| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
The main purpose of our research was to identify the epigenetic differences in skeletal muscles which experienced different physiological history. We found that 1) Exercise training attenuated the response of skeletal muscle to disuse in association with altered histone distribution at specific loci. 2) High fat feeding in early life improved age-related glucose intolerance, that assoicated with lowered incorporation of histone variant H3.3 into the loci related to lipod metabplism in skeletal muscle. 3) Resistance training in human increased histone acetylation at the loci responded to exercise, might lead to maintaining active status for gene transcription.
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