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Development of osteoclast differentiation inhibitors based on marine natural products that act on calcium pumps

Research Project

Project/Area Number 16H03285
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomolecular chemistry
Research InstitutionKeio University

Principal Investigator

Suenaga Kiyotake  慶應義塾大学, 理工学部(矢上), 教授 (60273215)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords海洋シアノバクテリア / マクロリド配糖体 / ビセリングビアサイド / 破骨細胞分化抑制 / 人工誘導体 / 構造活性相関 / 抗マラリア活性 / リポペプチド / カルシウムポンプ / 鎖状ペプチド / マクロライド / 破骨細胞分化 / 標的分子探索 / 全合成 / ジャハナイン / 作用機構解析 / HeLa細胞 / 破骨細胞 / 標的分子 / 有機合成 / 生物活性 / クラハイン / 有機化学
Outline of Final Research Achievements

A synthetic method of artificial analogs of biselyngbyaside (BLS), a macrolide glycoside isolated from marine cyanobacteria, has been established. Since glycosylation reactions in the middle or late stage of the synthesis were difficult, sugar moiety was introduced in the early stage. The 18-membered ring construction proceeded in good yields in various cyclization precursors, thus a synthetic method for BLS analogs was established. Natural and synthetic analogs of BLS showed weak antimalarial activities. Affinity purification experiments by using biotin probes of Jahanyne (JHN), a linear lipopeptide isolated from marine cyanobacteria, have identified anti-apoptosis protein (20 kDa) as a candidate of target molecule.

Academic Significance and Societal Importance of the Research Achievements

海洋シアノバクテリアから得られたビセリングビアサイド(BLS)は、骨を溶かす破骨細胞の分化を抑制することから新しい骨粗しょう症治療薬のリード化合物として期待される。本研究によりBLS類の種々の人工誘導体を化学合成する方法を確立し、ヒト細胞への毒性を低減した誘導体を合成することができた。さらにBLS類の抗マラリア薬リード化合物としての可能性を見出した。また、リポペプチドであるジャハナインの標的候補タンパク質を見出した。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (73 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Acknowledgement Compliant: 3 results) Presentation (54 results) (of which Int'l Joint Research: 12 results,  Invited: 12 results) Remarks (2 results)

  • [Journal Article] Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium2020

    • Author(s)
      Iwasaki Keitaro、Iwasaki Arihiro、Sumimoto Shimpei、Matsubara Teruhiko、Sato Toshinori、Nozaki Tomoyoshi、Saito-Nakano Yumiko、Suenaga Kiyotake
    • Journal Title

      Journal of Natural Products

      Volume: 83 Issue: 2 Pages: 481-488

    • DOI

      10.1021/acs.jnatprod.9b01147

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta2019

    • Author(s)
      Sumimoto Shimpei、Kobayashi Masayuki、Sato Rio、Shinomiya Seiichi、Iwasaki Arihiro、Suda Shoichiro、Teruya Toshiaki、Inuzuka Toshiyasu、Ohno Osamu、Suenaga Kiyotake
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 4 Pages: 1187-1190

    • DOI

      10.1021/acs.orglett.9b00135

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata2018

    • Author(s)
      Iwasaki Arihiro、Tadenuma Takato、Sumimoto Shimpe、Shiota Ikuma、Matsubara Teruhiko、Saito-Nakano Yumiko、Nozaki Tomoyoshi、Sato Toshinori、Suenaga Kiyotake
    • Journal Title

      Journal of Natural Products

      Volume: 81 Issue: 11 Pages: 2545-2552

    • DOI

      10.1021/acs.jnatprod.8b00643

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Croissamide, a proline-rich cyclic peptide with an N-prenylated tryptophan from a marine cyanobacterium Symploca sp.2018

    • Author(s)
      Keitaro Iwasaki, Arihiro Iwasaki, Shimpei Sumimoto, Takuya Sano, Yuki Hitomi, Osamu Ohno, Kiyotake Suenaga
    • Journal Title

      Tetrahedron Letters

      Volume: 59 Issue: 42 Pages: 3806-3809

    • DOI

      10.1016/j.tetlet.2018.09.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of Jahanene and Jahanane, and Total Synthesis of the Jahanyne Family2018

    • Author(s)
      Iwasaki Arihiro、Fujimura Haruka、Okamoto Shinichiro、Kudo Takafumi、Hoshina Shizuka、Sumimoto Shimpei、Teruya Toshiaki、Suenaga Kiyotake
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 83 Issue: 17 Pages: 9592-9603

    • DOI

      10.1021/acs.joc.8b00310

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium2018

    • Author(s)
      Kanamori Yuki、Iwasaki Arihiro、Sumimoto Shimpei、Matsubara Teruhiko、Sato Toshinori、Suenaga Kiyotake
    • Journal Title

      Journal of Natural Products

      Volume: 81 Issue: 7 Pages: 1673-1681

    • DOI

      10.1021/acs.jnatprod.8b00417

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of janadolide2018

    • Author(s)
      Ojima Daisuke、Mine Hitomi、Iwasaki Arihiro、Suenaga Kiyotake
    • Journal Title

      Tetrahedron Letters

      Volume: 59 Issue: 14 Pages: 1360-1362

    • DOI

      10.1016/j.tetlet.2018.02.034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caldorin, a new polyketide from the marine cyanobacterium Caldora penicillata2018

    • Author(s)
      Shiota Ikuma、Iwasaki Arihiro、Sumimoto Shimpei、Tomoda Hiroshi、Suenaga Kiyotake
    • Journal Title

      Tetrahedron Letters

      Volume: 59 Issue: 13 Pages: 1261-1263

    • DOI

      10.1016/j.tetlet.2018.02.046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca 2+ pump inhibitor from marine cyanobacteria2018

    • Author(s)
      Sato Eisuke、Morita Maho、Ogawa Haruo、Iwatsuki Masato、Hokari Rei、Ishiyama Aki、?mura Satoshi、Iwasaki Arihiro、Suenaga Kiyotake
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Volume: 28 Issue: 3 Pages: 298-301

    • DOI

      10.1016/j.bmcl.2017.12.050

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Kanamienamide and Clarification of Biological Activity2017

    • Author(s)
      Ojima Daisuke、Iwasaki Arihiro、Suenaga Kiyotake
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 82 Issue: 23 Pages: 12503-12510

    • DOI

      10.1021/acs.joc.7b02288

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Biselyngbyaside2017

    • Author(s)
      Sato Eisuke、Sato Miho、Tanabe Yurika、Nakajima Naoya、Ohkubo Akifumi、Suenaga Kiyotake
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 82 Issue: 13 Pages: 6770-6777

    • DOI

      10.1021/acs.joc.7b00905

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.2017

    • Author(s)
      Iwasaki A, Tadenuma T, Sumimoto S, Ohshiro T, Ozaki K, Kobayashi K, Teruya T, Tomoda H, Suenaga K.
    • Journal Title

      J Nat Prod.

      Volume: 80 Issue: 4 Pages: 1161-1166

    • DOI

      10.1021/acs.jnatprod.7b00137

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and Total Synthesis of Hoshinolactam, an Antitrypanoso-mal Lactam from a Marine Cyanobacterium2017

    • Author(s)
      Hidetoshi Ogawa, Arihiro Iwasaki, Shimpei Sumimoto, Masato Iwatsuki, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Satoshi Omura, and Kiyotake Suenaga
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 4 Pages: 890-893

    • DOI

      10.1021/acs.orglett.7b00047

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of Biselyngbyolide B.2016

    • Author(s)
      Eisuke Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, and Kiyotake Suenaga
    • Journal Title

      Organic Letters

      Volume: 18 Issue: 9 Pages: 2047-2049

    • DOI

      10.1021/acs.orglett.6b00660

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Janadolide, a Cyclic Polyketide-Peptide Hybrid Possessing a t-butyl Group from an Okeania sp. Marine Cyanobacterium.2016

    • Author(s)
      Hidetoshi Ogawa, Arihiro Iwasaki, Shinpei Sumimoto, Yuki Kanamori, Osamu Ohno, Masato Iwaztsuki, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Satoshi Omura, and Kiyotake Suenaga
    • Journal Title

      Journal of Natural Products

      Volume: 79 Issue: 7 Pages: 1862-1866

    • DOI

      10.1021/acs.jnatprod.6b00171

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.2016

    • Author(s)
      Yuki Kanamori, Arihiro Iwasaki, Shinpei Sumimoto, and Kiyotake Suenaga
    • Journal Title

      Tetrahedron Letters

      Volume: 57 Issue: 37 Pages: 4213-4216

    • DOI

      10.1016/j.tetlet.2016.08.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Kanamienamide, an Enamide with an Enol Ether from the Marine Cyanobacterium Moorea bouillonii.2016

    • Author(s)
      Shimpei Sumimoto, Arihiro Iwasaki, Osamu Ohno, Kosuke Sueyoshi, Toshiaki Teruya, and Kiyotake Suenaga
    • Journal Title

      Organic Letters

      Volume: 18 Issue: 19 Pages: 9886-9894

    • DOI

      10.1021/acs.orglett.6b02364

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 海洋シアノバクテリア由来の生物活性物質2020

    • Author(s)
      末永聖武
    • Organizer
      生物資源と触媒技術に基づく食・薬・材創生コンソーシアム・第3回 食・触コンソーシアム シンポジウム、産業技術総合研究所つくばセンター
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 海洋シアノバクテリア由来の生物活性物質2020

    • Author(s)
      末永聖武、岩﨑有紘、森田真布、佐藤英祐、照屋俊明、大野修
    • Organizer
      農芸化学会2020年度大会、九州大学伊都キャンパス、シンポジウム「農芸化学会シアノバクテリアと未来を描く」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 直接的アルキン濃縮精製法を駆使した海洋シアノバクテリア由来新規リポペプチド類の単離と構造決定2020

    • Author(s)
      髙橋寛樹・岩﨑有紘・大金賢司・中尾周平・どど孝介・袖岡幹子・末永聖武
    • Organizer
      日本化学会第100春季年会(東京理科大学野田キャンパス)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 海洋鎖状リポペプチド hoshinoamide C の全合成と絶対立体配置の決定2020

    • Author(s)
      大友啓介・末永聖武・岩﨑有紘
    • Organizer
      日本化学会第100春季年会(東京理科大学野田キャンパス)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来新規鎖状ペプチド Iheyamide 類の単離と構造決定2020

    • Author(s)
      栗澤尚瑛・岩﨑有紘・末永聖武
    • Organizer
      日本化学会第100春季年会(東京理科大学野田キャンパス)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Synthetic Studies on Ikoamide2020

    • Author(s)
      末永聖武、駱永翰、岩﨑有紘
    • Organizer
      日本化学会第100春季年会(東京理科大学野田キャンパス)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来リポペプチド Jahanyne 類のアポトーシス誘導活性の作用機序解明研究2020

    • Author(s)
      保科静香・岩﨑有紘・工藤隆文・田代 悦・照屋俊明・井本正哉・末永聖武
    • Organizer
      日本化学会第100春季年会(東京理科大学野田キャンパス)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Bioactive Marine Macrolides from Marine Cyanobacteria.2019

    • Author(s)
      Maho Morita, Eisuke Sato, Osamu Ohno, and Kiyotake Suenaga
    • Organizer
      The 4th Joint Conference Keio & Kaohsiung Medical University, National Museum of Marine Biology and Aquarium, Kenting, Taiwan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 海洋天然物 jahanyne 類の全合成および結合タンパク質の同定2019

    • Author(s)
      保科静香、岩﨑有紘、藤村遥、岡本慎一朗、工藤隆文、照屋俊明、末永聖武
    • Organizer
      日本ケミカルバイオロジー学会第14回年会(ウインクあいち)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 強力な抗トリパノソーマ活性を示す海洋天然物hoshinolactam類の単離、構造決定、 全合成と生物活性2019

    • Author(s)
      岩崎有紘、小川英俊、澄本慎平、鄭丞宰、岩月正人、石山亜紀、穂刈玲、乙黒一彦、大村智、中野由美子、野崎智義、末永聖武
    • Organizer
      第61回天然有機化合物討論会(広島国際会議場)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来マクロリドの作用機構2019

    • Author(s)
      末永聖武
    • Organizer
      部科学省新学術領域研究 学術研究支援基盤形成 平成30年度先端モデル動物支援プラットフォーム成果発表会、琵琶湖ホテル
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Structure and biological activity of polyketide-peptide hybrid compounds from marine cyanobacteria2019

    • Author(s)
      Kiyotake Suenaga
    • Organizer
      The 3rd Joint Conference Keio & Kaohsiung Medical University Keio University, Yokohama
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] チアゾール含有ポリケチドtomurulineの合成研究2019

    • Author(s)
      藤村 遥・工藤千尋・大野 修・岩﨑有紘・末永聖武
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 沖縄県産海洋シアノバクテリア由来新規鎖状リポペプチドの単離と構造決定2019

    • Author(s)
      岩﨑慶太郎・岩﨑有紘・澄本慎平・末永聖武
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来の新規ペプチド hoshinoamides C-E の単離と構造2019

    • Author(s)
      塩田育万・岩﨑有紘・澄本慎平・末永聖武
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋産リポペプチドMinnamide AにおけるC-9位メチル基の合成的手法による絶対立体配置の決定2019

    • Author(s)
      小林正幸・佐藤理央・澄本慎平・四宮誠一・照屋俊明・岩﨑有紘・末永聖武
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋産シアノバクテリア由来リポペプチドMinnamide Aの合成研究2019

    • Author(s)
      佐藤理央・末永聖武・澄本慎平
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Janadolideの標的たんぱく質同定のためのプローブ合成を志向した人工類縁体の合成研究2019

    • Author(s)
      大友啓介・小島大輔・小川英俊・岩﨑有紘・末永聖武
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 沖縄県産海洋シアノバクテリアにおける新規生理活性物質の探索2019

    • Author(s)
      尾崎香織・瀬澤 大・藤村 遥・岩﨑有紘・末永聖武・照屋俊明
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋産シアノバクテリア由来の新規スタチンの単離、構造決定2019

    • Author(s)
      牧 久美子・末永聖武
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋リポペプチドJahanyne類の結合タンパク質の探索及び同定2019

    • Author(s)
      保科静香・岩﨑有紘・工藤隆文・照屋俊明・末永聖武
    • Organizer
      日本化学会第99春季年会(甲南大学岡本キャンパス)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Biological activity and synthesis of marine macrolides, biselyngbyasides.2018

    • Author(s)
      Maho Morita, Eisuke Sato, Osamu Ohno, and Kiyotake Suenaga
    • Organizer
      National Sun Yat-sen University, Kaohsiung
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structure and synthetic study of lipopeptides, isolated from marine cyanobacteria.2018

    • Author(s)
      Shimpei Sumimoto, Daisuke Ojima, Masayuki Kobayashi, Seiichi Shinomiya, Arihiro Iwasaki, Toshiaki Teruya, Kiyotake Suenaga
    • Organizer
      2018 International Conferenece on Frontier Chemistry and Life Sciences, Kaohsiung Medical University, Kaohsiung
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Isolation, structure determination, and total synthesis of bioactive compounds from marine cyanobacteria2018

    • Author(s)
      Kiyotake Suenaga
    • Organizer
      Inner Mongolia University, Hohhot
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Isolation, structure determination, and total synthesis of bioactive compounds from marine cyanobacteria2018

    • Author(s)
      Kiyotake Suenaga
    • Organizer
      Ordos Institute of Technology, Ordos
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A marine lipopeptide, minnamide A: Synthetic studies for assignment of the C-9 methyl stereochemistry.2018

    • Author(s)
      Masayuki Kobayashi, Shimpei Sumimoto, Seiichi Shinomiya, Toshiaki Teruya, Arihiro Iwasaki, Kiyotake Suenaga
    • Organizer
      30th IUPAC Symposium on the Chemistry of Natural Products, Athens, Greece
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation and Structure Determination of Four New Compounds from Marine Cyanobacteria.2018

    • Author(s)
      Ikuma Shiota, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga
    • Organizer
      30th IUPAC Symposium on the Chemistry of Natural Products, Athens, Greece
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation and structure determination of two new peptides from marine cyanobacteria.2018

    • Author(s)
      Keitaro Iwasaki, Arihiro Iwasaki, Simpei Sumimoto, Kiyotake Suenaga
    • Organizer
      30th IUPAC Symposium on the Chemistry of Natural Products, Athens, Greece
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structure and Synthetic Study of Lipopeptides, isolated from Marine Cyanobacteria.2018

    • Author(s)
      Kiyotake Suenaga
    • Organizer
      30th IUPAC Symposium on the Chemistry of Natural Products, Athens, Greece
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cytotoxicity Structure-activity Relationship and Synthesis of Biotin Probes of Marine Lipopeptide Jahanyne and Related Compounds.2018

    • Author(s)
      Shizuka Hoshina, Arihiro Iwasaki, Takafumi Kudo, Toshiaki Teruya, Kiyotake Suenaga
    • Organizer
      30th IUPAC Symposium on the Chemistry of Natural Products, Athens, Greece
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗寄生虫活性を示す海洋天然物の作用機序解明を施行した合成研究2018

    • Author(s)
      岩﨑有紘・小島大輔・小川英俊・保科静香・鄭 丞宰・岩月正人・中野由美子・石山亜紀・穂刈 玲・乙黒一彦・大村智・野崎智義・末永聖武
    • Organizer
      日本ケミカルバイオロジー学会第13回年会(東京医科歯科大学)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋性鎖状リポペプチド、Jahanyne類の構造と合成、生物活性2018

    • Author(s)
      岩﨑有紘・岡本慎一朗・藤村 遥・工藤隆文・保科静香・澄本慎平・中野由美子・野崎智義・照屋俊明・末永聖武
    • Organizer
      第60回天然有機化合物討論会(久留米シティプラザ)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来の新規ポリケチド caldorin の単離と構造2018

    • Author(s)
      塩田育万・岩﨑有紘・澄本慎平・関 怜子・小林啓介・供田 洋・末永聖武
    • Organizer
      日本化学会第98春季年会(日本大学船橋キャンパス)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 海洋リポペプチドJahanyne類の構造活性相関とビオチンプローブの合成2018

    • Author(s)
      保科静香・岩﨑有紘・工藤隆文・照屋俊明・末永聖武
    • Organizer
      日本化学会第98春季年会(日本大学船橋キャンパス)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Total Synthesis and Biological Evaluations of Biselyngbyasides2018

    • Author(s)
      SATO, Eisuke; SATO, Miho; TABANE, Yurika; NAKAJIMA, Naoya; OHKUBO, Akifumi; IWATSUKI, Masato; OGAWA, Haruo; TOYOSHIMA, Chikashi; MORITA, Maho; IWASAKI, Arihiro; SUENAGA, Kiyotake
    • Organizer
      日本化学会第98春季年会(日本大学船橋キャンパス)
    • Related Report
      2017 Annual Research Report
  • [Presentation] エナミド構造を有する11員環マクロラクトンKanamienamideの合成研究2018

    • Author(s)
      小島大輔・岩﨑有紘・末永聖武
    • Organizer
      日本化学会第98春季年会(日本大学船橋キャンパス)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規チアゾール含有ポリケチドtomurulineの合成研究2017

    • Author(s)
      藤村 遥・工藤千尋・佐名恭平・大野 修・岩崎有紘・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] ビセリングビアサイド類の合成と生物活性2017

    • Author(s)
      佐藤美帆・佐藤英祐・田辺由利香・中島修弥・大久保哲志・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗トリパノソーマ活性を有する海洋シアノバクテリア由来新規ポリケチド-ペプチドハイブリッド Hoshinolactamの単離と構造決定2017

    • Author(s)
      小川英俊・岩崎有紘・澄本慎平・穂苅 玲・石山亜紀・岩月正人・乙黒一彦・大村 智・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗トリパノソーマ活性を有する海洋シアノバクテリア由来新規ポリケチド-ペプチドハイブリッド Hoshinolactamの全合成2017

    • Author(s)
      小川英俊・岩崎有紘・澄本慎平・穂苅 玲・石山亜紀・岩月正人・乙黒一彦・大村 智・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来の新規環状デプシペプチドkohamamide類の単離と構造2017

    • Author(s)
      塩田育万・澄本慎平・岩崎有紘・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来新規リポペプチド Minnamide 類の単離と構造決定2017

    • Author(s)
      澄本慎平・四宮誠一・岩崎有紘・犬塚俊康・照屋俊明・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 海洋産リポペプチドMinnamide Aの合成研究2017

    • Author(s)
      四宮誠一・澄本慎平・岩崎有紘・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] エナミド構造を有する環状デプシペプチドKanamienamideの合成研究2017

    • Author(s)
      小島大輔・岩崎有紘・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 末端アルキン含有リポペプチドjahanyneの合成研究2017

    • Author(s)
      岡本慎一朗・岩崎有紘・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 沖縄県産海洋シアノバクテリア由来チアゾール含有ペプチドの単離と構造2017

    • Author(s)
      岩崎有紘・蓼沼隆人・大城太一・尾崎香織・澄本慎平・照屋俊明・供田 洋・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 沖縄県産海洋シアノバクテリア由来、新規鎖状デプシペプチドの単離と構造決定2017

    • Author(s)
      金森祐紀・澄本慎平・岩崎有紘・末永聖武
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ビセリングビアサイドとビセリングビオライドBの全合成と生物活性2017

    • Author(s)
      佐藤英祐、佐藤美帆、田辺由利香、中島修弥、大久保哲史、末永聖武
    • Organizer
      第59回天然有機化合物討論会(札幌)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来新規天然物の構造と生物活性2017

    • Author(s)
      岩崎有紘、小川英俊、蓼沼隆人、澄本慎平、末永聖武
    • Organizer
      日本ケミカルバイオロジー学会第12回年会(北海道大学)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Synthesis and bioactivity of marine macrolide, biselyngbyasides2016

    • Author(s)
      末永聖武
    • Organizer
      8th US-Japan Symposium 21st Century Innovations in Natural Products
    • Place of Presentation
      Honolulu (USA)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ビセリングビアサイド類の合成と生物活性2016

    • Author(s)
      佐藤英祐、田辺由利香、中島修弥、大久保哲史、末永聖武
    • Organizer
      第110回有機合成シンポジウム
    • Place of Presentation
      早稲田大学(東京都・新宿区)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来のリポペプチドの構造2016

    • Author(s)
      澄本慎平、四宮誠一、岩﨑有紘、大野修、犬塚俊康、照屋俊明、末永聖武
    • Organizer
      第58回天然有機化合物討論会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 海洋シアノバクテリア由来マクロリドの構造・合成・生物活性2016

    • Author(s)
      末永聖武
    • Organizer
      第51回天然物化学談話会
    • Place of Presentation
      湯沢東映ホテル(新潟県・湯沢町)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 海洋シアノバクテリア由来のマクロリド、ビセリングビアサイド類の生物有機化学2016

    • Author(s)
      末永聖武
    • Organizer
      新規素材探索研究会第15回セミナー
    • Place of Presentation
      フジビューホテル(神奈川県・横浜市)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 研究室web

    • URL

      http://user.keio.ac.jp/~suenaga/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 末永研究室

    • URL

      http://user.keio.ac.jp/~suenaga/

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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