| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2019: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
Calcium phosphate-based nanoparticles are useful as a delivery carrier of imaging agents and drugs to immune cells and hence would be useful in diagnosis and treatment of arteriosclerosis and aneurysm. In this study, we established a simple, rapid and safe process for the fabrication of calcium phosphate-based nanoparticles carrying imaging agents and drugs. The resulting nanoparticles were effectively taken up by immune cells without showing cytotoxicity, and demonstrated the potential for early diagnosis and treatment of arterial lesion.
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