Investigation of titanium peroxide nanoparticles for cancer therapy application
| Project/Area Number |
16H03194
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kobe University |
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Principal Investigator |
Ogino Chiaki 神戸大学, 工学研究科, 教授 (00313693)
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| Co-Investigator(Kenkyū-buntansha) |
佐々木 良平 神戸大学, 医学部附属病院, 教授 (30346267)
西村 勇哉 神戸大学, 科学技術イノベーション研究科, 特命助教 (40728218)
中山 雅央 神戸大学, 医学研究科, 医学研究員 (60582004)
沼子 千弥 千葉大学, 大学院理学研究院, 准教授 (80284280)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 過酸化チタン / 放射線照射 / 過酸化水素 / 活性酸素種 / ナノ粒子 / 低侵襲治療システム / ナノテクノロジー / ドラッグデリバリーシステム / バイオナノカプセル / 二酸化チタン |
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| Outline of Final Research Achievements |
In present study, the size of PAATiOx nanoparticle is effective for accumulation in tissue, and 20nm nanoparticle could not be trapped by the liver than at 100 nm, and its accumulation effect to the tumor is also high. It was also shown that PEG modification is less likely to be trapped in the liver than that by PAA modification. Therefore, in the future, it is necessary to antibody modified PEG-modified PAATiOx, and to evaluate retention effect in blood, pharmacokinetics, and accumulation rate into a target tumor. Moreover, since the dominant radiosensitization effect was confirmed by multiple combination treatment with X-rays irradiations, this clinical application can be expected by examining a treatment protocol with more effective than existing X-ray therapy strategy.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の推進により、無機ナノ粒子と放射線治療を併用した新しいがん治療方法の構築が期待できる。これまでに、過酸化チタンナノ粒子による効果を確実にし、その分子レベルでの機序について解明を行ってきており、ほぼその機構を明らかにすることが出来た。更には、今年度、繰り返し照射を行う事で、根治的ながん治療効果が見出せたことで、より臨床サイドでの応用の可能性が高くなった。今後は、この成果をもとに、臨床応用に向けた展開を行っていく計画である。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo2016
Author(s)
Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
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Journal Title
Radiat Oncol.
Volume: 11(1)
Issue: 1
Pages: 91-91
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel Radiosensitizer,2016
Author(s)
Morita K, Miyazaki S, Numaki C, Ikeno S, Sasaki R, Nishimura Y, Ogino C, Kondo A,
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Journal Title
Free Radical Research,
Volume: 50(12)
Issue: 12
Pages: 1319-1328
DOI
Related Report
Peer Reviewed
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[Book] 粉砕2017
Author(s)
西村勇哉，森田健太，鈴木貴弘，荻野千秋，近藤昭彦
Total Pages
5
Publisher
無機とバイオの融合ナノ粒子によるがん治療戦略
Related Report
