Role of microRNAs in exercise-induced angiogenesis
| Project/Area Number |
16H03239
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 骨格筋 / メカニカルストレス / 可塑性 / 血管新生 / マイオカイン / 適応 / マイクロRNA / 代謝 / ミトコンドリア / 筋可塑性 / エクソソーム / 骨格筋可塑性 / ノンコーディングRNA / 筋線維タイプ / 毛細血管ネットワーク / 組織間相互作用 |
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| Outline of Final Research Achievements |
In this study, we determined exercise-induced angiogenesis in mice lacking almost all miRNAs by deleting Dicer, an enzyme essential for microRNA (miRNA) processing and in mice lacking specific miRNAs.
First, the tamoxifen-induced Dicer knockout mice died within 5 weeks after tamoxifen administration, suggesting that miRNAs play an important role in maintaining life.
With regard to analysis using specific miRNA-deficient mice, even in the mice lacking miR-23 cluster miRNAs showed normal exercise-induced angiogenesis in response to endurance exercise training. These findings suggest that the role of miR-23 cluster miRNAs in exercise-induced angiogenesis in skeletal muscle is limited.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によってマイクロRNAが生命維持に必須であることが示唆された．このため，マイクロRNAの機能を解析することは学術的にも社会的にも意義があると考えられる．
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.2016
Author(s)
I. Moretti*, S. Ciciliot*, K. A. Dyar, R. Abraham, M. Murgia, L. Agatea, T. Akimoto, S. Bicciato, M. Forcato, P. Pierre, N. H. Uhlenhaut, P.W. J. Rigby, J. Carvajal, B. Blaauw, E. Calabria, S. Schiaffino.
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Journal Title
Nat Commun
Volume: 7
Pages: 12397-12397
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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