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Development of simple quick and high-precision determination method of optimum irradiation position and a deviation detection device of irradiation position for BNCT

Research Project

Project/Area Number 16H03193
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

Tanaka Hiroki  京都大学, 複合原子力科学研究所, 准教授 (70391274)

Co-Investigator(Kenkyū-buntansha) 櫻井 良憲  京都大学, 複合原子力科学研究所, 准教授 (20273534)
川端 信司  大阪医科大学, 医学部, 准教授 (20340549)
小野 公二  京都大学, 原子炉実験所, 研究員 (90122407)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords硼素中性子捕捉療法 / 患者セットアップ / 3Dプリンター / 3Dスキャナ / 3Dプリンター / 3Dスキャナー / 3Dスキャナー / 3Dプリンター / 3Dスキャナー
Outline of Final Research Achievements

There is a need for a quick and easy patient setting procedure for BNCT irradiation. In this research, we succeeded in developing an irradiation positioning system using projection mapping technology, 3D scanner and 3D printer.In addition, it is desirable to detect positional deviation during irradiation. In this study, we developed a method to detect misalignment from thermal neutron flux information by installing several small neutron detectors on the affected area.
In the actual clinical irradiation field, the developed irradiation positioning system and the irradiation position deviation detection system were applied, and the effectiveness was able to be confirmed through the irradiation test.

Academic Significance and Societal Importance of the Research Achievements

加速器を用いたBNCTはこれから拡大していくと考えられる。BNCTの患者セッティングは放射線治療や陽子線治療と異なり、患部を照射場に近づける必要があり、困難さが伴う。実際に治療に携わる人材育成が重要である一方で、患者セッティングを簡便かつ迅速に行う手法、デバイスの開発が求められている。本研究ではその要望に応えるシステムの開発に成功した。今後は実際の治療の場で適応され、BNCTの発展、がん治療の発展につながることから社会的意義は大きいと考える。また、本研究で開発された技術は放射線検出器の新たな活用法にもつながり、学術的意義も大きいと考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (30 results)

All 2019 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (27 results) (of which Int'l Joint Research: 11 results,  Invited: 6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Development of proton beam irradiation system for small animals using FFAG accelerator2019

    • Author(s)
      Tanaka, H., Takata, T., Ishi, Y., Uesugi, T., Kuriyama, Y., Watanabe, T., Sakurai, Y., Kawabata, S., Masunaga, S.-I., Suzuki, M.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research, Section A

      Volume: 922 Pages: 230-234

    • DOI

      10.1016/j.nima.2018.12.081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proposal of absolute biologic effectiveness (ABE) dose for boron neutron capture therapy (BNCT) -The effect of 10B(n,a)7Li dose can be predicted by nucleo-cytoplasmic ratio or cell size-2018

    • Author(s)
      Koji Ono, Hiroki Tanaka, Yuki Tamari, Tsubasa Watanabe, Minoru Suzuki, Shin-ichiro Masunaga
    • Journal Title

      Jounal of radiation research

      Volume: 60 Issue: 1 Pages: 29-36

    • DOI

      10.1093/jrr/rry080

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of prompt gamma rays imaging detector using LaBr3(Ce) scintillator arrays for Boron Neutron Capture Therapy2018

    • Author(s)
      Keita Okazaki, Kiyotaka Akabori, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka
    • Organizer
      第115回日本医学物理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Introduction to KURNS BNCT & Yesterday, Today, and Tomorrow2018

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Shin-ichiro Masunaga, Akira Maruhashi and Koji Ono
    • Organizer
      BNCT forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 京都大学炉における BNCT のためのガンマ線テレスコープシステムの改良2018

    • Author(s)
      櫻井良憲、高田卓志、田中浩基、鈴木実
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 20MeV 陽子サイクロトロンを用いた熱中性子照射場の開発2018

    • Author(s)
      田中浩基、高田卓志、廣瀬勝己、伊藤秀彦、川端信司、櫻井良憲、 増永慎一郎、鈴木実、髙井良尋、小野公二
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Kinect センサーを用いた患者位置モニタリングの検討2018

    • Author(s)
      高田卓志、田中浩基、櫻井良憲、玉利勇樹、丸橋晃、鈴木実
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] BNCT のための LaBr(3 Ce)シンチレーターと 8x8 アレイ MPPC を用いた 即発ガンマ線イメージング検出器の開発2018

    • Author(s)
      岡崎啓太、赤堀清崇、高田卓志、櫻井良憲、田中浩基
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PET 用サイクロトロンとベリリウムターゲットを用いた BNCT基礎研究用熱中性子照射場の開発2018

    • Author(s)
      田中 浩基、高田 卓志、櫻井 良憲、宇根崎 博信、伊藤 秀彦、廣瀬 勝己、 高井 良尋、増永 慎一郎、鈴木 実
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Overview of accelerator-based neutron source for boron neutron capture therapy2018

    • Author(s)
      Hiroki Tanaka
    • Organizer
      The 10th Vietnam/Japan Research/HRD Forum on Nuclear Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of positional deviation detecting device using real-time neutron detector for BNCT2018

    • Author(s)
      H. Tanaka, T. Takata, K. Akabori, S. Kawabata, Y. Sakurai, M. Suzuki,S. Masunaga, K. Ono
    • Organizer
      2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of freely deformable neutron shielding for the reduction of normal tissue dose in boron neutron capture therapy2018

    • Author(s)
      Hiroki Tanaka, Takushi Takata, Yuki Tamari, Yoshinori Sakurai, Tsubasa Watanabe, Minoru Suzuki, Shin-ichiro Masunaga, Koji Ono
    • Organizer
      World congress on medical physics and biomedical engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of thermal neutron irradiation port for cells and small animals using 20MeV cyclotron and beryllium target2018

    • Author(s)
      Hiroki Tanaka, Takushi Takata, Yoshinori Sakurai, Shin-ichiro Masunaga, Minoru Suzuki Katsumi Hirose, Yoshihiro Takai Shinji Kawabata, koji Ono
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a prompt gamma ray imaging detector using LaBr3(Ce) scintillator and arrayed MPPC for Boron Neutron Capture Therapy2018

    • Author(s)
      Keita Okazaki, Kiyotaka Akabori , Takushi Takata , Yoshinori Sakurai , Hiroki Tanaka
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improvement of gamma-ray telescope system for BNCT at Kyoto University Reactor2018

    • Author(s)
      Yoshinori Sakurai, Takushi Takata , Hiroki Tanaka , Minoru Suzuki
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Patient-Position Monitoring System for BNCT Irradiation2018

    • Author(s)
      Takushi Takata, Hiroki Tanaka , Yoshinori Sakurai , Yuki Tamari , Akira Maruhashi , Minoru Suzuki
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BNCTの概要と現状2018

    • Author(s)
      田中浩基
    • Organizer
      放射線検出器の研究シーズと医療現場ニーズに関するシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Current status of cyclotron-based epithermal neutron source(C-BENS)2018

    • Author(s)
      Hiroki Tanaka,Yoshinori Sakurai, Minoru Suzuki, Toshinori Mitsumoto,Shin-ichiro Masunaga, Akira Maruhashi, Koji Ono
    • Organizer
      The 3rd academic meeting of Taiwan Society of Neutron Capture Therapy
    • Related Report
      2017 Annual Research Report
  • [Presentation] サイクロトロンベース中性子源を用いた 細胞・小動物用照射場の開発2018

    • Author(s)
      田中浩基、髙田卓志、櫻井良憲、 密本俊典、増永慎一郎、鈴木実
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of prompt gamma rays imaging detector using LaBr3(Ce) scintillator for boron neutron capture therapy2018

    • Author(s)
      H. Tanaka, T. Takata, K. Akabori, K. Okazaki, Y. Sakurai, T. Watanabe, M. Suzuki,S. Masunaga, K. Ono
    • Organizer
      IEEE Mulclear Science Symposium and Medical Imaging Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] BNCTのためのLaBr3(Ce)シンチレーターを用いた 即発γ線イメージング検出器の開発2018

    • Author(s)
      岡崎 啓太,赤堀 清崇,高田 卓志,櫻井 良憲,田中 浩基
    • Organizer
      2018年原子力学会春の年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] BNCT のためのリアルタイム線量評価システムに関する研究2017

    • Author(s)
      田中浩基
    • Organizer
      京都大学原子炉実験所平成29年度専門研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Current status of Cyclotron-based epithermal neutron source and the developed peripheral devices for BNCT2017

    • Author(s)
      Hiroki Tanaka
    • Organizer
      3rd International Symposium on The Application of Nuclear Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ホウ素中性子捕捉療法(BNCT)の状況について2016

    • Author(s)
      田中浩基
    • Organizer
      日本電機工業会加速器特別委員会
    • Place of Presentation
      電機工業会館(東京都千代田区)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dosimetric Impact Due to Intratreatment positioning error in Boron Neutron Capture Therapy For the High-grade Glioma2016

    • Author(s)
      T. Kato, K. Hirose, T. Harada, K. Arai, T. Motoyanagi, H. Ouchi, K. Takemasa, H. Tanaka, Y. Takai
    • Organizer
      the 17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missiuri,USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Boron Neutron Capture Therapy for Extensive Scalp Lesions : Treatment Planning Study2016

    • Author(s)
      T. Takata, N. Fujimoto, M. Suzuki, H. Tanaka, Y. Sakurai
    • Organizer
      the 17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missiuri,USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 加速器BNCTシステムについて2016

    • Author(s)
      田中浩基
    • Organizer
      革新的がん治療法BNCTシンポジウム
    • Place of Presentation
      三井住友銀行本店大ホール(東京都千代田区)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] BNCT照射時の患者位置ずれ計測システム2016

    • Author(s)
      高田卓志、櫻井良憲、田中浩基、鈴木実
    • Organizer
      第13回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 悪性神経膠腫に対するBNCTにおける患者ポジショニングを考慮に入れた治療計画シミュレーションの検討2016

    • Author(s)
      加藤貴弘、廣瀬勝己、新井一弘、原田崇臣、本柳智章、武政公大、菊地泰裕、後藤博美、田中浩基、鈴木実、髙井良尋
    • Organizer
      第13回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 中性子捕捉療法システム、及び中性子捕捉療法用治療計画システム2016

    • Inventor(s)
      山口喬、武川哲也、田中浩基
    • Industrial Property Rights Holder
      山口喬、武川哲也、田中浩基
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-185797
    • Filing Date
      2016-09-23
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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