Elucidation of the Gene and Environment factor for Allergic Diseases using an birth cohort study

• Project/Area Number: 16H03269
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Childhood science (childhood environment science)
• Research Institution: University of Tsukuba
• Principal Investigator: Emiko Noguchi 筑波大学, 医学医療系, 教授 (40344882)
• Co-Investigator(Kenkyū-buntansha): 岡田 随象 大阪大学, 医学系研究科, 教授 (70727411)
• Research Collaborator: Ohya Yukihiro ; Morii Wataru ; Koseki Ryota
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: アレルギー / 全ゲノム関連解析 / アレルゲン感作 / 遺伝子型 / 出生コホート / GWAS

Outline of Final Research Achievements

The aim of this study was to elucidate the genetic and environmental factors associated with allergic diseases/intermediate phenotypes such as specific IgE production. We performed genotyping on samples of an birth cohort study using SNP arrays with approximately 660,000 genetic markers per person.
We confirmed association between specific IgE production against Cry j 1 and HLA-DPB1*02 allele at 5 years old (P=0.00089, OR=0.61). We also found associations between several HLA alleles and specific IgE production against allergen components at 9 years old (P < 1×10-6).

Academic Significance and Societal Importance of the Research Achievements

喘息、アトピー性皮膚炎、花粉症、食物アレルギー等のアレルギー疾患は、近年我が国において全人口の約2分の１が罹患していることが明らかとなっている。このような社会的に大きな負担となっているアレルギー疾患の予防・治療のためには「遺伝・環境要因の相互作用」を検討する研究が不可欠である。本研究ではアレルギー疾患発症の前段階であるアレルゲン特異的IgE抗体産生に関与すると考えられるHLAアレルを複数検出しており、今後、発症予測法の開発につながることが期待される。

Research Products

• [Presentation] Effect of filaggrin loss of function mutations on atopic dermatitis in young age (2018)
  • Author(s): Koseki R., Morii W., Noguchi E., Yang L., Yamamoto-Hanada K., Narita M, Saito H, & Ohya Y
  • Organizer: Tsukuba Global Science Week 2018
  • Int'l Joint Research
• [Presentation] Association between HLA class II alleles and allergen sensitization: a case control study of 544 Japanese adolescent. (2018)
  • Author(s): Morii W., Sakai A., Kidoguchi M., Miyadera H., Fujieda S., Sumazaki R., & Noguchi E
  • Organizer: Tsukuba Global Science Week 2018
  • Int'l Joint Research
• [Presentation] 遺伝子から解くアレルギーの謎 (2017)
  • Author(s): 野口恵美子
  • Organizer: 第66回日本アレルギー学術大会
  • Invited