Effect of exercise on gene expression of clock gene and biological rhythm.
| Project/Area Number |
16H03254
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
麻見 直美 筑波大学, 体育系, 准教授 (10300005)
萱場 桃子 公益財団法人神経研究所, 研究部, 研究員 (20759055)
鍋倉 賢治 筑波大学, 体育系, 教授 (60237584)
緒形 ひとみ 広島大学, 総合科学研究科, 助教 (80455930)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
|---|
| Keywords | 体内時計 / 時計遺伝子 / BMAL1 / 運動 / 時計遺伝子発現 / 概日リズム / 生体リズム / 体温 / 朝練習 / 睡眠 / 早朝の運動 / 血糖 / 生活習慣 |
|---|
| Outline of Final Research Achievements |
Molecular mechanism of biological clock has been identified in central nervous system (SCN) and peripheral tissues such as liver, adipose tissue, skeletal muscle, leukocyte etc. Light-dark cycle entrains biological clock of SCN, and meal influence clock gene expression in liver. Present research assessed the effect of exercise on gene expression of clock genes in leukocyte.
10 young healthy male subjects exercise at 50% their maximal oxygen consumption for 60 min before breakfast or after lunch, and gene expression of clock genes (BMAL1, CLOCK, CRY1, etc) were assessed in leukocyte. Gene expression of BMAL1 was upregulated after exercise, resulting in forward and delayed shift of acrophase of gene expression assed by cosinor method. After a single bout of exercise gene expression of one clock gene BMAL1, but not the entire clock gene expression, was modified. Furthermore, physiological meaning of the change in BMAL1 in leukocyte remained to be studied.
|
| Academic Significance and Societal Importance of the Research Achievements |
２４時間社会と呼ばれる現在のわが国では、生活習慣の多様化に伴い、総務省の調査では運動する時間帯にも大きな個人差があることが示されている。夕食や就寝の時刻が年々遅くなっており、本来の生体リズムと乖離した状態の健康への悪影響が指摘されている。同様に運動する時間帯が異なればその健康作用も大きく異なる可能性が指摘されており本研究の担当者らは運動する時間帯が異なると脂肪酸化への影響が異なることを以前の基盤研究の成果で示してきた。本研究では見方を変えて、運動すること自体が体内時計を調節する可能性を示唆した。食事や就寝時刻が遅延する傾向が続く現状において運動、特に早朝の運動の新たな機能が示唆された。
|
Report
(4 results)
Research Products
(7 results)
-
[Journal Article] Effect of skipping breakfast for six days on energy metabolism and diurnal rhythm of blood glucose in young healthy Japanese males2019
Author(s)
Hitomi Ogata, Momoko Kayaba, Yoshiaki Tanaka, Katsuhiko Yajima, Kaito Iwayama, Akira Ando, Insung Park, Ken Kiyono, Naomi Omi, Makoto Satoh, and Kumpei Tokuyama
-
Journal Title
American Journal of Clinical Nutrition
Volume: 印刷中
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Exercise before breakfast increases 24-h fat oxidation in female subjects2017
Author(s)
Kaito Iwayama, Ryosuke Kawabuchi, Yoshiharu Nabekura, Reiko Kurihara, Insung Park, Masashi Kobayashi, Hitomi Ogata, Momoko Kayaba, Nomi Omi, Makoto Satoh, Kumpei Tokuyama
-
Journal Title
PLoS One.
Volume: 12
Issue: 7
Pages: e0180472-e0180472
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
[Presentation] 運動タイミングが生体リズムと時計遺伝子発現に及ぼす影響2018
Author(s)
田中喜晃, 緒形ひとみ, 萱場桃子, 岩山海渡, 矢島克彦, 安藤啓, 朴寅成, 大住陽香, 張思萌, 廣實ゆかり, 石原あすか, 荒木章裕, 麻見直美, 鍋倉賢治, 佐藤誠, 徳山薫平
Organizer
第72回日本栄養・食糧学会大会
Related Report
-
[Presentation] 運動が時計遺伝子発現に及ぼす影響2018
Author(s)
田中喜晃, 緒形ひとみ, 萱場桃子, 岩山海渡, 矢島克彦, 安藤啓, 朴寅成, 鈴木稚寛, 大住陽香, 張思萌, 荒木章裕, 高橋啓悟, 麻見直美, 鍋倉賢治, 佐藤誠, 徳山薫平
Organizer
第5回時間栄養科学研究会
Related Report
-
