| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
In this study, we determined exercise-induced angiogenesis in mice lacking almost all miRNAs by deleting Dicer, an enzyme essential for microRNA (miRNA) processing and in mice lacking specific miRNAs.
First, the tamoxifen-induced Dicer knockout mice died within 5 weeks after tamoxifen administration, suggesting that miRNAs play an important role in maintaining life.
With regard to analysis using specific miRNA-deficient mice, even in the mice lacking miR-23 cluster miRNAs showed normal exercise-induced angiogenesis in response to endurance exercise training. These findings suggest that the role of miR-23 cluster miRNAs in exercise-induced angiogenesis in skeletal muscle is limited.
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