Magnetoencephalography studies on the neural mechanisms related to fatigue sensation

• Project/Area Number: 16H03248
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Osaka City University
• Principal Investigator: Ishii Akira 大阪市立大学, 大学院医学研究科, 病院講師 (90587809)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000); Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 疲労感 / 疲労 / 脳磁図 / 神経メカニズム / 意識 / パフォーマンス / 意識下 / 無意識下

Outline of Final Research Achievements

We aimed to elucidate the neural mechanisms by which fatigue sensation regulate performance and those by which fatigue sensation is generated. We performed neuroimaging studies with healthy participants using magnetoencephalography. We obtained important clues to understand the neural mechanisms by which fatigue sensation regulate performance and also that for the possible mechanism of the generation of fatigue sensation.

Academic Significance and Societal Importance of the Research Achievements

疲労感がパフォーマンスを制御するメカニズムおよび疲労感の成因に関わる重要な知見を得ることが出来たことにより、疲労の病態生理をより明確に捉えるための基盤を構築することができた。疲労感と心理的ストレス・食欲などとの関連性について脳科学的にアプローチすることで、実生活の中に存在する疲労をより良く理解する素地を構築したことと合わせて、疲労への総合的な対処戦略の考案に大きく貢献できるものと考えられる。

Research Products

• [Journal Article] Neural effects of acute stress on appetite: A magnetoencephalography study (2020)
  • Author(s): Nakamura C, Ishii A, Matsuo T, Ishida R, Yamaguchi T, Takada K, Uji M, Yoshikawa T.
  • Journal Title: PLOS ONE Volume: 15 Issue: 1 Pages: 1-17
  • DOI: 10.1371/journal.pone.0228039
  • Peer Reviewed / Open Access
• [Journal Article] Neural effects of hand-grip-activity induced fatigue sensation on appetite: a magnetoencephalography study (2019)
  • Author(s): Matsuo Takashi、Ishii Akira、Nakamura Chika、Ishida Rika、Yamaguchi Takahiro、Takada Katsuko、Uji Masato、Yoshikawa Takahiro
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 1-11
  • DOI: 10.1038/s41598-019-47580-z
  • Peer Reviewed / Open Access
• [Journal Article] Decreased alpha-band oscillatory brain activity prior to movement initiated by perception of fatigue sensation (2019)
  • Author(s): Ishii Akira、Matsuo Takashi、Nakamura Chika、Uji Masato、Yoshikawa Takahiro、Watanabe Yasuyoshi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41598-019-40605-7
  • Peer Reviewed / Open Access
• [Journal Article] Neural activity induced by visual food stimuli presented out of awareness : a preliminary magnetoencephalography study (2018)
  • Author(s): Takada K, Ishii A, Matsuo T, Nakamura C, Uji M, Yoshikawa T.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 3119
  • DOI: 10.1038/s41598-018-21383-0
  • NAID: 120006404343
  • URL: https://ocu-omu.repo.nii.ac.jp/records/2020476
  • Peer Reviewed / Open Access
• [Journal Article] Evidence for unconscious regulation of performance in fatigue. (2017)
  • Author(s): Ishii A, Tanaka M, Yoshikawa T, Watanabe Y.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 16103-16103
  • DOI: 10.1038/s41598-017-16439-6
  • Peer Reviewed / Open Access
• [Journal Article] Neural effect of physical fatigue on mental fatigue: a magnetoencephalography study (2016)
  • Author(s): Tanaka M, Ishii A, Watanabe Y
  • Journal Title: Fatigue: Biomedicine, Health & Behavior Volume: 4 Pages: 101-114
  • Peer Reviewed
• [Journal Article] Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study (2016)
  • Author(s): Tanaka M, Ishii A, Watanabe Y
  • Journal Title: Fatigue: Biomedicine, Health & Behavior Volume: 4 Pages: 146-157
  • Peer Reviewed
• [Journal Article] The neural mechanisms of re-experiencing physical fatigue sensation: a magnetoencephalography study. (2016)
  • Author(s): Ishii, A., Tanaka, M., Watanabe, Y.
  • Journal Title: Exp.Brain Res. Volume: 23 Issue: 9 Pages: 2433-2446
  • DOI: 10.1007/s00221-016-4648-y
  • Peer Reviewed / Open Access
• [Journal Article] Neural mechanisms to predict subjective level of fatigue in the future: a magnetoencephalography study (2016)
  • Author(s): Ishii, A., Tanaka, M., Watanabe, Y.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 25097-25097
  • DOI: 10.1038/srep25097
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visual food stimulus changes resting oscillatory brain activities related to appetitive motive (2016)
  • Author(s): Yoshikawa, T., Tanaka, M., Ishii, A., Yamano, Y., Watanabe, Y.
  • Journal Title: Behav. Brain. Funct. Volume: 12 Issue: 1 Pages: 26
  • DOI: 10.1186/s12993-016-0110-3
  • NAID: 120006371281
  • URL: https://ocu-omu.repo.nii.ac.jp/records/2019662
  • Peer Reviewed / Open Access
• [Presentation] 疲労感が行動決定の直接の原因である可能性についての検討：脳磁図研究 (2019)
  • Author(s): 石井 聡、松尾貴司、中村千華、石田梨佳、宇治正人、田中雅彰、吉川貴仁、渡辺恭良
  • Organizer: 第15回日本疲労学会
• [Presentation] 急性身体性疲労における疲労負荷前・中・後の神経活動の検討：脳磁図研究 (2019)
  • Author(s): 田中雅彰、石井 聡、渡辺恭良
  • Organizer: 第15回日本疲労学会
• [Presentation] 周囲からの期待が精神的疲労に与える影響に関する脳磁図研究 (2019)
  • Author(s): 松尾貴司、隅 清隆、小淵 登生、石井 聡、中村千華、石田梨佳、宇治正人、吉川貴仁
  • Organizer: 第15回日本疲労学会
• [Presentation] 身体的疲労における無意識下でのパフォーマンス調節メカニズムに関する脳磁図研究 (2018)
  • Author(s): 石井 聡、田中 雅彰 、山野 恵美、松尾 貴司、中村 千華、高田 勝子、宇治 正人、吉川 貴仁、渡辺 恭良
  • Organizer: 日本疲労学会総会
  • Invited
• [Presentation] 急性の運動負荷による疲労感が食欲に与える影響に関する脳磁図研究 (2018)
  • Author(s): 松尾 貴司、石井 聡、中村 千華、高田 勝子、宇治 正人、山口 貴大、吉川 貴仁
  • Organizer: 日本疲労学会総会
• [Presentation] Neural and behavioral evidence for unconscious control of performance in fatigue: a magnetoencephalography study (2018)
  • Author(s): Akira Ishii, Masaaki Tanaka, Takahiro Yoshikawa, Yasuyoshi Watanabe
  • Organizer: 日本神経科学大会
• [Presentation] 疲労感をポジティブにとらえることがもたらす効果に関する脳磁図研究 (2017)
  • Author(s): 石井 聡
  • Organizer: 第13回日本疲労学会総会・学術集会
• [Presentation] The neural effects of positively and negatively re-experiencing mental fatigue sensation on motivation: a magnetoencephalography study (2017)
  • Author(s): 石井 聡
  • Organizer: 第40回日本神経科学大会
• [Presentation] 未来の疲労レベルの予測に関わる神経メカニズムの脳磁図研究 (2016)
  • Author(s): 石井 聡、田中 雅彰、山野 恵美、渡辺 恭良
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] 疲労レベルの予測に関わる神経メカニズムの脳磁図研究 (2016)
  • Author(s): 石井 聡、田中 雅彰、山野 恵美、渡辺 恭良
  • Organizer: 第12回日本疲労学会総会・学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-05-20