Mechanism and treatment of hyperalgesia originating in the muscle fascia
| Project/Area Number |
16H03202
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Niigata University of Health and Welfare (2017-2018)
University of Toyama (2016) |
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Principal Investigator |
Taguchi Toru 新潟医療福祉大学, リハビリテーション学部, 教授 (90464156)
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| Research Collaborator |
UTA Daisuke
OTA Hiroki
WAKATSUKI Koji
TSUBOSHIMA Katsuyuki
MIYAHARA Ken-ichiro
MATSUBARA Takanori
HAMAUE Yohei
MIZUMURA Kazue
KATANOSAKA Kimiaki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 筋膜 / 痛み / 筋・筋膜性疼痛 / 侵害受容 / 理学療法 / 線維筋痛症 / ストレッチ / 筋 / 痛覚過敏 |
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| Outline of Final Research Achievements |
Myofascial pain is quite common and important for rehabilitation medicine, since it seriously disturbs one's daily activities and quality of life. Using animal model of myofascial pain, such as delayed onset muscle soreness and fibromyalgia in the present study, we elucidated some of the peripheral and spinal mechanisms and identified responsible molecules. In addition, we showed the contribution of muscle fascia to hyperalgesia seen in the model of myofascial pain. The outcomes in this study help us not only to understand the mechanisms, but also to prevent and cure the symptoms of myofascial pain.
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| Academic Significance and Societal Importance of the Research Achievements |
肩こりや腰痛などの筋・筋膜性疼痛は本邦において罹患者の多い慢性難治性国民病である。本研究では筋・筋膜性疼痛の実験モデルを用いて、そのメカニズムの一端を末梢神経および脊髄レベルで解明し、またその物質的基盤の一部を明らかにすることができた。また、これまで基礎医学で等閑視されていた「筋膜」が筋・筋膜性疼痛の病態に関わるという知見を得ることができた。これらの研究成果は、筋・筋膜性疼痛の治療や予防に役立つなどの臨床的意義だけでなく、忘れ去られた筋膜に感覚組織としての新しい基礎医学的役割を付与する学術的意義があると考える。
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Hair follicle epidermal stem cells define a niche for tactile sensation2018
Author(s)
Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H.
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Journal Title
Elife
Volume: 7
Pages: 38883-38883
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Interleukin-27 controls basal pain threshold in physiological and pathological conditions.2018
Author(s)
Tomoko Sasaguri, Toru Taguchi, Yuzo Murata, Kimiko Kobayashi, Sayaka Iizasa, Ei’ichi Iizasa, Makoto Tsuda, Naomi Hirakawa, Hiromitsu Hara, Hiroki Yoshida, Toshiharu Yasaka
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 11022-11022
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Enhanced basal pain sensitivities observed in mice lacking interleukin-272018
Author(s)
Yasaka T, Sasaguri T, Taguchi T, Murata Y, Kobayashi K, Iizasa S, Iizasa E, Tsuda M, Hirakawa N, Hara H, Yoshida H.
Organizer
9th FAOPS Congress
Related Report
Int'l Joint Research
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