Basic research for molecular mechanisms underlying antiinflammatory and antioxidative effects of molecular hydrogen
Project/Area Number |
16H03267
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
Ikuroh Ohsawa 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (30343586)
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Co-Investigator(Kenkyū-buntansha) |
伊藤 雅史 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80393114)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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Keywords | 水素分子 / ミトホルミシス / 酸化ストレス / 炎症 / 動物モデル / 老化 / 加齢・老化 / 動脈硬化 / 抗がん剤副作用 / 抗炎症作用 / ミトコンドリア / 標的分子 / 敗血症 / 白内障 / 認知機能 / 臨床 / 糖尿病 |
Outline of Final Research Achievements |
We found that molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. Indeed, preadministration of hydrogen-rich water to mice was enough to protect against lipopolysaccharide-induced sepsis and attenuate liver injury. Furthermore, we found that molecular hydrogen attenuates gefitinib-induced exacerbation of acute lung injury in mice through a reduction in oxidative stress and inflammation. Hydrogen-rich water administration also prevents vascular aging of the aorta in LDL receptor-deficient mice.
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Academic Significance and Societal Importance of the Research Achievements |
水素分子の効果的な摂取は老化と疾患の要因となる酸化ストレスと炎症を効果的に軽減することを動物モデルで示すことで、健康増進に向けた適用可能領域を広げた。すでに市場に出回っている水素水などの関連製品を効果的に用いるには、水素分子の作用機序解明が必要である。今回、水素分子の摂取で酸化ストレスと炎症に対する生体防御機構が活性化されることを突き止めた。この知見は、疾患予防への応用といった水素分子医学の新たな展開を可能にした。
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation.2019
Author(s)
Terasaki Y, Suzuki T, Tonaki K, Terasaki M, Kuwahara N, Ohsiro J, Iketani M, Takahashi M, Hamanoue M, Kajimoto Y, Hattori S, Kawaguchi H, Shimizu A, Ohsawa I.
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Journal Title
Laboratory Investigation
Volume: 2
Issue: 6
Pages: 793-806
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer2017
Author(s)
Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi, Masafumi Ito
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Journal Title
BMC Cancer
Volume: 316
Issue: 1
Pages: 316-316
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hydrogen Gas Ameliorates Hepatic Reperfusion Injury After Prolonged Cold Preservation in Isolated Perfused Rat Liver2016
Author(s)
Shimada S, Wakayama K, Fukai M, Shimamura T, Ishikawa T, Fukumori D, Shibata M, Yamashita K, Kimura T, Todo S, Ohsawa I, Taketomi A
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Journal Title
Artif Organs
Volume: 40
Issue: 12
Pages: 1128-1136
DOI
Related Report
Peer Reviewed
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[Presentation] STED imaging of super complex in mitochondrion2016
Author(s)
Iketani M, Hata N, Ishigaki M, Sugaya M, Takahashi M, Tanaka M, Hattori S, Ohsawa I
Organizer
The 13th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), The 16th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)
Place of Presentation
TKP品川ガーデンシティ(東京都品川区)
Year and Date
2016-10-30
Related Report
Int'l Joint Research
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