Biopsychological mediation factor between adolescent bullying victimization and hallucinatory experiencees: a large-scale birth cohort study

• Project/Area Number: 16H03745
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical psychology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: YAMASAKI Syudo 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (10447401)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
• Keywords: 精神病症状 / 思春期 / ストレス / バイオマーカー

Outline of Final Research Achievements

Child and adolescent bullying victimization increases the risk of experiencing hallucinatory experiences in later life. It is theoretically suggested that bullying victimization leads to hallucinatory experiences through dissociative symptoms. However, the empirical data are scarce and the biological basis is still unclear. In this study, using the large-scale adolescent longitudinal cohort data (N=3000 or more), we investigated (1) dissociation symptoms mediate between bullying victimization and hallucinatory experiences, and (2) stress hormone metabolism as the basis of dissociation symptoms.
We confirmed the mediating process of dissociative symptoms between bullying victimization and hallucinatory experiences.We also found the metabolites which related the dissociation. The results of this study suggested that the traumatic stress caused by adolescent bullying would lead dissociation symptoms, and as a result, the bio-psychological basis leading to hallucinatory experiences.

Academic Significance and Societal Importance of the Research Achievements

本研究を通じて，①いじめ被害と幻覚様体験の間を，解離が媒介することを，大規模思春期縦断コホートデータから確認した．加えて，②解離症状の基盤として，ストレスホルモン代謝と関連の強い代謝産物の存在が見出された．本研究の結果から，いじめ被害などの強いストレスによるトラウマ体験により，解離症状が引き起こされ，その結果幻覚様体験につながる一連の心理的プロセスが示唆された．解離症状の生物学的基盤として，ストレスホルモン代謝の中枢である視床下部－下垂体－副腎皮質系（HPA 系）が関わる可能性が，本研究のデータからも示唆された．

Research Products

• [Int'l Joint Research] Medical Research Council/University of Bristol(英国)
• [Int'l Joint Research] Fordham University(米国)
• [Int'l Joint Research] Manchester University(英国)
• [Int'l Joint Research] Heidelberg University(ドイツ)
• [Journal Article] Dog and Cat Ownership Predicts Adolescents’ Mental Well-Being: A Population-Based Longitudinal Study (2020)
  • Author(s): Endo Kaori、Yamasaki Syudo、Ando Shuntaro、Kikusui Takefumi、Mogi Kazutaka、Nagasawa Miho、Kamimura Itsuka、Ishihara Junko、Nakanishi Miharu、Usami Satoshi、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 17 Issue: 3 Pages: 884-884
  • DOI: 10.3390/ijerph17030884
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study (2019)
  • Author(s): Syudo Yamasaki, Shuntaro Ando, Marcus Richards, Stephani L.Hatch, Shinsuke Koike ,Shinya Fujikawa, Sho Kanata, Kaori Endo, Yuko Morimoto, Makoto Arai, Haruo Okado, Satoshi Usami, Toshiaki A.Furukawa, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
  • Journal Title: Schizophrenia Research Volume: 印刷中 Pages: 30704-7
  • DOI: 10.1016/j.schres.2018.12.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The association between changes in depression/anxiety and trajectories of psychotic-like experiences over a year in adolescence (2017)
  • Author(s): Yamasaki Syudo, Usami Satoshi, Sasaki Ryo, Koike Shinsuke, Ando Shuntaro, Kitagawa Yuko, Matamura Misato, Fukushima Masako, Yonehara Hiromi, Foo Jerome Clifford, Nishida Atsushi, Sasaki Tsukasa
  • Journal Title: Schizophrenia Research Volume: - Pages: 149-153
  • DOI: 10.1016/j.schres.2017.10.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex differences in auditory verbal hallucinations in early, middle and late adolescence: results from a survey of 17,451 Japanese students aged 12-18 years (2017)
  • Author(s): Morokuma Yoko, Endo Kaori, Nishida Atushi, Yamasaki Syudo, Ando Shuntaro, Morimoto Yuko, Nakanishi Miharu, Okazaki Yuji, Furukawa Toshi A, Morinobu Shigeru, Shimodera Shinji
  • Journal Title: BMJ Open Volume: 7 Issue: 5 Pages: e015239-e015239
  • DOI: 10.1136/bmjopen-2016-015239
  • Peer Reviewed / Open Access
• [Journal Article] Sex differences in auditory verbal hallucinations in early, middle, and late adolescence: Results from a survey of 17,451 Japanese students aged 12-18 years (2017)
  • Author(s): Morokuma Y, Endo K, Nishida A, Yamasaki S, Ando S, Morimoto Y, Nakanishi M, Okazaki Y, Furukawa TA, Morinobu S, Shimodera S
  • Journal Title: BMJ Open Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dissociation mediates the relationship between peer victimization and hallucinatory experiences among early adolescents. (2016)
  • Author(s): Yamasaki S, Ando S, Koike S, Usami S, Endo K, French P, Sasaki T, Furukawa TA, Hiraiwa-Hasegawa M, Kasai K, Nishida A
  • Journal Title: Schizophr Res Cogn Volume: 4 Pages: 18-23
  • DOI: 10.1016/j.scog.2016.04.001
  • NAID: 120006346274
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Reciprocal relationships among psychotic symptoms, suicidal behaviour and help-seeking in adolescence: Evidence from Tokyo Teen Cohort Study. Longitudinal associations between psychotic experiences and psychosis with suicidality in children and youth. (2020)
  • Author(s): Yamasaki S, Nishida A, Ando S
  • Organizer: Congress of the Schizophrenia International Society.
  • Int'l Joint Research / Invited
• [Presentation] 言語・運動発達からみた思春期精神病症状体験と自閉スペクトラム傾向：大規模出生コホートと母子手帳情報を用いた解析 (2020)
  • Author(s): 山崎修道, Sarah Sullivan, 清野知樹, 遠藤香織, 星野彩, 安藤俊太郎, 笠井清登, 長谷川眞理子, 西田淳志
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 思春期発来前後での思春期精神病症状体験と自殺関連行動・抑うつ症状の関係～思春期出生コホートによるエビデンス (2019)
  • Author(s): 山崎修道, 安藤俊太郎, 遠藤香織, 小池進介, 長谷川眞理子, 笠井清登, 西田淳志
  • Organizer: 第14回日本統合失調症学会
• [Presentation] 合理的な予防介入に向けた思春期コホート研究 母子保健と思春期精神保健を連続的にとらえた地域保健戦略 母子手帳の科学的活用 (2019)
  • Author(s): 西田 淳志, 山崎 修道, 遠藤 香織, 安藤 俊太郎
  • Organizer: 第60回日本児童青年精神医学会総会
  • Invited
• [Presentation] Dissociation mediates the relationship between peer victimization and hallucinatory experiences among early adolescents (2017)
  • Author(s): Yamasaki S, Ando S, Koike S, Usami S, Endo K, French P, Sasaki T, Furukawa TA, Hiraiwa-Hasegawa M, Kasai K, Nishida A
  • Organizer: 20th International Congress of International Society for Psychological and Social Approaches to Psychosis
  • Int'l Joint Research
• [Presentation] 思春期のこころの健康を支える周産期要因：母子手帳研究から． (2017)
  • Author(s): 山崎修道
  • Organizer: 第21回日本精神保健・予防学会学術集会
  • Invited
• [Presentation] 母体の妊娠早期糖尿病罹患と10歳児の精神病症状体験・抑うつの縦断的関連 (2017)
  • Author(s): 山崎修道・安藤俊太郎・小池進介・藤川慎也・金田渉・遠藤香織・森本裕子・宇佐美慧・長谷川眞理子・笠井清登・西田淳志
  • Organizer: 第12回日本統合失調症学会
  • Place of Presentation: 米子コンベンションセンター（鳥取県・米子市）
• [Remarks] 公益財団法人 東京都医学総合研究所 心の健康プロジェクト ウェブサイト
  • URL: http://www.igakuken.or.jp/mental-health/