| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Quality of skeletal muscle is determined not only muscle function but also life span of individual. However, the question of what is "quality of skeletal muscle" is not answered currently. From my previous study, I hypothesized component of extracellular matrix (ECM) in basal lamina covered a skeletal muscle fiber is the substance of "quality of skeletal muscle". I compared between "good skeletal muscle" such as trained muscle and "bad skeletal muscle" such as denervated or diabetic muscle using qPCR array and identified Lamb3 gene as a muscle quality control gene. Lamb3 gene is poorly expressed in normal skeletal muscle and strongly induced during muscle hypertrophy and muscle regeneration. Lamb3 activates Akt pathway, resulting in muscle regeneration and hypertrophy. These results suggested that muscle ECM is an important internal environment and their manipulation can control muscle quality.
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