1223-1233

    • DOI

      10.1109/tuffc.2017.2718030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multifunctional pulse generator for high-intensity focused ultrasound system2017

    • Author(s)
      Tamano S., Yoshizawa S., Umemura S.-I.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7S1 Pages: 07JF21-07JF21

    • DOI

      10.7567/jjap.56.07jf21

    • NAID

      210000148083

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic study on ultrasonic monitoring using 1.5-dimensional ultrasound phased array for ultrasound-guided high-intensity focused ultrasound treatment2017

    • Author(s)
      Takagi R., Iwasaki R., Tomiyasu K., Yoshizawa S., Umemura S.-I.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7S1 Pages: 07JF22-07JF22

    • DOI

      10.7567/jjap.56.07jf22

    • NAID

      210000148084

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of thermal coagulation from the instantaneous strain distribution induced by high-intensity focused ultrasound2017

    • Author(s)
      Iwasaki R., Takagi R., Tomiyasu K., Yoshizawa S., Umemura S.-I.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7S1 Pages: 07JF23-07JF23

    • DOI

      10.7567/jjap.56.07jf23

    • NAID

      210000148085

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of thermal coagulation from the instantaneous strain distribution induced by high-intensity focused ultrasound2017

    • Author(s)
      Tomiyasu K., Takagi R., Iwasaki R., Yoshizawa S., Umemura S.-I.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7S1 Pages: 07JF28-07JF28

    • DOI

      10.7567/jjap.56.07jf28

    • NAID

      210000148085

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous observation of cavitation bubbles generated in biological tissue by high-speed optical and acoustic imaging methods2017

    • Author(s)
      Suzuki K., Iwasaki R., Takagi R., Yoshizawa S., Umemura S.-I.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7S1 Pages: 07JF27-07JF27

    • DOI

      10.7567/jjap.56.07jf27

    • NAID

      210000148089

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simulation of optical propagation based on wave optics for phase retrieval in shadowgraph of ultrasonic field2017

    • Author(s)
      Hanayama Hiroki、Nakamura Takuya、Takagi Ryo、Yoshizawa Shin、Umemura Shin-ichiro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7S1 Pages: 07JC13-07JC13

    • DOI

      10.7567/jjap.56.07jc13

    • NAID

      210000148035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computational cost reduction by avoiding ray-linking iteration in bent-ray method for sound speed image reconstruction in ultrasound computed tomography2017

    • Author(s)
      Qu X., Azuma T., Lin H., Nakamura H., Tamano S., Takagi S., Umemura S.-I., Sakuma I., Matsumoto Y.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7S1 Pages: 07JF14-07JF14

    • DOI

      10.7567/jjap.56.07jf14

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of high-intensity focused ultrasound heating by short-pulse generated cavitation2017

    • Author(s)
      Yoshizawa S., Takagi R., Umemura S.-I.
    • Journal Title

      Applied Sciences (Switzerland)

      Volume: 7 Issue: 3 Pages: 288-288

    • DOI

      10.3390/app7030288

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence2016

    • Author(s)
      K. Ichizuka, R. Matsuoka, H. Aoki, J. Hasegawa, T. Okai, S. Umemura
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 43 Issue: 4 Pages: 487-492

    • DOI

      10.1007/s10396-016-0725-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient generation of cavitation bubbles and reactive oxygen species using triggered high-intensity focused ultrasound sequence for sonodynamic treatment2016

    • Author(s)
      J. Yasuda, S. Yoshizawa, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KF24-07KF24

    • DOI

      10.7567/jjap.55.07kf24

    • NAID

      210000146849

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on cavitation behavior during high-intensity focused ultrasound exposure by using optical and ultrasonic imaging2016

    • Author(s)
      K. Taguchi, R. Takagi, J., Yasuda, S. Yoshizawa, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KF22-07KF22

    • DOI

      10.7567/jjap.55.07kf22

    • NAID

      210000146847

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration of lithotripsy using cavitation bubbles induced by second-harmonic superimposition2016

    • Author(s)
      M. Osuga, J. Yasuda, H., Jimbo, S. Yoshizawa, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KF18-07KF18

    • DOI

      10.7567/jjap.55.07kf18

    • NAID

      210000146843

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantage of annular focus generation by sector-vortex array in cavitation-enhanced high-intensity focused ultrasound treatment2016

    • Author(s)
      H. Jimbo, R. Takagi, K. Taguchi, S. Yoshizawa, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KF19-07KF19

    • DOI

      10.7567/jjap.55.07kf19

    • NAID

      210000146844

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative measurement of ultrasound pressure field by optical phase contrast method and acoustic holography2016

    • Author(s)
      S. Oyama, J. Yasuda, H. Hanayama, S. Yoshizawa, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KB09-07KB09

    • DOI

      10.7567/jjap.55.07kb09

    • NAID

      210000146783

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of high-voltage staircase drive circuit waveform for high-intensity therapeutic ultrasound2016

    • Author(s)
      S. Tamano, H. Jimbo, T. Azuma, S. Yoshizawa, K. Fujiwara, K. Itani, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KC10-07KC10

    • DOI

      10.7567/jjap.55.07kc10

    • NAID

      210000146842

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring of high-intensity focused ultrasound treatment by shear wave elastography induced by two-dimensional-array therapeutic transducer2016

    • Author(s)
      R. Iwasaki, R. Takagi, R. Nagaoka, H. Jimbo, S. Yoshizawa, Y. Saijo, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KF05-07KF05

    • DOI

      10.7567/jjap.55.07kf05

    • NAID

      210000146830

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on heavy matching layer transducer towards producing second harmonics2016

    • Author(s)
      Z. Zaini, M. Osuga, H. Jimbo, J. Yasuda, R. Takagi, S. Yoshizawa, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KF15-07KF15

    • DOI

      10.7567/jjap.55.07kf15

    • NAID

      210000146840

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of sonodynamically activated pyrrolidine tris-acid fullerene2016

    • Author(s)
      Y. Iwase, K. Nishi, J. Fujimori, T. Fukai, N. Yumita, T. Ikeda, F.-S. Chen, Y. Momose, S. Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S1 Pages: 07KF02-07KF02

    • DOI

      10.7567/jjap.55.07kf02

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RESEARCH Open Access Detection of tissue coagulation by decorrelation of ultrasonic echo signals in cavitation-enhanced high-intensity focused ultrasound treatment2016

    • Author(s)
      S. Yoshizawa, K. Matsuura, R. Takagi, M. Yamamoto, S. Umemura
    • Journal Title

      Journal of Therapeutic Ultrasound

      Volume: 4:15 Issue: 1 Pages: 1-13

    • DOI

      10.1186/s40349-016-0060-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Basic study on ultrasonic tissue monitoring using 1.5-dimensional ultrasound phased array for ultrasound-guided high intensity focused ultrasound treatment2017

    • Author(s)
      Takagi R., Yoshizawa S., Umemura S.-I.
    • Organizer
      IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basic study on ultrasonic tissue monitoring using 1.5-dimensional ultrasound phased array for ultrasound-guided high intensity focused ultrasound treatment2017

    • Author(s)
      Iwasaki R., Takagi R., Yoshizawa S., Umemura S.-I.
    • Organizer
      IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differentiation of vein and lymphatic vessel by photoacoustic imaging system with parabolic array transducer and tunable laser2017

    • Author(s)
      Tabata T., Nagaoka R., Umemura S., Saijo Y., Yoshizawa S.
    • Organizer
      IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization of the microcirculation in micro vasculatures by photoacoustic tomography with high frequency spherical array transducer2017

    • Author(s)
      Nagaoka R., Tabata T., Takagi R., Yoshizawa S., Umemura S.-I., Saijo Y.
    • Organizer
      IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three dimensional pressure field measurement of focused ultrasound by optical phase contrast method2017

    • Author(s)
      Yoshizawa S., Nakamura T., Sasaki Y., Lafond M., Umemura S.-I.
    • Organizer
      IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 体に優しい超音波治療

    • URL

      http://www.ecei.tohoku.ac.jp/ume/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 梅村・吉澤研究室

    • URL

      http://www.ecei.tohoku.ac.jp/ume/

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 超音波処置具2019

    • Inventor(s)
      伊藤 寛,梅村 晋一郎,吉澤 晋
    • Industrial Property Rights Holder
      オリンパス(株)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] トランスデューサアレイ、光音響プローブ、及び光音響計測装置2017

    • Inventor(s)
      梅村 晋一郎、長岡 亮、吉澤 晋、高木 亮、西條 芳文
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-053502
    • Filing Date
      2017-03-17
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi