| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
We found that molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. Indeed, preadministration of hydrogen-rich water to mice was enough to protect against lipopolysaccharide-induced sepsis and attenuate liver injury. Furthermore, we found that molecular hydrogen attenuates gefitinib-induced exacerbation of acute lung injury in mice through a reduction in oxidative stress and inflammation. Hydrogen-rich water administration also prevents vascular aging of the aorta in LDL receptor-deficient mice.
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