Visualization and regulation of the transcription factor activity in vivo

• Project/Area Number: 16H03298
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Tohoku University (2017-2018); Kyoto University (2016)
• Principal Investigator: Abe Kentaro 東北大学, 生命科学研究科, 教授 (70462653)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 転写因子 / 記憶学習 / 発達 / 可塑性 / 生後発達 / 学習 / 転写因子活性 / 記憶・学習 / 脳機能イメージング / 遺伝子発現制御 / 神経活動 / 脳イメージング / 脳・神経 / 脳神経疾患 / 発現制御 / 神経科学 / 遺伝子

Outline of Final Research Achievements

It is well known that the expression of genes changes according to the sensory information received, learning and memory, or even to the progression of the diseases. However, the activity of the transcription factors that regulate the expression of genes is not well known. This research aimed to quantify and visualize the activity of the transcription factors in the adult brain of the animal. This research succeeded to observe the dynamic activities of the transcription factors in vivo during social interaction, sensory input and the progression of diseases.

Academic Significance and Societal Importance of the Research Achievements

動物の神経系は個体外からの情報を受けて柔軟に変化する。生後発達、記憶学習の過程や加齢や疾患により脳内の神経細胞はその状態を可塑的に変化させ、遺伝子発現を制御する転写制御因子はその過程に重要な役割を果たす。転写因子のダイナミックな活性を観察し、人為的に操作することができれば、生命現象の理解のみならず、学習の人為的促進や高次脳機能障害に対する治療法を提供することに繋がる。

Research Products

• [Presentation] Mechanisms underlying the experience-dependent development of birdsongs (2018)
  • Author(s): Kentaro Abe
  • Organizer: 第41回日本神経科学大会
• [Presentation] 鳴禽類における世代を超えた情報の口承に関わる神経機構 (2018)
  • Author(s): 安部健太郎
  • Organizer: 第89回日本動物学会
• [Presentation] 生後能力発達に影響する「生まれ」と「育ち」 (2018)
  • Author(s): 安部健太郎
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] CREBの活性化が鳴禽類の社会学習を促進する (2017)
  • Author(s): 安部健太郎
  • Organizer: 第40回日本神経科学大会
• [Presentation] 鳴禽類における世代を超えた情報の口承に関わる神経機構 (2017)
  • Author(s): 安部健太郎
  • Organizer: 生理学研究所東北研究会
• [Presentation] Transcription factor-mediated interplay of genes and environment in the social learning of vocal skills in songbirds (2016)
  • Author(s): Kentaro Abe
  • Organizer: Wiring and Functional Principles of Neural Circuits
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] CREB-mediated interplay of genes and environment in the postnatal song learning in songbirds (2016)
  • Author(s): Kentaro Abe & Dai Watanabe
  • Organizer: Society of Neuroscience annual meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2016-11-12
  • Int'l Joint Research