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Role of intra-cortical inhibitory circuit in motor learning and sensory learning process

Research Project

Project/Area Number 16H03207
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

Onishi Hideaki  新潟医療福祉大学, リハビリテーション学部, 教授 (90339953)

Co-Investigator(Kenkyū-buntansha) 田巻 弘之  新潟医療福祉大学, リハビリテーション学部, 教授 (40253926)
佐藤 大輔  新潟医療福祉大学, 健康科学部, 教授 (60544393)
山代 幸哉  新潟医療福祉大学, 健康科学部, 准教授 (20570782)
大鶴 直史  新潟医療福祉大学, リハビリテーション学部, 講師 (50586542)
桐本 光  広島大学, 医歯薬保健学研究科(保), 教授 (40406260)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords脳磁図 / 体性感覚 / 経頭蓋磁気刺激 / 一次運動野 / 一次体性感覚野 / 二連発抑制 / 知覚学習 / 皮質内抑制 / 運動学習 / 感覚学習 / 運動後抑制 / 体性感覚刺激 / 体性感覚誘発磁界
Outline of Final Research Achievements

We investigated the relationship between cortical inhibitory function of primary motor area (M1) and primary somatosensory area (S1) under motor learning and/or sensory learning process. Several experiments were performed using magnetoencephalography and transcranial magnetic stimulation. First, we confirmed the inter-subject variability and reproducibility of the paired pulse depression (PPD) by peripheral nerve stimulation. Next, we investigated the effects of peripheral nerve stimulation, mechanical stimulation, and repetitive passive movement (RPM) on tactile discrimination performance, motor function, PPD, and cortical excitability. As results, we found that high-intensity PES can improve somatosensory perception, rubbing mechanical stimulation facilitate corticospinal excitability and motor function, and M1 excitability decreases after RPM through frequency-dependent enhancement of cortical inhibitory circuit in M1.

Academic Significance and Societal Importance of the Research Achievements

皮膚を擦るような刺激を20分間与えることにより一次運動野(M1)の興奮性を増大させるとともに,運動遂行能力が促進されることが判明した.また,電気刺激を高強度で皮膚に与えることにより,一次体性感覚野(S1)の抑制機能が減弱するとともに,感覚機能が一時的に向上することが明かになった.加えて,反復的な他動運動によりM1興奮性が減弱するが,他動運動肢に注意を向けるとM1興奮性が増大することが明らかになった.これらの結果は,運動機能および感覚機能を改善させるためのリハビリテーションに応用できるものである.

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (36 results)

All 2019 2018 2017 2016 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 14 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner2019

    • Author(s)
      Miyaguchi Shota、Otsuru Naofumi、Kojima Sho、Yokota Hirotake、Saito Kei、Inukai Yasuto、Onishi Hideaki
    • Journal Title

      Neuroscience Letters

      Volume: 694 Pages: 64-68

    • DOI

      10.1016/j.neulet.2018.11.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Reciprocal Ia Inhibition on Contraction Intensity of Co-contraction2019

    • Author(s)
      Hirabayashi Ryo、Edama Mutsuaki、Kojima Sho、Nakamura Masatoshi、Ito Wataru、Nakamura Emi、Kikumoto Takanori、Onishi Hideaki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 527-527

    • DOI

      10.3389/fnhum.2018.00527

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Repetitive Passive Movement Modulates Corticospinal Excitability: Effect of Movement and Rest Cycles and Subject Attention2019

    • Author(s)
      Tsuiki Shota、Sasaki Ryoki、Pham Manh Van、Miyaguchi Shota、Kojima Sho、Saito Kei、Inukai Yasuto、Otsuru Naofumi、Onishi Hideaki
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 13

    • DOI

      10.3389/fnbeh.2019.00038

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of combined transcranial direct current stimulation and peripheral nerve electrical stimulation on corticospinal excitability2019

    • Author(s)
      Tsuiki Shota、Sasaki Ryoki、Miyaguchi Shota、Kojima Sho、Saito Kei、Inukai Yasuto、Masaki Mitsuhiro、Otsuru Naofumi、Onishi Hideaki
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 3 Pages: e0214592-e0214592

    • DOI

      10.1371/journal.pone.0214592

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical excitability following passive movement2018

    • Author(s)
      Onishi H
    • Journal Title

      Physical Therapy Research

      Volume: 21 Issue: 2 Pages: 23-32

    • DOI

      10.1298/ptr.R0001

    • NAID

      130007536862

    • ISSN
      2189-8448
    • Year and Date
      2018-12-20
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation2018

    • Author(s)
      Onishi Hideaki、Otsuru Naofumi、Kojima Sho、Miyaguchi Shota、Saito Kei、Inukai Yasuto、Yamashiro Koya、Sato Daisuke、Tamaki Hiroyuki、Shirozu Hiroshi、Kameyama Shigeki
    • Journal Title

      Brain Topography

      Volume: 31 Issue: 5 Pages: 780-794

    • DOI

      10.1007/s10548-018-0648-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination2018

    • Author(s)
      Saito Kei、Otsuru Naofumi、Inukai Yasuto、Kojima Sho、Miyaguchi Shota、Tsuiki Shota、Sasaki Ryoki、Onishi Hideaki
    • Journal Title

      Neuroscience

      Volume: 384 Pages: 262-274

    • DOI

      10.1016/j.neuroscience.2018.05.032

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcranial Alternating Current Stimulation With Gamma Oscillations Over the Primary Motor Cortex and Cerebellar Hemisphere Improved Visuomotor Performance2018

    • Author(s)
      Miyaguchi Shota、Otsuru Naofumi、Kojima Sho、Saito Kei、Inukai Yasuto、Masaki Mitsuhiro、Onishi Hideaki
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 12 Pages: 132-132

    • DOI

      10.3389/fnbeh.2018.00132

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomised controlled trial2018

    • Author(s)
      Inukai Yasuto、Masaki Mitsuhiro、Otsuru Naofumi、Saito Kei、Miyaguchi Shota、Kojima Sho、Onishi Hideaki
    • Journal Title

      Journal of NeuroEngineering and Rehabilitation

      Volume: 15 Issue: 1

    • DOI

      10.1186/s12984-018-0407-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Somatosensory Inputs Induced by Passive Movement Facilitate Primary Motor Cortex Excitability Depending on the Interstimulus Interval, Movement Velocity, and Joint Angle2018

    • Author(s)
      Sasaki Ryoki、Tsuiki Shota、Miyaguchi Shota、Kojima Sho、Saito Kei、Inukai Yasuto、Otsuru Naofumi、Onishi Hideaki
    • Journal Title

      Neuroscience

      Volume: 386 Pages: 194-204

    • DOI

      10.1016/j.neuroscience.2018.06.042

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Repetitive Passive Finger Movement Modulates Primary Somatosensory Cortex Excitability2018

    • Author(s)
      Sasaki Ryoki、Tsuiki Shota、Miyaguchi Shota、Kojima Sho、Saito Kei、Inukai Yasuto、Otsuru Naofumi、Onishi Hideaki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12

    • DOI

      10.3389/fnhum.2018.00332

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticospinal excitability following repetitive voluntary movement2018

    • Author(s)
      Ishikawa Natsumi、Miyao Ryunosuke、Tsuiki Shota、Sasaki Ryoki、Miyaguchi Shota、Onishi Hideaki
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 57 Pages: 93-98

    • DOI

      10.1016/j.jocn.2018.08.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of Corticospinal Excitability Depends on the Pattern of Mechanical Tactile Stimulation2018

    • Author(s)
      Kojima Sho、Onishi Hideaki、Miyaguchi Shota、Kotan Shinichi、Sasaki Ryoki、Nakagawa Masaki、Kirimoto Hikari、Tamaki Hiroyuki
    • Journal Title

      Neural Plasticity

      Volume: 2018 Pages: 1-9

    • DOI

      10.1155/2018/5383514

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of short-latency afferent inhibition and short-interval intracortical inhibition by test stimulus intensity and motor-evoked potential amplitude2017

    • Author(s)
      Miyaguchi Shota、Kojima Sho、Sasaki Ryoki、Tamaki Hiroyuki、Onishi Hideaki
    • Journal Title

      NeuroReport

      Volume: 28 Issue: 18 Pages: 1202-1207

    • DOI

      10.1097/wnr.0000000000000896

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-exercise cortical depression following repetitive passive finger movement2017

    • Author(s)
      Otsuka Ryohei、Sasaki Ryoki、Tsuiki Shota、Kojima Sho、Onishi Hideaki
    • Journal Title

      Neuroscience Letters

      Volume: 656 Pages: 89-93

    • DOI

      10.1016/j.neulet.2017.07.030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of primary motor cortex excitability by repetitive passive finger movement frequency2017

    • Author(s)
      Sasaki Ryoki、Nakagawa Masaki、Tsuiki Shota、Miyaguchi Shota、Kojima Sho、Saito Kei、Inukai Yasuto、Masaki Mitsuhiro、Otsuru Naofumi、Onishi Hideaki
    • Journal Title

      Neuroscience

      Volume: 357 Pages: 232-240

    • DOI

      10.1016/j.neuroscience.2017.06.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Passive Finger Movement on Cortical Excitability2017

    • Author(s)
      Nakagawa Masaki、Sasaki Ryoki、Tsuiki Shota、Miyaguchi Shota、Kojima Sho、Saito Kei、Inukai Yasuto、Onishi Hideaki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 11 Pages: 1-7

    • DOI

      10.3389/fnhum.2017.00216

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability2017

    • Author(s)
      Sasaki Ryoki、Kotan Shinichi、Nakagawa Masaki、Miyaguchi Shota、Kojima Sho、Saito Kei、Inukai Yasuto、Onishi Hideaki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 11 Pages: 1-9

    • DOI

      10.3389/fnhum.2017.00146

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in short-latency afferent inhibition during corticomotor post-exercise depression following repetitive finger movement2017

    • Author(s)
      Shota Miyaguchi, Sho Kojima, Ryoki Sasaki, Shinichi Kotan, Hikari Kirimoto, Hiroyuki Tamaki, Hideaki Onishi
    • Journal Title

      Brain and Behavior

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 一次運動野における皮質内抑制指標の被験者間のバラツキ2018

    • Author(s)
      佐々木亮樹,立木翔太,宮口翔太,小島翔,齊藤慧,犬飼康人,大鶴直史,長岡輝之,山崎一徳,大西秀明
    • Organizer
      第48回日本臨床神経生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 一次運動野における皮質内抑制指標の被験者内の再現性と各皮質内抑制指標間の関連性2018

    • Author(s)
      佐々木亮樹,立木翔太,宮口翔太,小島翔,齊藤慧,犬飼康人,大鶴直史,長岡輝之,山崎一徳,大西秀明.
    • Organizer
      第23回日本基礎理学療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Influence of passive finger movement with and without duty cycle on corticospinal excitability2017

    • Author(s)
      Tsuiki S, Sasaki R, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of hand position in external space on the integration of bilateral tactile stimulation in the primary somatosensory cortex2017

    • Author(s)
      Otsuru N, Kojima S, Miyaguchi S, Sasaki R, Tsuiki S, Saito K, Inukai Y, Masaki M, Yamashiro K, Shirozu H, Kameyama S, Onishi H
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 体性感覚誘発磁界と刺激前皮質活動との関係2017

    • Author(s)
      大西秀明,大鶴直史,小島翔,宮口翔太,白水洋史,亀山茂樹
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 反復的他動運動が皮質内抑制回路に与える影響2017

    • Author(s)
      佐々木亮樹,中川昌樹,立木翔太,宮口翔太,小島翔,齊藤慧,犬飼康人,正木光裕,大鶴直史,大西秀明
    • Organizer
      第52回_日本理学療法学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機械的触覚刺激が手指運動機能と皮質脊髄路興奮性に及ぼす影響2017

    • Author(s)
      小島 翔,宮口翔太,立木翔太,齊藤 慧,犬飼康人,正木光裕,大鶴直史,大西秀明
    • Organizer
      第47回日本臨床神経生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機械的触覚刺激による刺激方法の違いが皮質脊髄路の興奮性に及ぼす影響2016

    • Author(s)
      小島 翔, 大西 秀明, 宮口 翔太, 佐々木 亮樹, 中川 昌樹, 立木 翔太, 桐本 光, 田巻 弘之
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 反復的他動運動の運動頻度の違いが体性感覚誘発電位に与える影響2016

    • Author(s)
      佐々木亮樹,中川昌樹,立木翔太,宮口翔太,小島翔,犬飼康人,齊藤慧,大西秀明
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 他動運動時の関節角度および運動方向の違いが運動誘発電位に与える影響2016

    • Author(s)
      中川 昌樹,佐々木亮樹,立木 翔太,宮口 翔太,小島 翔,犬飼 康人,齊藤 慧,大西 秀明
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 経頭蓋陰極直流電流刺激と末梢神経電気刺激の組み合わせが皮質脊髄路の興奮性に及ぼす影響2016

    • Author(s)
      立木翔太,佐々木亮樹,中川昌樹,宮口翔太,小島翔,齊藤慧,犬飼康人,大西秀明
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 軽負荷反復運動課題によるPost exercise depression期間中の皮質内抑制回路の変化2016

    • Author(s)
      宮口翔太,小島 翔,小丹晋一,中川晶樹,佐々木亮樹,田巻弘之,大西秀明
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 末梢神経電気刺激による筋収縮の有無が体性感覚誘発電位に与える影響2016

    • Author(s)
      佐々木亮樹,中川昌樹,立木翔太,宮口翔太,小島翔,齊藤慧,犬飼康人,正木光裕,大鶴直史,大西秀明
    • Organizer
      第17回日本電気生理運動学会学術大会
    • Place of Presentation
      新潟
    • Related Report
      2016 Annual Research Report
  • [Book] リハビリテーション神経科学2019

    • Author(s)
      大西秀明,他
    • Total Pages
      355
    • Publisher
      メジカルビュー
    • ISBN
      9784758319379
    • Related Report
      2018 Annual Research Report
  • [Remarks] 新潟医療福祉大学運動機能医科学研究所

    • URL

      http://www.ihmms.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 新潟医療福祉大学SHAINプロジェクト

    • URL

      https://www.nuhw.ac.jp/shain/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 運動機能医科学研究所

    • URL

      http://www.ihmms.jp/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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