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Importance of postexercise calcium ion dynamics to regulate the adaptation of myocytes

Research Project

Project/Area Number 16H03240
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionThe University of Electro-Communications

Principal Investigator

Kano Yutaka  電気通信大学, 大学院情報理工学研究科, 教授 (90293133)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords骨格筋 / カルシウムイオン / 可塑性 / 性差 / 筋収縮 / 熱ストレス / タンパク質合成 / エキセントリック収縮 / 廃用性筋萎縮 / 糖尿病 / 細胞内カルシウムイオン / 筋損傷 / 筋肥大 / バイオイメージング / in vivo / 生理学
Outline of Final Research Achievements

The mechanism of skeletal muscle adaptation to maintain muscle mass and strength is not fully understood. This study investigated the possibility that intracellular calcium ion controls muscle mass and muscle function. It was revealed that intracellular calcium ion changes continuously for a while after muscle contractions. These changes were different depending on the type of exercise stress and male/female. The characteristic calcium ion dynamics may control skeletal muscle mass due to exercise stress.

Academic Significance and Societal Importance of the Research Achievements

加齢や寝たきりなどの不活動状態,あるいは代謝的疾患(糖尿病など)に関連した筋肉量の減少は,Quality of Life(QOL)や健康寿命などに直結するリスクファクターである.本研究によって解明された運動時のカルシウムイオン変動パターンは,筋肉量を維持するための運動トレーニングやリハビリテーションのプログラム開発への応用が期待される.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (21 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (8 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (4 results)

  • [Int'l Joint Research] カンザス州立大学/ユタ州立大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Kansas stete University/University of Utah School of Medicine(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] カンザス州立大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カンザス州立大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Sex differences in mitochondrial Ca2+ handling in mouse fast-twitch skeletal muscle in vivo2020

    • Author(s)
      Watanabe Daiki、Hatakeyama Koji、Ikegami Ryo、Eshima Hiroaki、Yagishita Kazuyoshi、Poole David C.、Kano Yutaka
    • Journal Title

      Journal of Applied Physiology

      Volume: 128 Issue: 2 Pages: 241-251

    • DOI

      10.1152/japplphysiol.00230.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Accumulation of intramyocyte TRPV1-mediated calcium during heat stress is inhibited by concomitant muscle contractions2019

    • Author(s)
      Ikegami Ryo、Eshima Hiroaki、Mashio Takuro、Ishiguro Tomosada、Hoshino Daisuke、Poole David C.、Kano Yutaka
    • Journal Title

      Journal of Applied Physiology

      Volume: 126 Issue: 3 Pages: 691-698

    • DOI

      10.1152/japplphysiol.00668.2018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regional differences in Ca2+ entry along the proximal-middle-distal muscle axis during eccentric contractions in rat skeletal muscle2019

    • Author(s)
      Tabuchi Ayaka、Eshima Hiroaki、Tanaka Yoshinori、Nogami Shunsuke、Inoue Naoki、Sudo Mizuki、Okada Hidetaka、Poole David C.、Kano Yutaka
    • Journal Title

      Journal of Applied Physiology

      Volume: 127 Issue: 3 Pages: 828-837

    • DOI

      10.1152/japplphysiol.01005.2018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Muscle hypertrophy following blood flow-restricted low force isometric electrical stimulation in rat tibialis anterior: Role for muscle hypoxia.2018

    • Author(s)
      Nakajima T, Koide S, Yasuda T, Hasegawa T, Yamasoba T, Obi S, Toyoda S, Nakamura F, Inoue T, Poole DC, Kano Y
    • Journal Title

      J Appl Physiol

      Volume: 印刷中 Issue: 1 Pages: 134-145

    • DOI

      10.1152/japplphysiol.00972.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microvascular Permeability of Skeletal Muscle After Eccentric Contraction-Induced Muscle Injury: In Vivo Imaging Using Two-Photon Laser Scanning Microscopy2018

    • Author(s)
      Kazuki Hotta, Bradley Behnke, Kazuto Masamoto, Rie Shimotsu, Naoya Onodera, Akihiko Yamaguchi, David Poole, Yutaka Kano
    • Journal Title

      Journal of Applied Physiology

      Volume: 125 Issue: 2 Pages: 369-380

    • DOI

      10.1152/japplphysiol.00046.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α.2017

    • Author(s)
      Eshima, H., Miura, S., Senoo, N., Hatakeyama, K., Poole, D.C., and Kano, Y.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 印刷中 Issue: 6 Pages: 1017-1028

    • DOI

      10.1152/ajpregu.00032.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo Ca2+ dynamics induced by Ca2+ injection in individual rat skeletal muscle fibers2016

    • Author(s)
      Mario Wakizaka, Hiroaki Eshima, Yoshinori Tanaka, Hideki Shirakawa, David C. Poole, Yutaka Kano
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 5

    • DOI

      10.14814/phy2.13180

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] pH buffering of single rat skeletal muscle fibers in the in vivo environment.2016

    • Author(s)
      Yoshinori Tanaka, Tadakatsu Inagaki, David C. Poole and Yutaka Kano.
    • Journal Title

      American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.

      Volume: in press Issue: 10 Pages: R926-R933

    • DOI

      10.1152/ajpregu.00501.2015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] バイオイメージング科学の筋細胞研究への応用2019

    • Author(s)
      狩野 豊
    • Organizer
      第74回 日本体力医学会大会 つくば
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 損傷再生過程における細胞内カルシウムイオンダイナミクスとmTOR系の変化2018

    • Author(s)
      田渕絢香,白川英樹,芝口翼,杉浦崇夫,狩野豊
    • Organizer
      第73回 日本体力医学会 学会大会 福井
    • Related Report
      2018 Annual Research Report
  • [Presentation] 熱ストレスおよび筋収縮が筋細胞質内カルシウムイオン濃度に及ぼす影響2018

    • Author(s)
      池上諒,江島弘晃,星野太佑,狩野豊
    • Organizer
      第73回 日本体力医学会 学会大会 福井
    • Related Report
      2018 Annual Research Report
  • [Presentation] In vivo intracellular Ca2+ dynamics over 7 days following novel eccentric contractions in rat skeletal muscle2017

    • Author(s)
      Ayaka Tabuchi, Hideki Shirakawa, David C Poole, Yutaka Kano
    • Organizer
      第64回アメリカスポーツ医学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 伸張性筋収縮後に観察される筋細胞内Ca2+ダイナミクス2016

    • Author(s)
      田渕絢香,狩野豊
    • Organizer
      第71回日本体力医学会
    • Place of Presentation
      市民文化ホール(岩手県盛岡市)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Remarks] 電気通信大学 基盤理工学専攻 化学生命工学プログラム 狩野研究室

    • URL

      http://www.ecc.es.uec.ac.jp/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] Research Highlights: In vivo bioimaging

    • URL

      http://www.ru.uec.ac.jp/e-bulletin/research-highlights/2020/in-vivo-bioimaging-technology-to-elucidate-sex-dependent-differences-in-skeletal-muscle-function.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 電気通信大学 基盤理工学専攻 狩野研究室

    • URL

      http://www.ecc.es.uec.ac.jp/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 電気通信大学狩野研究室ホームページ

    • URL

      http://www.ecc.es.uec.ac.jp/index.html

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-02-28  

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